Random effects compound Poisson model to represent data with extra zeros

This paper describes a compound Poisson-based random effects structure for modeling zero-inflated data. Data with large proportion of zeros are found in many fields of applied statistics, for example in ecology when trying to model and predict species counts (discrete data) or abundance distributions (continuous data). Standard methods for modeling such data include mixture and two-part conditional models. Conversely to these methods, the stochastic models proposed here behave coherently with regards to a change of scale, since they mimic the harvesting of a marked Poisson process in the modeling steps. Random effects are used to account for inhomogeneity. In this paper, model design and inference both rely on conditional thinking to understand the links between various layers of quantities : parameters, latent variables including random effects and zero-inflated observations. The potential of these parsimonious hierarchical models for zero-inflated data is exemplified using two marine macroinvertebrate abundance datasets from a large scale scientific bottom-trawl survey. The EM algorithm with a Monte Carlo step based on importance sampling is checked for this model structure on a simulated dataset : it proves to work well for parameter estimation but parameter values matter when re-assessing the actual coverage level of the confidence regions far from the asymptotic conditions.Comment: 4

Asymptotic behavior of the local score of independent and identically distributed random sequences

AbstractLet (Xn)n⩾1 be a sequence of real random variables. The local score is Hn=max1⩽i<j⩽n(Xi+⋯+Xj). If (Xn)n⩾1 is a “good” Markov chain under its invariant measure, the Xi are centered, we prove that Hn/n converges in distribution to B1∗ when n→+∞, where B1∗=max0⩽u⩽1|Bu| and (Bu,u⩾0) is a standard Brownian motion, B0=0. If (Xn)n⩾1 a sequence of i.i.d. random variables, E(X1)=δ/n and Var(X1)=σ2>0, we prove the convergence of Hn/n to σξδ/σ where ξγ=max0⩽u⩽1{(B(u)+γu)−min0⩽s⩽u(B(s)+γs)}. We approximate the probability distribution function of ξγ and we determine the asymptotic behavior of P(ξγ⩾a),a→+∞

A Formal Approach to P3P Privacy Policies Evaluation

Colloque avec actes et comité de lecture. internationale.International audienceWriting and evaluating policies is a recurrent problem over the Internet. These policies, which deal with fields like privacy (P3P), security (P3P) and provisioning (COPS-PR) are often made of many ordered rules. In this paper, we present our work related to P3P rules formalization and validation in an evaluation environnement based on rewriting process. We also develop an environnement which returns the right behavior regarding Internet ressources, P3P policies and APPEL user's preferences

Changes in urine composition after trauma facilitate bacterial growth.

International audienceUNLABELLED: ABSTRACT: BACKGROUND: Critically ill patients including trauma patients are at high risk of urinary tract infection (UTI). The composition of urine in trauma patients may be modified due to inflammation, systemic stress, rhabdomyolysis, life support treatment and/or urinary catheter insertion. METHODS: Prospective, single-centre, observational study conducted in patients with severe trauma and without a history of UTIs or recent antibiotic treatment. The 24-hour urine samples were collected on the first and the fifth days and the growth of Escherichia coli in urine from patients and healthy volunteers was compared. Biochemical and hormonal modifications in urine that could potentially influence bacterial growth were explored. RESULTS: Growth of E. coli in urine from trauma patients was significantly higher on days 1 and 5 than in urine of healthy volunteers. Several significant modifications of urine composition could explain these findings. On days 1 and 5, trauma patients had an increase in glycosuria, in urine iron concentration, and in the concentrations of several amino acids compared to healthy volunteers. On day 1, the urinary osmotic pressure was significantly lower than for healthy volunteers. CONCLUSION: We showed that urine of trauma patients facilitated growth of E. coli when compared to urine from healthy volunteers. This effect was present in the first 24 hours and until at least the fifth day after trauma. This phenomenon may be involved in the pathophysiology of UTIs in trauma patients. Further studies are required to define the exact causes of such modifications

The extreme UV imager telescope on-board the Solar Orbiter mission: overview of phase C and D

The Solar Orbiter mission is composed of ten scientific instruments dedicated to the observation of the Sun’s atmosphere and its heliosphere, taking advantage of an out-of ecliptic orbit and at perihelion reaching a proximity close to 0.28 A.U. On board Solar Orbiter, the Extreme Ultraviolet Imager (EUI) will provide full-Sun image sequences of the solar corona in the extreme ultraviolet (17.1 nm and 30.4 nm), and high-resolution image sequences of the solar disk in the extreme ultraviolet (17.1 nm) and in the vacuum ultraviolet (121.6 nm). The EUI concept uses heritage from previous similar extreme ultraviolet instrument. Additional constraints from the specific orbit (thermal and radiation environment, limited telemetry download) however required dedicated technologies to achieve the scientific objectives of the mission. The development phase C of the instrument and its sub-systems has been successfully completed, including thermo-mechanical and electrical design validations with the Structural Thermal Model (STM) and the Engineering Model (EM). The instrument STM and EM units have been integrated on the respective spacecraft models and will undergo the system level tests. In parallel, the Phase D has been started with the sub-system qualifications and the flight parts manufacturing. The next steps of the EUI development will be the instrument Qualification Model (QM) integration and qualification tests. The Flight Model (FM) instrument activities will then follow with the acceptance tests and calibration campaigns

Development of an in Vitro Rat Intestine Segmental Perfusion Model to Investigate Permeability and Predict Oral Fraction Absorbed

Purpose: The aims of the study are to develop and evaluate an in vitro rat intestine segmental perfusion model for the prediction of the oral fraction absorbed of compounds and to assess the ability of the model to study intestinal metabolism. Methods: The system consisted of a perfusion cell with a rat intestinal segment and three perfusion circulations (donor, receiver, and rinsing circulation). Lucifer yellow (LY) was applied as internal standard together with test compounds in the donor circulation. To validate the model, the permeability of eight noncongeneric passively absorbed drugs was determined. Intestinal N-demethylation of verapamil into norverapamil was followed in the donor and receiver circulations by high-performance liquid chromatography analysis. Results: The in vitro model allowed ranking of the tested compounds according to their in vivo absorption potential. The Spearman's correlation coefficient between the oral fraction absorbed in humans and the ratio of permeation coefficient of test compound to the permeation coefficient of LY within the same experiment was 0.98 (P < 0.01). Moreover, intestinal N-demethylation of verapamil, its permeation, and the permeation of its metabolite norverapamil could be assessed in parallel. Conclusions: Up to six permeation kinetics can be obtained per rat, and the method has shown to be a valuable tool to estimate human oral absorptio

Diversity and P-solubilizing ability of mycorrhizosphere bacteria associated with Pinus pinaster in the Landes forest ecosystem

Ectomycorrhizal fungi (ECM) and their associated mycorrhizosphere bacteria (MB) play a major role in phosphorous (P) nutrition of maritime pine, particularly in the Landes forest ecosystem considering the low bioavailability of P in its sandy-acidic soils. In order to characterize the MB associated to ECM, three collection campaigns of ECM root tips were performed from autumn 2005 to autumn 2006 throughout three forest stations. Five MB and nine ECM genera were identified overall through sequencing of 16S rDNA and mitochondrial large subunit rDNA fragment respectively. Dramatic seasonal changes were observed in the different MB-ECM associations especially in Burkholderia-Lactarius and Bacillus-Russula that were the most abundant ones. P-solubilizing ability of MB was shown to be taxon-dependent with a large majority of P-solubilizing isolates among Burkholderia, Pseudomonas and Paenibacillus contrary to Bacillus. Relationships between functional diversity of the MB-ECM associations and bioavailability of soil P remain to be investigated. (Résumé d'auteur)

Impact of Mycobacterium ulcerans Biofilm on Transmissibility to Ecological Niches and Buruli Ulcer Pathogenesis

The role of biofilms in the pathogenesis of mycobacterial diseases remains largely unknown. Mycobacterium ulcerans, the etiological agent of Buruli ulcer, a disfiguring disease in humans, adopts a biofilm-like structure in vitro and in vivo, displaying an abundant extracellular matrix (ECM) that harbors vesicles. The composition and structure of the ECM differs from that of the classical matrix found in other bacterial biofilms. More than 80 proteins are present within this extracellular compartment and appear to be involved in stress responses, respiration, and intermediary metabolism. In addition to a large amount of carbohydrates and lipids, ECM is the reservoir of the polyketide toxin mycolactone, the sole virulence factor of M. ulcerans identified to date, and purified vesicles extracted from ECM are highly cytotoxic. ECM confers to the mycobacterium increased resistance to antimicrobial agents, and enhances colonization of insect vectors and mammalian hosts. The results of this study support a model whereby biofilm changes confer selective advantages to M. ulcerans in colonizing various ecological niches successfully, with repercussions for Buruli ulcer pathogenesis