Clustering as an example of optimizing arbitrarily chosen objective functions

This paper is a reflection upon a common practice of solving various types of learning problems by optimizing arbitrarily chosen criteria in the hope that they are well correlated with the criterion actually used for assessment of the results. This issue has been investigated using clustering as an example, hence a unified view of clustering as an optimization problem is first proposed, stemming from the belief that typical design choices in clustering, like the number of clusters or similarity measure can be, and often are suboptimal, also from the point of view of clustering quality measures later used for algorithm comparison and ranking. In order to illustrate our point we propose a generalized clustering framework and provide a proof-of-concept using standard benchmark datasets and two popular clustering methods for comparison

Measurement of snow water equivalent using drone-mounted ultra-wide-band radar

The use of unmanned aerial vehicle (UAV)-mounted radar for obtaining snowpack parameters has seen considerable advances over recent years. However, a robust method of snow density estimation still needs further development. The objective of this work is to develop a method to reliably and remotely estimate snow water equivalent (SWE) using UAV-mounted radar and to perform initial field experiments. In this paper, we present an improved scheme for measuring SWE using ultra-wide-band (UWB) (0.7 to 4.5 GHz) pseudo-noise radar on a moving UAV, which is based on airborne snow depth and density measurements from the same platform. The scheme involves autofocusing procedures with the frequency–wavenumber (F–K) migration algorithm combined with the Dix equation for layered media in addition to altitude correction of the flying platform. Initial results from field experiments show high repeatability (R > 0.92) for depth measurements up to 5.5 m, and good agreement with Monte Carlo simulations for the statistical spread of snow density estimates with standard deviation of 0.108 g/cm3. This paper also outlines needed system improvements to increase the accuracy of a snow density estimator based on an F–K migration technique

Learning representations of multivariate time series with missing data

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordLearning compressed representations of multivariate time series (MTS) facilitates data analysis in the presence of noise and redundant information, and for a large number of variates and time steps. However, classical dimensionality reduction approaches are designed for vectorial data and cannot deal explicitly with missing values. In this work, we propose a novel autoencoder architecture based on recurrent neural networks to generate compressed representations of MTS. The proposed model can process inputs characterized by variable lengths and it is specifically designed to handle missing data. Our autoencoder learns fixed-length vectorial representations, whose pairwise similarities are aligned to a kernel function that operates in input space and that handles missing values. This allows to learn good representations, even in the presence of a significant amount of missing data. To show the effectiveness of the proposed approach, we evaluate the quality of the learned representations in several classification tasks, including those involving medical data, and we compare to other methods for dimensionality reduction. Successively, we design two frameworks based on the proposed architecture: one for imputing missing data and another for one-class classification. Finally, we analyze under what circumstances an autoencoder with recurrent layers can learn better compressed representations of MTS than feed-forward architectures.Norwegian Research Counci

The deep kernelized autoencoder

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordAutoencoders learn data representations (codes) in such a way that the input is reproduced at the output of the network. However, it is not always clear what kind of properties of the input data need to be captured by the codes. Kernel machines have experienced great success by operating via inner-products in a theoretically well-defined reproducing kernel Hilbert space, hence capturing topological properties of input data. In this paper, we enhance the autoencoder's ability to learn effective data representations by aligning inner products between codes with respect to a kernel matrix. By doing so, the proposed kernelized autoencoder allows learning similarity-preserving embeddings of input data, where the notion of similarity is explicitly controlled by the user and encoded in a positive semi-definite kernel matrix. Experiments are performed for evaluating both reconstruction and kernel alignment performance in classification tasks and visualization of high-dimensional data. Additionally, we show that our method is capable to emulate kernel principal component analysis on a denoising task, obtaining competitive results at a much lower computational cost.Norwegian Research Council FRIPR

Structural and functional studies of Escherichia coli Aggregative Adherence Fimbriae (AAF/V) reveal a deficiency in extracellular matrix binding

Enteroaggregative Escherichia coli (EAEC) is an emerging cause of acute and persistent diarrhea worldwide. The pathogenesis of different EAEC stains is complicated, however, the early essential step begins with attachment of EAEC to intestinal mucosa via aggregative adherence fimbriae (AAFs). Currently, five different variants have been identified, which all share a degree of similarity in the gene organization of their operons and sequences. Here, we report the solution structure of Agg5A from the AAF/V variant. While preserving the major structural features shared by all AAF members, only Agg5A possesses an inserted helix at the beginning of the donor strand, which together with altered surface electrostatics, renders the protein unable to interact with fibronectin. Hence, here we characterize the first AAF variant with a binding mode that varies from previously described AAF

Beta cell function after weight loss: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention

The effects of various weight loss strategies on pancreatic beta cell function remain unclear. We aimed to compare the effect of intensive lifestyle intervention (ILI) and Roux-en-Y gastric bypass surgery (RYGB) on beta cell function. Design One year controlled clinical trial (ClinicalTrials.gov identifier NCT00273104). One hundred and nineteen morbidly obese participants without known diabetes from the MOBIL study (mean (s.d.) age 43.6 (10.8) years, body mass index (BMI) 45.5 (5.6) kg/m2, 84 women) were allocated to RYGB (n=64) or ILI (n=55). The patients underwent repeated oral glucose tolerance tests (OGTTs) and were categorised as having either normal (NGT) or abnormal glucose tolerance (AGT). Twenty-nine normal-weight subjects with NGT (age 42.6 (8.7) years, BMI 22.6 (1.5) kg/m2, 19 women) served as controls. OGTT-based indices of beta cell function were calculated. One year weight reduction was 30 % (8) after RYGB and 9 % (10) after ILI (P<0.001). Disposition index (DI) increased in all treatment groups (all P<0.05), although more in the surgery groups (both P<0.001). Stimulated proinsulin-to-insulin (PI/I) ratio decreased in both surgery groups (both P<0.001), but to a greater extent in the surgery group with AGT at baseline (P<0.001). Post surgery, patients with NGT at baseline had higher DI and lower stimulated PI/I ratio than controls (both P<0.027). Gastric bypass surgery improved beta cell function to a significantly greater extent than ILI. Supra-physiological insulin secretion and proinsulin processing may indicate excessive beta cell function after gastric bypass surgery

Benefits of ecological engineering practices

With the intention to further promote the field of ecological engineering and the solutions it provides, a workshop on “Benefits of Ecological Engineering Practices” was held 3 December 2009. It was conducted by the International Ecological Engineering Society in Paris at the conference “Ecological Engineering: from Concepts to Application” organized by the Ecological Engineering Applications Group GAIE. This paper presents the results of the workshop related to three key questions: (1) what are the benefits of ecological engineering practices to human and ecosystem well-being, (2) which concepts are used or useful to identify, reference, and measure the benefits of ecological engineering practices, and (3) how and to whom shall benefits of ecological engineering practices be promoted. While benefits of ecological engineering practices are diverse, general conclusions can be derived to facilitate communication. Identifying benefits requires valuation frameworks reaching beyond the scope of ecology and engineering. A distinction between human and ecosystem well-being in this regard may not be easy or useful, but instead humans embedded in ecosystems should be addressed as a whole. The concepts of resource efficiency, ecosystem services, ecosystem health, and multifunctional land use could serve as suitable references to frame ecological engineering benefits, as well as referring to international political goals such as biodiversity protection, climate change mitigation and poverty reduction. Sector and application specific criteria of good practice could be worked out. Regional, area specific reference systems for sustainable development could provide comparative advantages for ecologically engineered solutions. Besides people with high decision making power and people with high motivation for change are good target groups to be addressed