169 research outputs found
Another tetraquark structure in the invariant mass distribution
In this article, we assume that there exists a scalar hidden charm tetraquark
state in the invariant mass distribution, and study its mass
using the QCD sum rules. The numerical result is
consistent with the mass of the Z(4250). The Z(4250) may be a tetraquark state,
other possibilities, such as a hadro-charmonium resonance and a
molecular state are not excluded.Comment: 14 pages, 14 figure, correct some type error
Engineering Pathways in Central Carbon Metabolism Help to Increase Glycan Production and Improve N-Type Glycosylation of Recombinant Proteins in E. coli.
Escherichia coli strains have been modified in a variety of ways to enhance the production of different recombinant proteins, targeting membrane protein expression, proteins with disulphide bonds, and more recently, proteins which require N-linked glycosylation. The addition of glycans to proteins remains a relatively inefficient process and here we aimed to combine genetic modifications within central carbon metabolic pathways in order to increase glycan precursor pools, prior to transfer onto polypeptide backbones. Using a lectin screen that detects cell surface representation of glycans, together with Western blot analyses using an O-antigen ligase mutant strain, the enhanced uptake and phosphorylation of sugars (ptsA) from the media combined with conservation of carbon through the glyoxylate shunt (icl) improved glycosylation efficiency of a bacterial protein AcrA by 69% and over 100% in an engineered human protein IFN-α2b. Unexpectedly, overexpression of a gene involved in the production of DXP from pyruvate (dxs), which was previously seen to have a positive impact on glycosylation, was detrimental to process efficiency and the possible reasons for this are discussed
Mass spectrum of the axial-vector hidden charmed and hidden bottom tetraquark states
In this article, we perform a systematic study of the mass spectrum of the
axial-vector hidden charmed and hidden bottom tetraquark states using the QCD
sum rules, and identify the as an axial-vector tetraquark state
tentatively.Comment: 24 pages, 38 figures, slight revisio
Gravitational Coupling and Dynamical Reduction of The Cosmological Constant
We introduce a dynamical model to reduce a large cosmological constant to a
sufficiently small value. The basic ingredient in this model is a distinction
which has been made between the two unit systems used in cosmology and particle
physics. We have used a conformal invariant gravitational model to define a
particular conformal frame in terms of large scale properties of the universe.
It is then argued that the contributions of mass scales in particle physics to
the vacuum energy density should be considered in a different conformal frame.
In this manner, a decaying mechanism is presented in which the conformal factor
appears as a dynamical field and plays a key role to relax a large effective
cosmological constant. Moreover, we argue that this model also provides a
possible explanation for the coincidence problem.Comment: To appear in GR
Inclusive production of and mesons in charged current interactions
The inclusive production of the meson resonances ,
and in neutrino-nucleus charged current interactions has been
studied with the NOMAD detector exposed to the wide band neutrino beam
generated by 450 GeV protons at the CERN SPS. For the first time the
meson is observed in neutrino interactions. The statistical
significance of its observation is 6 standard deviations. The presence of
in neutrino interactions is reliably established. The average
multiplicity of these three resonances is measured as a function of several
kinematic variables. The experimental results are compared to the
multiplicities obtained from a simulation based on the Lund model. In addition,
the average multiplicity of in antineutrino - nucleus
interactions is measured.Comment: 23 pages, 14 figures, 8 tables. To appear in Nucl. Phys.
Nepafenac 0.3% after Cataract Surgery in Patients with Diabetic Retinopathy : Results of 2 Randomized Phase 3 Studies
PURPOSE:
To demonstrate the efficacy and safety of once-daily nepafenac 0.3% ophthalmic suspension versus vehicle, based on clinical outcomes, after cataract surgery in patients with diabetes.
DESIGN:
Two prospective, randomized, multicenter, double-masked, vehicle-controlled phase 3 studies.
PARTICIPANTS:
Total, 615 patients in study 1 and 605 patients in study 2.
METHODS:
Patients were randomized (1:1) to topical nepafenac 0.3% or vehicle once-daily starting the day before surgery and continuing for 90 days thereafter.
MAIN OUTCOME MEASURES:
Key efficacy variables were: patients (%) in whom macular edema (ME) developed ( 6530% increase from preoperative baseline central subfield macular thickness) within 90 days after cataract surgery and the patients (%) with a best-corrected visual acuity (BCVA) improvement of 6515 letters from preoperative baseline through day 14 maintained through day 90. Secondary end points included: patients (%) with a BCVA improvement of 6515 letters from preoperative baseline through days 90 and 60 and safety over 3 months.
RESULTS:
A significantly lower percentage of patients demonstrated ME within 90 days after surgery with nepafenac 0.3% versus vehicle (study 1: 2.3% vs. 17.3%; P < 0.001; study 2: 5.9% vs. 14.3%; P = 0.001; pooled: 4.1% vs. 15.9%; P < 0.001). The percentage of patients achieving a 6515-letter improvement from baseline through day 14 maintained through day 90 with nepafenac 0.3% versus vehicle was 61.7% versus 43.0% (P < 0.001) in study 1, 48.8% versus 50.5% (P = 0.671) in study 2, and 55.4% versus 46.7% (P = 0.003) in the pooled analysis. A greater percentage of patients treated with nepafenac 0.3% versus vehicle in study 1 and similar percentage in study 2 had a BCVA improvement of 6515 letters from preoperative baseline through day 90 (77.2% vs. 67.7% [P = 0.009] and 65.4% vs. 65.9% [P = 0.888]) and through day 60 (76.2% vs. 64.7% [P = 0.002] and 68.9% vs. 62.1% [P = 0.092]). No unanticipated adverse events were observed.
CONCLUSIONS:
These studies demonstrated the clinical benefits of nepafenac 0.3% over vehicle in reducing the risk of postoperative ME, with the integrated analysis showing improved BCVA after cataract surgery in patients with diabetic retinopathy, with no unanticipated safety events
Update of the Search for the Neutrinoless Decay
We present an update of the search for the lepton family number violating
decay using a complete CLEO II data sample of 12.6 million
pairs. No evidence of a signal has been found and the
corresponding upper limit is \BR(\tau \to \mu\gamma) < 1.0 \times 10^{-6}
at 90% CL, significantly smaller than previous limits. All quoted results are
preliminary.Comment: 9 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Measurement of the Mass Splittings between the States
We present new measurements of photon energies and branching fractions for
the radiative transitions: Upsilon(2S)->gamma+chi_b(J=0,1,2). The masses of the
chi_b states are determined from the measured radiative photon energies. The
ratio of mass splittings between the chi_b substates,
r==(M[J=2]-M[J=1])/(M[J=1]-M[J=0]) with M the chi_b mass, provides information
on the nature of the bbbar confining potential. We find
r(1P)=0.54+/-0.02+/-0.02. This value is in conflict with the previous world
average, but more consistent with the theoretical expectation that r(1P)<r(2P);
i.e., that this mass splittings ratio is smaller for the chi_b(1P) triplet than
for the chi_b(2P) triplet.Comment: 11 page postscript file, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
Heavy quarkonium: progress, puzzles, and opportunities
A golden age for heavy quarkonium physics dawned a decade ago, initiated by
the confluence of exciting advances in quantum chromodynamics (QCD) and an
explosion of related experimental activity. The early years of this period were
chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in
2004, which presented a comprehensive review of the status of the field at that
time and provided specific recommendations for further progress. However, the
broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles
could only be partially anticipated. Since the release of the YR, the BESII
program concluded only to give birth to BESIII; the -factories and CLEO-c
flourished; quarkonium production and polarization measurements at HERA and the
Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the
deconfinement regime. All these experiments leave legacies of quality,
precision, and unsolved mysteries for quarkonium physics, and therefore beg for
continuing investigations. The plethora of newly-found quarkonium-like states
unleashed a flood of theoretical investigations into new forms of matter such
as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the
spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b},
and b\bar{c} bound states have been shown to validate some theoretical
approaches to QCD and highlight lack of quantitative success for others. The
intriguing details of quarkonium suppression in heavy-ion collisions that have
emerged from RHIC have elevated the importance of separating hot- and
cold-nuclear-matter effects in quark-gluon plasma studies. This review
systematically addresses all these matters and concludes by prioritizing
directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K.
Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D.
Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A.
Petrov, P. Robbe, A. Vair
Phenomenology of Pc(4380)+, Pc(4450)+ and related states
The and states recently discovered at LHCb have
masses close to several relevant thresholds, which suggests they can be
described in terms of meson-baryon degrees of freedom. This article explores
the phenomenology of these states, and their possible partners, from this point
of view. Competing models can be distinguished by the masses of the neutral
partners which have yet to be observed, and the existence or otherwise of
further partners with different isospin, spin, and parity. Future experimental
studies in different decay channels can also discriminate among models, using
selection rules and algebraic relations among decays. Among the several
possible meson-baryon pairs which could be important, one implies that the
states are mixtures of isospins 1/2 and 3/2, with characteristic signatures in
production and decay. A previous experimental study of a Cabibbo-suppressed
decay showed no evidence for the states, and further analysis is required to
establish the significance of this non-observation. Several intriguing
similarities suggest that is related to the meson.Comment: 16 pages, 1 figure. Journal version (some very minor changes from
arXiv v1
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