312 research outputs found

    Pengawasan Badan Permusyawaratan Desa Dalam Penggunaan Dana Desa Di Desa Eemokolo Kabupaten Bombana

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    This study purposed to find out the Supervision of the Village Consultative Agency (BPD) in the Use of Village Funds in Eemokolo Village, Bombana Regency. This study used a qualitative research that aimed to determine the supervision of BPD based on the problems discussed, namely the problems that occured in the research location. Informants in this study amounted to 5 people, data collection by interview, observation and documentation. Data analysis through data reduction, data presentation and conclusion making, while the validity of the data using triangulation of sources, techniques and time. The results showed that the Eemokolo Village BPD in carrying out its supervisory function was not maximal. The Eemokolo Village BPD's functions and duties were still at the planning stage, such as accommodating the aspirations of residents regarding the management of the Village Fund, while the use and supervision of the budget was still very weak and tended to be uninvolved. The obstacles for BDP in carrying out the function of overseeing human  resources were still low. Lack of cooperation between village governments.  The supervision was not optimal.Keywords: Supervision, Village Consultative Agency, Village Fund

    The incidence of late prosthetic joint infections A registry-based study of 112,708 primary hip and knee replacements

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    Background and purpose - Late prosthetic joint infections (PJIs) are a growing medical challenge as more and more joint replacements are being performed and the expected lifespan of patients is increasing. We analyzed the incidence rate of late PJI and its temporal trends in a nationwide population. Patients and methods - 112,708 primary hip and knee replacements performed due to primary osteoarthritis (OA) between 1998 and 2009 were followed for a median time of 5 (1-13) years, using data from nationwide Finnish health registries. Late PJI was detected > 2 years postoperatively, and very late PJI was detected > 5 years postoperatively. Results - During the follow-up, involving 619,299 prosthesis-years, 1,345 PJIs were registered: cumulative incidence 1.20% (95% CI: 1.13-1.26) (for knees, 1.41%; for hips, 0.92%). The incidence rate of late PJI was 0.069% per prosthesis-year (CI: 0.061-0.078), and it was greater after knee replacement than after hip replacement (0.080% vs. 0.057%, p = 0.006). The incidence rate of very late PJI was 0.051% per prosthesis-year (CI: 0.042-0.063), 0.058% for knees and 0.044% for hips (p = 0.2). The incidence rate of late PJI varied between 0.041% and 0.107% during the years of observation without any temporal trend (incidence rate ratio (IRR) = 0.98, 95% CI: 0.93-1.03). Very late PJI increased from 0.026% in 2004 to 0.056% in 2010 (IRR = 1.11, 95% CI: 1.02-1.20). Interpretation - In our nationwide study, the incidence rate of late PJI after hip or knee arthroplasty was approximately 0.07% per prosthesis-year. The incidence of very late PJI appeared to increase.Peer reviewe

    PERANAN KEMITRAAN GEREJA DENGAN LEMBAGA KRISTEN DALAM MENINGKATKAN PENDAPATAN JEMAAT

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    Poverty in Indonesia is still evident in areas with a large population of Christians. According to the data from the Central Bureau of Statistics in 2020, the provinces of Papua, Maluku and NTT are areas with a high percentage of population poverty rates. Even though in these areas the church has been serving the people for a long time. The existence of the church in the midst of society wherever it is is expected to be able to answer the problem of poverty that plagues church congregants and society in general. Churches that serve in poor community face challenges in playing an active role in increasing congregational income. The limited resources owned by the church and the limited financial support of congregational make the church unable to serve the congregation maximally in terms of supporting the increase in the income of the congregation who are still living in poverty. Unlike the case with churches that have good resources such as human resources and strong financial resources. Realizing the limited resources owned by the church, it is necessary to involve third parties from outside the church and the congregation to equip and provide support to the church in developing the economic potential of the congregation. Keeping Christ-centered Christian values ​​from being degraded, the church builds partnership with institutions that have the same service values ​​as the church and have the same goal of increasing the income of congregation. Cooporation can be carried out through partnerships to achieve common goals to increase income of congregation. Each party has rights and obligations that support each other in the partnership that is built.Kemiskinan secara ekonomi di Indonesia masih tampak dengan jelas berada di wilayah-wilayah dengan populasi penduduk yang banyak beragama Kristen. Menurut data Bada Pusat Statistik tahun 2020 provinsi Papua, Maluku dan NTT merupakan wilayah dengan persentasi tingkat kemiskinan penduduk yang tinggi. Padahal di wilayah-wilayah ini gereja sudah melayani umat sejak lama. Keberadaan gereja ditengah-tengah masyarakat dimanapun berada diharapkan dapat menjawab permasalahan kemiskinan yang mendera jemaat gereja secara khusus dan masyarakat pada umumnya. Gereja yang melayani di lingkungan masyarakat miskin mengahadapi tantangan dalam berperan aktif untuk meningkatkan penghasilan jemaat. Keterbatasan sumber daya yang dimiliki oleh gereja dan dukungan jemaat dalam keuangan yang terbatas membuat gereja tidak dapat melayani jemaat dengan maksimal dalam hal mendukung peningkatan penghasilan jemaat yang masih hidup dalam kemiskinan. Berbeda halnya dengan gereja yang memiliki sumber-sumber daya yang baik seperti sumber daya manusia dan sumber daya keuangan yang kuat. Menyadari keterbatasan sumber daya yang dimiliki oleh gereja, maka perlu melibatkan pihak ketiga dari luar gereja dan jemaat untuk memperlengkapi dan memberi dukungan kepada gereja dalam mengembangkan potensi ekonomi jemaat. Menjaga nilai-nilai kekristenan yang berpusat pada Kristus agar tidak terdegradasi, maka gereja membangun kerjasama dengan lembaga yang memiliki nilai-nilai pelayanan yang sama dengan gereja dan tujuan yang sama meningkatkan pendapatan jemaat. Kerjasama dapat dilakukan melalui kemitraan untuk mencapai tujuan bersama yaitu meningkatkan pendapatan jemaat. Masing-masing pihak memiliki hak dan kewajiban yang saling mendukung dalam kemitraan yang dibangu

    Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

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    <p>Abstract</p> <p>Background</p> <p>Currently, population pharmacokinetic (PK) studies of anti-malarial drugs are designed primarily by the logistical and ethical constraints of taking blood samples from patients, and the statistical models that are fitted to the data are not formally considered. This could lead to imprecise estimates of the target PK parameters, and/or designs insufficient to estimate all of the parameters. Optimal design methodology has been developed to determine blood sampling schedules that will yield precise parameter estimates within the practical constraints of sampling the study populations. In this work optimal design methods were used to determine sampling designs for typical future population PK studies of dihydroartemisinin, the principal biologically active metabolite of oral artesunate.</p> <p>Methods</p> <p>Optimal designs were derived using freely available software and were based on appropriate structural PK models from an analysis of data or the literature and key sampling constraints identified in a questionnaire sent to active malaria researchers (3-4 samples per patient, at least 15 minutes between samples). The derived optimal designs were then evaluated via simulation-estimation.</p> <p>Results</p> <p>The derived optimal sampling windows were 17 to 29 minutes, 30 to 57 minutes, 2.5 to 3.7 hours and 5.8 to 6.6 hours for non-pregnant adults; 16 to 29 minutes, 31 minutes to 1 hour, 2.0 to 3.4 hours and 5.5 to 6.6 hours for designs with non-pregnant adults and children and 35 to 59 minutes, 1.2 to 3.4 hours, 3.4 to 4.9 hours and 6.0 to 8.0 hours for pregnant women. The optimal designs resulted in acceptable precision of the PK parameters.</p> <p>Conclusions</p> <p>The proposed sampling designs in this paper are robust and efficient and should be considered in future PK studies of oral artesunate where only three or four blood samples can be collected.</p

    Advising and limiting medical treatment during phone consultation : a prospective multicentre study in HEMS settings

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    Background We investigated paramedic-initiated consultation calls and advice given via telephone by Helicopter Emergency Medical Service (HEMS) physicians focusing on limitations of medical treatment (LOMT). Methods A prospective multicentre study was conducted on four physician-staffed HEMS bases in Finland during a 6-month period. Results Of all 6115 (mean 8.4/base/day) paramedic-initiated consultation calls, 478 (7.8%) consultation calls involving LOMTs were included: 268 (4.4%) cases with a pre-existing LOMT, 165 (2.7%) cases where the HEMS physician issued a new LOMT and 45 (0.7%) cases where the patient already had an LOMT and the physician further issued another LOMT. The most common new limitation was a do-not-attempt cardiopulmonary resuscitation (DNACPR) order (n = 122/210, 58%) and/or 'not eligible for intensive care' (n = 96/210, 46%). In 49 (23%) calls involving a new LOMT, termination of an initiated resuscitation attempt was the only newly issued LOMT. The most frequent reasons for issuing an LOMT during consultations were futility of the overall situation (71%), poor baseline functional status (56%), multiple/severe comorbidities (56%) and old age (49%). In the majority of cases (65%) in which the HEMS physician issued a new LOMT for a patient without any pre-existing LOMT, the physician felt that the patient should have already had an LOMT. The patient was in a health care facility or a nursing home in half (49%) of the calls that involved issuing a new LOMT. Access to medical records was reported in 29% of the calls in which a new LOMT was issued by an HEMS physician. Conclusion Consultation calls with HEMS physicians involving patients with LOMT decisions were common. HEMS physicians considered end-of-life questions on the phone and issued a new LOMT in 3.4% of consultations calls. These decisions mainly concerned termination of resuscitation, DNACPR, intubation and initiation of intensive care.Peer reviewe

    Adolescents’ use of purpose built shade in secondary schools: cluster randomised controlled trial

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    Objective To examine whether students use or avoid newly shaded areas created by shade sails installed at schools

    The Clinical Frailty Scale is a useful tool for predicting postoperative complications following elective colon cancer surgery at the age of 80 years and above: A prospective, multicentre observational study

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    Aim Identification of the risks of postoperative complications may be challenging in older patients with heterogeneous physical and cognitive status. The aim of this multicentre, observational study was to identify variables that affect the outcomes of colon cancer surgery and, especially, to find tools to quantify the risks related to surgery. Method Patients aged >= 80 years with electively operated Stage I-III colon cancer were recruited. The prospectively collected data included comorbidities, results of the onco-geriatric screening tool (G8), Clinical Frailty Scale (CFS), Charlson Comorbidity Index (CCI) and Mini Nutritional Assessment-Short Form (MNA-SF), and operative and postoperative outcomes. Results A total of 161 patients (mean 84.5 years, range 80-97, 60% female) were included. History of cerebral stroke (64% vs. 37%, p = 0.02), albumin level 31-34 g/l compared with >= 35 g/l (57% vs. 32%, p = 0.007), CFS 3-4 and 5-9 compared with CFS 1-2 (49% and 47% vs. 16%, respectively) and American Society of Anesthesiologists score >3 (77% vs. 28%, P = 0.006) were related to a higher risk of complications. In multivariate logistic regression analysis CFS >= 3 (OR 6.06, 95% CI 1.88-19.5, p = 0.003) and albumin level 31-34 g/l (OR 3.88, 1.61-9.38, p = 0.003) were significantly associated with postoperative complications. Severe complications were more common in patients with chronic obstructive pulmonary disease (43% vs. 13%, p = 0.047), renal failure (25% vs. 12%, p = 0.021), albumin level 31-34 g/l (26% vs. 8%, p = 0.014) and CCI >6 (23% vs. 10%, p = 0.034). Conclusion Surgery on physically and cognitively fit aged colon cancer patients with CFS 1-2 can lead to excellent operative outcomes similar to those of younger patients. The CFS could be a useful screening tool for predicting postoperative complications.Peer reviewe

    A simple, robust flow cytometry-based whole blood assay for investigating sex differential interferon alpha production by plasmacytoid dendritic cells

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    Central to sex differences observed in outcome from infection and vaccination is the innate immune response, and specifically production of type I interferons by plasmacytoid dendtiric cells (pDCs), the main producers of IFN-α. Evaluation of IFN-α production by pDCs is therefore critical for studies of innate immune function. However, reliable measurement of pDC IFN-α is hampered by reduced cell yields and cytokine production after cryopreservation or after even short delays in stimulating freshly isolated cells. We here describe a simple yet robust method for measuring IFN-α production in pDCs that preserves cell activation and cytokine production through immediate stimulation of whole blood and subsequent maintenance at 37 °C

    Two-stage revision for prosthetic joint infection: predictors of outcome and the role of reimplantation microbiology

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    We describe rates of success for two-stage revision of prosthetic joint infection (PJI), including data on reimplantation microbiology. Methods: We retrospectively collected data from all the cases of PJI that were managed with two-stage revision over a 4 year period. Patients were managed with an antibiotic-free period before reimplantation, in order to confirm, clinically and microbiologically, that infection was successfully treated. Results: One hundred and fifty-two cases were identified. The overall success rate (i.e. retention of the prosthesis over 5.75 years of follow-up) was 83%, but was 89 % for first revisions and 73 % for re-revisions [hazard ratio2.9, 95 % confidence interval (CI) 1.2–7.4, P0.023]. Reimplantation microbiology was frequently positive (14%), but did not predict outcome (hazard ratio1.3, 95 % CI 0.4–3.7, P0.6). Furthermore, most unplanned debridements following the first stage were carried out before antibiotics were stopped (25 versus 2 debridements). Conclusions: We did not identify evidence supporting the use of an antibiotic-free period before reimplantation and routine reimplantation microbiology. Re-revision was associated with a significantly worse outcome
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