471 research outputs found
IGDS/TRAP Interface Program (ITIP). Detailed Design Specification (DDS)
The software modules which comprise the IGDS/TRAP Interface Program are described. A hierarchical input processing output (HIPO) chart for each user command is given. The description consists of: (1) function of the user command; (2) calling sequence; (3) moduls which call this use command; (4) modules called by this user command; (5) IGDS commands used by this user command; and (6) local usage of global registers. Each HIPO contains the principal functions performed within the module. Also included with each function are a list of the inputs which may be required to perform the function and a list of the outputs which may be created as a result of performing the function
Type Ia Supernovae, Evolution, and the Cosmological Constant
We explore the possible role of evolution in the analysis of data on SNe Ia
at cosmological distances. First, using a variety of simple sleuthing
techniques, we find evidence that the properties of the high and low redshift
SNe Ia observed so far differ from one another. Next, we examine the effects of
including simple phenomenological models for evolution in the analysis. The
result is that cosmological models and evolution are highly degenerate with one
another, so that the incorporation of even very simple models for evolution
makes it virtually impossible to pin down the values of and
, the density parameters for nonrelativistic matter and for the
cosmological constant, respectively. Moreover, we show that if SNe Ia evolve
with time, but evolution is neglected in analyzing data, then, given enough SNe
Ia, the analysis hones in on values of and which
are incorrect. Using Bayesian methods, we show that the probability that the
cosmological constant is nonzero (rather than zero) is unchanged by the SNe Ia
data when one accounts for the possibility of evolution, provided that we do
not discriminate among open, closed and flat cosmologies a priori. The case for
nonzero cosmological constant is stronger if the Universe is presumed to be
flat, but still depends sensitively on the degree to which the peak
luminosities of SNe Ia evolve as a function of redshift. The estimated value of
, however, is only negligibly affected by accounting for possible
evolution.Comment: 45 pages, 15 figures; accepted for publication in The Astrophysical
Journal. Minor revisions and clarifications made including addition of recent
reference
Contact lens-related complications in austere conditions among military personnel:a systematic review
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Psychopathology in Williams syndrome: the effect of individual differences across the lifespan
The present research aimed to comprehensively explore psychopathology in Williams syndrome (WS) across the lifespan and evaluate the relationship between psychopathology and age category (child or adult), gender and cognitive ability. The parents of 50 participants with WS, aged 6-50 years, were interviewed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS-PL). The prevalence of a wide range of Axis I DSM-IV disorders was assessed. In addition to high rates of anxiety and Attention Deficit Hyperactivity Disorder (ADHD) (38% and 20% respectively), 14% of our sample met criteria for a depressive disorder and 42% of participants were not experiencing any significant psychopathological difficulties. There was some evidence for different patterns of psychopathology between children and adults with WS and between males and females. These relationships were largely in keeping with those found in the typically developing population, thus supporting the validity of applying theory and treatment approaches for psychopathology in the typically developing population to WS
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The Distance To The Hyades Cluster Based On Hubble Space Telescope Fine Guidance Sensor Parallaxes
Trigonometric parallax observations made with the Hubble Space Telescope (HST) Fine Guidance Sensor (FGS) 3 of seven Hyades members in six fields of view have been analyzed along with their proper motions to determine the distance to the cluster. Knowledge of the convergent point and mean proper motion of the Hyades is critical to the derivation of the distance to the center of the cluster. Depending on the choice of the proper-motion system, the derived cluster center distance varies by 9%. Adopting a reference distance of 46.1 pc or m - M = 3.32, which is derived from the ground-based parallaxes in the General Catalogue of Trigonometric Stellar Parallaxes (1995 edition), the FK5/PPM proper-motion system yields a distance 4% larger, while the Hanson system yields a distance 2% smaller. The HST FGS parallaxes reported here yield either a 14% or 5% larger distance, depending on the choice of the proper-motion system. Orbital parallaxes (Torres et al.) yield an average distance 4% larger than the reference distance. The variation in the distance derived from the HST data illustrates the importance of the proper-motion system and the individual proper motions to the derivation of the distance to the Hyades center; therefore, a full utilization of the HST FGS parallaxes awaits the establishment of an accurate and consistent proper-motion system.NASA HST GTO, HF-1042.01-93A, HF-1046.01-93A, NAS526555Astronom
Central Masses and Broad-Line Region Sizes of Active Galactic Nuclei. II. A Homogeneous Analysis of a Large Reverberation-Mapping Database
We present improved black hole masses for 35 active galactic nuclei (AGNs)
based on a complete and consistent reanalysis of broad emission-line
reverberation-mapping data. From objects with multiple line measurements, we
find that the highest precision measure of the virial product is obtained by
using the cross-correlation function centroid (as opposed to the
cross-correlation function peak) for the time delay and the line dispersion (as
opposed to full width half maximum) for the line width and by measuring the
line width in the variable part of the spectrum. Accurate line-width
measurement depends critically on avoiding contaminating features, in
particular the narrow components of the emission lines. We find that the
precision (or random component of the error) of reverberation-based black hole
mass measurements is typically around 30%, comparable to the precision attained
in measurement of black hole masses in quiescent galaxies by gas or stellar
dynamical methods. Based on results presented in a companion paper by Onken et
al., we provide a zero-point calibration for the reverberation-based black hole
mass scale by using the relationship between black hole mass and host-galaxy
bulge velocity dispersion. The scatter around this relationship implies that
the typical systematic uncertainties in reverberation-based black hole masses
are smaller than a factor of three. We present a preliminary version of a
mass-luminosity relationship that is much better defined than any previous
attempt. Scatter about the mass-luminosity relationship for these AGNs appears
to be real and could be correlated with either Eddington ratio or object
inclination.Comment: 61 pages, including 8 Tables and 16 Figures. Accepted for publication
in The Astrophysical Journa
Evidence for a Long-period Planet Orbiting Epsilon Eridani
High precision radial velocity (RV) measurements spanning the years
1980.8--2000.0 are presented for the nearby (3.22 pc) K2 V star Eri.
These data, which represent a combination of six independent data sets taken
with four different telescopes, show convincing variations with a period of
7 yrs. A least squares orbital solution using robust estimation
yields orbital parameters of period, = 6.9 yrs, velocity -amplitude
19 {\ms}, eccentricity 0.6, projected companion mass sin = 0.86
, and semi-major axis 3.3 AU. Ca II H&K S-index
measurements spanning the same time interval show significant variations with
periods of 3 and 20 yrs, yet none at the RV period. If magnetic activity were
responsible for the RV variations then it produces a significantly different
period than is seen in the Ca II data. Given the lack of Ca II variation with
the same period as that found in the RV measurements, the long-lived and
coherent nature of these variations, and the high eccentricity of the implied
orbit, Keplerian motion due to a planetary companion seems to be the most
likely explanation for the observed RV variations. The wide angular separation
of the planet from the star (approximately 1 arc-second) and the long orbital
period make this planet a prime candidate for both direct imaging and
space-based astrometric measurements.Comment: To appear in Astrophysical Journal Letters. 9 pages, 2 figure
Rapid clearance profile of plasma circulating tumor HPV type 16 DNA during chemoradiotherapy correlates with disease control in HPV-associated oropharyngeal cancer
Purpose: To identify a profile of circulating tumor human papilloma virus (HPV) DNA (ctHPVDNA) clearance kinetics that is associated with disease control after chemoradiotherapy (CRT) for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). Experimental Design: A multi-institutional prospective biomarker trial was conducted in 103 patients with (i) p16- positive OPSCC, (ii) M0 disease, and (iii) receipt of definitive CRT. Blood specimens were collected at baseline, weekly during CRT, and at follow-up visits. Optimized multianalyte digital PCR assays were used to quantify ctHPVDNA (types 16/18/31/33/35) in plasma. A control cohort of 55 healthy volunteers and 60 patients with non-HPV-associated malignancy was also analyzed. Results: Baseline plasma ctHPVDNA had high specificity (97%) and high sensitivity (89%) for detecting newly diagnosed HPV-associated OPSCC. Pretreatment ctHPV16DNA copy number correlated with disease burden, tumor HPV copy number, and HPV integration status. We define a ctHPV16DNA favorable clearance profile as having high baseline copy number (>200 copies/mL) and >95% clearance of ctHPV16DNA by day 28 of CRT. Nineteen of 67 evaluable patients had a ctHPV16DNA favorable clearance profile, and none had persistent or recurrent regional disease after CRT. In contrast, patients with adverse clinical risk factors (T4 or >10 pack years) and an unfavorable ctHPV16DNA clearance profile had a 35% actuarial rate of persistent or recurrent regional disease after CRT (P = 0.0049). Conclusions: A rapid clearance profile of ctHPVDNA may predict likelihood of disease control in patients with HPVassociated OPSCC patients treated with definitive CRT and may be useful in selecting patients for deintensified therapy
A detailed analysis of the HD 73526 2:1 resonant planetary system
We present six years of new radial velocity data from the Anglo-Australian and Magellan Telescopes on the HD 73526 2:1 resonant planetary system. We investigate both Keplerian and dynamical ( interacting) fits to these data, yielding four possible configurations for the system. The new data now show that both resonance angles are librating, with amplitudes of 40 degrees and 60 degrees, respectively. We then perform long-term dynamical stability tests to differentiate these solutions, which only differ significantly in the masses of the planets. We show that while there is no clearly preferred system inclination, the dynamical fit with i = 90 degrees provides the best combination of goodness-of-fit and long-term dynamical stability.Peer reviewe
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