309 research outputs found
Architecture for quadruple precision floating point division with multi-precision support
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Architecture for dual-mode quadruple precision floating point adder
This paper presents a configurable dual-mode architecture for floating point (F.P.) adder. The architecture (named as QPdDP) works in dual-mode which can operates either for quadruple precision or dual (two-parallel) double precision. The architecture follows the standard state-of-the-art flow for floating point adder. It is aimed for the computation of normal as well as sub-normal operands, along with the support for the exceptional case handling. The key sub-components in the architecture are re-designed & optimized for on-the-fly dual-mode processing, which enables efficient resource sharing for dual precision operands. The data-path is optimized for minimal multiplexing circuitry overhead. The presented dual- mode architecture provide SIMD support for double precision operands, along with high (quadruple) precision support. The proposed architecture is synthesized using UMC 90nm technology ASIC implementation. It is compared with the best available literature works, and have shown better design metrics in terms of area, period and area Γ period, along with more computational support.published_or_final_versio
Series Expansion based Efficient Architectures for Double Precision Floating Point Division
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Configurable Architecture for Double/Two-Parallel Single Precision Floating Point Division
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Differentiation-Dependent Secretion of Proangiogenic Factors by Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are a promising cell population for cell-based bone repair due to their proliferative potential, ability to differentiate into bone-forming osteoblasts, and their secretion of potent trophic factors that stimulate angiogenesis and neovascularization. To promote bone healing, autogenous or allogeneic MSCs are transplanted into bone defects after differentiation to varying degrees down the osteogenic lineage. However, the contribution of the stage of osteogenic differentiation upon angiogenic factor secretion is unclear. We hypothesized that the proangiogenic potential of MSCs was dependent upon their stage of osteogenic differentiation. After 7 days of culture, we observed the greatest osteogenic differentiation of MSCs when cells were cultured with dexamethasone (OM+). Conversely, VEGF protein secretion and upregulation of angiogenic genes were greatest in MSCs cultured in growth media (GM). Using conditioned media from MSCs in each culture condition, GM-conditioned media maximized proliferation and enhanced chemotactic migration and tubule formation of endothelial colony forming cells (ECFCs). The addition of a neutralizing VEGF165/121 antibody to conditioned media attenuated ECFC proliferation and chemotactic migration. ECFCs seeded on microcarrier beads and co-cultured with MSCs previously cultured in GM in a fibrin gel exhibited superior sprouting compared to MSCs previously cultured in OM+. These results confirm that MSCs induced farther down the osteogenic lineage possess reduced proangiogenic potential, thereby providing important findings for consideration when using MSCs for bone repair
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