Cost-effectiveness of a nurse-based intervention (AIMS) to improve adherence among HIV-infected patients : Design of a multi-centre randomised controlled trial

Peer reviewedPublisher PD

Le guide des PMP

Le monde complexe et interconnecté d’aujourd’hui a clairement besoin de collaboration et de partenariat entre des groupes d’intérêt décloisonnés issus du milieu des affaires, des pouvoirs publics, de la société civile et du monde des sciences. Mais il n’est pas si simple d’engendrer cette collaboration. Cela nécessite de bien comprendre ce qui permet aux gens de travailler ensemble ou au contraire ce qui les en empêche. Il faut de la patience, du temps et un engagement de la part des dirigeants. Toutefois, sous réserve de l’état d’esprit qui convient et en utilisant les étapes et les outils pratiques proposés dans ce guide, on peut accomplir bien des choses pour libérer le potentiel de collaboration et d’innovation des gens au service du progrès social et environnemental. Le guide intègre des connaissances pratiques et des fondements et principes théoriques. Si des méthodes et outils pratiques de facilitation sont essentiels, il est encore plus important de pouvoir concevoir des processus autour de la dynamique qui sous-tend les systèmes humains, les apports de force, les conflits et le travail d’équipe. Nous nous inspirons de divers courants de pensée pour offrir aux facilitateurs et aux parties prenantes des partenariats une série de principes et de modèles conceptuels pour les aider à engendrer des processus de changement créatifs et critiques

Ferrocene-Decorated Hyperbranched Poly(aroxycarbonylphenylene)s: Synthesis, Light Refraction, Photopatterning and Precursor to Magnetic Ceramics

Ferrocene-decorated hyperbranched poly[1,3,5-tri(aroycarbonyl)phenylene]s (hb-PTACPs) are prepared in moderate yields with high molecular weights by one-pot polycyclotrimerization of 4,4'-isopropylidenediphenyl bipropiolate with 4-(ferrocenylmethyl)phenyl propiolate in reflux dimethylformamide. All the polymers are soluble and film-forming. They enjoy high thermal stability and lost little of their weight when heated to 300 °C under nitrogen. Thin solid films of the organometallic polymers shows high refractive indices (RI = 1.7038–1.6295) in the wavelength region of 400–1,700 nm. Ceramization of the organometallic hb-PTACPs at high temperature under inert atmosphere gives iron nanoparticles with high magnetizabilities. The organometallic polymers are readily cross-linked under UV irradiation and pyrolysis of the patterned polymer films produces magnetic ceramic patterns with good shape retention

Vegetation recovery in tidal marshes reveals critical slowing down under increased inundation

A declining rate of recovery following disturbance has been proposed as an important early warning for impending tipping points in complex systems. Despite extensive theoretical and laboratory studies, this \u27critical slowing down\u27 remains largely untested in the complex settings of real-world ecosystems. Here, we provide both observational and experimental support of critical slowing down along natural stress gradients in tidal marsh ecosystems. Time series of aerial images of European marsh development reveal a consistent lengthening of recovery time as inundation stress increases. We corroborate this finding with transplantation experiments in European and North American tidal marshes. In particular, our results emphasize the power of direct observational or experimental measures of recovery over indirect statistical signatures, such as spatial variance or autocorrelation. Our results indicate that the phenomenon of critical slowing down can provide a powerful tool to probe the resilience of natural ecosystems

Updated estimate of aerosol direct radiative forcing from satellite observations and comparison against the Hadley Centre climate model

The fourth assessment report of the Intergovernmental Panel on Climate Change (IPCC) includes a comparison of observation-based and modeling-based estimates of the aerosol direct radiative forcing. In this comparison, satellite-based studies suggest a more negative aerosol direct radiative forcing than modeling studies. A previous satellite-based study, part of the IPCC comparison, uses aerosol optical depths and accumulation-mode fractions retrieved by the Moderate Resolution Imaging Spectroradiometer (MODIS) at collection 4. The latest version of MODIS products, named collection 5, improves aerosol retrievals. Using these products, the direct forcing in the shortwave spectrum defined with respect to present-day natural aerosols is now estimated at −1.30 and −0.65 Wm−2 on a global clear-sky and all-sky average, respectively, for 2002. These values are still significantly more negative than the numbers reported by modeling studies. By accounting for differences between present-day natural and preindustrial aerosol concentrations, sampling biases, and investigating the impact of differences in the zonal distribution of anthropogenic aerosols, good agreement is reached between the direct forcing derived from MODIS and the Hadley Centre climate model HadGEM2-A over clear-sky oceans. Results also suggest that satellite estimates of anthropogenic aerosol optical depth over land should be coupled with a robust validation strategy in order to refine the observation-based estimate of aerosol direct radiative forcing. In addition, the complex problem of deriving the aerosol direct radiative forcing when aerosols are located above cloud still needs to be addressed

The Ursinus Weekly, October 24, 1969

Six seniors vie for Homecoming Queen • Ursinus students, faculty observe nationwide Vietnam Moratorium; Hundreds attend night procession • President\u27s statement • Editorial: A day of moratorium, a lifetime of commitment • Focus: Vicki Van Horn • Byerly probes Moratorium, SFARC • The psychiatrist is in • In our mail bag: Sig Nu replies; Moratorium Day; Orientation • Interaction • Deprived students complain • Faculty portrait: Mr. Ehrlich • In the spotlight: Mr. Prindle, custodian • Administration answers: Scholarship cancellations • Sisters speak • Wailing wall shouts • Better homes • Student body rejects current US draft system • Ursinus on display for annual Parents Day fete • Ursinus hosts studies group • Bill Brown elected frosh president • Ten Ursinus seniors selected for \u2770 Who\u27s Who rating • Late Ursinus pass downs Mules • Bear football tide turning • Bakermen even record; Team called balanced • Harriers cop 28th straight • Soph phenom Cash leads Bearettes • October 15, 1969: Vietnam Moratorium at Ursinushttps://digitalcommons.ursinus.edu/weekly/1150/thumbnail.jp

Development of a multi-locus sequence typing scheme for Laribacter hongkongensis, a novel bacterium associated with freshwater fish-borne gastroenteritis and traveler's diarrhea

<p>Abstract</p> <p>Background</p> <p>Laribacter hongkongensis is a newly discovered, facultative anaerobic, Gram-negative, motile, sea gull-shaped rod associated with freshwater fish borne gastroenteritis and traveler's diarrhea. A highly reproducible and discriminative typing system is essential for better understanding of the epidemiology of <it>L. hongkongensis</it>. In this study, a multilocus sequence typing (MLST) system was developed for <it>L. hongkongensis</it>. The system was used to characterize 146 <it>L. hongkongensis </it>isolates, including 39 from humans and 107 from fish.</p> <p>Results</p> <p>Fragments (362 to 504 bp) of seven housekeeping genes were amplified and sequenced. Among the 3068 bp of the seven loci, 332 polymorphic sites were observed. The median number of alleles at each locus was 34 [range 22 (<it>ilvC</it>) to 45 (<it>thiC</it>)]. All seven genes showed very low <it>d</it>_<it>n</it>/<it>d</it>_{<it>s </it>}ratios of < 0.04, indicating that no strong positive selective pressure is present. A total of 97 different sequence types (STs) were assigned to the 146 isolates, with 80 STs identified only once. The overall discriminatory power was 0.9861. eBURST grouped the isolates into 12 lineages, with six groups containing only isolates from fish and three groups only isolates from humans. Standardized index of association (<it>I</it>^<it>S</it>_<it>A</it>) measurement showed significant linkage disequilibrium in isolates from both humans and fish. The <it>I</it>^<it>S</it>_{<it>A </it>}for the isolates from humans and fish were 0.270 and 0.636, indicating the isolates from fish were more clonal than the isolates from humans. Only one interconnected network (<it>acnB</it>) was detected in the split graphs. The P-value (P = 0) of sum of the squares of condensed fragments in Sawyer's test showed evidence of intragenic recombination in the <it>rho, acnB </it>and <it>thiC </it>loci, but the P-value (P = 1) of maximum condensed fragment in these gene loci did not show evidence of intragenic recombination. Congruence analysis showed that all the pairwise comparisons of the 7 MLST loci were incongruent, indicating that recombination played a substantial role in the evolution of <it>L. hongkongensis</it>. A website for <it>L. hongkongensis </it>MLST was set up and can be accessed at <url>http://mlstdb.hku.hk:14206/MLST_index.html</url>.</p> <p>Conclusion</p> <p>A highly reproducible and discriminative MLST system was developed for <it>L. hongkongensis</it>.</p