Church-based social support and suicidality among African Americans and Black Caribbeans

This study explores the relationship between church-based informal social support and lifetime prevalence of suicide ideation and attempts within a representative national sample of African American and Black Caribbean adults. Characteristics of church-based social support networks, as well as emotional support and negative interaction with church members were examined in relation to lifetime suicide ideation and attempts. This study used data from the National Survey of American Life (2001–2003). Frequency of interaction with church members was positively associa- ted with suicide attempts, while subjective closeness to church members was negatively associated with suicide ideation. Emotional support, service attendance, and negative interaction with church members were unrelated to both suicide ideation and attempts. Findings are discussed in relation to research on church-based support networks, dif- ferent models linking church support and suicidality, and the mechanisms by which church-based networks deter suicide ideation and attempts.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107407/1/Church based social support Chatters et al 2011.pdfDescription of Church based social support Chatters et al 2011.pdf : Main articl

Draft Nuclear Genome Sequence of the Liquid Hydrocarbon-Accumulating Green Microalga Botryococcus braunii Race B (Showa).

Botryococcus braunii has long been known as a prodigious producer of liquid hydrocarbon oils that can be converted into combustion engine fuels. This draft genome for the B race of B. braunii will allow researchers to unravel important hydrocarbon biosynthetic pathways and identify possible regulatory networks controlling this unusual metabolism

Demonstrable Evidence of Beneficial Physical Outcomes from University Physical Education Activity Courses

Introduction: Engagement in physical activity (PA) is often dramatically reduced during the transition from high school into college. There appears to be more stability in PA patterns during the transition from college into post-graduate life. Consequently, researchers have highlighted the years in higher education as pivotal for shaping lasting PA habits. Sadly, there is a widespread lack of evidence regarding the outcomes from physical education activity courses (PEAC) offered on campuses of higher education. Thus, their overall value lacks validation. The purpose of this work was to offer evidence of outcomes from engagement in a single, semester-long university PEAC class. Methods: Students were recruited from a variety of classes. There were no directions provided to the instructors of the courses. For grouping, classes were categorized as aerobic- (aerobics, jogging, and walking) or sport-activity (badminton, pickle ball, self-defense, strength training, and ultimate frisbee). Students in the aerobic-activity arm were randomized to aerobic testing where they underwent a submaximal treadmill protocol and grip strength (GS) testing or body composition testing (air displacement plethysmography) and GS. Those in the sport-activity arm underwent vertical jump and GS testing. Students reported to the human performance lab in the first two and final two weeks of the semester. Paired t-tests were conducted to identify differences in pre-post outcomes. Values were carried forward, not dropped, when a subject failed to return at post-test. Results: A total of 46 students (age = 21.7 ± 4.1) were randomized into the aerobic (n=25; m/f = 11/14) or body composition arms (n=21; m/f = 7/14). Additionally, 45 students (age = 20.8 ± 3.2; m/f = 23/22) from sport-activity classes were enrolled. Participation in aerobic-activity classes resulted in improvements in estimated maximal aerobic ability (p = 0.030; 42.9 ± 9.9 vs. 44.6 ± 10.1). Participation also resulted in increases in GS for those allocated to both the aerobic (p = 0.010; 56.4 ± 21.5 vs. 60.3 ± 22.3) and body composition (p = 0.022; 54.1 ± 22.1 vs. 58.1 ± 24.6) arms. Participation did not result in changes in body composition (p = 0.817; 24.7 ± 8.5 vs. 24.6 ± 7.4) despite a near-significant increase in weight (p = 0.057; 152.7 ± 38.5 vs. 154.5 ± 37.7). Participation in sport-activity classes resulted in an improvement in vertical jump (p = 0.007; 18.2 ± 6.1 vs. 18.9 ± 6.0) and GS (p = 0.002; 65.3 ± 25.6 vs. 70.0 ± 27.8). Discussion: An important first step in rebutting challenges about the credibility and worthiness of PEAC offerings is evidencing beneficial outcomes. These results represent simple, but important, markers of change. Additional demonstrable evidence is needed to ascertain elements such as what outcomes are achievable, what classes are most effective classes, and what components from class support lasting change

Survey Responses From “Wellness for Life” Classes: Overall Value and Barriers, Motivators, and Motives Towards Physical Activity

Introduction: Skill-based sport activity classes were the historical trend, but greater numbers of higher education institutions now offer courses that encompass “wellness for life” concepts. The goal of these offerings is to guide students in the development of knowledge, skills, and behaviors to adopt and maintain healthful behaviors. There is a need to amass evidence of the outcomes arising from engagement in these classes. Purpose: The purpose of this work was to document outcomes from participation in a single, semester-long, university wellness for life class. Methods: Students were recruited from courses at two universities. Survey responses were collected in the first two and final two weeks of class. The survey items included identification of: engagement in regular physical activity (PA), perceptions about PA (“view of self as an exerciser”, “contentment with current PA level”, among others), and barriers, motivators, and motives towards PA. There were no intervention suggestions provided to instructors. Results: A total of 173 students (m/f/not identified = 51/118/4; age 19.6 ± 1.4) participated. When questioned, many students identified as being an “exerciser.” Some perceived “no need to change their program” (n=37) but most “wanted more regular exercise” (n=88). A lesser number of students identified as being a “non-exerciser.” Most all “wanted more regular exercise” (n=46), but two had “no desire to start a program.” At post-test, the respective numbers were: 37, 95, 41, and 3. Numbers did not always align due to incomplete survey responses. The perceived value of the class to current and future health, rated on a scale from 0 (no impact)-100 (most influential), improved pre-post class (p \u3c 0.001) from 61.7 (±24.5) to 67.8 (±23.5). The top barrier, motivator, and motive at pre-test were: “I need to do better at managing my time to exercise more often,” “If I better organized my time or schedule I could exercise more,” and “I get pleasure or enjoy sports so I exercise,” respectively. There was shuffling among the top choices from pre- to post-test, but the top barrier remained the same. The top motivator became, “If I had more time I would exercise more,” and the top motive became, “I feel less stress after I exercise.” Discussion: Evidenced by the pre-post responses, students feel that wellness for life classes have some benefit and that perception improves after experiencing the class. There appears to be consistency in those who view themselves as “exercisers” and “non-exercisers,” which might represent a precarious situation. There is constancy in the primary barrier to exercise – the socially acceptable answer – time. It is obvious that time management is a critical element for inclusion in these classes. Students may also benefit more if instructors would offer insight on the use of motivators and motives in overcoming personal barriers

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

On the Dialectics of Charisma in Marina Abramović’s The Artist is Present

While ‘charisma’ can be found in dramatic and theatrical parlance, the term enjoys only minimal critical attention in theatre and performance studies, with scholarly work on presence and actor training methods taking the lead in defining charisma’s supposed ‘undefinable’ quality. Within this context, the article examines the appearance of the term ‘charismatic space’ in relation to Marina Abramovic’s retrospective The Artist is Present at New York’s Museum of Modern Art in 2010. Here Abramovic uses this term to describe the shared space in which performer and spectator connect bodily, psychically, and spiritually through a shared sense of presence and energy in the moment of performance. Yet this is a space arguably constituted through a number of dialectical tensions and contradictions which, in dialogue with existing theatre scholarship on charisma, can be further understood by drawing on insights into charismatic leaders and charismatic authority in leadership studies. By examining the performance and its documentary traces in terms of dialectics we consider the political and ethical implications for how we think about power relations between artist/spectator in a neoliberal, market-driven art context. Here an alternative approach to conceiving of and facilitating a charismatic space is proposed which instead foregrounds what Bracha L. Ettinger calls a ‘matrixial encounter-event’: A relation of coexistence and compassion rather than dominance of self over other; performer over spectator; leader over follower. By illustrating the dialectical tensions in The Artist is Present, we consider the potential of the charismatic space not as generated through the seductive power or charm of an individual whose authority is tied to his/her ‘presence’, but as something co-produced within an ethical and relational space of trans-subjectivity

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN