Mean-field and two-body nuclear effects in inclusive electron scattering on argon, carbon, and titanium: The superscaling approach

We compare the predictions of the superscaling approach (SuSAv2) model including two-particle two-hole meson-exchange currents with the recent JLab data for inclusive electron scattering on three different targets (C, Ar, and Ti). The agreement is very good over the full energy spectrum, with some discrepancy seen only in the deep inelastic region. The 2p2h response, peaked in the dip region between the quasielastic and Δ-resonance peak, is essential to reproduce the data. We also analyze the kF (Fermi momentum) dependence of the data in terms of scaling of the second kind, showing that the 2p2h response scales very differently from the quasielastic one, in full accord with what is predicted by the model. The results represent a valuable test of the applicability of the model to neutrino scattering processes on different nuclei.Spanish Ministerio de Economia y Competitividad y ERDF (European Regional Development Fund) FIS2017-88410-PJunta de Andalucía FQM160U.S. Department of Energy United States Department of Energy (DOE), DE-FC0294ER4081

Oxidative stress parameters and antioxidants in patients with bipolar disorder: Results from a meta-analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls

Abstract Objective: To investigate oxidative stress markers and antioxidants in bipolar disorder (BD). Methods: Electronic MEDLINE/PubMed/Cochrane-Library/Scopus/TripDatabase search until 06/30/2019 for studies comparing antioxidant or oxidative stress markers between BD and healthy controls (HCs). Standardized mean differences (SMD) and 95% confidence intervals (CIs) were calculated for ≥3 studies. Results: Forty-four studies (n = 3,767: BD = 1,979; HCs = 1,788) reported on oxidative stress markers malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARS), and total nitrites; antioxidants glutathione (GSH), uric acid, and zinc; or antioxidantenhancing enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and GSH-transferase (GST). Compared with HCs, BD was associated with higher GST (P = .01), CAT (P = .02), nitrites (P < .0001), TBARS (P < .0001), MDA (P = .01), uric acid (P < .0001), and lower GSH (P = .006), without differences in SOD, GPX, and zinc. Compared to HCs, levels were higher in BD-mania for TBARS (P < .0001) and uric acid (P < .0001); in BD-depression for TBARS (P = .02); and BD-euthymia for uric acid (P = .03). Uric acid levels were higher in BD-mania vs BD-depression (P = .002), but not vs BD euthymia. TBARS did not differ between BD-mania and BD-depression. Medication-free BD-mania patients had higher SOD (P = .02) and lower GPX (P < .0001) than HCs. After treatment, BD did not differ from HCs regarding SOD and GPX. Conclusions: Beyond a single biomarker of oxidative stress, the combination of several parameters appears to be more informative for BD in general and taking into account illness polarity. BD is associated with an imbalance in oxidative stress with some phase-specificity for uric acid and TBARS and possible treatment benefits for SOD and GPX. Future studies should take into account confounding factors that can modify oxidative stress status and simultaneously measure oxidative stress markers and antioxidants including different blood sources

Charged-current inclusive neutrino cross sections in the SuperScaling model

SuperScaling model (SuSA) predictions to neutrino-induced charged-current π+ production in the Δ-resonance region are explored under MiniBooNE experimental conditions. The SuSA charged-current π+ results are in good agreement with data on neutrino flux-averaged double-differential cross sections. The SuSA model for quasielastic scattering and its extension to the pion production region are used for predictions of charged-current inclusive neutrino- nucleus cross sections. The contribution of two-particle-two-hole vector meson-exchange current excitations is also considered within a fully relativistic model. Results are compared with the T2K experimental data for inclusive scattering.España, DGI y Fundación FEDER FIS2011-28738-C02-01, FPA2013-41267Junta de Andalucía CSD2007-0004

Final state interactions in semi-inclusive neutrino-nucleus scattering: Applications to the T2K and MINERνA experiments

We present a complete comparison of semi-inclusive νμ−12C cross section measurements by T2K and MINERνA collaborations with the predictions from the SuSAv2-MEC model implemented in the neutrino-nucleus event generator GENIE and an unfactorized approach based on the relativistic distorted wave impulse approximation. Results, that include cross sections as function of the final muon and proton kinematics and correlations between both, show that the agreement with data obtained by the relativistic distorted wave impulse approximation approach, that accounts for final-state interactions, matches or improves GENIE-SuSAv2 predictions for very forward angles where scaling violations are relevant.Ministerio de Ciencia e Innovación PID2020–114687-GB-100 and RTI2018-098868-B-I00Junta de Andalucía FQM160, SOMM17/61015/UGR and P20-01247University of Turin BARM-RILO-21Government of Madrid and Complutense University PR65/19–2243

Automated axial right ventricle to left ventricle diameter ratio computation in computed tomography pulmonary angiography

Automated medical image analysis requires methods to localize anatomic structures in the presence of normal interpatient variability, pathology, and the different protocols used to acquire images for different clinical settings. Recent advances have improved object detection in the context of natural images, but they have not been adapted to the 3D context of medical images. In this paper we present a 2.5D object detector designed to locate, without any user interaction, the left and right heart ventricles in Computed Tomography Pulmonary Angiography (CTPA) images. A 2D object detector is trained to find ventricles on axial slices. Those detections are automatically clustered according to their size and position. The cluster with highest score, representing the 3D location of the ventricle, is then selected. The proposed method is validated in 403 CTPA studies obtained in patients with clinically suspected pulmonary embolism. Both ventricles are properly detected in 94.7% of the cases. The proposed method is very generic and can be easily adapted to detect other structures in medical images

Meson-exchange currents and quasielastic predictions for charged-current neutrino-12C scattering in the superscaling approach

We evaluate and discuss the impact of meson-exchange currents (MECs) on charged-current quasielastic neutrino cross sections. We consider the nuclear transverse response arising from two-particle two-hole states excited by the action of electromagnetic, purely isovector meson-exchange currents in a fully relativistic framework based on the work by the Torino Collaboration [A. D. Pace, M. Nardi, W. M. Alberico, T. W. Donnelly, and A. Molinari, Nucl. Phys. A726, 303 (2003)]. An accurate parametrization of this MEC response as a function of the momentum and energy transfers involved is presented. Results of neutrino-nucleus cross sections using this MEC parametrization together with a recent scaling approach for the one-particle one-hole contributions (named SuSAv2) are compared with experimental data.DGI FIS2011-28738-C02-0Junta de Andalucía QM-160U.S. Department of Energy DE- SC001109DGI FIS2011-24149Junta de Andalucía FQM22

Constraints in modeling the quasielastic response in inclusive lepton-nucleus scattering

We show that the quasielastic (QE) response calculated with the superscaling approach (SuSAv2) model, that relies on the scaling phenomenon observed in the analysis of (e,e′) data and on the relativistic mean-field theory, is very similar to that from a relativistic distorted-wave impulse approximation model when only the real part of the optical potentials is employed. The coincidence between the results from these two completely independent approaches, which satisfactorily agree with the inclusive data, reinforces the reliability of the quasielastic predictions stemming from both models and sets constraints for the QE response. We also study the low-energy and momentum-transfer region of the inclusive response by confronting the results of the relativistic mean-field model with those of the Hartree-Fock continuum random-phase approximation model, which accounts for nuclear long-range correlations. Finally, we present a comparison of our results with the recent Jefferson Laboratory (JLab) (e,e′) data for argon, titanium, and carbon, finding good agreement with the three data sets.Spanish Ministerio de Economia y Competitividad and European Regional Development Fund) FIS2017-88410-PJunta de Andalucia FQM 160, SOMM17/6105/UGRConsolider-Ingenio 2000 program CPAN (CSD2007-0042)Spanish Government (FPA2015-65035P and RTI2018-098868-B-I00

Evaluating the optimal number of burr-holes for treating chronic subdural haematomas: good results from a single burr-hole?

Introduction. Chronic subdural haematomas (cSDH) are one of the most common types of traumatic intracranial lesion. Burr-hole craniostomy followed by closed-system drainage has become the treatment of choice. However, there is no definitive indication as to the number of burr-holes needed. Our aim was to to assess clinical and radiological outcomes taking into account the number of burr-holes made.Material and methods. A retrospective single-centre-study was performed including patients treated for cSDH by performing burr-hole craniostomy from 2012 to 2018. After collecting data regarding demographics, comorbidities, and clinical and radiological records, haematomas were grouped depending on the number of burr-holes made (Group 1: single burr-hole; Group 2: double burr-holes). Clinical and radiological outcomes were statistically compared between groups, as well as the main complications.Results. After collecting 171 patients, 205 cSDHs were analysed. 173 were treated with a single burr-hole (we called these Group 1) and 32 with double burr-holes (Group 2). No differences in preoperative characteristics were found between the groups, except for diabetes mellitus and previous antiplatelet/anticoagulation treatment. No radiological differences were found regarding haematoma volume (p = 0.7) or thickness (p = 0.3). Surgical site infection (p = 0.13), recurrence (p = 0.6), acute rebleeding (p = 0.25) and mortality (p = 0.94) were assessed without evidencing statistically significant differences. At the time of hospital discharge, most patients showed a remarkable clinical improvement, regardless of the number of burr-holes made (p = 0.7).Conclusions. This study suggests that cSDH can be efficiently evacuated by a single burr-hole craniostomy, a less invasive and shorter surgical procedure with quite good clinical outcomes and a low rate of complications

Implementation and performance of automated software to compute the RV/LV diameter ratio from CT pulmonary angiography images

Objective: The aim of this study was to prospectively test the performance and potential for clinical integration of software that automatically calculates the right-to-left ventricular (RV/LV) diameter ratio from computed tomography pulmonary angiography images. Methods: Using 115 computed tomography pulmonary angiography images that were positive for acute pulmonary embolism, we prospectively evaluated RV/LV ratio measurements that were obtained as follows: (1) completely manual measurement (reference standard), (2) completely automated measurement using the software, and (3 and 4) using a customized software interface that allowed 2 independent radiologists to manually adjust the automatically positioned calipers. Results: Automated measurements underestimated (P < 0.001) the reference standard (1.09 [0.25] vs1.03 [0.35]). With manual correction of the automatically positioned calipers, the mean ratio became closer to the reference standard (1.06 [0.29] by read 1 and 1.07 [0.30] by read 2), and the correlation improved (r = 0.675 to 0.872 and 0.887). The mean time required for manual adjustment (37 [20] seconds) was significantly less than the time required to perform measurements entirely manually (100 [23] seconds). Conclusions: Automated CT RV/LV diameter ratio software shows promise for integration into the clinical workflow for patients with acute pulmonary embolism

Metabolomic profile of neuroendocrine tumors (NETs) identifies methionine, porphyrin and tryptophan metabolism as key dysregulated pathways associated with patient survival

Objective: Metabolic profiling is a valuable tool to characterize tumor biology but remains largely unexplored in neuroendocrine tumors (NETs). Our aim was to comprehensively assess the metabolomic profile of NETs and identify novel prognostic biomarkers and dysregulated molecular pathways.Design and Methods: Multiplatform untargeted metabolomic profiling (GC-MS, CE-MS, and LC-MS) was performed in plasma from 77 patients with G1-2 extra-pancreatic NETs enrolled in the AXINET trial (NCT01744249) (study cohort) and from 68 non-cancer individuals (control). The prognostic value of each differential metabolite (n = 155) in NET patients (P < .05) was analyzed by univariate and multivariate analyses adjusted for multiple testing and other confounding factors. Related pathways were explored by Metabolite Set Enrichment Analysis (MSEA) and Metabolite Pathway Analysis (MPA).Results: Thirty-four metabolites were significantly associated with progression-free survival (PFS) (n = 16) and/or overall survival (OS) (n = 27). Thirteen metabolites remained significant independent prognostic factors in multivariate analysis, 3 of them with a significant impact on both PFS and OS. Unsupervised clustering of these 3 metabolites stratified patients in 3 distinct prognostic groups (1-year PFS of 71.1%, 47.7%, and 15.4% (P = .012); 5-year OS of 69.7%, 32.5%, and 27.7% (P = .003), respectively). The MSEA and MPA of the 13-metablolite signature identified methionine, porphyrin, and tryptophan metabolisms as the 3 most relevant dysregulated pathways associated with the prognosis of NETs.Conclusions: We identified a metabolomic signature that improves prognostic stratification of NET patients beyond classical prognostic factors for clinical decisions. The enriched metabolic pathways identified reveal novel tumor vulnerabilities that may foster the development of new therapeutic strategies for these patients