833 research outputs found
Notes on the Threats to the Endemic Bengal Mongoose from the Nalban Fisheries Complex in West Bengal, India
A lack of current data on Bengal mongoose Herpestes palustris in India inhibits the development of conservation strategies for this endemic wetland mammal. Structured interviews were conducted to assess the threats and examine the ecological importance of the Bengal mongoose in the Nalban fisheries complex in West Bengal for four months (May to August 2017). Over half of the interviewees perceived that the Bengal mongoose faces several threats and that its population has declined over the years. The respondents said that the removal of vegetation is the main reason for the declining mongoose numbers. The ecological importance of the mongoose was apparent among most interviewees. The results suggest that the endemic Bengal mongoose faces multiple anthropogenic hazards and emphasize the critical need for conservation efforts
Optical nonlinearity and charge transfer analysis of 4-[(E)-2-(2,4,6-Trinitrophenyl) ethylidene] benzonitrile adsorbed on silver nanoparticles : Computational and experimental investigations
The search for a potential nonlinear optical (NLO) material has led to the investigation of an organic compound 4-[(E)-2-(2,4,6-Trinitrophenyl)ethylidene]benzonitrile (TEB), which has a possibility of enhancing the NLO properties by the charge transfer mechanism if metal atoms are adsorbed on it. The experimental characterization of TEB is done using Fourier Transform Infrared (FT-IR), Fr-Raman, Ultraviolet-visible (UV-Visible), Photoluminescence (PL), Thermogravimetric/Differential Thermal Analysis (TG/DTA) and Z-scan techniques. The third order NLO properties evaluated using Z-scan technique proves that the material can be used as a good optical limiter. TEB is attached with silver atoms and the theoretical studies including geometry optimization, NBO analysis and hyperpolarizability calculations are carried out. The TEB molecule with silver atoms adsorbed is found to have increased hyperpolarizability values. The charge transfer from the metal atom to the nitrile group of the molecule is evident from the Surface Enhanced Raman Scattering (SERS) spectra using the silver nanoparticles. (C) 2018 Elsevier Ltd. All rights reserved.Peer reviewe
Restraint-induced Corticosterone Secretion and Hypothalamic CRH mRNA Expression are Augmented During Acute Withdrawal from Chronic Cocaine Administration
Stress responses during cocaine withdrawal likely contribute to drug relapse and may be intensified as a consequence of prior cocaine use. The present study examined changes in stressor-induced activation of the hypothalamic–pituitary–adrenal (HPA) axis during acute withdrawal from chronic cocaine administration. Adult male Sprague–Dawley rats received daily administration of cocaine (30 mg/kg, i.p.) or saline for 14 days. Twenty-four hours after the last injection, rats in each group were sacrificed under stress-free conditions or following 30 min of immobilization. Plasma corticosterone (CORT) was measured in trunk-blood using radioimmunoassay, corticotropin-releasing hormone (CRH) mRNA levels in the paraventricularnucleus (PVN) of the hypothalamus were measured using in situ hybridization and glucocorticoid receptor (GR) protein expression in the pituitary gland and dissected brain regions was measured using Western blot analysis. Basal CRH mRNA in the PVN was unaltered as a result of prior cocaine administration. However, a significant increase in CRH mRNA was observed 90 min following the termination of restraint in cocaine withdrawn, but not saline-treated, rats. Basal CORT was also unaffected by prior cocaine administration, but the CORT response measured immediately after restraint was significantly augmented in cocaine-withdrawn rats. Differences in GR protein expression in number of regions implicated in negative feedback regulation of HPA function, including the hypothalamus, were not observed. These findings indicate that the HPA response to stressors is intensified during early withdrawal from cocaine administration and may be independent of changes in GR-mediated negative feedback
AN ASSESSMENT OF LEGALLY PROTECTED MARINE FAUNA IN CURIO TRADE – A MARKET STUDY FROM TAMIL NADU, INDIA
In an endeavor to prioritize the conservation of marine environment, species that are threatened were given protection under various Schedules of the Indian Wildlife (Protection) Act, 1972. Though the protection is sturdy on paper, marine fauna, such as sea shells, corals and sea horses are often illegally collected from their natural environment and are traded as marine curiosities. To assess those protected marine species in the curio trade in the state of Tamil Nadu, South India, certain major tourist and pilgrimage hot spots were surveyed during 2007. Among surveyed curio markets, Kanyakumari was found to have an alarming number of protected species being traded through huge number of marine curio shops. 15 species of legally protected mollusks, 10 species of corals and one sea horse species were found, along with other non-protected marine taxa in curio trade. Species protected through Schedule I were often highly priced than those under Schedule IV. The present survey suggests that protected marine species are an integral part in the growing marine curio business. High market demand, coupled with a lack of awareness and an inadequate enforcement were found to be major driving forces for the illegal marine curio trade. Awareness campaigns, along with a promotion of viable and alternate sources of income for seashell / coral collectors and strengthening of law enforcement may curtail the illegal marine curio trade
First record of the twostripe goby, Valenciennea helsdingenii (Gobiidae, Gobiiformes) from the southeast coast of India
Two specimens of Valenciennea helsdingenii (Bleeker, 1858) were collected off Punnakayal coast, from Gulf of Mannar, southeast coast of India in November 2012. The morphometric and meristic characters of the recorded specimens are described and discussed. This is the first record of the species from the Indian waters that is a range extension of its known range within the Indian Ocean
First record of the twostripe goby, Valenciennea helsdingenii (Gobiidae, Gobiiformes) from the southeast coast of India
Two specimens of Valenciennea helsdingenii (Bleeker, 1858) were collected off Punnakayal coast, from Gulf of Mannar, southeast coast of India in November 2012. The morphometric and meristic characters of the recorded specimens are described and discussed. This is the first record of the species from the Indian waters that is a range extension of its known range within the Indian Ocean
Primary transcriptomes of Mycobacterium avium subsp. paratuberculosis reveal proprietary pathways in tissue and macrophages
<p>Abstract</p> <p>Background</p> <p><it>Mycobacterium avium </it>subsp. <it>paratuberculosis </it>(MAP) persistently infects intestines and mesenteric lymph nodes leading to a prolonged subclinical disease. The <it>MAP </it>genome sequence was published in 2005, yet its transcriptional organization in natural infection is unknown. While prior research analyzed regulated gene sets utilizing defined, in vitro stress related or advanced surgical methods with various animal species, we investigated the intracellular lifestyle of MAP in the intestines and lymph nodes to understand the MAP pathways that function to govern this persistence.</p> <p>Results</p> <p>Our transcriptional analysis shows that 21%, 8% and 3% of the entire MAP genome was represented either inside tissues, macrophages or both, respectively. Transcripts belonging to latency and cell envelope biogenesis were upregulated in the intestinal tissues whereas those belonging to intracellular trafficking and secretion were upregulated inside the macrophages. Transcriptomes of natural infection and in vitro macrophage infection shared genes involved in transcription and inorganic ion transport and metabolism. MAP specific genes within large sequence polymorphisms of ancestral <it>M. avium </it>complex were downregulated exclusively in natural infection.</p> <p>Conclusions</p> <p>We have unveiled common and unique MAP pathways associated with persistence, cell wall biogenesis and virulence in naturally infected cow intestines, lymph nodes and in vitro infected macrophages. This dichotomy also suggests that in vitro macrophage models may be insufficient in providing accurate information on the events that transpire during natural infection. This is the first report to examine the primary transcriptome of MAP at the local infection site (i.e. intestinal tissue). Regulatory pathways that govern the lifecycle of MAP appear to be specified by tissue and cell type. While tissues show a "shut-down" of major MAP metabolic genes, infected macrophages upregulate several MAP specific genes along with a putative pathogenicity island responsible for iron acquisition. Many of these regulatory pathways rely on the advanced interplay of host and pathogen and in order to decipher their message, an interactome must be established using a systems biology approach. Identified MAP pathways place current research into direct alignment in meeting the future challenge of creating a MAP-host interactome.</p
A Brewster route to Cherenkov detectors.
Cherenkov detectors enable a valuable tool to identify high-energy particles. However, their sensitivity and momentum coverage are limited by the refractive index of host materials. Especially, identifying particles with energy above multiple gigaelectronvolts requires host materials with a near-unity refractive index, which are limited to bulky gas chambers. Overcoming this fundamental material limit is important for future particle detectors yet remains a long-standing challenge. Here, we propose a different paradigm for Cherenkov detectors that utilizes the broadband angular filter made from stacks of variable one-dimensional photonic crystals. Owing to the Brewster effect, the angular filter is transparent only to Cherenkov photons from a precise incident angle. Particle identification is achieved by mapping each Cherenkov angle to the peak-intensity position of transmitted photons in the detection plane. Such angular filtering effect, although decreases the photon number collected in the detection plane, enables the realization of a non-dispersive pseudo refractive index over the entire visible spectrum. Moreover, the pseudo refractive index can be flexibly designed to different values close to unity. Our angular-selective Brewster paradigm offers a feasible solution to implement compact and highly sensitive Cherenkov detectors especially in beam lines with a small angular divergence using regular dielectrics
Isolated Neurogenic Bladder Associated With Human T-Lymphotropic Virus Type 1 Infection in a Renal Transplant Patient From Central Australia: A Case Report
© 2018 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/
This author accepted manuscript is made available following 12 month embargo from date of publication (Sept 2018) in accordance with the publisher’s archiving policyHuman T-lymphotropic virus type 1 (HTLV-1) is endemic amongst the Aborigines of the Northern Territory of Australia. HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) has been associated with this infection. In general population, isolated neurogenic bladder dysfunction in HTLV-1-infected individuals without HAM/TSP has been reported, and the HTLV-1 proviral load has been found to be higher in such patients compared with asymptomatic carriers. In solid organ transplantation, few cases of HAM/TSP have been reported worldwide, but not an isolated neurogenic bladder.
Case
A 50-year-old indigenous women from Alice Springs with end stage renal disease secondary to diabetic nephropathy with no prior history of bladder dysfunction received a cadaveric renal allograft following which she developed recurrent urinary tract infections. The recipient was seropositive for HTLV-1 infection. HTLV-1 status of donor was not checked. Urodynamic studies revealed stress incontinence and detrusor overactivity without urethral intrinsic sphincter deficiency. She had no features of myelopathy. There was elevation of the serum and cerebrospinal fluid HTLV-1 proviral load. The magnetic resonance imaging myelogram was normal. Pyelonephritis was diagnosed based on clinical features, positive cultures, and renal allograft biopsy. Continuous suprapubic catheter drainage helped preventing further episodes of allograft pyelonephritis in spite of chronic colonization of the urinary tract.
Conclusion
Isolated bladder dysfunction is a rare manifestation of HTLV-1 infection and is probably associated with high proviral loads. This may adversely affect renal allograft and patient outcomes
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