639 research outputs found
Hyperbolic chaos in self-oscillating systems based on mechanical triple linkage: Testing absence of tangencies of stable and unstable manifolds for phase trajectories
Dynamical equations are formulated and a numerical study is provided for
self-oscillatory model systems based on the triple linkage hinge mechanism of
Thurston -- Weeks -- Hunt -- MacKay. We consider systems with holonomic
mechanical constraint of three rotators as well as systems, where three
rotators interact by potential forces. We present and discuss some quantitative
characteristics of the chaotic regimes (Lyapunov exponents, power spectrum).
Chaotic dynamics of the models we consider are associated with hyperbolic
attractors, at least, at relatively small supercriticality of the
self-oscillating modes; that follows from numerical analysis of the
distribution for angles of intersection of stable and unstable manifolds of
phase trajectories on the attractors. In systems based on rotators with
interacting potential the hyperbolicity is violated starting from a certain
level of excitation.Comment: 30 pages, 18 figure
Unified description of long-time tails and long-range correlation functions for sheared granular liquids
Unified description on the long-time tail of velocity autocorrelation
function and the long-range correlation for the equal-time spatial correlation
functions is developed based on the generalized fluctuating hydrodynamics. The
cross-over of the long-time tail from to is predicted
independent of the density, and the equal-time spatial density correlation
function and the equal-time spatial velocity correlation function respectively
satisfy and for large limit.Comment: 10 pages. to be published in Euro. Phys. J.
Extragenic suppressor mutations in ΔripA disrupt stability and function of LpxA
Background: Francisella tularensis is a Gram-negative bacterium that infects hundreds of species including humans, and has evolved to grow efficiently within a plethora of cell types. RipA is a conserved membrane protein of F. tularensis, which is required for growth inside host cells. As a means to determine RipA function we isolated and mapped independent extragenic suppressor mutants in ΔripA that restored growth in host cells. Each suppressor mutation mapped to one of two essential genes, lpxA or glmU, which are involved in lipid A synthesis. We repaired the suppressor mutation in lpxA (S102, LpxA T36N) and the mutation in glmU (S103, GlmU E57D), and demonstrated that each mutation was responsible for the suppressor phenotype in their respective strains. We hypothesize that the mutation in S102 altered the stability of LpxA, which can provide a clue to RipA function. LpxA is an UDP-N-acetylglucosamine acyltransferase that catalyzes the transfer of an acyl chain from acyl carrier protein (ACP) to UDP-N-acetylglucosamine (UDP-GlcNAc) to begin lipid A synthesis. Results: LpxA was more abundant in the presence of RipA. Induced expression of lpxA in the ΔripA strain stopped bacterial division. The LpxA T36N S102 protein was less stable and therefore less abundant than wild type LpxA protein. Conclusion: These data suggest RipA functions to modulate lipid A synthesis in F. tularensis as a way to adapt to the host cell environment by interacting with LpxA
A nonlinear hydrodynamical approach to granular materials
We propose a nonlinear hydrodynamical model of granular materials. We show
how this model describes the formation of a sand pile from a homogeneous
distribution of material under gravity, and then discuss a simulation of a
rotating sandpile which shows, in qualitative agreement with experiment, a
static and dynamic angle of repose.Comment: 17 pages, 14 figures, RevTeX4; minor changes to wording and some
additional discussion. Accepted by Phys. Rev.
Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.
Frontometaphyseal dysplasia (FMD) is a progressive sclerosing skeletal dysplasia affecting the long bones and skull. The cause of FMD in some individuals is gain-of-function mutations in FLNA, although how these mutations result in a hyperostotic phenotype remains unknown. Approximately one half of individuals with FMD have no identified mutation in FLNA and are phenotypically very similar to individuals with FLNA mutations, except for an increased tendency to form keloid scars. Using whole-exome sequencing and targeted Sanger sequencing in 19 FMD-affected individuals with no identifiable FLNA mutation, we identified mutations in two genes-MAP3K7, encoding transforming growth factor β (TGF-β)-activated kinase (TAK1), and TAB2, encoding TAK1-associated binding protein 2 (TAB2). Four mutations were found in MAP3K7, including one highly recurrent (n = 15) de novo mutation (c.1454C>T [ p.Pro485Leu]) proximal to the coiled-coil domain of TAK1 and three missense mutations affecting the kinase domain (c.208G>C [p.Glu70Gln], c.299T>A [p.Val100Glu], and c.502G>C [p.Gly168Arg]). Notably, the subjects with the latter three mutations had a milder FMD phenotype. An additional de novo mutation was found in TAB2 (c.1705G>A, p.Glu569Lys). The recurrent mutation does not destabilize TAK1, or impair its ability to homodimerize or bind TAB2, but it does increase TAK1 autophosphorylation and alter the activity of more than one signaling pathway regulated by the TAK1 kinase complex. These findings show that dysregulation of the TAK1 complex produces a close phenocopy of FMD caused by FLNA mutations. Furthermore, they suggest that the pathogenesis of some of the filaminopathies caused by FLNA mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex
Towards an understanding of heavy baryon spectroscopy
The recent observation at CDF and D0 of , and
baryons opens the door to the advent of new states in the bottom baryon sector.
The states measured provide sufficient constraints to fix the parameters of
phenomenological models. One may therefore consistently predict the full bottom
baryon spectra. For this purpose we have solved exactly the three-quark problem
by means of the Faddeev method in momentum space. We consider our guidance may
help experimentalists in the search for new bottom baryons and their findings
will help in constraining further the phenomenological models. We identify
particular states whose masses may allow to discriminate between the dynamics
for the light-quark pairs predicted by different phenomenological models.
Within the same framework we also present results for charmed, doubly charmed,
and doubly bottom baryons. Our results provide a restricted possible assignment
of quantum numbers to recently reported charmed baryon states. Some of them are
perfectly described by wave excitations with , as the , , and .Comment: Accepted for publication in Eur. Phys. J.
Measurement of the p-pbar -> Wgamma + X cross section at sqrt(s) = 1.96 TeV and WWgamma anomalous coupling limits
The WWgamma triple gauge boson coupling parameters are studied using p-pbar
-> l nu gamma + X (l = e,mu) events at sqrt(s) = 1.96 TeV. The data were
collected with the DO detector from an integrated luminosity of 162 pb^{-1}
delivered by the Fermilab Tevatron Collider. The cross section times branching
fraction for p-pbar -> W(gamma) + X -> l nu gamma + X with E_T^{gamma} > 8 GeV
and Delta R_{l gamma} > 0.7 is 14.8 +/- 1.6 (stat) +/- 1.0 (syst) +/- 1.0 (lum)
pb. The one-dimensional 95% confidence level limits on anomalous couplings are
-0.88 < Delta kappa_{gamma} < 0.96 and -0.20 < lambda_{gamma} < 0.20.Comment: Submitted to Phys. Rev. D Rapid Communication
Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt{s} = 1.96 TeV using Kinematic Characteristics of Lepton + Jets Events
We present a measurement of the top quark pair ttbar production cross section
in ppbar collisions at a center-of-mass energy of 1.96 TeV using 230 pb**{-1}
of data collected by the DO detector at the Fermilab Tevatron Collider. We
select events with one charged lepton (electron or muon), large missing
transverse energy, and at least four jets, and extract the ttbar content of the
sample based on the kinematic characteristics of the events. For a top quark
mass of 175 GeV, we measure sigma(ttbar) = 6.7 {+1.4-1.3} (stat) {+1.6- 1.1}
(syst) +/-0.4 (lumi) pb, in good agreement with the standard model prediction.Comment: submitted to Phys.Rev.Let
Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt(s)=1.96 TeV using Lepton + Jets Events with Lifetime b-tagging
We present a measurement of the top quark pair () production cross
section () in collisions at TeV
using 230 pb of data collected by the D0 experiment at the Fermilab
Tevatron Collider. We select events with one charged lepton (electron or muon),
missing transverse energy, and jets in the final state. We employ
lifetime-based b-jet identification techniques to further enhance the
purity of the selected sample. For a top quark mass of 175 GeV, we
measure pb, in
agreement with the standard model expectation.Comment: 7 pages, 2 figures, 3 tables Submitted to Phys.Rev.Let
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