POTALA KATUROHINYADI KWATHA IN KAPHAJA YAKRIT DALLUDARA (NON-ALCOHOLIC FATTY LIVER DISEASE): A CASE STUDY

Non- alcoholic fatty liver disease (NAFLD) is also otherwise termed as Hepatic steatosis and Kaphaja yakrit dalludara in Ayurveda. 34 years male patient, highly educated from a high socio-economic group of Non vegetarian diet habit came to hospital with complain of anorexia, indigestion and distention for three months. The clinical findings revealed that he is slightly obese, hyperglycaemia and dyslipidimia along elevated liver enzymes with fatty liver in USG and Fibro scan. The case was treated with Patolakaturohinyadi Kwatham (PKK) in the dose was 30ml Kasaya with equal quantity of luke warm water twice daily in empty stomach preferable morning and evening for six months. This study proved that PKK can significantly reduced blood sugar, serum Lipids and liver enzymes within three months along with reduction weight and BMI, but change in liver architecture required six months in this therapy. The BARD score and NAFLD score changed to normal after six months of therapy. The patient was kept in observation for further one year without medication and advised to practice yoga, exercise and low carbohydrate and fat diet to study the recurrence of disease. The liver architecture as well as biochemical profile of liver is maintained after one year also. PKK may correct the metabolic dysfunction by increase Agni, digest Ama which helped in the correction of hyperglycaemia and dyslipidaemia. PKK is safe in for six months of use in recommended dose (30ml BID) as there was no adverse sign and symptom observed and no change in biochemical and Haematological profile of Patients.PKK is safe and effective in this case of Kaphaja Yakrit dalludara (NAFLD). It can study further in large population to generated evidence for its efficacy and efficacy in larger group

A COMPREHENSIVE REVIEW ON IN VITRO ANTHELMINTIC ACTIVITIES OF SOME AYURVEDIC PLANTS

Ayurveda, the Science of life, commonly uses medicinal plants for treating various diseases. Numerous medicinal plants are being used traditionally for treating parasitic infections in India. In Ayurveda, worm infestation in the gastro intestinal tract is known as Krimi roga. Many Ayurvdeic medicinal plants are used traditionally for treating Krimi roga. Use of synthetic drugs anthelmintic for treating parasitic infestations causes serious toxic side effects in human. Use of Ayurvedic plants has no such side effects and, economical. The paper highlights anthelmintic activities of some of the most important Ayurvedic medicinal plants carried out in vitro in various pharmacological models. A brief review of In vitro anthelmintic activities of thirteen Ayurvedic medicinal plants published by various researchers is illustrated in this paper. The medicinal plants discussed here are Vidanga: Embelia ribes Burm. F, Kalmegh: Andrographis paniculata (Burm.f.) Nees, Gunja: Abrus precatorius L., Kiratatikta: Swertia chirata L., Khadira: Acacia catechu (L.f.) Willd., Ativisha: Aconitum heterophyllum Wall. ex Royle, Saptaparna: Alstonia scholaris (L.) R. Br., Aragvadha: Cassia fistula L., Nimba (Azadirahcta indica A. Juss.), Brahmi: Bacopa monnieri (L.) Penn., Mandukaparni: Centella asiatica (L.) Urban, Vacha: Acorus calamus L. and Chirbhita: Carica papaya L

Seasonal dynamics of Shatavarin-IV, a potential biomarker of Asparagus racemosus by HPTLC: Possible validation of the ancient Ayurvedic text.

The medicinal property of Asparagus racemosus is primarily attributed to its constituent steroidal saponins, particularly the major component, shatavarin-IV. Thus, it can serve as a biomarker and its level can decide of the utility of the plant cultivar as a drug. Hence, a sensitive, reliable and quantitative High Performance Thin Layer Chromatography (HPTLC) method has been established for quantification of shatavarin-IV in the methanolic extracts of the roots collected in both summer and rainy seasons. The extracts of the powders of dried roots were applied to silica gel 60 F254 aluminum-supported precoated TLC plates and developed with n-hexane: ethyl acetate: methanol, 80:10:10 (v/v), as the mobile phase. Shatavarin-IV was detected and quantified by densitometry at λ = 336 nm. The accuracy of the method was checked by conducting recovery studies at three different levels of shatavarin-IV. The average recovery was found to be 101% and 107% for summer and rainy seasons respectively. The shatavarin-IV contents, as estimated by the proposed method were 12.5 μg gm-1 and 10.9 μg gm-1 in summer and rainy roots respectively. The entire method was performed six times (n=6) to check the repeatability. The proposed HPTLC method for quantitative monitoring of shatavarin-IV in A. racemosus roots collected in different seasons strictly adhered to the validation issues laid down by the ICH guidelines. The method is reliable reproducible and highly precise and selective

PHARMACOLOGICAL AND THERAPEUTIC PROFILE OF ANANTAMULA (HEMIDESMUS INDICUS (L.) R. BR.): A COMPREHENSIVE REVIEW

The vast field of Ayurvedic science is gaining more importance and popularity throughout the world because of its amazing therapeutic value. Since the beginning of human civilization, medicinal plants have been used by mankind for its therapeutic value. The World Health Organization estimated that 80% of people worldwide rely on herbal medicines for some aspect of their primary healthcare. Hemidesmus indicus is a widely used shrub in Indian folk medicine and considered as magical spiritual dream herb in Ayurvedic medication. It is used as a vital herb for healing many ailments and to treat diversified diseases. Following a large number of claims on the wide range of traditional medicinal properties of the plants, considerable effort have been made to verify its efficacy as a curative agent through pharmacological investigations. Different pharmacological experiments in vitro and in vivo models convincingly demonstrated the ability of Anantamula to exhibit analgesic, anti-inflammatory, antipyretic, antiarthritic, antioxidant, hepatoprotective, nephroprotective, antiepileptic, anticonvulsant, antileprotic, antiacne, antipsychotic, nootropic, antinociceptive, antidiarrhoeal, antigenotoxic, antiangiogenic, wound healing, antiulcer, larvicidal, antivenom, antithrombotic, antihyperlipaedaemic, antimicrobial and anticarcinogenic activities due to its remarka­ble biological activity and bioactive constituents. This plant is a good source of different bioactive chemical compound like Hemidesmin-1 and Hemidesmin-2, α-amyrin, β-amyrin, lupeol acetate, β-sitosterol, hemidesmol and hemidesterol which were responsible for many of the pharmacological activities. This review aims at providing an up-to-date overview of comprehensive account of the phytochemical investigation, therapeutic potential and pharmacological studies of Hemidesmus indicus