The Comet Interceptor Mission

Here we describe the novel, multi-point Comet Interceptor mission. It is dedicated to the exploration of a little-processed long-period comet, possibly entering the inner Solar System for the first time, or to encounter an interstellar object originating at another star. The objectives of the mission are to address the following questions: What are the surface composition, shape, morphology, and structure of the target object? What is the composition of the gas and dust in the coma, its connection to the nucleus, and the nature of its interaction with the solar wind? The mission was proposed to the European Space Agency in 2018, and formally adopted by the agency in June 2022, for launch in 2029 together with the Ariel mission. Comet Interceptor will take advantage of the opportunity presented by ESA’s F-Class call for fast, flexible, low-cost missions to which it was proposed. The call required a launch to a halo orbit around the Sun-Earth L2 point. The mission can take advantage of this placement to wait for the discovery of a suitable comet reachable with its minimum ΔV capability of 600 ms−1. Comet Interceptor will be unique in encountering and studying, at a nominal closest approach distance of 1000 km, a comet that represents a near-pristine sample of material from the formation of the Solar System. It will also add a capability that no previous cometary mission has had, which is to deploy two sub-probes – B1, provided by the Japanese space agency, JAXA, and B2 – that will follow different trajectories through the coma. While the main probe passes at a nominal 1000 km distance, probes B1 and B2 will follow different chords through the coma at distances of 850 km and 400 km, respectively. The result will be unique, simultaneous, spatially resolved information of the 3-dimensional properties of the target comet and its interaction with the space environment. We present the mission’s science background leading to these objectives, as well as an overview of the scientific instruments, mission design, and schedule

Endométriose pelvienne profonde et infertilité (quelle chirurgie)

ANGERS-BU Médecine-Pharmacie (490072105) / SudocSudocFranceF

BLEXVFR: Designing a Mobile Assistant for Pilots Through a User-Centered Approach

International audiencePiloting an aircraft is a difficult task that requires high-level cognitive abilities. Few studies have investigated the use of cognitive assistants to support pilots. This study is a first step toward an in-flight assistant for light aircraft pilots. We applied a user-centered approach to develop BLEXVFR, a mobile application that enables pilots to access information and program alerts. A pilot study in a simulator with four pilots showed that the user experience of BLEXVFR was at least comparable to existing applications. CCS Concepts: • Human-centered computing → HCI design and evaluation methods; Interactive systems and tools; Touch screens

Carte de la forest de Bierre dite de Fontainebleau, et de ses environs depuis trois jusques à Sept lieües communes de France avec les noms des Seig[neu]rs à qui appartiennent les terres qui y sont enclavées. Dédiée au Roy / par son très humble très obeissant et très fidel sujet, l'Abbé Guilbert, précepteur des Pages de Sa Majesté. Echelle de 2000 perches [=Om. 135], 2 grandes lieues [=Om. 105], 3 lieues parisiennes [=Om. 110], 5 lieues communes de France [Om. 206], 4400 toises [=Om. 080 ; 1 : 107 250 ] ; Scotin sculp

Appartient à l’ensemble documentaire : IledeFr

Facteurs de radiorésistance des cellules souches cancéreuses et perspectives de radiosensibilisation : l'exemple du glioblastome

International audienceLes cellules souches cancéreuses sont l'objet d'un intérêt croissant. En particulier, plusieurs données suggèrent leur implication dans les mécanismes de radiorésistance tumorale, pouvant ainsi expliquer les échappements thérapeutiques après radiothérapie. De par son pronostic péjoratif et son taux élevé de rechutes après irradiation, le glioblastome constitue un modèle très souvent étudié dans la recherche de nouveaux radiosensiblisants. Il existe plusieurs données précliniques suggérant que les cellules souches cancéreuses pourraient constituer une cible thérapeutique potentielle dans la perspective d'améliorer l'efficacité biologique de l'irradiation. À travers l'exemple du glioblastome, nous effectuons une revue des principales voies de signalisation intervenant dans les mécanismes de radiorésistance des cellules souches cancéreuses et pour lesquelles un ciblage pharmacologique laisse entrevoir des perspectives de radiosensibilisation