Comment on the Nature of the Ds1∗(2710)D_{s1}^*(2710) and DsJ∗(2860)D_{sJ}^*(2860) Mesons

Two charm-strange mesons, the $D_{s1}^*(2710)$ and the $D_{sJ}^*(2860)$, have recently been observed by several experiments. There has been speculation in the literature that the $D_{s1}^*(2710)$ is the $2^3S_1(c\bar{s})$ state and the $D_{sJ}^*(2860)$ is the $1^3D_1(c\bar{s})$ state. In this paper we explore this and other explanations in the context of the relativized quark model and the pseudoscalar emission decay model. We conclude that the $D_{s1}^*(2710)$ is most likely the $1^3D_1 (c\bar{s})$ state and the $D_{sJ}^*(2860)$ is most likely the $1^3D_3 (c\bar{s})$ state with the $1D_2$ resonances also contributing to the observed signals and explaining the observed ratios of branching ratios to $D^*K$ and $DK$ final states. We point out that measuring the $D_{sJ}^*(2860)$ spin can support or eliminate this explanation and that there are six excited $D_s$ states in this mass region; the $2^3S_1$, $2^1S_0$, $1^3D_1$, $1^3D_3$ and two $1D_2$ states. Observing some of the missing states would help confirm the nature of the $D_{s1}^*(2710)$ and the $D_{sJ}^*(2860)$ states.Comment: 8 pages, 2 figure

Operator mixing in deformed D1D5 CFT and the OPE on the cover

We consider the D1D5 CFT near the orbifold point and develop methods for computing the mixing of untwisted operators to first order by using the OPE on the covering surface. We argue that the OPE on the cover encodes both the structure constants for the orbifold CFT and the explicit form of the mixing operators. We show this explicitly for some example operators. We start by considering a family of operators dual to supergravity modes, and show that the OPE implies that there is no shift in the anomalous dimension to first order, as expected. We specialize to the operator dual to the dilaton, and show that the leading order singularity in the OPE reproduces the correct structure constant. Finally, we consider an unprotected operator of conformal dimension (2,2), and show that the leading order singularity and one of the subleading singularies both reproduce the correct structure constant. We check that the operator produced at subleading order using the OPE method is correct by calculating a number of three point functions using a Mathematica package we developed. Further development of this OPE technique should lead to more efficient calculations for the D1D5 CFT perturbed away from the orbifold point.Comment: 23 page

Conformal Invariance of (0,2) Sigma Models on Calabi-Yau Manifolds

Long ago, Nemeschansky and Sen demonstrated that the Ricci-flat metric on a Calabi-Yau manifold could be corrected, order by order in perturbation theory, to produce a conformally invariant (2,2) nonlinear sigma model. Here we extend this result to (0,2) sigma models for stable holomorphic vector bundles over Calabi-Yaus.Comment: 15 pages; references adde

Cell salvage and donor blood transfusion during cesarean section: A pragmatic, multicentre randomised controlled trial (SALVO)

BACKGROUND: Excessive haemorrhage at cesarean section requires donor (allogeneic) blood transfusion. Cell salvage may reduce this requirement. METHODS AND FINDINGS: We conducted a pragmatic randomised controlled trial (at 26 obstetric units; participants recruited from 4 June 2013 to 17 April 2016) of routine cell salvage use (intervention) versus current standard of care without routine salvage use (control) in cesarean section among women at risk of haemorrhage. Randomisation was stratified, using random permuted blocks of variable sizes. In an intention-to-treat analysis, we used multivariable models, adjusting for stratification variables and prognostic factors identified a priori, to compare rates of donor blood transfusion (primary outcome) and fetomaternal haemorrhage ≥2 ml in RhD-negative women with RhD-positive babies (a secondary outcome) between groups. Among 3,028 women randomised (2,990 analysed), 95.6% of 1,498 assigned to intervention had cell salvage deployed (50.8% had salvaged blood returned; mean 259.9 ml) versus 3.9% of 1,492 assigned to control. Donor blood transfusion rate was 3.5% in the control group versus 2.5% in the intervention group (adjusted odds ratio [OR] 0.65, 95% confidence interval [CI] 0.42 to 1.01, p = 0.056; adjusted risk difference -1.03, 95% CI -2.13 to 0.06). In a planned subgroup analysis, the transfusion rate was 4.6% in women assigned to control versus 3.0% in the intervention group among emergency cesareans (adjusted OR 0.58, 95% CI 0.34 to 0.99), whereas it was 2.2% versus 1.8% among elective cesareans (adjusted OR 0.83, 95% CI 0.38 to 1.83) (interaction p = 0.46). No case of amniotic fluid embolism was observed. The rate of fetomaternal haemorrhage was higher with the intervention (10.5% in the control group versus 25.6% in the intervention group, adjusted OR 5.63, 95% CI 1.43 to 22.14, p = 0.013). We are unable to comment on long-term antibody sensitisation effects. CONCLUSIONS: The overall reduction observed in donor blood transfusion associated with the routine use of cell salvage during cesarean section was not statistically significant. TRIAL REGISTRATION: This trial was prospectively registered on ISRCTN as trial number 66118656 and can be viewed on http://www.isrctn.com/ISRCTN66118656

Estimating magnetic filling factors from Zeeman–Doppler magnetograms

V.S., S.P.M., and A.J.F.acknowledge funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (grant agreement No. 682393 AWESoMeStars). S.B.S. acknowledges funding via the Austrian Space Application Programme (ASAP) of the Austrian Research Promotion Agency (FFG) within ASAP11, the FWF NFN project S11601-N16 and the sub-project S11604-N16. A. A.V. acknowledges funding received from the Irish Research Council Laureate Awards 2017/2018.Low-mass stars are known to have magnetic fields that are believed to be of dynamo origin. Two complementary techniques are principally used to characterize them. Zeeman–Doppler imaging (ZDI) can determine the geometry of the large-scale magnetic field while Zeeman broadening can assess the total unsigned flux including that associated with small-scale structures such as spots. In this work, we study a sample of stars that have been previously mapped with ZDI. We show that the average unsigned magnetic flux follows an activity-rotation relation separating into saturated and unsaturated regimes. We also compare the average photospheric magnetic flux recovered by ZDI, BV, with that recovered by Zeeman broadening studies, BI. In line with previous studies, BV ranges from a few % to ~20% of BI. We show that a power-law relationship between BV and BI exists and that ZDI recovers a larger fraction of the magnetic flux in more active stars. Using this relation, we improve on previous attempts to estimate filling factors, i.e., the fraction of the stellar surface covered with magnetic field, for stars mapped only with ZDI. Our estimated filling factors follow the well-known activity-rotation relation, which is in agreement with filling factors obtained directly from Zeeman broadening studies. We discuss the possible implications of these results for flux tube expansion above the stellar surface and stellar wind models.Publisher PDFPeer reviewe

Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1

To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized llamas were studied via deep sequencing analysis using broadly neutralizing monoclonal HCAbs as a guides. Distinct neutralizing antibody lineages were identified in each animal, including two defined by novel antibodies (as variable regions called VHH) identified by robotic screening of over 6000 clones. The combined application of five VHH against viruses from clades A, B, C and CRF_AG resulted in neutralization as potent as any of the VHH individually and a predicted 100% coverage with a median IC50 of 0.17 µg/ml for the panel of 60 viruses tested. Molecular analysis of the VHH repertoires of two sets of immunized animals showed that each neutralizing lineage was only observed following immunization, demonstrating that they were elicited de novo. Our results show that immunization can induce potent and broadly neutralizing antibodies in llamas with features similar to human antibodies and provide a framework to analyze the effectiveness of immunization protocols