Index spaces and standard indices in metric modelling

We analyze the basic structure of certain metric models, which are constituted by an index I acting on a metric space (D; d) representing a relevant property of the elements of D. We call such a structure (D; d; I) an index space and define on it normalization and consistency constants that measure to what extent I is compatible with the metric d. The “best” indices are those with such constants equal to 1 (standard indices), and we show an approximation method for other indices using them. With the help of Lipschitz extensions, we show how to apply these tools: a new model for the triage process in the emergency department of a hospital is presented

Contribution to the study of pre-roman and republican roman Seville. Pottery repertories and building sequence in the stratigraphy of 41-43 abades street

Uno de los períodos de la historia urbana de Sevilla peor conocidos desde el punto de vista arqueológico es el que transcurre entre la consolidación urbana de la ciudad durante el siglo IV a.C. y el establecimiento colonial romano de mediados del siglo I a.C. Las recientes excavaciones (2002) llevadas a cabo en el edificio de la calle Abades 41-43, antigua sede de la Escuela Francesa de Sevilla, han ofrecido la oportunidad de avanzar en su conocimiento. En este trabajo analizamos el Corte 15A de dicha intervención, cuyos resultados permiten una primera aproximación a la evolución de la edilicia doméstica y de los conjuntos cerámicos en uso en el área nuclear del viejo oppidum turdetano. Ambos aspectos ilustran igualmente acerca de los ritmos y del carácter mismo del proceso de “Romanización” en Hispalis.Uno de los períodos de la historia urbana de Sevilla peor conocidos desde el punto de vista arqueológico es el que transcurre entre la consolidación urbana de la ciudad durante el siglo IV a.C. y el establecimiento colonial romano de mediados del siglo I a.C. Las recientes excavaciones (2002) llevadas a cabo en el edificio de la calle Abades 41-43, antigua sede de la Escuela Francesa de Sevilla, han ofrecido la oportunidad de avanzar en su conocimiento. En este trabajo analizamos el Corte 15A de dicha intervención, cuyos resultados permiten una primera aproximación a la evolución de la edilicia doméstica y de los conjuntos cerámicos en uso en el área nuclear del viejo oppidum turdetano. Ambos aspectos ilustran igualmente acerca de los ritmos y del carácter mismo del proceso de “Romanización” en Hispalis.España. Ministerio de Educación y Ciencia HUM-2005-0782

Self-defined information indices: application to the case of university rankings

University rankings are now relevant decision-making tools for both institutional and private purposes in the management of higher education and research. However, they are often computed only for a small set of institutions using some sophisticated parameters. In this paper we present a new and simple algorithm to calculate an approximation of these indices using some standard bibliometric variables, such as the number of citations from the scientific output of universities and the number of articles per quartile. To show our technique, some results for the ARWU index are presented. From a technical point of view, our technique, which follows a standard machine learning scheme, is based on the interpolation of two classical extrapolation formulas for Lipschitz functions defined in metric spaces—the so-called McShane and Whitney formulae—. In the model, the elements of the metric space are the universities, the distances are measured using some data that can be extracted from the Incites database, and the Lipschitz function is the ARWU index

Self-defined information indices: application to the case of university rankings

[EN] University rankings are now relevant decision-making tools for both institutional and private purposes in the management of higher education and research. However, they are often computed only for a small set of institutions using some sophisticated parameters. In this paper we present a new and simple algorithm to calculate an approximation of these indices using some standard bibliometric variables, such as the number of citations from the scientific output of universities and the number of articles per quartile. To show our technique, some results for the ARWU index are presented. From a technical point of view, our technique, which follows a standard machine learning scheme, is based on the interpolation of two classical extrapolation formulas for Lipschitz functions defined in metric spaces-the so-called McShane and Whitney formulae-. In the model, the elements of the metric space are the universities, the distances are measured using some data that can be extracted from the Incites database, and the Lipschitz function is the ARWU index.The third and fourth authors gratefully acknowledge the support of the Ministerio de Ciencia, Innovacion y Universidades (Spain), Agencia Estatal de Investigacion, and FEDER, under Grant MTM2016-77054-C2-1-P. The first author gratefully acknowledge the support of Catedra de Transparencia y Gestion de Datos, Universitat Politecnica de Valencia y Generalitat Valenciana, Spain.Ferrer Sapena, A.; Erdogan, E.; Jiménez-Fernández, E.; Sánchez Pérez, EA.; Peset Mancebo, MF. (2020). Self-defined information indices: application to the case of university rankings. Scientometrics. 124(3):2443-2456. https://doi.org/10.1007/s11192-020-03575-6S244324561243Aguillo, I., Bar-Ilan, J., Levene, M., & Ortega, J. (2010). Comparing university rankings. Scientometrics, 85(1), 243–256.Asadi, K., Dipendra, M., & Littman, M. L. (2018). Lipschitz continuity in model-based reinforcement learning. In Proceedings of the 35th International Conference on Machine Learning, Proc. Mach. Lear. Res., Vol. 80, pp. 264–273.Bougnol, M. L., & Dulá, J. H. (2013). A mathematical model to optimize decisions to impact multi-attribute rankings. Scientometrics, 95(2), 785–796.Çakır, M. P., Acartürk, C., Alaşehir, O., & Çilingir, C. (2015). A comparative analysis of global and national university ranking systems. Scientometrics, 103(3), 813–848.Cancino, C. A., Merigó, J. M., & Coronado, F. C. (2017). A bibliometric analysis of leading universities in innovation research. Journal of Innovation & Knowledge, 2(3), 106–124.Chen, K.-H., & Liao, P.-Y. (2012). A comparative study on world university rankings: A bibliometric survey. Scientometrics, 92(1), 89–103.Cinzia, D., & Bonaccorsi, A. (2017). Beyond university rankings? Generating new indicators on universities by linking data in open platforms. Journal of the Association for Information Science and Technology, 68(2), 508–529.Cobzaş, Ş., Miculescu, R., & Nicolae, A. (2019). Lipschitz functions. Berlin: Springer.Deza, M. M., & Deza, E. (2009). Encyclopedia of distances. Berlin: Springer.2019 U-Multirank ranking: European universities performing well. https://ec.europa.eu/education/news/u-multirank-publishes-sixth-edition-en .Dobrota, M., Bulajic, M., Bornmann, L., & Jeremic, V. (2016). A new approach to the QS university ranking using the composite I-distance indicator: Uncertainty and sensitivity analyses. Journal of the Association for Information Science and Technology, 67(1), 200–211.Falciani, H., Calabuig, J. M., & Sánchez Pérez, E. A. (2020). Dreaming machine learning: Lipschitz extensions for reinforcement learning on financial markets. Neurocomputing, 398, 172–184.Kehm, B. M. (2014). Global university rankings—Impacts and unintended side effects. European Journal of Education, 49(1), 102–112.Lim, M. A., & Øerberg, J. W. (2017). Active instruments: On the use of university rankings in developing national systems of higher education. Policy Reviews in Higher Education, 1(1), 91–108.Luo, F., Sun, A., Erdt, M., Raamkumar, A. S., & Theng, Y. L. (2018). Exploring prestigious citations sourced from top universities in bibliometrics and altmetrics: A case study in the computer science discipline. Scientometrics, 114(1), 1–17.Marginson, S. (2014). University rankings and social science. European Journal of Education, 49(1), 45–59.Pagell, R. A. (2014). Bibliometrics and university research rankings demystified for librarians. Library and information sciences (pp. 137–160). Berlin: Springer.Rao, A. (2015). Algorithms for Lipschitz extensions on graphs. Yale University: ProQuest Dissertations Publishing, 10010433.Rosa, K. D., Metsis, V., & Athitsos, V. (2012). Boosted ranking models: A unifying framework for ranking predictions. Knowledge and Information Systems, 30(3), 543–568.Saisana, M., d’Hombres, B., & Saltelli, A. (2011). Rickety numbers: Volatility of university rankings and policy implications. Research Policy, 40(1), 165–177.Tabassum, A., Hasan, M., Ahmed, S., Tasmin, R., Abdullah, D. M., & Musharrat, T. (2017). University ranking prediction system by analyzing influential global performance indicators. In 2017 9th International Conference on Knowledge and Smart Technology (KST) (pp. 126–131) IEEE.Van Raan, A. F. J., Van Leeuwen, T. N., & Visser, M. S. (2011). Severe language effect in university rankings: Particularly Germany and France are wronged in citation-based rankings. Scientometrics, 88(2), 495–498.von Luxburg, U., & Bousquet, O. (2004). Distance-based classification with Lipschitz functions. Journal of Machine Learning Research, 5, 669–695

Inhibición de la actividad de acetilcolinesterasa por el extracto hidroalcohólico y sus fracciones de Bouvardia ternifolia (Cav.) Shcltdl (Rubiaceae)

El extracto hidroalcohólico (BtHA) y fracciones provenientes de Bouvardia ternifolia fueron evaluadas como inhibidores de la enzima acetilcolinesterasa  utilizando el método enzimático propuesto por Ellman. BtHA  inhibe a la enzima de manera competitiva (IC50 = 0.6 g/ml); la fracción de acetato de etilo  (BtF-AcOEt) provoca una inhibición mixta (IC50 = 0.96 g/ml). La fracción insoluble en metanol (Bt-Faq-1) mostró una inhibición tipo mixta (CI50 = 0.96  g/ml). Finalmente la fracción soluble en metanol, Bt-Faq-2, inhibe a la enzima presentando una inhibición mixta que corresponde a un sistema C5 (  = 0.740  and  = 0.842). Mediante HPLC se detectó rutina, quercetina, canferol y ácido ursólico la concentración de estos compuestos fue diferente en cada fracción

White dwarf-main-sequence binaries from Gaia EDR3: The unresolved 100 pc volume-limited sample

We use the data provided by the Gaia Early Data Release 3 to search for a highly-complete volume-limited sample of unresolved binaries consisting of a white dwarf and a main sequence companion (i.e. WDMS binaries) within 100 pc. We select 112 objects based on their location within the Hertzsprung-Russell diagram, of which 97 are new identifications. We fit their spectral energy distributions (SED) with a two-body fitting algorithm implemented in VOSA (Virtual Observatory SED Analyser) to derive the effective temperatures, luminosities and radii (hence surface gravities and masses) of both componentsARM acknowledges financial support from the MINECO under the Ramón y Cajal program (RYC-2016-20254). ST and ARM acknowledge support from the MINECO under the AYA2017-86274-P grant, and the AGAUR grant SGR-661/2017. ESM and FJE acknowledge financial support from the MINECO under the AYA2017-86274-P grant. FJE acknowledges support from the H2020 ESCAPE project (Grant Agreement no. 824064). LMC, LGA and AHC acknowledge support from AGENCIA through the Programa de Modernización Tecnológica BID 1728/OC-AR, and from CONICET through the PIP 2017-2019 GI grant. This publication makes use of VOSA and SVO DiscTool, developed under the Spanish Virtual Observatory project supported from the Spanish MINECO through grant AyA2017-84089. This research has made use of Aladin sky atlas developed at CDS, Strasbourg Observatory, France (Bonnarel et al. 2000; Boch & Fernique 2014). TOPCAT (Taylor 2005) and STILTS (Taylor 2006) have also been widely used in this paper. We thank the anonymous referee for the helpful suggestions. The authors are greatly indebted to Detlev Koester for sharing his grid of model atmosphere white dwarf spectra. The authors also thank Roberto Raddi for sharing the grid of white dwarf absolute magnitudes calculated for the Gaia EDR3 bandpasses. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/ gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/ consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral AgreementPostprint (updated version

Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice.

Chronic cerebral hypoperfusion due to carotid artery stenosis is a major cause of vascular cognitive impairment and dementia (VCID). Bilateral carotid artery stenosis (BCAS) in rodents is a well-established model of VCID where most studies have focused on white matter pathology and subsequent cognitive deficit. Therefore, our aim was to study the implication of adult hippocampal neurogenesis in hypoperfusion-induced VCID in mice, and its relationship with cognitive hippocampal deficits. Mice were subjected to BCAS; 1 and 3 months later, hippocampal memory and neurogenesis/cell death were assessed, respectively, by the novel object location (NOL) and spontaneous alternation performance (SAP) tests and by immunohistology. Hypoperfusion was assessed by arterial spin labeling-magnetic resonance imaging (ASL-MRI). Hypoperfused mice displayed spatial memory deficits with decreased NOL recognition index. Along with the cognitive deficit, a reduced number of newborn neurons and their aberrant morphology indicated a remarkable impairment of the hippocampal neurogenesis. Both increased cell death in the subgranular zone (SGZ) and reduced neuroblast proliferation rate may account for newborn neurons number reduction. Our data demonstrate quantitative and qualitative impairment of adult hippocampal neurogenesis disturbances associated with cerebral hypoperfusion-cognitive deficits in mice. These findings pave the way for novel diagnostic and therapeutic targets for VCID.This work was supported by grants from Spanish Ministry of Science and Innovation (MCIN) PID2019-106581RB-I00 (MM), from Leducq Foundation for Cardiovascular Research TNE-19CVD01 (MM) and TNE-21CVD04 (MM and IL), and from Instituto de Salud Carlos III (ISCIII) and co-financed by the European Development Regional Fund “A Way to Achieve Europe” PI20/00535 and RICORS-ICTUS RD21/0006/0001 (IL). CNIC was supported by ISCIII, MCIN, and ProCNIC Foundation, and is a Severo Ochoa Center of Excellence (CEX2020-001041-S). The microscopy experiments were performed in Unidad de Microscopía e Imagen Dinámica, CNIC, ICTS-ReDib, co-funded by MCIN/AEI/10.13039/501100011033 and FEDER “Una manera de hacer Europa” (#ICTS-2018- 04-CNIC-16). Part of the research work included in this publication has been carried out in the ReDIB ICTS infrastructure BioImaC, MCIN.S

Extracts and Fractions from Edible Roots of Sechium edule

Sechium edule is traditionally used in Mexico as a therapeutic resource against renal diseases and to control high blood pressure. The purpose of this work is to evaluate the antihypertensive effect of the hydroalcoholic extract obtained from the roots of this plant, including its fractions and subfractions, on different hypertension models induced with angiotensin II (AG II). The hydroalcoholic extract was tested on an in vitro study of isolated aorta rings denuded of endothelial cells, using AG II as the agonist; this assay proved the vasorelaxant effect of this extract. Vagotomized rats were administered different doses of AG II as well as the Hydroalcoholic extract, which reduced blood pressure in 30 mmHg approximately; subsequently this extract was separated into two fractions (acetone and methanol) which were evaluated in the acute hypertension mouse model induced with AG II, where the acetone fraction was identified as the most effective one and was subsequently subfractioned using an open chromatographic column packed with silica gel. The subfractions were also evaluated in the acute hypertension model. Finally, the extract, fraction, and active subfraction were analyzed by MS-PDA-HPLC, identifying cinnamic derivative compounds like cinnamic acid methyl ester

Protagonismo del mentor en una actividad tutorial de carácter multidisciplinar en Ingeniería

XIX Congreso Universitario de Innovación Educativa en las Enseñanzas Técnicas : Barcelona, 6 a 8 de julio de 2011En la Escuela Politécnica Superior (EPS) de la Universidad de Sevilla se ha trabajado, por tercer curso consecutivo, en un Plan de Acción Tutorial desarrollado por 16 profesores tutores y 20 alumnos mentores de 5 titulaciones de Ingeniería Técnica. El objetivo perseguido en este curso ha sido potenciar actividades que han surgido del propio albedrío de los alumnos mentores, lo que ha dado como resultado la realización de una serie de actividades de mentoría motivadas y dirigidas desde el principio por los alumnos mentores. La actividad conjunta de todos ellos ha llevado a organizar unos subgrupos de mentorías en función de determinadas características del alumnado de primer curso (deportistas, trabajadores, becarios de otras universidades…), a realizar reuniones presenciales de mentores para puesta a punto de estas actividades así como de puesta al día de los resultados que se iban consiguiendo, además de organizar una segunda captación de mentorizados tras las notas del primer cuatrimestre, y la protagonización de una Jornada de Mentoría al final del curso.A third edition with 16 tutorial lecturers and 20 tutorial students from five different degrees (Technical Engineering of the Polytechnical School, EPS, at University of Seville) in a Tutorial Plan development, has been prepared. During the present year, the main characteristic has been a serial of mentoring actions motivated and directed by these mentors. This activity has been organized considering several subgroups of mentoring depending on special characteristics in first year students (sportsplayers, workers, grant holders from other universities…), moreover the organization of a second recruiting of new students after the first term marks, updating meetings for mentors only, and to be main figures in a Congress on Mentoring at the end of the academic year

Impacto del cambio climático en el territorio de la Mancomunidad de Municipios Sostenibles de Cantabria: resultados aplicables a la gestión del territorio

RESUMEN: Dentro del marco del proyecto ADAPTACLIMA, del programa INTERREG, se ha analizado el impacto del cambio climático en diez y siete municipios de Cantabria. En primer lugar se identificaron los impactos previsibles a través de la elaboración de matrices. Posteriormente se analizaron los impactos y las posibles medidas de adaptación teniendo en cuenta cuatro aspectos básicos: Potencialidad forestal, Potencialidad agrícola y agro-ganadera, Reservas hídricas y Ordenación del territorio. Se ha analizado la evolución a lo largo del presente siglo de las especies forestales autóctonas y de los cultivos de posible implantación y máximo interés comercial en Cantabria, que incluye la utilización de variedades autóctonas y tradicionales, a la vista de la evolución de la demanda de productos agrarios en el mercado regional, nacional y europeo. Finalmente se han propuesto medidas de adaptación que pasan por una protección estricta de especies forestales autóctonas, por el control y aprovechamiento de las aguas subterráneas y, en última instancia, por la aplicación de un plan de Ordenación Territorial que proteja los elementos más valiosos del territorio, entre ellos los suelos de máxima productividad y los ecosistemas incluidos en la RED NATURA 2000, como protección a la biodiversidad.ABSTRACT: The impact of climate change has been analyzed in eighteen municipalities of Cantabria, within the framework of the project “ADAPTACLIMA” (INTERREG SUDOE IVB). Firstly, the expected impacts were identified by means of matrices. Secondly, those impacts and possible mitigation measures were analyzed considering four aspects: potential forest, potential farming and crops potential, groundwater and land management. The evolution in the course of this century of natural woods and crops with significant trading interest has been analyzed for Cantabria. Such analysis has been carried out considering the farmland products demanded on regional, national and European markets. Finally, in order to protect high productivity soils and the ecosystems included in the “Nature Network 2000”, some impact mitigation measures have been proposed: land and groundwater management and protection of forest native species