POTALA KATUROHINYADI KWATHA IN KAPHAJA YAKRIT DALLUDARA (NON-ALCOHOLIC FATTY LIVER DISEASE): A CASE STUDY

Non- alcoholic fatty liver disease (NAFLD) is also otherwise termed as Hepatic steatosis and Kaphaja yakrit dalludara in Ayurveda. 34 years male patient, highly educated from a high socio-economic group of Non vegetarian diet habit came to hospital with complain of anorexia, indigestion and distention for three months. The clinical findings revealed that he is slightly obese, hyperglycaemia and dyslipidimia along elevated liver enzymes with fatty liver in USG and Fibro scan. The case was treated with Patolakaturohinyadi Kwatham (PKK) in the dose was 30ml Kasaya with equal quantity of luke warm water twice daily in empty stomach preferable morning and evening for six months. This study proved that PKK can significantly reduced blood sugar, serum Lipids and liver enzymes within three months along with reduction weight and BMI, but change in liver architecture required six months in this therapy. The BARD score and NAFLD score changed to normal after six months of therapy. The patient was kept in observation for further one year without medication and advised to practice yoga, exercise and low carbohydrate and fat diet to study the recurrence of disease. The liver architecture as well as biochemical profile of liver is maintained after one year also. PKK may correct the metabolic dysfunction by increase Agni, digest Ama which helped in the correction of hyperglycaemia and dyslipidaemia. PKK is safe in for six months of use in recommended dose (30ml BID) as there was no adverse sign and symptom observed and no change in biochemical and Haematological profile of Patients.PKK is safe and effective in this case of Kaphaja Yakrit dalludara (NAFLD). It can study further in large population to generated evidence for its efficacy and efficacy in larger group

TIME SERIES MODELLING OF HOSPITAL CENSUS: APPLICATION ON OUT PATIENT DEPARTMENT DATA OF AN AYURVEDIC SECONDARY CARE HOSPITAL

The main objective of this paper is to fitt a curve on OPD data, for predicting the hospital OPD data. Four models were selected for curve fitting. All four models were fitted to old and new OPD patients for male and female separately. Models equations and coefficient of determination were calculated. Second order polynomial model was fitted well in all situations though exponential model was fitted well on old OPD patient data

MANAGEMENT OF A CASE OF LUMBAR STENOSIS WITH AYURVEDIC INTERVENTION

ABSTRACTAyurveda intervention is gaining popularity for chronic and degenerative disorders. Lumbar stenosis is narrowing of spaces of lumbar spine causemorbidity in old age. Surgical laminectomy is the only answer in conventional therapy. However, the disease can be better managed in Ayurvedathrough panchakarma and rasayana treatment.Keywords: Low back pain, Lumbar stenosis, Panchakarma, Katigraha

A COMPREHENSIVE REVIEW ON IN VITRO ANTHELMINTIC ACTIVITIES OF SOME AYURVEDIC PLANTS

Ayurveda, the Science of life, commonly uses medicinal plants for treating various diseases. Numerous medicinal plants are being used traditionally for treating parasitic infections in India. In Ayurveda, worm infestation in the gastro intestinal tract is known as Krimi roga. Many Ayurvdeic medicinal plants are used traditionally for treating Krimi roga. Use of synthetic drugs anthelmintic for treating parasitic infestations causes serious toxic side effects in human. Use of Ayurvedic plants has no such side effects and, economical. The paper highlights anthelmintic activities of some of the most important Ayurvedic medicinal plants carried out in vitro in various pharmacological models. A brief review of In vitro anthelmintic activities of thirteen Ayurvedic medicinal plants published by various researchers is illustrated in this paper. The medicinal plants discussed here are Vidanga: Embelia ribes Burm. F, Kalmegh: Andrographis paniculata (Burm.f.) Nees, Gunja: Abrus precatorius L., Kiratatikta: Swertia chirata L., Khadira: Acacia catechu (L.f.) Willd., Ativisha: Aconitum heterophyllum Wall. ex Royle, Saptaparna: Alstonia scholaris (L.) R. Br., Aragvadha: Cassia fistula L., Nimba (Azadirahcta indica A. Juss.), Brahmi: Bacopa monnieri (L.) Penn., Mandukaparni: Centella asiatica (L.) Urban, Vacha: Acorus calamus L. and Chirbhita: Carica papaya L

Seasonal dynamics of Shatavarin-IV, a potential biomarker of Asparagus racemosus by HPTLC: Possible validation of the ancient Ayurvedic text.

The medicinal property of Asparagus racemosus is primarily attributed to its constituent steroidal saponins, particularly the major component, shatavarin-IV. Thus, it can serve as a biomarker and its level can decide of the utility of the plant cultivar as a drug. Hence, a sensitive, reliable and quantitative High Performance Thin Layer Chromatography (HPTLC) method has been established for quantification of shatavarin-IV in the methanolic extracts of the roots collected in both summer and rainy seasons. The extracts of the powders of dried roots were applied to silica gel 60 F254 aluminum-supported precoated TLC plates and developed with n-hexane: ethyl acetate: methanol, 80:10:10 (v/v), as the mobile phase. Shatavarin-IV was detected and quantified by densitometry at λ = 336 nm. The accuracy of the method was checked by conducting recovery studies at three different levels of shatavarin-IV. The average recovery was found to be 101% and 107% for summer and rainy seasons respectively. The shatavarin-IV contents, as estimated by the proposed method were 12.5 μg gm-1 and 10.9 μg gm-1 in summer and rainy roots respectively. The entire method was performed six times (n=6) to check the repeatability. The proposed HPTLC method for quantitative monitoring of shatavarin-IV in A. racemosus roots collected in different seasons strictly adhered to the validation issues laid down by the ICH guidelines. The method is reliable reproducible and highly precise and selective

Seasonal dynamics of Shatavarin-IV, a potential biomarker of Asparagus racemosus by HPTLC: Possible validation of the ancient Ayurvedic text.

174-181The medicinal property of Asparagus racemosus is primarily attributed to its constituent steroidal saponins, particularly the major component, shatavarin-IV. Thus, it can serve as a biomarker and its level can decide of the utility of the plant cultivar as a drug. Hence, a sensitive, reliable and quantitative High Performance Thin Layer Chromatography (HPTLC) method has been established for quantification of shatavarin-IV in the methanolic extracts of the roots collected in both summer and rainy seasons. The extracts of the powders of dried roots were applied to silica gel 60 F254 aluminum-supported precoated TLC plates and developed with n-hexane: ethyl acetate: methanol, 80:10:10 (v/v), as the mobile phase. Shatavarin-IV was detected and quantified by densitometry at λ = 336 nm. The accuracy of the method was checked by conducting recovery studies at three different levels of shatavarin-IV. The average recovery was found to be 101% and 107% for summer and rainy seasons respectively. The shatavarin-IV contents, as estimated by the proposed method were 12.5 μg gm-1 and 10.9 μg gm-1 in summer and rainy roots respectively. The entire method was performed six times (n=6) to check the repeatability. The proposed HPTLC method for quantitative monitoring of shatavarin-IV in A. racemosus roots collected in different seasons strictly adhered to the validation issues laid down by the ICH guidelines. The method is reliable reproducible and highly precise and selective

Pharmacognostical and phytochemical blueprint of Abroma augusta L. stem bark

Uses of Abroma augusta L. stem and root are mentioned in traditional texts where the presence of the alkaloid, betaine in these parts is known. The study was undertaken to generate a pharmacognostical and phytochemical blueprint of Abroma augusta stem bark and detection of the bioactive alkaloid, betaine in it. Authenticated plant materials were subjected to pharmacognostical, physicochemical, and phytochemical studies. HPTLC, HPLC, and FTIR were used for chemical fingerprinting of the plant materials. Diagnostic features of A. augusta stem bark such as organoleptic evaluation, powder microscopic characters, fluorescence profile with various reagents were established. Phytochemical screening of different solvent extracts showed the presence of alkaloids, steroids, saponins, tannins, phenolics, glycosides, but fewer terpenoids, flavonoids, and carbohydrates. This was rationalized by FTIR spectroscopy of the chloroform extract that gave maximum extractive yield. HPTLC and HPLC fingerprint profiling with marker identification was generated. The alkaloid, betaine was isolated and identified by mass spectrum. The botanical and chemical screening suggested that A. augusta stem bark may be a potential substitute for the root or stem of the plant. However, further, bio-evaluations are required to ascertain its possible clinical applications. The generated profile may serve as a reference document in future for identification and authentication of the plant material

Pharmacognostical and phytochemical blueprint of Abroma augusta L. stem bark

271-280Uses of Abroma augusta L. stem and root are mentioned in traditional texts where the presence of the alkaloid, betaine in these parts is known. The study was undertaken to generate a pharmacognostical and phytochemical blueprint of Abroma augusta stem bark and detection of the bioactive alkaloid, betaine in it. Authenticated plant materials were subjected to pharmacognostical, physicochemical, and phytochemical studies. HPTLC, HPLC, and FTIR were used for chemical fingerprinting of the plant materials. Diagnostic features of A. augusta stem bark such as organoleptic evaluation, powder microscopic characters, fluorescence profile with various reagents were established. Phytochemical screening of different solvent extracts showed the presence of alkaloids, steroids, saponins, tannins, phenolics, glycosides, but fewer terpenoids, flavonoids, and carbohydrates. This was rationalized by FTIR spectroscopy of the chloroform extract that gave maximum extractive yield. HPTLC and HPLC fingerprint profiling with marker identification was generated. The alkaloid, betaine was isolated and identified by mass spectrum. The botanical and chemical screening suggested that A. augusta stem bark may be a potential substitute for the root or stem of the plant. However, further, bio-evaluations are required to ascertain its possible clinical applications. The generated profile may serve as a reference document in future for identification and authentication of the plant material

Development of quality standards of Triphala Kwatha churna with its ingredients through HPTLC and mass spectroscopy

113-119In recent years there has been rapid growth in the field of herbal medicine. Drugs belonging to Asian traditional systems of medicine are accepted universally only after standardisation. It is therefore, very important to develop essential techniques for standardisation of herbal drugs. The present study has focused on development of quality standards of Triphala Kwatha churna under WHO/API guidelines along with HPTLC and mass spectroscopy. This polyherbal Kwatha churna is used to treat constipation and other gastric disorders. In this study, an in-house prepared Triphala Kwatha churna was botanically and chemically standardised by HPTLC and mass spectroscopic studies with the reference standard gallic acid. The botanical standardisation of the above formulation was done by evaluation of macroscopic and microscopic studies of the powder formulation along with its ingredients. Physicochemical parameters like LOD, ash value, acid insoluble ash, water and alcohol extractives were determined. Safety parameters, viz., heavy metals, microbial content, specific pathogens, pesticide residue and aflatoxins detection have been also estimated. The results obtained in the present study defining quality control parameters help to develop the quality standards of Triphala Kwatha churna formulation. The HPTLC fingerprint profiling of the formulation along with its ingredients complies with the reference standards gallic acid. This observation is also found in Mass Spectroscopic study of the methanolic extract of the formulation with this reference standard. Preliminary phytochemical screening test revealed the presence of bioactive constituents including phenols, flavonoids, tannins and carbohydrate

Therapeutic uses of Tamra (copper) Bhasma - A review through Ayurved Samgraha and other texts

Materia Medica of Ayurveda is using best scientific and applied Rasa Chikitsa and Rasa Ausadhi occupied an important place in the field of Ayurvedic practice. It deals with metal, minerals and poisonous drug. Starting from 9th century AD to 16th century AD was the sunshine period of Rasa Chikitsa, then gradually decline probably due to introduction of western medicine. It’s efficacy is superior than plant formulation due to its unlimited expiry, effective in small dose, abundant resource and quickly effective on the target tissue even it can handle emergency situations also but the most important background of Rasa Ausadhi received highly technical processing (Shodhan, Marana, Jarana[1]) for the treatment of diseases. In this content liver function test and estimation of renal profile (before and after) will help for gaining confidence both in patient and physician prior to use compound formulations containing Tamra Bhasma. Tamra Bhasma is a metal compound which is used for treatment of various disease like Jwara, Bala Roga, Grahani Roga, Pandu, Visarpa, Brishya, Yakrit Roga, Pliha Roga etc