Excitation and Imaging of Resonant Optical Modes of Au Triangular Nano-Antennas Using Cathodoluminescence Spectroscopy

Cathodoluminescence (CL) imaging spectroscopy is an important technique to understand resonant behavior of optical nanoantennas. We report high-resolution CL spectroscopy of triangular gold nanoantennas designed with near-vacuum effective index and very small metal-substrate interface. This design helped in addressing issues related to background luminescence and shifting of dipole modes beyond visible spectrum. Spatial and spectral investigations of various plasmonic modes are reported. Out-of-plane dipole modes excited with vertically illuminated electron beam showed high-contrast tip illumination in panchromatic imaging. By tilting the nanostructures during fabrication, in-plane dipole modes of antennas were excited. Finite-difference time-domain simulations for electron and optical excitations of different modes showed excellent agreement with experimental results. Our approach of efficiently exciting antenna modes by using low index substrates is confirmed both with experiments and numerical simulations. This should provide further insights into better understanding of optical antennas for various applications.Comment: To be published in JVST B (accepted, Sep 2010) (15 pages, 6 figures, originally presented at EIPBN 2010

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production

Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts. It is not known whether this tolerance-immunity switch requires global rewiring of the signaling apparatus or if it can arise from a single molecular change. By introducing individual CARD11 mutations found in human lymphomas into antigen-activated mature B lymphocytes in mice, we find here that lymphoma-derived CARD11 mutations switch the effect of self-antigen from inducing B cell death into T cell- independent proliferation, Blimp1-mediated plasmablast differentiation, and autoantibody secretion. Our findings demonstrate that regulation of CARD11 signaling is a critical switch governing the decision between death and proliferation in antigen-stimulated mature B cells and that mutations in this switch represent a powerful initiator for aberrant B cell responses in vivo

Stepping On Fall Prevention Project

Background: Falls are a major problem in the United States among the older adult population and provide opportunity for community outreach via student-led physical therapy projects. Objective: The purpose of this project was to investigate the relationship between fall related outcome measures and questionnaires with the completion of the Stepping On Fall Prevention program along with evaluating the benefits of Physical Therapy student development with participation in service learning projects. Methods: The research quantified the fall risk of 13 participants with assessment of: gait speed (Timed Up and Go), lower extremity strength (30-Second Chair Stand), balance (4-Stage Balance Test), and psychological factors (Stay Independent Questionnaire, Falls Efficacy Scale-International, and Geriatric Depression Scale). Results: Of the functional measures, significant improvements were observed in the Timed up and Go (TUG) (∆1.72s ± 1.66, p=0.003), the 30-second chair stand (∆4.54 ± 4.27, p= 0.002), Stage 4 of the 4-Stage Balance Test (∆3.37s ± 3.26, p= 0.003), and the Stay Independent questionnaire (∆1.77 ± 2.52, p=0.026). Conclusion: Stepping On demonstrated improvements in gait speed, strength, and balance. These improvements allow older adults to improve their overall safety in both their own homes and the community. More research is needed to evaluate the psychological benefits of completing Stepping On. Furthermore, service learning project opportunities should become more of a standard practice across physical therapy programs

COMPATIBILITY TESTING FOR CAMERA APPLICATIONS TO FACILITATE SOFTWARE DEVELOPMENT

A system is described that provides a consistent application programming interface and enables compatibility testing for applications that interface with cameras across various mobile devices. The system includes one or more controlled testing environment modules that isolate mobile devices from ambient light and provide test charts and consistent internal lighting for camera testing. The controlled testing environment modules enable operating system developers to capture both landscape and portrait images, access features, and test applications in consistent testing environments across various mobile devices. Such testing may enable development of software shims to facilitate interaction with a wide variety of cameras across different vendors and implementations within individual mobile devices

Impact ejecta at the Paleocene-Eocene boundary

Extraterrestrial impacts have left a substantial imprint on the climate and evolutionary history of Earth. A rapid carbon cycle perturbation and global warming event about 56 million years ago at the Paleocene-Eocene (P-E) boundary (the Paleocene-Eocene Thermal Maximum) was accompanied by rapid expansions of mammals and terrestrial plants and extinctions of deep-sea benthic organisms. Here, we report the discovery of silicate glass spherules in a discrete stratigraphic layer from three marine P-E boundary sections on the Atlantic margin. Distinct characteristics identify the spherules as microtektites and microkrystites, indicating that an extraterrestrial impact occurred during the carbon isotope excursion at the P-E boundary

Pathologic analysis of liver transplantation for primary biliary cirrhosis

A retrospective histopathologic review of all pathologic specimens from 394 adult liver transplant patients was undertaken with clinical correlation to determine if primary biliary cirrhosis has affected the posttrans‐plant course compared to all other indications for liver transplantation and if recurrent primary biliary cirrhosis has occurred after liver transplantation. We also compared the histopathologic features seen in native livers with primary biliary cirrhosis to failed allografts with chronic rejection. One hundred six of the 394 adult patients transplanted during this time (1981 to July, 1986) fulfilled clinicopathologic criteria for a diagnosis of primary biliary cirrhosis. Neither the incidence nor any qualitative pathologic feature of histologically documented acute cellular rejection differentiated subjects transplanted for primary biliary cirrhosis vs. other diseases. No correlation between the titers of antimitochon‐drial antibody and the presence of posttransplant hepatic dysfunction based on liver enzyme profiles or the development of chronic rejection was seen in patients transplanted for primary biliary cirrhosis. Minor differences noted in the posttransplant course of primary biliary cirrhosis patients as compared to other conditions (higher incidence of chronic rejection as a cause of graft failure) was seen, but this did not significantly affect graft or patient survival. Recurrent primary biliary cirrhosis could not be diagnosed with certainty in any patient. A comparison of failed chronically rejected allografts vs. native hepatectomies obtained from patients with primary biliary cirrhosis revealed the presence of chronic obliterative vasculopathy, centrilobular cholestasis, and lack of granulomas, cirrhosis, cholan‐giolar proliferation, copper‐associated protein deposition and Mallory's hyalin in specimens with chronic rejection. In contrast, livers removed from patients with primary biliary cirrhosis demonstrated a mild vasculopathy, cirrhosis, granulomas, copper‐associated protein deposition, Mallory's hyalin and periportal cholestasis. Both conditions demonstrated a nonsuppurative destructive cholangitis with bile duct paucity. Copyright © 1988 American Association for the Study of Liver Disease