What Physical Education Teachers Know About Asthma: Impact of a Training Course

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Genital tract involvements in a bull affected by bovine besnoitiosis

Objective To describe the gross and histopathological testicular lesions observed in a 14-months.old Limousine bull, imported from France and referred for thickening of the skin and enlargement of the testis and finally diagnosed as affected by Besnoitiosis. The diagnosis was confirmed by histological investigation of skin sampled via biopsy. Materials and Methods Gross examination and histological investigation were carried out on the reproductive tract of the bull sampled during slaughtering. The considered parts were skin of the scrotum, testis, testicular coverings, epididymis, penis, and penis retractor muscle. These tissue were fixed in 10% buffered formalin, embedded in paraffin wax, and processed for histological investigation. Results Gross examination showed: thickening and lichenification of the scrotal skin (a), visible cysts at the level of the testicular coverings (b), preputial mucosa (c), hyperemia of the right testis (d). The main microscopical finding was the presence of several Besnoitia. spp cysts in the skin and subcutaneous tissue of the scrotum, in the testicular coverings as well as in the testicular tubules (e), and epididymis. (f) The Besnoitia spp. cysts ranged in size from 250 to 300 μm in diameter. They had a 10-20 μm thick wall with three layers: an outer hyaline layer, a middle layer with host cells cytoplasm and nuclei, and an inner membrane with the parasitophorous vacuole containing typical 7.0×2.0 μm basophilic banana-shaped Besnoitia spp. Bradyzoites. Plasmocytic and histiocytic inflammatory reaction, with sparse eosinophilic granulocytes infiltration were observed around some broken cysts. Numerous Besnoitia spp. cysts were also observed in the cross section of the penis (g) and the penis retractor muscle (h). A moderate inflammatory response, composed by macrophages, eosinophils and scattered lymphocytes, was seen near and around the cysts. Discussion and conclusions The presence of cysts and its secondary inflammatory reactions may explain the impaired fertility that has been already described in the case of Besnoitiosis. Potential explanations may be: • interference with normal spermatogenesis by the cysts in the interstitial spaces and under the epithelial cells in the seminiferous tubules; • direct pressure on the germinal epithelial cells by the cysts that can cause pressure atrophy of epididymal and/or testicular tissues; • reduction of the blood flow, local testicular necrosis and development of fibrotic foci due to the inflammation caused by the cysts in the blood vessel walls of the testis and pampiniform plexus, with repercussion on the seminiferous tubule health; • abnormal thermoregulation of the testis due to the thickened scrotum; • abnormal thermoregulation of the testis due to vascular lesions in pampiniform plexus provokiong testicular degeneration; • tissutal fibrosis due to the inflammatory reaction to the presence of the cysts

Effects of age-related cognitive deficits on EEG phase coherence

Body and brain undergo several changes with aging. One of these changes is the loss of neuroplasticity, which leads to the decrease of cognitive abilities. Hence the necessity of stopping or reversing these changes is of utmost importance to contemporary society. In the present work, electroencephalogram (EEG) markers of cognitive decline are sought whilst the subjects perform the Wisconsin Card Sorting Test (WCST). Considering the expected age-related cognitive deficits, WCST was applied to young and elder participants. The results suggest that coherence on theta and alpha EEG rhythms decrease with aging and increase with performance. Additionally, theta phase coherence seems more sensitive to performance, while alpha synchronization appears as a potential ageing markerFCT-Foundation for Science and Technology and Compete Program with the project reference FCOMP-01-0124-FED ER-021145 (PTDC/SAU-ENB/118383/2010

A De Novo Mutation in COL1A1 in a Holstein Calf with Osteogenesis Imperfecta Type II

Osteogenesis imperfecta (OI) type II is a genetic connective tissue disorder characterized by bone fragility, severe skeletal deformities and shortened limbs. OI usually causes perinatal death of affected individuals. OI type II diagnosis in humans is established by the identification of heterozygous mutations in genes coding for collagens. The purpose of this study was to characterize the pathological phenotype of an OI type II-affected neonatal Holstein calf and to identify the causative genetic variant by whole-genome sequencing (WGS). The calf had acute as well as intrauterine fractures, abnormally shaped long bones and localized arthrogryposis. Genetic analysis revealed a private heterozygous missense variant in COL1A1 (c.3917T>A) located in the fibrillar collagen NC1 domain (p.Val1306Glu) that most likely occurred de novo. This confirmed the diagnosis of OI type II and represents the first report of a pathogenic variant in the fibrillar collagen NC domain of COL1A1 associated to OI type II in domestic animals. Furthermore, this study highlights the utility of WGS-based precise diagnostics for understanding congenital disorders in cattle and the need for continued surveillance for rare lethal genetic disorders in cattle

Modelado 3D de la muralla de la Macarena (Sevilla). Propuesta metodológica para su integración en trabajos de gestión cartográfica digital

[EN] Conservation studies of an architectural asset constitute a solid support for future interventions. In particular, Digital Cartographic Management advocates the use of simplified models that allow different levels of definition to be achieved, depending on the desired architectural scale. Based on previous studies in which four levels of definition have been achieved, the aim is to define a fifth level from a 3D model. For this purpose, the Macarena Wall (Seville) is proposed as a case study. In this work, a photogrammetric survey of a section of the sector of this medieval wall is carried out, from which the entities that will form part of a fifth level of definition are identified.[ES] Los estudios de conservación sobre un bien arquitectónico constituyen un soporte sólido para futuras intervenciones. En concreto, la Gestión Cartográfica Digital aboga por el uso de modelos simplificados que permiten alcanzar distintos niveles de definición, según la escala arquitectónica deseada. Partiendo de estudios previos en los que se han logrado obtener cuatro niveles de definición, se tiene como objetivo definir un quinto nivel a partir de un modelo 3D. Para ello, se propone como caso de estudio la Muralla de La Macarena (Sevilla). En este trabajo se realiza el levantamiento fotogramétrico de un tramo del sector de esta muralla medieval, a partir del cual se identifican las entidades que formarán parte de un quinto nivel de definición.Los autores expresan su agradecimiento a la Gerencia de Urbanismo del Ayuntamiento de Sevilla, especialmente al Servicio de Conservación Urbana y Renovación de la Edificación, al Servicio de Planeamiento y Desarrollo Urbanístico y a la Infraestructura de Datos Espaciales de Sevilla (IDE Sevilla).Cabrera-Revuelta, E.; Mascort-Albea, EJ.; Hidalgo-Sánchez, FM.; Romero-Hernández, R.; Canivell, J. (2021). 3D modeling of the Macarena Wall (Seville). Methodological proposal for its integration in digital cartographic management studies. EGE Revista de Expresión Gráfica en la Edificación. 0(14):4-23. https://doi.org/10.4995/ege.2021.15584OJS423014Alshawabkeh, Y., El-Khalili, M., Almasri, E., Bala'awi, F., & Al-Massarweh, A. 2020. Heritage documentation using laser scanner and photogrammetry. The case study of Qasr Al-Abidit, Jordan. Digital Applications in Archaeology and Cultural Heritage, vol. 16, e00133. https://doi.org/10.1016/j.daach.2019.e00133Angulo, R., Pinto, F., Rodríguez, J., & Palomino, A. 2017. Digital Anastylosis of the Remains of a Portal by Master Builder Hernán Ruiz: Knowledge Strategies, Methods and Modelling Results. Digital Applications in Archaeology and Cultural Heritage, vol. 7 (March), pp. 32-41. https://doi.org/10.1016/j.daach.2017.09.003Barrera, J.A., Macías, D.H., & Boquera, J.H. 2005. La muralla almohade de Sevilla: aplicación de tecnologías de vanguardia a los levantamientos en arqueología y restauración. Aparejadores: Boletín Del Colegio Oficial de Aparejadores y Arquitectos Técnicos de Sevilla, no. 69, p. 48.Barrera Vera, J.A. 2005. Generation of virtual models of historical tapial 1 walls in Seville (Spain).Benavides López, J.A., & Barrera Vera, J A. 2020. Evaluación de los Sistemas de Mapeo Móvil (MMS) en la documentación gráfica del tholo de El Romeral (Conjunto Arqueológico Dólmenes de Antequera). Arqueología de la Arquitectura, vol. 17, e095. https://doi.org/10.3989/arq.arqt.2020.004Cabeza Méndez, J.M. 1993. Restauración de las murallas de Sevilla. Arquitectura y Ciudad II y III: Seminarios celebrados en Melilla, los días 25, 26 y 27 de septiembre de 1990 y los días 24, 25 y 26 de septiembre de 1991, pp. 341-348.Cabrera-Revuelta, E., & Molero-Alonso, B. 2016. Fotogrametría terrestre. Trabajos previos a la toma de datos. EGE Revista de Expresión Gráfica en la Edificación, no. 9, pp. 33-44. https://doi.org/10.4995/ege.2016.12458Cabrera-Revuelta, E., Chávez, M.J., Barrera-Vera, J.A., Fernández-Rodríguez, Y., & Caballero Sánchez, M. 2021. Optimization of laser scanner positioning networks for architectural surveys through the design of genetic algorithms. Measurement, vol. 174, 108898. https://doi.org/10.1016/j.measurement.2020.108898Calama, J.M., & Canivell, J. 2006. Análisis patológico de los paramentos de la muralla almohade de Sevilla (tramo comprendido entre la Puerta de la Macarena y el Jardín del Valle). V SIACOT. I SAACT. Construir con Tierra. Ayer y Hoy. Libro de Resúmenes. 14-17 june 2006, Mendoza, Argentina, pp. 117-118.Canivell, Jacinto et al. 2020. "A Methodological Framework for the Preventive Conservation of Historic Walls Located in Urban Contexts. Spatial Data Standards for the Medieval Wall of Seville (Spain): The Case of the Macarena Sector." Ge-Conservacion 18(1): 44-55. https://doi.org/10.37558/gec.v18i1.762Canivell, J., Jaramillo-Morilla, A., Mascort-Albea, E.J., & Romero-Hernández, R. 2019. Metodología de evaluación y monitorización del patrimonio basado en la gestión cartográfica digital. La muralla de Sevilla. In M.D. Sivo, D. Ladiana (Ed.), Le Mura Urbane Crollano: Conservazione e Manutenzione Programmata Della Cinta Muraria Dei Centri Storici: Atti del Seminario Internazionale.(pp. 119-135). Pisa: Pisa University Press. https://hdl.handle.net/11441/88061Canivell, J., Mascort-Albea, E.J., Cabrera-Revuelta, E., Romero-Hernández, R., Jaramillo-Morilla, A., & Serrano-Chacón, Á. 2020. A methodological framework for the preventive conservation of historic walls located in urban contexts. Spatial data standards for the medieval wall of Seville (Spain): the case of the Macarena sector. Ge-Conservacion, vol. 18, no. 1, pp. 44-55. https://doi.org/10.37558/gec.v18i1.762Chiabrando, F., Colucci, E., Lingua, A., Matrone, F., Noardo, F., & Spanòa, A. 2018. A European Interoperable Database (EID) to increase resilience of cultural heritage. International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, vol. 42, no. 3/W4, pp. 151-158. https://doi.org/10.5194/isprs-archives-XLII-3-W4-151-2018Henriques, F., Bailão, A., Rocha, J., & Costa, J. 2020. Restoration of an 18th century frame: 3D modelling, printing and matching color of decorative flowers elements. Ge-Conservacion, vol. 18, no. 1, pp. 313-322. https://doi.org/10.37558/gec.v18i1.854Hidalgo-Sánchez, F.M. 2018. Interoperatividad entre SIG y BIM aplicada al patrimonio arquitectónico, exploración de posibilidades mediante la realización de un modelo digitalizado de la Antigua Iglesia de Santa Lucía y posterior análisis. Final Degree Work. Universidad de Sevilla, Sevilla. https://hdl.handle.net/11441/79394Jiménez-Maqueda, D., & Pérez-Quesada, P. 2012. La muralla huérfana. A vueltas con el último recinto amurallado de Madnat Išblia. Romula, no. 11, pp. 273-347. López-Martínez, F.J. 1999. Tapias y tapiales. Loggia: Arquitectura y Restauración, no. 8, pp. 74-89. https://doi.org/10.4995/loggia.1999.5288Martín-del-Río, J.J., Alejandre, F.J., Blasco-López, F.J., & Márquez-Martínez, G. 2008. Hormigones de cal islámicos: altas resistencias en los tapiales del sector oriental de la Muralla de Sevilla (España). Actas de IX CICOP 2008. Congreso Internacional de Rehabilitación del Patrimonio Arquitectónico y Edificación. Patrimonio Construido e Innovación., Sevilla, vol. I, pp. 81-86.Masciotta, M.G., Morais, M.J., Ramos, L.F., Oliveira, D.V, Sánchez-Aparicio, L.J., & González-Aguilera, D. 2019. A Digital-based Integrated Methodology for the Preventive Conservation of Cultural Heritage: The Experience of HeritageCare Project. International Journal of Architectural Heritage, pp. 1-20. https://doi.org/10.1080/15583058.2019.1668985Mascort-Albea, E.J., Jaramillo-Morilla, A., Romero-Hernández, R., & Hidalgo-Sánchez, F.M. 2020. BIM-GIS interoperability applied to architectonic heritage: 2D and 3D digital models for the study of the ancient church of Santa Lucía in Seville (Spain). Science and Digital Technology for Cultural Heritage: Interdisciplinary Approach to Diagnosis, Vulberability, Risk Assessment and Graphic Information Models, CRC Press. pp. 31-35. https://doi.org/10.1201/9780429345470-5Merchán, M.J., & Pérez, E. 2020. Conservation to overcome oblivion. New methods for the survival of lost heritage memory. Ge-Conservacion, no. 17, pp. 160-170. https://doi.org/10.37558/gec.v17i1.753Piaia, E., Maietti, F., Di Giulio, R., Schippers-Trifan, O., Van Delft, A., Bruinenberg, S., & Olivadese, R. 2020. BIM-based cultural heritage asset management tool. Innovative solution to orient the preservation and valorization of historic buildings. International Journal of Architectural Heritage, pp. 1-24. https://doi.org/10.1080/15583058.2020.1734686Pierdicca, R. 2018. Mapping Chimu's settlements for conservation purposes using UAV and close range photogrammetry. The virtual reconstruction of Palacio Tschudi, Chan Chan, Peru. Digital Applications in Archaeology and Cultural Heritage, vol. 8, pp. 27-34. https://doi.org/10.1016/j.daach.2017.11.004Quattrini, R., Pierdicca, R., Paolanti, M., Clini, P., Nespeca, R., & Frontoni, E. 2020. Digital interaction with 3D archaeological artefacts: evaluating user's behaviours at different representation scales. Digital Applications in Archaeology and Cultural Heritage, vol. 18, e00148. https://doi.org/10.1016/j.daach.2020.e00148Rubio, J.M., Martín, J.J.F., & Alonso, J.I.S.J. 2018. Implementation of 3D scanner and digital photogrammetry in the documentation process of la Merced Church, Panama. EGA Revista de Expresion Grafica Arquitectonica, vol. 23, no. 32, pp. 208-219. https://doi.org/10.4995/ega.2018.9811Sequenzia, G., Fatuzzo, G., & Oliveri, S.M. 2021. A computer-based method to reproduce and analyse ancient series-produced moulded artefacts. Digital Applications in Archaeology and Cultural Heritage, vol. 20, e00174. https://doi.org/10.1016/j.daach.2021.e0017

Magnetic upconverting fluorescent NaGdF4:Ln3+ and iron-oxide@NaGdF4:Ln3+ nanoparticles

CAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORFAPEMA - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MARANHÃOFAPEAL - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE ALAGOASMicrowave assisted solvothermal method has been employed to synthesize multifunctional upconverting beta-NaGdF4:Ln(3+) and magnetic-upconverting Fe3O4/gamma-Fe2O3@ NaGdF4:Ln3+ ( Ln = Yb and Er) nanoparticles. The powder x-ray diffraction data confirms the hexagonal structure of NaGdF4:Ln(3+) and high resolution transmission electron microscopy shows the formation of rod shaped NaGdF4:Ln(3+) (similar to 20 nm) and ovoid shaped Fe3O4/gamma-Fe2O3@NaGdF4:Ln(3+) (similar to 15 nm) nanoparticles. The magnetic hysteresis at 300 K for beta-NaGdF4:Ln(3+) demonstrates paramagnetic features, whereas iron-oxide@beta-NaGdF4:Ln(3+) exhibits superparamagnetic behavior along with a linear component at large applied field due to paramagnetic NaGdF4 matrix. Both nanoparticle samples provide an excellent green emitting [(H-2(11/ 2), S-4(3/2))-> I-4(15/2) (similar to 540 nm)] upconversion luminescence emission under excitation at 980 nm. The energy migration between Yb and Er in NaGdF4 matrix has been explored from 300-800 nm. Intensity variation of blue, green and red lines and the observed luminescence quenching due to the presence of Fe3O4/gamma-Fe2O3 in the composite has been proposed. These kinds of materials contain magnetic and luminescence characteristics into single nanoparticle open new possibility for bioimaging applications.8516CAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORFAPEMA - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MARANHÃOFAPEAL - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE ALAGOASCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORFAPEMA - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MARANHÃOFAPEAL - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE ALAGOAS62. Annual Conference on Magnetism and Magnetic Materials2017Pittsburgh, PAIEEE Magnetics SocietyAIP PublishingAgências de fomento estrangeiras apoiaram essa pesquisa, mais informações acesse artig

Swarm hybrid optimization for a piecewise model fitting applied to a glucose model

[EN] Purpose ¿ The purpose of this paper is to study insulin pump therapy and accurate monitoring of glucose levels in diabetic patients, which are current research trends in diabetology. Both problems have a wide margin for improvement and promising applications in the control of parameters and levels involved. Design/methodology/approach ¿ The authors have registered data for the levels of glucose in diabetic patients throughout a day with a temporal resolution of 5 minutes, the amount and time of insulin administered and time of ingestion. The estimated quantity of carbohydrates is also monitored. A mathematical model for Type 1 patients was fitted piecewise to these data and the evolution of the parameters was analyzed. Findings ¿ They have found that the parameters for the model change abruptly throughout a day for the same patient, but this set of parameters account with precision for the evolution of the glucose levels in the test patients. This fitting technique could be used to personalize treatments for specific patients and predict the glucose-level variations in terms of hours or even shorter periods of time. This way more effective insulin pump therapies could be developed. Originality/value ¿ The proposed model could allow for the development of improved schedules on insulin pump therapiesAcedo Rodríguez, L.; Botella, M.; Cortés, J.; Hidalgo, J.; Maqueda, E.; Villanueva Micó, RJ. (2018). Swarm hybrid optimization for a piecewise model fitting applied to a glucose model. Journal of Systems and Information Technology. 20(4):9618-9627. https://doi.org/10.1108/JSIT-10-2017-0103S9618962720