Informe de la gestión y estrategias de la empresa Chester (industria c60202) en el simulador de negocios Capsim

El presente documento muestra el análisis y evolución de la toma de decisiones de la empresa Chester, que forma parte de la industria de los sensores, dentro de un ambiente de simulación en la plataforma Capsim. Se plantean los objetivos estratégicos, los principales indicadores de desempeño monitoreados a través de la herramienta de cuadro de mando integral y la definición de la estrategia que se siguió para cumplir con los objetivos

Polymeric Prosthesis as Acoustic, Pressure, Temperature, and Light Sensor Fabricated by Three-Dimensional Printing

There have been new developments in prosthetic technology over the past 30 years, and the union of bionics and prosthetics has improved mobility and aesthetics, however, a person who lacks a limb will have to continue without a valuable sense, touch. As a result of stimulation of the receptors under the skin and subcutaneous tissue, touch is sensitive to mechanical stimuli and stimuli that produce heat, cold, and pain. In this chapter, the results presented include the stages of design, construction, and characterization of an ear prosthesis manufactured with a 3D printer in polyvinylidene fluoride (PVDF), which is a biocompatible and ferroelectric smart material (exhibits piezoelectric and pyroelectric properties). Thus, the behavior of the prosthesis in response to external stimuli such as pressure, heat, cold, acoustic waves, and light is presented, thereby, extending the purpose of a prosthesis to the area of sensory perception

Subchasis de integración modular para el despliegue de antenas en un Cubesat

El presente artículo propone un sistema de despliegue de antenas para Cubesat por medio de una línea de pesca, basado en un subchasis de integración que permite tener un mecanismo modular, fácil de instalar, con un circuito de despliegue activado por una señal modulada por ancho de pulso (Pulse Width Modulation - PWM), el cual evita el uso de resistencias de potencia y ofrece mejoras en tamaño, peso, consumo de potencia, confiabilidad y facilidad de ensamble

School Management to Improve Educational Quality in Ecuadorian Basic Education

La presente investigación tuvo como objetivo analizar la relación entre la gestión escolar y la calidad educativa en instituciones de educación básica de la provincia de Pichincha, Ecuador. Se utilizó un enfoque cuantitativo con un diseño descriptivo y correlacional. Se aplicaron encuestas a una muestra representativa de directivos, docentes y padres de familia, complementadas con observaciones y análisis documental. Los resultados mostraron correlaciones positivas y significativas entre las variables de gestión escolar (liderazgo directivo, planificación estratégica, gestión de recursos y participación de la comunidad) y las variables de calidad educativa (calidad de la enseñanza y rendimiento académico). La participación de la comunidad educativa fue el factor de gestión escolar que presentó la correlación más alta con la calidad de la enseñanza. Se concluye que una gestión escolar efectiva, con énfasis en la participación de todos los actores involucrados, contribuye a mejorar la calidad educativa. Se recomienda fortalecer la formación en gestión escolar, implementar modelos de gestión participativos y orientados a la mejora continua, promover la participación comunitaria, asignar adecuadamente los recursos y establecer mecanismos de seguimiento y evaluación.This research aimed to analyze the relationship between school management and educational quality in basic education institutions in the province of Pichincha, Ecuador. A quantitative approach with a descriptive and correlational design was used. Surveys were applied to a representative sample of principals, teachers, and parents, complemented by observations and document analysis. The results showed positive and significant correlations between school management variables (principal leadership, strategic planning, resource management, and community participation) and educational quality variables (teaching quality and academic performance). Community participation was the school management factor that showed the highest correlation with teaching quality. It is concluded that effective school management, with an emphasis on the participation of all stakeholders, contributes to improving educational quality. It is recommended to strengthen training in school management, implement participatory management models oriented toward continuous improvement, promote community participation, adequately allocate resources, and establish monitoring and evaluation mechanisms

Obstetric and Perinatal Outcomes after Very Early Preterm Premature Rupture of Membranes (PPROM)-A Retrospective Analysis over the Period 2000-2020

Background and Objectives: Pre-term premature rupture of membranes (PPROM) responds for one third of preterm births, and it is associated with other complications that increase the risk of maternal or fetal poor outcome. To reduce uncertainty and provide accurate information to patients, the analysis of the large series is of great importance. In order to learn about the evolution over the time of the obstetric and perinatal outcomes in cases of PPROM at, or before, 28 weeks (very early PPROM) managed with an expectant/conservative protocol, we have designed the present study. Materials and Methods: We retrospectively studied all cases of very early PPROM attended in Malaga University Regional Hospital from 2000 to 2020. Results: Among 119,888 deliveries assisted, 592 cases of PPROM occurred in pregnancies at or before 28 weeks (0.49% of all deliveries, 3.9% of all preterm births and 12.9% of all cases of PPROM). The mean duration of the latency period between PPROM and delivery was 13.5 days (range 0 to 88 days), enlarging over the years. The mean gestational age at delivery was 27 weeks (SD 2.9; range 17-34). The proportion of cesarean deliveries was 52.5%. The overall perinatal mortality rate was 26.5%, decreasing over the period with a significant correlation Pearson's coefficient -0.128 (p < 0.05). Conclusions: In the period 2000-2020, there was an improvement in the outcomes of very early PPROM cases and perinatal mortality showed a clear trend to decrease.This publication was financed with funds from the University of Malaga

N-substituted Aminobiphenyl Palladacycles Stabilized by Dialkylterphenyl Phosphanes: Preparation and Applications in C[sbnd]N Cross-coupling Reactions

Neutral and cationic N-methyl- and N-phenyl-2-aminobiphenyl methanesulfonate palladacycles stabilized with dialkylterphenyl phosphanes have been prepared and characterized. Neutral structures are favored with the less bulky phosphane PMe2ArXyl2, L1, while more sterically demanding ligands PiPr2ArXyl2, L3, and PCyp2ArXyl2 (Cyp = cyclopentyl), L4, lead to cationic complexes in which the phosphane exhibits a bidentate κ1-P, η1-Carene coordination mode involving one of the ipso carbon atoms of a flanking terphenyl aryl ring. The complexes were evaluated for activity in C[sbnd]N cross-coupling reactions and [Pd(N-methyl-2-aminobiphenyl)L4](OMs) (OMs = mesylate) was identified as the most efficient precatalyst, facilitating the coupling of aryl chlorides with secondary and primary amines and indoles.Ministerio de Economía y Competitividad CTQ2017-82893-C2-2-RJunta de Andalucía US-126226

Evaluación del uso de microorganismos de montaña activados en el cultivo de rosas, Zinacantán, Chiapas, México

The research was carried out in the municipality of Zinacantán, Chiapas, Mexico, in an area of rose’s production in plastic greenhouses, located at 16° 45′ 35″ N latitude, 92° 43′ 20″ W and at an altitude of 2162 masl. The climate is dub-humid temperate with rains in summer, the temperature reaches an average of 21 °C and the accumulated annual average precipitation is 599 mm. The objective of this study was to evaluate the effect on plant growth of Activated Mountain Microorganisms (MMA) sprayed under two doses (10 % and 20 %) and two spraying frequencies (every 8 and every 15 days). The four treatments were evaluated under the conventional rose crop management, and one control of conventional crop management and another control of ecological crop management were included. The six treatments were set up in a completely randomized design, each treatment consisting of a seedbed, where two rows of rose plants were planted under a three-point planting system, each bed containing a total of 530 plants. The results indicate that the bio-fertilizer MMA at doses of 20 % sprayed every 15 days, and the MMA at doses of 20 % sprayed every 8 days were statistically superior, for stem length, stem diameter, number of leaves, length of leaves, width of leaves, flower size, and shelf life. Therefore, it is concluded that MMA at 20 % dose improves rose production indicators under greenhouse conditions.La investigación se desarrolló en el municipio de Zinacantán, Chiapas, México, en invernaderos de producción de rosas, localizado a 16° 45′ 35″ latitud norte, 92° 43′ 20″, longitud oeste y a una altitud de 2.162 msnm.  El clima de esta región es templado, subhúmedo, con lluvias en verano, con una temperatura media de 21 °C y una precipitación media anual acumulada de 599 mm. El objetivo de este estudio fue evaluar el efecto en el crecimiento de la planta de la utilización de microorganismos de montaña activados (MMA), asperjados bajo dos dosis (10% y 20 %) y dos frecuencias de aplicación (cada 8 y cada 25 días). Los tratamientos se evaluaron bajo el manejo convencional de rosas de la región, y se incluyéron un testigo de manejo convencional y un testigo de manejo ecológico, Los seis tratamientos se expusieron en un diseño completamente al azar, cada uno constituido por una cama de siembra, donde se sembraron dos filas de plantas de rosas bajo un sistema de plantación de tres bolillos; y cada cama presentó un total de 530 plantas. Los resultados indican que los tratamientos de uso del biofertilizante MMA en manejo convencional al 20 % cada 15 días y el tratamiento de MMA al 20% cada 8 días manejado de forma orgánica, fueron estadísticamente mejores para las variables: longitud del tallo, diámetro del tallo, número de hojas, largo de hojas, ancho de hojas, tamaño de la flor y mayor vida de anaquel. Se concluye que la dosis de 20 % de MMA favorece los indicadores de producción de rosas bajo condiciones de invernadero

DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints

Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive and frequent malignancy, but it is rare in the epithelium of the mammary gland. The mechanisms leading to SQM in the lung have been very poorly investigated. We have studied this issue on human freshly isolated cells and organoids. Here we show that human lung or mammary cells strikingly undergo SQM with polyploidisation when they are exposed to genotoxic or mitotic drugs, such as Doxorubicin or the cigarette carcinogen DMBA, Nocodazole, Taxol or inhibitors of Aurora-B kinase or Polo-like kinase. To note, the epidermoid response was attenuated when DNA repair was enhanced by Enoxacin or when mitotic checkpoints where abrogated by inhibition of Chk1 and Chk2. The results show that DNA damage has the potential to drive SQM via mitotic checkpoints, thus providing novel molecular candidate targets to tackle lung SCC. Our findings might also explain why SCC is frequent in the lung, but not in the mammary gland and why chemotherapy often causes complicating skin toxicity