Effect of Yugan Sanjie decoction on expressions of regulatory T cells, serum P21 protein and vascular endothelial growth factor in mice with hepatocellular carcinoma

Purpose: To investigate the effect of Yugan Sanjie decoction on the expressions of regulatory T cells (Tregs), serum P21 protein and vascular endothelial growth factor (VEGF) in mice with hepatocellular carcinoma. Methods: A total of forty specific-pathogen-free (SPF) Kunming mice were randomly assigned to four groups of 10 mice each. Except for normal control group, the other three groups were transfected with hepatoma-22 (H22) cells to establish a mouse model of liver cancer. Mice in the cyclophosphamide group was given cyclophosphamide at a dose of 20 mg/kg daily intragastrically, while those in decoction group were treated with Yugan Sanjie decoction (0.4 ml/kg/day) intraperitoneally. After 30 days of treatment, serum levels of CD4+ Th17, CD4+CD25+ Treg, Th17/Treg, TNF-α, and VEGF were determined. Results: There was lower serum level of CD4+ Th17 in the decoction group than in negative control and cyclophosphamide groups (p < 0.05). However, higher serum levels of CD4+CD25+ Treg and Th17/Treg were seen in the decoction group, relative to the negative control and cyclophosphamide groups (p < 0.05). Serum TNF-α was also markedly elevated in decoction group, when compared with negative control and cyclophosphamide groups (p < 0.05). Serum VEGF was markedly lower in decoction group than in negative control and cyclophosphamide groups, and was appreciably lower in cyclophosphamide group than in negative control group (p < 0.05). Conclusion: Yugan Sanjie decoction effectively alleviates clinical symptoms of LC, and improves immune function of mice by regulating serum levels of T lymphocytes. These findings provide scientific support for a new treatment strategy

Tendency of soil erosion dynamics by coupling radioisotopes and RUSLE model on the Southeastern Tibetan Plateau in response to climate warming and human activity

Soil erosion has created landscape problems in many parts of the world and in particular in cold regions where the sensitive permafrost conditions have changed due to climate warming. Such a case occurred in the Tibetan Plateau (TP), which has been strongly affected by global warming and human activities. Monitoring technologies, like remote sensing and field surveys were used to explore soil erosion rates in the TP, but they were limited by the resolution and meteorological disturbance factors or the spatial and time scales. Here, we present for the first time 210Pbex (excess lead-210) and 137Cs (caesium-137) data of soils from the southeastern TP (SETP) covering an area of 640,000 km2. In the permafrost-dominant areas, the results show mean soil-erosion rates in the last 56–100 years that were relatively higher (1891 t·km−2·a-1) based on 210Pbex than those based on 137Cs (1623 t·km−2·a-1). Modelling results from the Revised Universal Soil Loss Equation (RUSLE) indicate relatively high mean soil erosion rates of 4363 and 4394 t·km−2·a-1 using a period covering the last 40 or 10 years respectively. Our data suggest accelerating erosion rates on the SETP that are linked to permafrost degradation, and glacier and snow melting due to accelerating global climate warming. The increase in ground surface temperature of ∼2 °C in the last four decades has further shifted the regional hydrology, affecting the degeneration of vegetation cover and a further increase in soil-erosion rates. However, our radionuclides data also expose low erosion rates in the seasonally frozen ground at some sampling sites which indicates the complex nature of erosion trends in cold regions that require careful adaptation of soil management

Effect of Mo on the Microstructures and Mechanical Properties of the Polycrystalline Superalloy with High W Content

The effect of the Mo contents of 1.0 wt.%, 1.5 wt.%, 2.0 wt.%, and 3.0 wt.% on the microstructures and mechanical properties of the polycrystalline superalloy with a high W content was studied. The typical dendrite morphology was observed in the high-W superalloy with different Mo contents, containing γ matrix, γ′ phase, eutectic, and MC carbide. After the heat treatment, the primary MC carbides were decomposed into M6C carbides, while a needle-like topologically close-packed (TCP) phase was formed in the alloy with high Mo content, in contrast to the other three alloys with low Mo content. The Mo addition increased the lattice parameter of the γ and γ′ phases and also changed the lattice misfits of the γ and γ′ phase lattice misfits towards a larger negative. The addition of Mo improved the yield strength at room temperature due to the solid solution strengthening and coherency strengthening. The improvement of the stress rupture lives at 975 °C/225 MPa was due to the combination of the suppressed propagation of the microcracks by the carbides and a more negative misfit. When the Mo content reached 3.0 wt.%, the TCP phases formed and decreased the ultimate tensile strength and the stress rupture lives as a result

Optimal grain size distribution in gradient nano-grained nickel

Gradient nano-grained (GNG) metals are a unique class of metallic materials by manipulating the gradient size distribution, but the optimal grain size distribution producing the best strength–ductility synergy is still unclear. Here, the mechanical behavior and deformation mechanism of GNG Ni with different spatial distribution of grain size varying in the inverse Hall-Petch regime are investigated by molecular dynamics method. The results show that the GNG structure has the optimal strength–ductility synergy when the distribution of grain size gradient satisfies a linear relationship (i.e. the gradient rate n = 1). The strengthening and toughening mechanisms of the optimal GNG structure are further illustrated. It is found that the stress gradient and strain gradient in the GNG Ni with gradient rate n = 1 are the largest among different gradient structures. The optimal strength-ductility synergy in GNG structures with linear distribution of grain size is attributed to the remarkable enhancement of dislocations and the diminution of GB activities. These results would provide an insight into the mechanical performance tuning of GNG structures experimentally

Supplement Number 1

Figures of XRD, resistivity, current induced switching sequence and spin Hall conductivit