130 research outputs found

    Development of wireless vehicle remote control for fuel lid operation

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    Nowadays, the evolution of the vehicle technology had made the vehicle especially car to be equipped with a remote control to control the operation of the locking and unlocking system of the car’s door and rear’s bonnet. However, for the fuel or petrol lid, it merely can be opened from inside the car’s cabin by handling the fuel level inside the car’s cabin to open the fuel lid. The petrol lid can be closed by pushing the lid by hand. Due to the high usage of using fuel lever to open the fuel lid when refilling the fuel, the car driver might encounter the malfunction of fuel lid (fail to open) when pushing or pulling the fuel lever. Thus, the main aim of the research is to enhance the operation of an existing car remote control where the car fuel lid can be controlled using two techniques; remote control-based and smartphone-based. The remote control is constructed using Arduino microcontroller, wireless sensors and XCTU software to set the transmitting and receiving parameters. Meanwhile, the smartphone can control the operation of the fuel lid by communicating with Arduino microcontroller which is attached to the fuel lid using Bluetooth sensor to open the petrol lid. In order to avoid the conflict of instruction between wireless systems with the existing mechanical-based system, the servo motor will be employed to release the fuel lid merely after receiving the instruction from Arduino microcontroller and smartphone. As a conclusion, the prototype of the multipurpose vehicle remote control is successfully invented, constructed and tested. The car fuel lid can be opened either using remote control or smartphone in a sequential manner. Therefore, the outcome of the project can be used to serve as an alternative solution to solve the car fuel lid problem even though the problem rarely occurred

    Solar irradiance uncertainty management based on Monte Carlo-beta probability density function: case in Malaysian tropical climate

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    In recent years, solar PV power generation has seen a rapid growth due to environmental benefits and zero fuel costs. In Malaysia, due to its location near the equator, makes solar energy the most utilized renewable energy resources. Unlike conventional power generation, solar energy is considered as uncertain generation sources which will cause unstable energy supplied. The uncertainty of solar resource needs to be managed for the planning of the PV system to produce its maximum power. The statistical method is the most prominent to manage and model the solar irradiance uncertainty patterns. Based on one-minute time interval meteorological data taken in Pekan, Pahang, West Malaysia, the Monte Carlo-Beta probability density function (Beta PDF) is performed to model continuous random variable of solar irradiance. The uncertainty studies are needed to optimally plan the photovoltaic system for the development of solar PV technologies in generating electricity and enhance the utilization of renewable energy; especially in tropical climate region

    Improvement of Harmonics Using Passive Harmonics Filter

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    Power quality problems are continuously increased and received a great attention due to the impacts on both utilities and consumers. The most frequently reported power quality problem is the harmonics. The aim of this project is to enhance the system performance under the load variation effect through desirable filter placement. In this project, two types of passive filter called single tuned and 3rd order C-type are studied. Load flow analysis is performed to calculate the load bus voltage and total harmonic distortion (THD) that determine the effectiveness of filter application. The work was simulated using Electrical Transient Analyzer Program (ETAP) and tested on two test systems namely the 4-bus and IEEE 14-bus. The results of this work show that single tuned filter is more effective in filtering the harmonic compared to the 3rd order C-type. Furthermore, installing the single tuned filter near to the source of harmonics produces a better result

    Development of Smart Security System for Building or Laboratory Entrance based on human’s brain (EEG) and Voice Signals

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    The drastic increment in cyber-crimes and violent attacks involving our properties and lives made the world become much vigilant towards ill-intentioned peoples. Thus, it leads to the booming of smart security system industry which relies heavily on biometrics technology. However, due to certain circumstances, some users may find the existing biometrics technologies such as fingerprint, palm, iris and face recognition are unable to detect the necessary data precisely due to the physical injuries of the users. Furthermore, the fact that these biometrics technologies are easily retrieved from the user and be used as counterfeit to access to the security system undetected. Thus, in this research, in order to enhance the existing security system based on the biometric technologies, the combination of the human physiological signals such as brain and voice signals will be employed in order to unlock the magnetic door entrance to the laboratory, building or office. This research has utilized mobile Electroencephalogram (EEG) headset and voice recognizer to capture human’s brain and voice signals respectively. The extracted features from the captured signals then are analyzed, classified and translated to determine the device command for the microcontroller to control the door entrance’s locking system. The high rate of classification results of the selected features of EEG and voice signals at 96.7% and 99.3% respectively show that selected features can be translated to command parameters to control device

    Midgut microbiota of the malaria mosquito vector Anopheles gambiae and Interactions with plasmodium falciparum Infection

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    The susceptibility of Anopheles mosquitoes to Plasmodium infections relies on complex interactions between the insect vector and the malaria parasite. A number of studies have shown that the mosquito innate immune responses play an important role in controlling the malaria infection and that the strength of parasite clearance is under genetic control, but little is known about the influence of environmental factors on the transmission success. We present here evidence that the composition of the vector gut microbiota is one of the major components that determine the outcome of mosquito infections. A. gambiae mosquitoes collected in natural breeding sites from Cameroon were experimentally challenged with a wild P. falciparum isolate, and their gut bacterial content was submitted for pyrosequencing analysis. The meta-taxogenomic approach revealed a broader richness of the midgut bacterial flora than previously described. Unexpectedly, the majority of bacterial species were found in only a small proportion of mosquitoes, and only 20 genera were shared by 80% of individuals. We show that observed differences in gut bacterial flora of adult mosquitoes is a result of breeding in distinct sites, suggesting that the native aquatic source where larvae were grown determines the composition of the midgut microbiota. Importantly, the abundance of Enterobacteriaceae in the mosquito midgut correlates significantly with the Plasmodium infection status. This striking relationship highlights the role of natural gut environment in parasite transmission. Deciphering microbe-pathogen interactions offers new perspectives to control disease transmission.Institut de Recherche pour le Developpement (IRD); French Agence Nationale pour la Recherche [ANR-11-BSV7-009-01]; European Community [242095, 223601]info:eu-repo/semantics/publishedVersio

    Vector control in a malaria epidemic occurring within a complex emergency situation in Burundi: a case study

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    BACKGROUND: African highlands often suffer of devastating malaria epidemics, sometimes in conjunction with complex emergencies, making their control even more difficult. In 2000, Burundian highlands experienced a large malaria outbreak at a time of civil unrest, constant insecurity and nutritional emergency. Because of suspected high resistance to the first and second line treatments, the provincial health authority and Médecins Sans Frontières (Belgium) decided to implement vector control activities in an attempt to curtail the epidemic. There are few reported interventions of this type to control malaria epidemics in complex emergency contexts. Here, decisions and actions taken to control this epidemic, their impact and the lessons learned from this experience are reported. CASE DESCRIPTION: Twenty nine hills (administrative areas) were selected in collaboration with the provincial health authorities for the vector control interventions combining indoor residual spraying with deltamethrin and insecticide-treated nets. Impact was evaluated by entomological and parasitological surveys. Almost all houses (99%) were sprayed and nets use varied between 48% and 63%. Anopheles indoor resting density was significantly lower in treated as compared to untreated hills, the latter taken as controls. Despite this impact on the vector, malaria prevalence was not significantly lower in treated hills except for people sleeping under a net. DISCUSSION: Indoor spraying was feasible and resulted in high coverage despite being a logistically complex intervention in the Burundian context (scattered houses and emergency situation). However, it had little impact on the prevalence of malaria infection, possibly because it was implemented after the epidemic's peak. Nevertheless, after this outbreak the Ministry of Health improved the surveillance system, changed its policy with introduction of effective drugs and implementation of vector control to prevent new malaria epidemics. CONCLUSION: In the absence of effective drugs and sufficient preparedness, present study failed to demonstrate any impact of vector control activities upon the course of a short-duration malaria epidemic. However, the experience gained lead to increased preparedness and demonstrated the feasibility of vector control measures in this specific context

    Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.

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    Orofacial clefting is amongst the most common of birth defects, with both genetic and environmental components. Although numerous studies have been undertaken to investigate the complexities of the genetic etiology of this heterogeneous condition, this factor remains incompletely understood. Here, we describe mutations in the HYAL2 gene as a cause of syndromic orofacial clefting. HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix. Transfection assays demonstrated that the gene mutations destabilize the molecule, dramatically reducing HYAL2 protein levels. Consistent with the clinical presentation in affected individuals, investigations of Hyal2-/- mice revealed craniofacial abnormalities, including submucosal cleft palate. In addition, cor triatriatum sinister and hearing loss, identified in a proportion of Hyal2-/- mice, were also found as incompletely penetrant features in affected humans. Taken together our findings identify a new genetic cause of orofacial clefting in humans and mice, and define the first molecular cause of human cor triatriatum sinister, illustrating the fundamental importance of HYAL2 and hyaluronan turnover for normal human and mouse development

    Spatial targeted vector control in the highlands of Burundi and its impact on malaria transmission

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    BACKGROUND: Prevention of malaria epidemics is a priority for African countries. The 2000 malaria epidemic in Burundi prompted the government to implement measures for preventing future outbreaks. Case management with artemisinin-based combination therapy and malaria surveillance were nationally improved. A vector control programme was initiated in one of the most affected highland provinces. The focal distribution of malaria vectors in the highlands was the starting point for designing a targeted vector control strategy. The objective of this study was to present the results of this strategy on malaria transmission in an African highland region. METHODS: In Karuzi, in 2002-2005, vector control activities combining indoor residual spraying and long-lasting insecticidal nets were implemented. The interventions were done before the expected malaria transmission period and targeted the valleys between hills, with the expectation that this would also protect the populations living at higher altitudes. The impact on the Anopheles population and on malaria transmission was determined by nine cross-sectional surveys carried out at regular intervals throughout the study period. RESULTS: Anopheles gambiae s.l. and Anopheles funestus represented 95% of the collected anopheline species. In the valleys, where the vector control activities were implemented, Anopheles density was reduced by 82% (95% CI: 69-90). Similarly, transmission was decreased by 90% (95% CI: 63%-97%, p = 0.001). In the sprayed valleys, Anopheles density was further reduced by 79.5% (95% CI: 51.7-91.3, p < 0.001) in the houses with nets as compared to houses without them. No significant impact on vector density and malaria transmission was observed in the hill tops. However, the intervention focused on the high risk areas near the valley floor, where 93% of the vectors are found and 90% of the transmission occurs. CONCLUSION: Spatial targeted vector control effectively reduced Anopheles density and transmission in this highland district. Bed nets have an additional effect on Anopheles density though this did not translate in an additional impact on transmission. Though no impact was observed in the hilltops, the programme successfully covered the areas most at risk. Such a targeted strategy could prevent the emergence and spread of an epidemic from these high risk foci

    Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

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    Modern humans have populated Europe for more than 45,000 years1,2. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. This&nbsp;ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean&nbsp;culture, and with&nbsp;the following Magdalenian culture&nbsp;that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers,&nbsp;who were also characterized by marked differences in phenotypically relevant variants
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