By E-Care Pharmacy Web Application, the Medicines Needed for Daily Human Life Can be Easily Delivered to Them

This project offers knowledge on creating and putting in place a pharmaceutical management system. And here, the major objective is to increase the efficacy, efficiency, and accuracy of the drug. In today's world, management is one of the most crucial organizational components. Additionally, complexity is added when management does a certain activity in any way. In other words, the availability of computers and advancements in information technology have made it possible for us to swiftly and effectively gather and communicate vast volumes of data on patient treatment. The pharmacy management system should be able to get prescriptions and non-prescription medications with the assistance of certified, trained pharmacists in order to provide patients with the medications they require. Today, many of these types of pharmacy management systems are used to better manage pharmacy-related activities

Interfacial Molecular Imprinting in Nanoparticle-Stabilized Emulsions

A new interfacial nano and molecular imprinting approach is developed to prepare spherical molecularly imprinted polymers with well-controlled hierarchical structures. This method is based on Pickering emulsion polymerization using template-modified colloidal particles. The interfacial imprinting is carried out in particle-stabilized oil-in-water emulsions, where the molecular template is presented on the surface of silica nanoparticles during the polymerization of the monomer phase. After polymerization, the template-modified silica nanoparticles are removed from the new spherical particles to leave tiny indentations decorated with molecularly imprinted sites. The imprinted microspheres prepared using the new interfacial nano and molecular imprinting have very interesting features: a well-controlled hierarchical structure composed of large pores decorated with easily accessible molecular binding sites, group selectivity toward a series of chemicals having a common structural moiety (epitopes), and a hydrophilic surface that enables the MIPs to be used under aqueous conditions

Optimization of spray-drying conditions for lulo (Solanum quitoense L.) pulp

The spray drying of lulo was optimized by using the central composite design of the response surface methodology, to study the effect of inlet air temperature (120-180 degrees C), arabic gum concentration (0-10% w/w), and maltodextrin DE16.5-19.5 concentration (0-10% w/w) on some product and process aspects. Arabic gum and maltodextrin, more than inlet air temperature, improved the product yield, reduced the hygroscopicity and the water content of the obtained powder, and contributed to the retention of its nutritive and functional properties through an increase in ascorbic acid, vitamin C, total phenol and total flavonoid content and antioxidant capacity. Significant (p < 0.05) response surface models were obtained in every case, with the linear terms of solute concentration being the factors that affected the response variables most significantly. The overall optimum spray drying conditions for obtaining lulo powder were 125 degrees C inlet air temperature, 3% (w/w) arabic gum, and 13.4% (w/w) maltodextrin DE16.5-19.5. (C) 2014 Elsevier B.V. All rights reserved.The authors thank the Universidad Politecnica de Valencia for the financial support given throughout the Project ADSIDEO-COOPERACION 2010 "Adaptacion de procesos de secado para favorecer la comercializacion de super frutas de origen colombiano".Igual Ramo, M.; Ramires, S.; Mosquera, LH.; Martínez Navarrete, N. (2014). Optimization of spray-drying conditions for lulo (Solanum quitoense L.) pulp. Powder Technology. 256:233-238. doi:10.1016/j.powtec.2014.02.003S23323825

Worldwide Argus II implantation: recommendations to optimize patient outcomes

Abstract Background A position paper based on the collective experiences of Argus II Retinal Prosthesis System investigators to review strategies to optimize outcomes in patients with retinitis pigmentosa undergoing retinal prosthesis implantation. Methods Retinal surgeons, device programmers, and rehabilitation specialists from Europe, Canada, Middle East, and the United States were convened to the first international Argus II Investigator Meeting held in Ann Arbor, MI in March 2015. The recommendations from the collective experiences were collected. Factors associated with successful outcomes were determined. Results Factors leading to successful outcomes begin with appropriate patient selection, expectation counseling, and preoperative retinal assessment. Challenges to surgical implantation include presence of staphyloma and inadequate Tenon’s capsule or conjunctiva. Modified surgical technique may reduce risks of complications such as hypotony and conjunctival erosion. Rehabilitation efforts and correlation with validated outcome measures following implantation are critical. Conclusions Bringing together Argus II investigators allowed the identification of strategies to optimize patient outcomes. Establishing an on-line collaborative network will foster coordinated research efforts to advance outcome assessment and rehabilitation strategies.http://deepblue.lib.umich.edu/bitstream/2027.42/134581/1/12886_2016_Article_225.pd

Case Report: melioidosis - poor compliance resulting in a relapse

No abstract availabl

Impact of milk protein type on the viability and storage stability of microencapsulated Lactobacillus acidophilus using spray drying

Three different milk proteins — skim milk powder (SMP), sodium caseinate (SC) and whey protein concentrate (WPC) — were tested for their ability to stabilize microencapsulated L. acidophilus produced using spray drying. Maltodextrin (MD) was used as the primary wall material in all samples, milk protein as the secondary wall material (7:3 MD/milk protein ratio) and the simple sugars, d-glucose and trehalose were used as tertiary wall materials (8:2:2 MD/protein/sugar ratio) combinations of all wall materials were tested for their ability to enhance the microbial and techno-functional stability of microencapsulated powders. Of the optional secondary wall materials, WPC improved L. acidophilus viability, up to 70 % during drying; SMP enhanced stability by up to 59 % and SC up to 6 %. Lactose and whey protein content enhanced thermoprotection; this is possibly due to their ability to depress the glass transition and melting temperatures and to release antioxidants. The resultant L. acidophilus powders were stored for 90 days at 4 °C, 25 °C and 35 °C and the loss of viability calculated. The highest survival rates were obtained at 4 °C, inactivation rates for storage were dependent on the carrier wall material and the SMP/d-glucose powders had the lowest inactivation rates (0.013 day−1) whilst the highest was observed for the control containing only MD (0.041 day−1) and the SC-based system (0.030 day−1). Further increase in storage temperature (25 °C and 35 °C) was accompanied by increase of the inactivation rates of L. acidophilus that followed Arrhenius kinetics. In general, SMP-based formulations exhibited the highest temperature dependency whilst WPC the lowest. d-Glucose addition improved the storage stability of the probiotic powders although it was accompanied by an increase of the residual moisture, water activity and hygroscopicity, and a reduction of the glass transition temperature in the tested systems

A low cost novel sensing system for detection of dangerous marine biotoxins in seafood

A novel planar interdigital sensor-based sensing system has been developed for detection of dangerous marine biotoxins in seafood. Our main objective is to sense the presence of dangerous contaminated acid in mussels and other seafood by observing the change of reactive impedance of the planar interdigital sensors. Initial studies were conducted with three peptide derivatives namely sarcosine, proline and hydroxylproline. These three chemicals are structurally closely related to our target molecule. The proline molecule is arguably the most important amino acid in peptide conformation, contains the basic structural similarity to the domoic acid. Three novel interdigital sensors have been designed and fabricated. All sensors have the same effective area but having different sensor configurations. The initial results show that sensors respond very well to the chemicals and it is possible to discriminate the different chemicals from the output of the sensor. The sensors were also being tested with three seafood products. Results from the analysis have shown that one configuration has better sensitivity compared to other configurations. The sensor with the best sensitivity was chosen for experiment using proline and mussels. The changes in sensor sensitivity were analyzed with mussels before and after adding the proline. The presence of proline on the mussel surface and also injected proline to the mussels was very clearly detected by the sensor. Further experiment was conducted with small amount of domoic acid (0.5–5.0 μg) injected to a mussel and it was found that the chosen sensor was able to detect small amount of domoic acid (1.0 μg) injected into the mussel sample. The result shows that the sensor was able to detect approximately 12.6 μg/g of domoic acid in mussel meat. The outcomes from the experiments provide chances of opportunity for further research in developing a low cost miniature type of sensors for reliable sensing system for commercial use.9 page(s

Initial Investigation of Using Planar Interdigital Sensors for Assessment of Quality in Seafood

A planar interdigital sensor-based sensing system has been fabricated for assessment of seafood quality. Our main objective is to sense the molecule of domoic acid presence in mussels. Three peptide derivatives namely sarcosine, proline, and hydroxylproline were used for the initial studies which are structurally closely related to our target molecule. The proline molecule is arguably the most important amino acid in peptide conformation, containing the basic structural similarity to the domoic acid. Three novel interdigital sensors have been designed and fabricated. The initial result shows that sensors respond very well to the chemicals and it is possible to discriminate the different chemicals from the output of the sensor. Results from the analysis have shown that Sensor_1 has better sensitivity compared to other sensors. Sensor_1 was chosen for further analysis with real mussels. The changes in sensor impedance were then analysed with real mussels before and after adding the proline. The presence of proline on the mussel samples was detected by the sensor. Results also showed a good correlation of 2 = 0.717 between sensitivity and sample thickness