People, culture, and society a researcher's guide to psychological studies in Hong Kong /

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Gold in irish coal : Palaeo-concentration from metalliferous groundwaters

Peer reviewedPublisher PD

Final Report on the Consequences of LHC Civil Engineering for the SPS and LEP

The excavation of the shafts and caverns for the ATLAS and CMS experiments and the transfer lines between the SPS and LHC will start whilst LEP and the SPS are running. This will be during a period when LEP should be at its peak performance and the SPS will be providing beams for LEP, fixed target physics and LHC test beams. Simulations show that movements of the machine tunnels can be expected during the excavation and it is essential that this does not affect the performance of the SPS and LEP. The predicted movements are of sufficient amplitude to prevent machine operation if no precautions are taken. This report contains the conclusions of the working group which has been studying these problems

Report on the Working Group set up to Study the Requirements for Operating the SPS within the INB Framework (INBOPS)

The convention signed with the French authorities for the LHC defines a new Installation Nucléaire de Base (INB). The LHC machine tunnel, the experiments, some buildings which cover access shafts to the machine and the SPS with its extraction lines up to the targets are all inside the new perimeter. The new convention came into effect in September 2000 and therefore the SPS fell within the new context from that time. As a consequence, SL has to operate the SPS within this new regulatory framework and a small working group was set up to look at the requirements and to estimate the resources required. The conclusions of the working group are reported in this paper

Emerging nuclear collectivity in 124-130Te

The emergence of nuclear collectivity near doubly-magic 132Sn was explored along the stable, eveneven 124−130Te isotopes. Preliminary measurements of the B(E2; 41+ → 21+) transition strengths are reported from Coulomb excitation experiments primarily aimed at measuring the g factors of the 41+ states. Isotopically enriched Te targets were excited by 198-205 MeV 58Ni beams. A comparison of transition strengths obtained is made to large-scale shell-model calculations with successes and limitations discussed

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

The leishmaniases are diseases that affect millions of people across the world, in particular visceral leishmaniasis (VL) which is fatal unless treated. Current standard of care for VL suffers from multiple issues and there is a limited pipeline of new candidate drugs. As such, there is a clear unmet medical need to identify new treatments. This paper describes the optimization of a phenotypic hit against Leishmania donovani, the major causative organism of VL. The key challenges were to balance solubility and metabolic stability while maintaining potency. Herein, strategies to address these shortcomings and enhance efficacy are discussed, culminating in the discovery of preclinical development candidate GSK3186899/DDD853651 (<b>1</b>) for VL

The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage

Background: We describe the genome of the western painted turtle, Chrysemys picta bellii, one of the most widespread, abundant, and well-studied turtles. We place the genome into a comparative evolutionary context, and focus on genomic features associated with tooth loss, immune function, longevity, sex differentiation and determination, and the species' physiological capacities to withstand extreme anoxia and tissue freezing.Results: Our phylogenetic analyses confirm that turtles are the sister group to living archosaurs, and demonstrate an extraordinarily slow rate of sequence evolution in the painted turtle. The ability of the painted turtle to withstand complete anoxia and partial freezing appears to be associated with common vertebrate gene networks, and we identify candidate genes for future functional analyses. Tooth loss shares a common pattern of pseudogenization and degradation of tooth-specific genes with birds, although the rate of accumulation of mutations is much slower in the painted turtle. Genes associated with sex differentiation generally reflect phylogeny rather than convergence in sex determination functionality. Among gene families that demonstrate exceptional expansions or show signatures of strong natural selection, immune function and musculoskeletal patterning genes are consistently over-represented.Conclusions: Our comparative genomic analyses indicate that common vertebrate regulatory networks, some of which have analogs in human diseases, are often involved in the western painted turtle's extraordinary physiological capacities. As these regulatory pathways are analyzed at the functional level, the painted turtle may offer important insights into the management of a number of human health disorders