ROLE OF COMPLEMENT COMPONENT 1, Q SUBCOMPONENT BINDING PROTEIN (C1QBP) IN BREAST CARCINOGENESIS

Ph.DDOCTOR OF PHILOSOPH

Whiteness and land in Indigenous education in Canadian teacher education

After decades of advocacy by Indigenous scholars and communities, Indigenous education in Canadian teacher education is gaining support and status. Throughout Canadian teacher education, the ‘common knowledge’ of pre-service teachers does not include complex understandings of Indigenous peoples, Lands, or history in what is currently known as Canada. Using multiple qualitative research methods in the methodology of the Self-Study of Teacher Education Practices (S-STEP), I investigate how I and eight teacher educators enact critical Place-based education (cPBE) in our Indigenous education in teacher education practice in Canada to trouble whiteness, centre Land, and disrupt settler colonialism. The decolonization of teacher education practices, and of the administrative structures and practices of faculties of education, is necessary to support learning with, from and for Indigenous peoples in support of Indigenous futurities. As I struggled to teach with Land at the centre and in right relation to Anishinaabe Lands and communities, I examined and transformed my own practice-in-relation alongside my students and colleagues. As the Indigenization of universities proliferates, more questions are emerging about how to do this work well. This research deeply confirms the dual oppression of Land and of Indigenous peoples that is at the heart of the Canadian identity, but it also offers some answers. Indigenous education in Canadian teacher education must include anti-racist education that contends with white privilege, Land-based learning both in and beyond the classroom, and centring local Indigenous communities by prioritizing relationships and learning contexts with them. These elements, which represent the ethical relationality and right relation necessary to cPBE in Canada, are not supported, rewarded, or remunerated in current university structures. This demands change in how universities hire, how they support critical, Land- and community-based pedagogies, and in how they conduct themselves in relation to the Lands and communities they stand on and serve

YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro

Non-coding genes that were differentially expressed following YB-1 silencing in MDA-MB-231 cells. (XLSX 10 kb

Entanglement dynamics of two-bipartite system under the influence of dissipative environments

An experimental scheme is suggested that permits a direct measure of entanglement in a two-qubit cavity system. It is realized in the cavity-QED technology utilizing atoms as flying qubits. With this scheme we generate two different measures of entanglement, namely logarithmic negativity and concurrence. The phenomenon of sudden death entanglement (ESD) in a bipartite system subjected to dissipative environment is examined. We show that the sudden death time of the entangled states depends on the initial preparation of the entangled state and the temperature of the reservoir.Comment: 21 pages, 13 figure

Entangled two cavity modes preparation via a two-photon process

We propose a scheme for entangling two field modes in two high-Q optical cavities. Making use of a virtual two-photon process, our scheme achieves maximally entangled states without any real transitions of atomic internal states, hence it is immune to the atomic decay.Comment: 4 pages, latex, 7 figure

Aquilegia, Vol. 19 No. 2, April-June 1995: Newsletter of the Colorado Native Plant Society

https://epublications.regis.edu/aquilegia/1075/thumbnail.jp

The effect of artificial selection on phenotypic plasticity in maize

Remarkable productivity has been achieved in crop species through artificial selection and adaptation to modern agronomic practices. Whether intensive selection has changed the ability of improved cultivars to maintain high productivity across variable environments is unknown. Understanding the genetic control of phenotypic plasticity and genotype by environment (G × E) interaction will enhance crop performance predictions across diverse environments. Here we use data generated from the Genomes to Fields (G2F) Maize G × E project to assess the effect of selection on G × E variation and characterize polymorphisms associated with plasticity. Genomic regions putatively selected during modern temperate maize breeding explain less variability for yield G × E than unselected regions, indicating that improvement by breeding may have reduced G × E of modern temperate cultivars. Trends in genomic position of variants associated with stability reveal fewer genic associations and enrichment of variants 0–5000 base pairs upstream of genes, hypothetically due to control of plasticity by short-range regulatory elements

Breast tumor copy number aberration phenotypes and genomic instability

BACKGROUND: Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mutated (e.g. those involved in mitosis, replication, repair, and telomeres) are rarely mutated in chromosomally unstable sporadic tumors, even though such mutations are associated with some heritable cancer prone syndromes. METHODS: We applied array comparative genomic hybridization (CGH) to the analysis of breast tumors. The variation in the levels of genomic instability amongst tumors prompted us to investigate whether alterations in processes/genes involved in maintenance and/or manipulation of the genome were associated with particular types of genomic instability. RESULTS: We discriminated three breast tumor subtypes based on genomic DNA copy number alterations. The subtypes varied with respect to level of genomic instability. We find that shorter telomeres and altered telomere related gene expression are associated with amplification, implicating telomere attrition as a promoter of this type of aberration in breast cancer. On the other hand, the numbers of chromosomal alterations, particularly low level changes, are associated with altered expression of genes in other functional classes (mitosis, cell cycle, DNA replication and repair). Further, although loss of function instability phenotypes have been demonstrated for many of the genes in model systems, we observed enhanced expression of most genes in tumors, indicating that over expression, rather than deficiency underlies instability. CONCLUSION: Many of the genes associated with higher frequency of copy number aberrations are direct targets of E2F, supporting the hypothesis that deregulation of the Rb pathway is a major contributor to chromosomal instability in breast tumors. These observations are consistent with failure to find mutations in sporadic tumors in genes that have roles in maintenance or manipulation of the genome

Immune activation in irritable bowel syndrome: can neuroimmune interactions explain symptoms?

Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal (GI) tract characterized by pain or discomfort from the lower abdominal region, which is associated with altered bowel habit. Despite its prevalence, there is currently a lack of effective treatment options for patients. IBS has long been considered as a neurological condition resulting from alterations in the brain gut axis, but immunological alterations are increasingly reported in IBS patients, consistent with the hypothesis that there is a chronic, but low-grade, immune activation. Mediators released by immune cells act to either dampen or amplify the activity of GI nerves. Release of a number of these mediators correlates with symptoms of IBS, highlighting the importance of interactions between the immune and the nervous systems. Investigation of the role of microbiota in these interactions is in its early stages, but may provide many answers regarding the mechanisms underlying activation of the immune system in IBS. Identifying what the key changes in the GI immune system are in IBS and how these changes modulate viscerosensory nervous function is essential for the development of novel therapies for the underlying disorder.Patrick A. Hughes, Heddy Zola, Irmeli A. Penttila, L. Ashley Blackshaw, Jane M. Andrews, and Doreen Krumbiege