The influence of structural inheritance and multiphase extension on rift development, the northern North Sea

The northern North Sea rift evolved through multiple rift phases within a highly heterogeneous crystalline basement. The geometry and evolution of syn‐rift depocentres during this multiphase evolution, and the mechanisms and extent to which they were influenced by pre‐existing structural heterogeneities remain elusive, particularly at the regional scale. Using an extensive database of borehole‐constrained 2D seismic reflection data, we examine how the physiography of the northern North Sea rift evolved throughout late Permian‐Early Triassic (RP1) and Late Jurassic‐Early Cretaceous (RP2) rift phases, and assess the influence of basement structures related to the Caledonian orogeny and subsequent Devonian extension. During RP1, the location of major depocentres, the Stord and East Shetland basins, was controlled by favorably oriented Devonian shear zones. RP2 shows a diminished influence from structural heterogeneities, activity localises along the Viking‐Sogn graben system and the East Shetland Basin, with negligible activity in the Stord Basin and Horda Platform. The Utsira High and the Devonian Lomre Shear Zone form the eastern barrier to rift activity during RP2. Towards the end of RP2, rift activity migrated northwards as extension related to opening of the proto‐North Atlantic becomes the dominant regional stress as rift activity in the northern North Sea decreases. Through documenting the evolving syn‐rift depocentres of the northern North Sea rift, we show how structural heterogeneities and prior rift phases influence regional rift physiography and kinematics, controlling the segmentation of depocentres, as well as the locations, styles and magnitude of fault activity and reactivation during subsequent events

Challenges of stroke management in resource-limited settings: A case- based reflection

A 19-year-old man presented with a 1-year history of headache, generalised body weakness, progressive memory loss, and disorientation. One month prior to admission, there was aggravation of the weakness of the right upper limb, with new-onset difficulty with mastication, speech impairment, apathy, and urinary incontinence. On clinical examination, the patient had a motor aphasia and a right-sided hemiparesis with increased muscle tone and hyperreflexia. A noncontrast computed tomography (CT) scan of the brain revealed large ischaemic strokes extending beyond the classical vascular territories. Cerebrospinal fluid analysis showed a mildly increased protein level. The electrocardiogram revealed an irregular sinus bradycardia. The remainder of the cardiovascular and laboratory workup was unremarkable. Considering a working diagnosis of central nervous system vasculitis, the patient was treated with aspirin, prednisolone, and physiotherapy. However, he died suddenly a few weeks later. Based on this case, we discuss the challenges of stroke management in resource-limited settings, provide practical tips for general practitioners, reflect on the potential avenues for short- and long-term action, and introduce the budding collaboration platform between the University College London, the University of Liverpool, the Queen Elizabeth Central Hospital, and the Malawi-Liverpool-Wellcome Trust Clinical Research Programme

Interactions between a Trawl Fishery and Spatial Closures for Biodiversity Conservation in the Great Barrier Reef World Heritage Area, Australia

Background\ud The Queensland East Coast Otter Trawl Fishery (ECOTF) for penaeid shrimp fishes within Australia's Great Barrier Reef World Heritage Area (GBRWHA). The past decade has seen the implementation of conservation and fisheries management strategies to reduce the impact of the ECOTF on the seabed and improve biodiversity conservation. New information from electronic vessel location monitoring systems (VMS) provides an opportunity to review the interactions between the ECOTF and spatial closures for biodiversity conservation.\ud \ud Methodology and Results\ud We used fishing metrics and spatial information on the distribution of closures and modelled VMS data in a geographical information system (GIS) to assess change in effort of the trawl fishery from 2001–2009 and to quantify the exposure of 70 reef, non-reef and deep water bioregions to trawl fishing. The number of trawlers and the number of days fished almost halved between 2001 and 2009 and new spatial closures introduced in 2004 reduced the area zoned available for trawl fishing by 33%. However, we found that there was only a relatively minor change in the spatial footprint of the fishery as a result of new spatial closures. Non-reef bioregions benefited the most from new spatial closures followed by deep and reef bioregions.\ud \ud Conclusions/Significance\ud Although the catch of non target species remains an issue of concern for fisheries management, the small spatial footprint of the ECOTF relative to the size of the GBRWHA means that the impact on benthic habitats is likely to be negligible. The decline in effort as a result of fishing industry structural adjustment, increasing variable costs and business decisions of fishers is likely to continue a trend to fish only in the most productive areas. This will provide protection for most benthic habitats without any further legislative or management intervention

Insights into the Mechanism for Orogen-Related Carbonate Remagnetization from Growth of Authigenic Fe-Oxide: A Scanning Electron Microscopy and Rock Magnetic Study of Devonian Carbonates from Northern Spain

A rock magnetic and SEM study of Devonian carbonates from the Cantabria-Asturias Region, northern Spain, was undertaken to further our understanding of the pervasive remagnetization of carbonate rocks during the Late Paleozoic, and the mechanism by which these remagnetizations occur. These rocks contain three ancient Late Paleozoic magnetizations. The rock magnetic properties of mineral extracts were compared with those of whole rock chips and nonmagnetic\u27\u27 residue to deduce magnetic carrier(s) and grain sizes. Hysteresis measurements for rock chips show typical\u27\u27 wasp-waisted loops, whereas extract shows typical pseudosingle-domain-like (PSD) unrestricted loops. Within all sites, there is a noticeable contribution of superparamagnetic (SP) grains seen in hysteresis properties and low-temperature magnetization measurements of whole rock chips, whereas a trend away from a strong SP contribution is seen when hysteresis properties of whole rock are compared with those of residue and extract. Consequently, our extraction process (predictably) removes SP grains, while preserving the characteristic fraction of remanence-carrying material, which behaves like a typical mixture of single-domain (SD) and PSD magnetite. Paradoxically, the typical fingerprint\u27\u27 of remagnetized carbonates, as seen in the whole rock data, seems to be a response to abundant SP grains associated with the acquisition of chemical remanent magnetizations (CRM), and not the actual remanence carrying population itself. Scanning electron microscopy (SEM) observations of magnetic extract reveal abundant authigenic Fe-oxides, characterized as either 10-100 mum Ni-free spherules or individual 0.1-10 mum euhedral grains. SEM observations of thin sections reveal abundant evidence of fluid flow driven chemical reactions that resulted in formation of new Fe oxide. Such reactions occurred along cracks and grain boundaries and within void space, and are associated with Fe-rich clay and calcite-dolomite reactions or as oxidation of Fe-sulfide framboids. Together, the SEM observations and rock magnetic experiments reveal that the three Late Paleozoic remagnetizations experienced by Cantabria-Asturias Paleozoic carbonates are CRMs facilitated by the presence of fluids activated during Late Paleozoic Variscan deformation

Air quality and mental health: evidence, challenges and future directions

Background: Poor air quality is associated with poor health. Little attention is given to the complex array of environmental exposures and air pollutants that affect mental health during the life course. // Aims: We gather interdisciplinary expertise and knowledge across the air pollution and mental health fields. We seek to propose future research priorities and how to address them. // Method: Through a rapid narrative review, we summarise the key scientific findings, knowledge gaps and methodological challenges. // Results: There is emerging evidence of associations between poor air quality, both indoors and outdoors, and poor mental health more generally, as well as specific mental disorders. Furthermore, pre-existing long-term conditions appear to deteriorate, requiring more healthcare. Evidence of critical periods for exposure among children and adolescents highlights the need for more longitudinal data as the basis of early preventive actions and policies. Particulate matter, including bioaerosols, are implicated, but form part of a complex exposome influenced by geography, deprivation, socioeconomic conditions and biological and individual vulnerabilities. Critical knowledge gaps need to be addressed to design interventions for mitigation and prevention, reflecting ever-changing sources of air pollution. The evidence base can inform and motivate multi-sector and interdisciplinary efforts of researchers, practitioners, policy makers, industry, community groups and campaigners to take informed action. // Conclusions: There are knowledge gaps and a need for more research, for example, around bioaerosols exposure, indoor and outdoor pollution, urban design and impact on mental health over the life course

The Contribution of High Levels of Somatic Symptom Severity to Sickness Absence Duration, Disability and Discharge

Introduction: The primary objectives were to compare the duration of sickness absence in employees with high levels of somatic symptom severity (HLSSS) with employees with lower levels of somatic symptom severity, and to establish the long-term outcomes concerning return to work (RTW), disability and discharge. Secondary objective was to evaluate determinants of the duration of sickness absence in employees with HLSSS. Methods: 489 sick-listed employees registered with five Occupational Health Physician (OHP) group practices were included in this study. We measured their baseline scores for somatic symptoms severity, depressive disorders, anxiety disorders, health anxiety, distress and functional impairment. The OHPs filled in a questionnaire on their diagnosis. A prospective 2-year follow-up was carried out to assess the long-term outcomes concerning sickness absence, and retrospective information was gathered with regard to sickness absence during the 12 months before the employees were sick-listed. Results: The median duration of sickness absence was 78 days longer for employees with HLSSS. They more often remained disabled and were discharged more often, especially due to problems in the relationship between the employer and the employee. HLSSS, health anxiety and older age contributed to a longer duration of sickness absence of employees. Conclusion: High levels of somatic symptom severity are a determinant of prolonged sickness absence, enduring disabilities and health-related job loss. Occupational health physicians should identify employees who are at risk and adhere to guidelines for medically unexplained somatic symptoms

Evolutionary connectionism: algorithmic principles underlying the evolution of biological organisation in evo-devo, evo-eco and evolutionary transitions

The mechanisms of variation, selection and inheritance, on which evolution by natural selection depends, are not fixed over evolutionary time. Current evolutionary biology is increasingly focussed on understanding how the evolution of developmental organisations modifies the distribution of phenotypic variation, the evolution of ecological relationships modifies the selective environment, and the evolution of reproductive relationships modifies the heritability of the evolutionary unit. The major transitions in evolution, in particular, involve radical changes in developmental, ecological and reproductive organisations that instantiate variation, selection and inheritance at a higher level of biological organisation. However, current evolutionary theory is poorly equipped to describe how these organisations change over evolutionary time and especially how that results in adaptive complexes at successive scales of organisation (the key problem is that evolution is self-referential, i.e. the products of evolution change the parameters of the evolutionary process). Here we first reinterpret the central open questions in these domains from a perspective that emphasises the common underlying themes. We then synthesise the findings from a developing body of work that is building a new theoretical approach to these questions by converting well-understood theory and results from models of cognitive learning. Specifically, connectionist models of memory and learning demonstrate how simple incremental mechanisms, adjusting the relationships between individually-simple components, can produce organisations that exhibit complex system-level behaviours and improve the adaptive capabilities of the system. We use the term “evolutionary connectionism” to recognise that, by functionally equivalent processes, natural selection acting on the relationships within and between evolutionary entities can result in organisations that produce complex system-level behaviours in evolutionary systems and modify the adaptive capabilities of natural selection over time. We review the evidence supporting the functional equivalences between the domains of learning and of evolution, and discuss the potential for this to resolve conceptual problems in our understanding of the evolution of developmental, ecological and reproductive organisations and, in particular, the major evolutionary transitions