A framework for assessing the quality of green infrastructure in the built environment in the UK

The advocacy argument for green infrastructure has largely been won. Policy and statutory guidance for green infrastructure planning and development exists at international, national and regional/local levels and the functions and benefits of green infrastructure interventions are well evidenced in academic literature. To support this, professional bodies and experts from the built and natural environment have produced a multitude of practice guidance on the delivery of individual green infrastructure features. And yet, examples of high quality green infrastructure in new development schemes remain difficult to find, and the success of statutory guidance to accelerate this phenomenon surprisingly ineffective to manage change within the development sector. This paper presents a new framework for the delivery of high quality green infrastructure. Consultation with stakeholders in the UK suggested that a key factor affecting the translation of green infrastructure evidence, and policy and practice guidance, into delivery through planning and development is a lack of confidence amongst practitioners regarding the qualities and characteristics of high quality green infrastructure in the built environment. The key characteristics of high quality green infrastructure, based on a review of both academic and grey literature, and extensive work with stakeholders are grouped into principles that underpin high quality green infrastructure (including the presence of a multifunctional network, and provision for long-term management), and principles related to health and wellbeing, water management and nature conservation. The resulting framework is presented as twenty three principles for delivering green infrastructure. This can be used internationally as a set of standards to assess the quality of green infrastructure to ensure that it contributes to quality of life, health and wellbeing of individuals and communities, flood resilient towns and cities, and places where nature can flourish and be more viable as a result of development

Building with nature - a new benchmark for green infrastructure

This paper outlines the aims, development and proposed operation of Building with Nature, a new benchmark for appraising the quality of green infrastructur

Raising the standard: Developing a benchmark for green infrastructure

© 2018 WIT Press Green infrastructure (GI) is globally recognised as an essential component of liveable and sustainable places. It is valued for its multifunctionality and the connectedness of the individual features to each other, the surrounding countryside and urban populations. It brings together many land uses (e.g. parks, gardens, cemeteries, allotments, nature reserves, surface water), urban design (e.g. street trees, landscaping) and functional features (e.g. sustainable urban drainage systems, green roofs) operating at differing spatial scales. It is widely acknowledged that GI is the primary mechanism for delivering ecosystem services in towns and cities, and there is a substantial body of research demonstrating the multiple benefits of GI to urban populations. Despite this evidence base, there is still considerable uncertainty about the best way to design, deliver and maintain GI. This paper presents an emerging benchmark that has been developed through a combination of literature review and engagement with key stakeholders. It provides a suite of standards that are flexible enough to be used across different spatial scales depending on the specific needs of the location, covering the form and function of GI including nature conservation, water management, health and well-being, environmental and design quality. It allows an assessment of GI policy, and the planning, design, delivery and long-term management of GI in new and existing places, ensuring that current good practice is adopted at all stages. The development of the benchmark to date is summarised along with the outcome of preliminary testing using the outline planning applications for two contrasting mixed-use developments. This found that the benchmark performed well, with standards set at a level to ensure that high-quality GI is rewarded but without requiring a level of GI provision and quality that would only be expected on truly exemplary developments. Plans for the future development and testing of the benchmark are provided

Project Report for the Teachers and Citizenship Knowledge Project – Seed Funded by Centre for Teachers and Teaching Research

This project report covers the purpose, experience, findings and recommendations of the seed funded Centre for Teachers and Teaching Research project examining Teachers and their Citizenship knowledge

Setting the Standard for Green Infrastructure: The Need for, and Features of, a Benchmark in England

© 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Green infrastructure is an essential component of health and sustainable places. The quality of green infrastructure often represents a missed opportunity to achieve this. This paper presents a review examining how built environment assessment systems evaluate the quality of green infrastructure. This was used to develop proposals for a new benchmark, which were examined by experts in terms of the demand, scope and operation. The findings suggest that current systems are not providing a robust assessment of green infrastructure and that a benchmark for green infrastructure would overcome some of the challenges associated with its planning, design and delivery

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect novel common variants. We performed a GWAS of the modified Stumvoll Insulin Sensitivity Index (ISI) within the Meta-Analyses of Glucose and Insulin-Related Traits Consortium. Discovery for genetic association was performed in 16,753 individuals, and replication was attempted for the 23 most significant novel loci in 13,354 independent individuals. Association with ISI was tested in models adjusted for age, sex, and BMI and in a model analyzing the combined influence of the genotype effect adjusted for BMI and the interaction effect between the genotype and BMI on ISI (model 3). In model 3, three variants reached genome-wide significance: Rs13422522 (NYAP2; P = 8.87 × 10-11), rs12454712 (BCL2; P = 2.7 × 10-8), and rs10506418 (FAM19A2; P = 1.9 × 10-8). The association at NYAP2 was eliminated by conditioning on the known IRS1 insulin sensitivity locus; the BCL2 and FAM19A2 associations were independent of known cardiometabolic loci. In conclusion, we identified two novel loci and replicated known variants associated with insulin sensitivity. Further studies are needed to clarify the causal variant and function at the BCL2 and FAM19A2 loci

The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics.

ABSTRACT: A global genome database of all of Earth’s species diversity could be a treasure trove of scientific discoveries. However, regardless of the major advances in genome sequencing technologies, only a tiny fraction of species have genomic information available. To contribute to a more complete planetary genomic database, scientists and institutions across the world have united under the Earth BioGenome Project (EBP), which plans to sequence and assemble high-quality reference genomes for all ∼1.5 million recognized eukaryotic species through a stepwise phased approach. As the initiative transitions into Phase II, where 150,000 species are to be sequenced in just four years, worldwide participation in the project will be fundamental to success. As the European node of the EBP, the European Reference Genome Atlas (ERGA) seeks to implement a new decentralised, accessible, equitable and inclusive model for producing high-quality reference genomes, which will inform EBP as it scales. To embark on this mission, ERGA launched a Pilot Project to establish a network across Europe to develop and test the first infrastructure of its kind for the coordinated and distributed reference genome production on 98 European eukaryotic species from sample providers across 33 European countries. Here we outline the process and challenges faced during the development of a pilot infrastructure for the production of reference genome resources, and explore the effectiveness of this approach in terms of high-quality reference genome production, considering also equity and inclusion. The outcomes and lessons learned during this pilot provide a solid foundation for ERGA while offering key learnings to other transnational and national genomic resource projects.info:eu-repo/semantics/publishedVersio

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Stock identification: advancing in the knowledge of stock structure as a requirement for stock assessment

DEMERSTEM- Objectives of WP 1: -Improve the knowledge on the selected demersal stocks with a particular effort to solve the problems of stock identification and improvement of the quality of the data used for the assessment. -This follows the recommendations regularly made by CECAF.Peer reviewe

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.

Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African countries that are able to sequence domestically and highlight that local sequencing enables faster turnaround times and more-regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and illuminate the distinct dispersal dynamics of variants of concern-particularly Alpha, Beta, Delta, and Omicron-on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve while the continent faces many emerging and reemerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century