Electronic system for data acquisition and control of a automotive brake test bench

Trabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Faculdade UnB Gama (FGA), 2018.With the evolution of the automotive industry, vehicles come out of the factory each time with more power and faster top speeds. Along with this enhancement in performance the concern in effectiviness of brake systems should also increase. There are already consolidated standards rules for brake system testing, this project is focused with respect to SAE J2522 regulation that addresses on brakes tests on passenger vehicles. This paper aims to study the major factors regarding brake tests and electronic instrumentation in order to develop an electronic instrument system for automation of a testbench used to perform brake tests. The major output of the project is to design an electronic system able to measure all the relevant physical data and to control the needed actuators

Criação de um framework para ajuste fino de parâmetros usando testes estatísticos

Neste trabalho, foi criado um framework para realização do ajuste fino de parâmetros em uma meta-heurística evolutiva para problemas de eficiência energética. Foi realizado o ajuste fino no Canonical Differential Evolutionary Particle Swarm Optimization (C-DEEPSO), um algoritmo de otimização criado a partir da fusão de duas outras meta-heurísticas, o Differential Evolution (DE) e o Evolutionary Particle Swarm Optimization (EPSO). Esse ajuste fino foi efetuado pelo método de corrida iterativa com ajuda de um pacote chamado iRace. Neste método, são realizadas várias simulações do algoritmo com diferentes parâmetros e são identificadas as melhores configurações possíveis com a aplicação de testes de hipóteses. Em um primeiro momento, o framework foi testado em duas funções de benchmark, as funções de Rastrigin e Rosenbrock para 30, 50 e 100 dimensões. Uma vez validada a eficácia do framework, o mesmo foi aplicado a um problema de eficiência energética de uma usina eólica offshore, com foco na redução da perda de energia. Este problema de eficiência energética possui natureza dinâmica, sendo composto por 96 instâncias, que caracterizam a discretização de 24 horas divididas entre intervalos de 15 minutos. A partir dos resultados obtidos via framework, uma comparação com o método estado da arte, o Mean-Variance Mapping Optimization (MVMO) foi realizada com uso da ferramenta DSCTool. Os resultados mostraram que o algoritmo C-DEEPSO com seus principais parâmetros ajustados obtém em média resultados otimizados mais robustos que os apresentados pelo MVMO. É evidenciado que a aplicação do C-DEEPSO com parâmetros tunados no lugar do MVMO resultaria em uma redução de perdas de 70.02MWh, energia suficiente para abastecimento de cerca de 450 residências

Microsurgical Testicular Denervation for the Treatment of Chronic Testicular Pain – Initial Results

INTRODUCTION: Chronic testicular pain remains an important challenge for urologists. Currently, the treatment plan is primarily empirical, with the first approach consisting of clinical measures. However, some patients remain in pain despite a conservative treatment protocol and, for them, it is possible to perform a surgical procedure that involves severing the scrotal and spermatic branches of the genitofemoral and ilioinguinal nerve fibers. METHODS: In our institution, 60 patients were evaluated and treated for idiopathic chronic testicular pain between January 2003 and July 2007. Priority was give to clinical treatment, which evolved from simple to more complex measures. Microsurgical treatment was performed on those who experienced no considerable pain relief (10 individuals in our study). RESULTS: Over a twenty-four-month follow-up period, 70% of patients showed complete remission and 20% exhibited partial relief from pain

Análise de aerofólios de alta sustentação para aplicação em aeronave cargueira não tripulada da equipe araero aerodesign / Analysis of high-sustainable airlines for Application in aircraft unraveled load of the araero aerodesign team

O presente trabalho desenvolveu uma metodologia de escolha de perfis de alta sustentação com base em perfis já existentes e amplamente utilizadas por equipes de aerodesign, de forma a ser aproveitada no progresso de projetos futuros da Equipe Araero Aerodesig do Ifes Campus Aracruz, além da criação de um perfil aerodinâmico de maior eficiência para a Equipe. Foram realizados cálculos estatísticos de informações fornecidas pela SAE Brasil das equipes participantes em torneios anteriores, de modo a estabelecer critérios mais apropriados ao projeto. Também se utilizaram os softwares XFLR5 para análise de coeficientes aerodinâmicos de momento, sustentação e arrasto dos perfis e o Microsoft Excel no auxílio de cálculos. Percebeu-se que a metodologia criada foi efetiva para a escolha e aplicação do perfil no projeto de 2019 da Equipe Araero no Torneio de Acesso por conceder uma estratégia criteriosa de definição dos aerofólios, além da diminuição considerável de tempo na designação dos demais parâmetros, sendo possível sua utilização em projetos futuros. O software XFLR5 se mostrou sensível aos dados fornecidos, permitindo uma melhor eficiência na análise além da fácil projeção gráfica de apresentação. Por fim, o perfil desenvolvido se apresenta como eficaz em projetos futuros da Equipe Araero e também abre oportunidades de pesquisas específicas na área de desenvolvimento de aerofólios

Fatores preditivos para resposta da Lamivudine na hepatite crônica B

BACKGROUND: Lamivudine has been shown to be an efficient drug for chronic hepatitis B (CHB) treatment. AIM: To investigate predictive factors of response, using a quantitative method with high sensitivity. METHODS: We carried out a prospective trial of lamivudine in 35 patients with CHB and evidence for viral replication, regardless to their HBeAg status. Lamivudine was given for 12 months at 300 mg daily and 150 mg thereafter. Response was considered when DNA was undetectable by PCR after 6 months of treatment. Viral replication was monitored by end-point dilution PCR. Mutation associated with resistance to lamivudine was detected by DNA sequencing in non-responder patients. RESULTS: Response was observed in 23/35 patients (65.7%) but only in 5/15 (33.3%) HBeAg positive patients. Only three pre-treatment variables were associated to low response: HBeAg (p = 0.006), high viral load (DNA-VHB >; 3 x 10(6) copies/ml) (p = 0.004) and liver HBcAg (p = 0.0028). YMDD mutations were detected in 7/11 non-responder patients. CONCLUSIONS: HBeAg positive patients with high viral load show a high risk for developing drug resistance. On the other hand, HBeAg negative patients show a good response to lamivudine even with high viremia.INTRODUÇÃO: A Lamivudina tem-se mostrado útil no tratamento da hepatite crônica pelo vírus B (HC-VHB). OBJETIVO: Investigar os fatores preditivos da resposta à Lamivudina na HC-VHB. MATERIAL E MÉTODOS: Estudo prospectivo com Lamivudina em 35 pacientes com HC-VHB e evidência de multiplicação viral, independentemente do resultado do AgHBe. Administrou-se a Lamivudina na dose diária de 300 mg por 12 meses, seguida de 150 mg diários. Critério de resposta: DNA-VHB negativo (por técnica de PCR) aos 6 meses de tratamento. Nos pacientes não respondedores, pesquisaram-se mutações associadas com resistência à Lamivudina, através do sequenciamento do DNA viral. RESULTADOS: Observou-se resposta em 23/35 pacientes (65,7%). Dos 15 pacientes com AgHBe positivo antes do tratamento, apenas 5 (33,3%) responderam. As variáveis prévias ao tratamento que puderam prever uma má resposta foram: AgHBe positivo (p = 0,006), carga viral elevada (>; 3 x 10(6) genomas/ml) (p = 0,004) e AgHBc no tecido positivo (p = 0,0028). Mutações na região YMDD foram detectadas em 7/11 pacientes não respondedores. CONCLUSÕES: Pacientes com AgHBe positivo e com alta carga viral apresentam um alto risco de desenvolver resistência à Lamivudina. Por outro lado, pacientes com AgHBe negativo, mesmo com alta carga viral, mostraram uma boa resposta à Lamivudina

Reação a drogas com eosinofilia e sintomas sistêmicos (DRESS) / Síndrome da hipersensibilidade induzida por droga (DIHS): revisão dos conceitos atuais

The Drug Reaction with Eosinophilia and Systemic Symptoms syndrome, also known as Drug Induced Hypersensitivity Syndrome presents clinically as an extensive mucocutaneous rash, accompanied by fever, lymphadenopathy, hepatitis, hematologic abnormalities with eosinophilia and atypical lymphocytes, and may involve other organs with eosinophilic infiltration, causing damage to several systems, especially to the kidneys, heart, lungs, and pancreas. Recognition of this syndrome is of paramount importance, since the mortality rate is about 10% to 20%, and a specific therapy may be necessary. The pathogenesis is related to specific drugs, especially the aromatic anticonvulsants, altered immune response, sequential reactivation of herpes virus and association with HLA alleles. Early recognition of the syndrome and withdrawal of the offending drug are the most important and essential steps in the treatment of affected patients. Corticosteroids are the basis of the treatment of the syndrome, which may be associated with intravenous immunoglobulin and, in selected cases, Ganciclovir. The article reviews the current concepts involving this important manifestation of adverse drug reaction

Solução salina hipertônica aumenta a pressão de perfusão cerebral no transplante do fígado para hepatite fulminante: resultados preliminares

During orthotopic liver transplantation for fulminant hepatic failure, some patients may develop sudden deterioration of cerebral perfusion and oxygenation, mainly due to increased intracranial pressure and hypotension, which are likely responsible for postoperative neurological morbidity and mortality. In the present study, we hypothesized that the favorable effects of hypertonic saline solution (NaCl 7.5%, 4 mL/kg) infusion on both systemic and cerebral hemodynamics, demonstrated in laboratory and clinical settings of intracranial hypertension and hemorrhagic shock resuscitation, may attenuate the decrease in cerebral perfusion pressure that often occurs during orthotopic liver transplantation for fulminant hepatic failure. METHODS: 10 patients with fulminant hepatic failure in grade IV encephalopathy undergoing orthotopic liver transplantation with intracranial pressure monitoring were included in this study. The effect on cerebral and systemic hemodynamics in 3 patients who received hypertonic saline solution during anhepatic phase (HSS group) was examined, comparing their data with historical controls obtained from surgical procedure recordings in 7 patients (Control group). The maximal intracranial pressure and the corresponding mean arterial pressure values were collected in 4 time periods: (T1) the last 10 min of the dissection phase, (T2) the first 10 minutes at the beginning of anhepatic phase, (T3) at the end of the anhepatic phase, and (T4) the first 5 minutes after graft reperfusion. RESULTS: Immediately after hypertonic saline solution infusion, intracranial pressure decreased 50.4%. During the first 5 min of reperfusion, the intracranial pressure remained stable in the HSS group, and all these patients presented an intracranial pressure lower than 20 mm Hg, while in the Control group, the intracranial pressure increased 46.5% (P < 0.001). The HSS group was the most hemodynamically stable; the mean arterial pressure during the first 5 min of reperfusion increased 21.1% in the HSS group and decreased 11.1% in the Control group (P < 0.001). During the first 5 min of reperfusion, cerebral perfusion pressure increased 28.3% in the HSS group while in the Control group the cerebral perfusion pressure decreased 28.5% (P < 0.001). Serum sodium at the end of the anhepatic phase and 3 hours after reperfusion was significantly higher in the HSS group (153.00 &plusmn; 2.66 and 149.00 &plusmn; 1.73 mEq/L) than in the Control group (143.71 &plusmn; 3.30 and 142.43 &plusmn; 1.72 mEq/L), P = 0.003 and P < 0.001 respectively. CONCLUSION: Hypertonic saline solution can be successfully used as an adjunct in the neuroprotective strategy during orthotopic liver transplantation for fulminant hepatic failure, reducing intracranial pressure while restoring arterial blood pressure, promoting sustained increase in the cerebral perfusion pressure.Neste estudo testamos a hipótese de que os efeitos benéficos decorrentes da administração da solução salina hipertônica (NaCl 7,5%, 4 mL/kg) sobre a hemodinâmica sistêmica e cerebral na hipertensão intracraniana e no choque hemorrágico, possam atenuar a diminuição da pressão de perfusão cerebral que freqüentemente acompanha o transplante do fígado para hepatite fulminante. MÉTODO: Foram estudados 10 pacientes com hepatite fulminante em encefalopatia grau IV e monitorização de pressão intracraniana submetidos ao transplante do fígado. A hemodinâmica sistêmica e cerebral de 3 pacientes que receberam solução salina hipertônica durante a fase anepática (Grupo SSH) foi analisada comparando com os dados obtidos de 7 pacientes transplantados anteriormente nas mesmas condições (Grupo Controle). Os valores de pressão intracraniana máxima e a correspondente pressão arterial média foram coletados em quatro tempos: (T1) nos últimos 10 min da fase de disseccão, (T2) nos primeiros 10 minutos da fase anepática, (T3) no final da fase anepática e (T4) nos primeiros 5 min da reperfusão RESULTADO: Imediatamente após a infusão da solução salina hipertônica a pressão intracraniana diminuiu 50,4%. Nos primeiros 5 min da reperfusão a pressão intracraniana no Grupo SSH se manteve estável e todos os pacientes apresentavam pressão intracraniana menor que 20 mmHg enquanto no Grupo Controle a pressão intracraniana aumentou 46,5% (

Hyperkalemia Accompanies Hemorrhagic Shock and Correlates with Mortality

OBJECTIVE: This study was designed to evaluate the effects of terlipressin versus fluid resuscitation with normal saline, hypertonic saline or hypertonic-hyperoncotic hydroxyethyl starch, on hemodynamics, metabolics, blood loss and short-term survival in hemorrhagic shock. METHOD: Twenty-nine pigs were subjected to severe liver injury and treated 30 min later with either: (1) 2 mg terlipressin in a bolus, (2) placebo-treated controls, (3) 4 mL/kg 7.5% hypertonic NaCl, (4) 4 mL/kg 7.2% hypertonic-hyperoncotic hydroxyethyl starch 200/0.5, or (5) normal saline at three times lost blood volume. RESULTS: The overall mortality rate was 69%. Blood loss was significantly higher in the hypertonic-hyperoncotic hydroxyethyl starch and normal saline groups than in the terlipressin, hypertonic NaCl and placebo-treated controls groups (p<0.005). Hyperkalemia (K>5 mmol/L) before any treatment occurred in 66% of the patients (80% among non-survivors vs. 22% among survivors, p=0.019). Post-resuscitation hyperkalemia occurred in 86.66% of non-survivors vs. 0% of survivors (p<0.001). Hyperkalemia was the first sign of an unsuccessful outcome for the usual resuscitative procedure and was not related to arterial acidemia. Successfully resuscitated animals showed a significant decrease in serum potassium levels relative to the baseline value. CONCLUSION: Hyperkalemia accompanies hemorrhagic shock and, in addition to providing an early sign of the acute ischemic insult severity, may be responsible for cardiac arrest related to hemorrhagic shock

Dynamic Electric Dispatch for Wind Power Plants: A New Automatic Controller System Using Evolutionary Algorithms

In this paper, we use an evolutionary swarm intelligence approach to build an automatic electric dispatch controller for an offshore wind power plant (WPP). The optimal power flow (OPF) problem for this WPP is solved by the Canonical Differential Evolutionary Particle Swarm Optimization algorithm (C-DEEPSO). In this paper, C-DEEPSO works as a control system for reactive sources in energy production. The control operation takes place in a daily energy dispatch, scheduled into 15 min intervals and resulting in 96 operating test scenarios. As the nature of the optimization problem is dynamic, a fine-tuning of the initialization parameters of the optimization algorithm is performed at each dispatch interval. Therefore, a version of the C-DEEPSO algorithm has been built to automatically learn the best set of initialization parameters for each scenario. For this, we have coupled C-DEEPSO with the irace tool (an extension of the iterated F-race (I/F-Race)) by using inferential statistic techniques. The experiments carried out showed that the methodology employed here is robust and able to tackle this OPF-like modeling. Moreover, the methodology works as an automatic control system for a dynamic schedule operation