Flavor Structure of the Nucleon Sea

The recent progress on our understanding of the flavor structure of unpolarized and polarized nucleon sea is reviewed. The large flavor asymmetry between the up and down sea quark distributions is now well established. This asymmetry strongly suggests the importance of the mesonic degrees of freedom in the description of the nucleon sea. The strong connection between the flavor structure and the spin structure of the nucleon sea is emphasized. Possible future measurements for testing various theoretical models are also discussed.Comment: 5pages, 4 figures, Invited talk presented at the QNP2002 conference, Julich, June 200

Strangeness in the nucleon and the ratio of proton-to-neutron neutrino-induced quasi-elastic yield

The electroweak form factors of the nucleon as obtained within a three flavor pseudoscalar vector meson soliton model are employed to predict the ratio of the proton and neutron yields from $^{12}C$, which are induced by quasi-elastic neutrino reactions. These predictions are found to vary only moderately in the parameter space allowed by the model. The antineutrino flux of the up-coming experiment determining this ratio was previously overestimated. The corresponding correction is shown to have only a small effect on the predicted ratio. However, it is found that the experimental result for the ratio crucially depends on an accurate measurement of the energy of the knocked out nucleon.Comment: 17 pages, LaTeX, 2 tables, 4 figures, Discussion on shape of strange form factors added, Z. Phys. A, to be publishe

Strangeness in the proton and N*(1535)

The newest progress on the study of the strangeness in the proton and in the lowest negative parity nucleon excited state $N^*(1535)$ is reviewed. Implications on the internal quark structure of the proton, $N^*(1535)$ and other baryons are discussed. The diquark cluster picture for the 5-quark components in baryons gives a natural explanation not only to the empirical indications for a positive strangeness magnetic moment $\mu_s$ and positive strangeness radius of the proton but also the longstanding mass-reverse problem of $N^*(1535)$, $N^*(1440)$ and $\Lambda^*(1405)$ resonances as well as the unusual decay pattern of the $N^*(1535)$ resonance. Evidence for possible existence of $N^*(1535)$'s ${1/2}^-$ SU(3) nonet partners in this picture is pointed out, and suggestion is made to search for these $1/2^-$ hyperon excited states under the well known $\Sigma^*(1385)$, $\Lambda^*(1520)$ and $\Xi^*(1530)$ peaks in various reactions.Comment: 6 pages, 2 figures, Plenary talk at 18th International IUPAP Conference on Few-Body Problems in Physics August 21-26. 2006 Santos SP Brazil; to be published in Nuclear Physics

Structural Atrophy of the Right Superior Frontal Gyrus in Adolescents With Severe Irritability

Severe irritability is common in youths with psychiatric disorders and results in significant dysfunction across domains (academic, social, and familial). Prior structural MRI studies in the pediatric population demonstrated that aberrations of cortical thickness (CT) and gray matter volume (GMV) in the fronto-striatal-temporal regions which have been associated with irritability. However, the directions of the correlations between structural alteration and irritability in the individual indices were not consistent. Thus, we aim to address this by implementing comprehensive assessments of CT, GMV, and local gyrification index (LGI) simultaneously in youths with severe levels of irritability by voxel-based morphometry and surface-based morphometry. One hundred and eight adolescents (46 youths with severe irritability and 62 healthy youths, average age = 14.08 years, standard deviation = 2.36) were scanned with a T1-weighted MRI sequence. The severity of irritability was measured using the affective reactivity index. In youths with severe irritability, there was decreased CT, GMV, and LGI in the right superior frontal gyrus (SFG) compared to healthy youths, and negative correlations between these indices of the SFG and irritability. Our findings suggest that structural deficits in the SFG, potentially related to its role in inhibitory control, may be critical for the neurobiology of irritability

A Study of Off-Forward Parton Distributions

An extensive theoretical analysis of off-forward parton distributions (OFPDs) is presented. The OFPDs and the form factors of the quark energy-momentum tensor are estimated at a low-energy scale using a bag model. Relations among the second moments of OFPDs, the form factors, and the fraction of the nucleon spin carried by quarks are discussed.Comment: 29 pages revtex, 12 postscript figures, minor corrections, references update

Strange Asymmetries in the Nucleon Sea

Relativistic corrections to the strange axial form factor are evaluated within a light-cone formalism, taking into account effects due to the breaking of Lorentz covariance associated with the use of one-body currents. Similar corrections are known to also be needed for the magnetic form factor, and we discuss the importance of these for recent data on strange electromagnetic form factors from the HAPPEX Collaboration at Jefferson Lab. The strange vector form factors, the strange axial charge, and the asymmetries in strange quark distributions are shown to be consistently correlated within the chiral cloud model.Comment: 13 pages revtex, 4 figures, minor additions, to appear in Phys. Lett.

Chiral dynamics and the growth of the nucleon's gluonic transverse size at small x

We study the distribution of gluons in transverse space in the nucleon at moderately small x (~10^{-2}). At large transverse distances (impact parameters) the gluon density is generated by the 'pion cloud' of the nucleon, and can be calculated in terms of the gluon density in the pion. We investigate the large-distance behavior in two different approaches to chiral dynamics: i) phenomenological soft-pion exchange, ii) the large-N_c picture of the nucleon as a classical soliton of the pion field, which corresponds to degenerate N and Delta states. The large-distance contributions from the 'pion cloud' cause a \~20% increase in the overall transverse size of the nucleon if x drops significantly below M_pi/M_N. This is in qualitative agreement with the observed increase of the slope of the t-dependence of the J/psi photoproduction cross section at HERA compared to fixed-target energies. We argue that the glue in the pion cloud could be probed directly in hard electroproduction processes accompanied by 'pion knockout', gamma^* + N -> gamma (or rho, J/psi) + pi + N', where the transverse momentum of the emitted pion is large while that of the outgoing nucleon is restricted to values of order M_pi.Comment: 20 pages, revtex4, 10 eps figure

Androgen Receptor Inhibition Suppresses Anti-Tumor Neutrophil Response Against Bone Metastatic Prostate Cancer via Regulation of TβRI Expression

Bone metastatic disease of prostate cancer (PCa) is incurable and progression in bone is largely dictated by tumor-stromal interactions in the bone microenvironment. We showed previously that bone neutrophils initially inhibit bone metastatic PCa growth yet metastatic PCa becomes resistant to neutrophil response. Further, neutrophils isolated from tumor-bone lost their ability to suppress tumor growth through unknown mechanisms. With this study, our goal was to define the impact of metastatic PCa on neutrophil function throughout tumor progression and to determine the potential of neutrophils as predictive biomarkers of metastatic disease. Using patient peripheral blood polymorphonuclear neutrophils (PMNs), we identified that PCa progression dictates PMN cell surface markers and gene expression, but not cytotoxicity against PCa. Importantly, we also identified a novel phenomenon in which second generation androgen deprivation therapy (ADT) suppresses PMN cytotoxicity via increased transforming growth factor beta receptor I (TβRI). High dose testosterone and genetic or pharmacologic TβRI inhibition rescued androgen receptor-mediated neutrophil suppression and restored neutrophil anti-tumor immune response. These studies highlight the ability to leverage standard-care ADT to generate neutrophil anti-tumor responses against bone metastatic PCa

The Pandora multi-algorithm approach to automated pattern recognition of cosmic-ray muon and neutrino events in the MicroBooNE detector.

The development and operation of liquid-argon time-projection chambers for neutrino physics has created a need for new approaches to pattern recognition in order to fully exploit the imaging capabilities offered by this technology. Whereas the human brain can excel at identifying features in the recorded events, it is a significant challenge to develop an automated, algorithmic solution. The Pandora Software Development Kit provides functionality to aid the design and implementation of pattern-recognition algorithms. It promotes the use of a multi-algorithm approach to pattern recognition, in which individual algorithms each address a specific task in a particular topology. Many tens of algorithms then carefully build up a picture of the event and, together, provide a robust automated pattern-recognition solution. This paper describes details of the chain of over one hundred Pandora algorithms and tools used to reconstruct cosmic-ray muon and neutrino events in the MicroBooNE detector. Metrics that assess the current pattern-recognition performance are presented for simulated MicroBooNE events, using a selection of final-state event topologies

Measurement of the Proton and Deuteron Spin Structure Function g_1 in the Resonance Region

We have measured the proton and deuteron spin structure functions g_1^p and g_1^d in the region of the nucleon resonances for W^2 < 5 GeV^2 and $Q^2\simeq 0.5$ and $Q^2\simeq 1.2$ GeV^2 by inelastically scattering 9.7 GeV polarized electrons off polarized $^{15}NH_3$ and $^{15}ND_3$ targets. We observe significant structure in g_1^p in the resonance region. We have used the present results, together with the deep-inelastic data at higher W^2, to extract $\Gamma(Q^2)\equiv\int_0^1 g_1(x,Q^2) dx$. This is the first information on the low-Q^2 evolution of Gamma toward the Gerasimov-Drell-Hearn limit at Q^2 = 0.Comment: 7 pages, 2 figure