Materia Medica of Ayurveda is using best scientific and applied Rasa Chikitsa and Rasa Ausadhi occupied an important place in the field of Ayurvedic practice. It deals with metal, minerals and poisonous drug. Starting from 9th century AD to 16th century AD was the sunshine period of Rasa Chikitsa, then gradually decline probably due to introduction of western medicine. It’s efficacy is superior than plant formulation due to its unlimited expiry, effective in small dose, abundant resource and quickly effective on the target tissue even it can handle emergency situations also but the most important background of Rasa Ausadhi received highly technical processing (Shodhan, Marana, Jarana[1]) for the treatment of diseases. In this content liver function test and estimation of renal profile (before and after) will help for gaining confidence both in patient and physician prior to use compound formulations containing Tamra Bhasma. Tamra Bhasma is a metal compound which is used for treatment of various disease like Jwara, Bala Roga, Grahani Roga, Pandu, Visarpa, Brishya, Yakrit Roga, Pliha Roga etc