66 research outputs found

    Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

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    BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

    Sewing Clothes Kids Love : Sawing Patterns and Instructions for Boy's and Girl's outfits.

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    Dalam buku ini, jahit Pakaian Anak Cinta Pakaian anak-anak. Pakaian berwarna-warni dan imajinatif dirancang sesuai dengan kepribadian anak-anak. Mereka nyaman, fashion ke depan, dan menyenangkan untuk memakai-dijamin untuk mengejutkan, menyenangkan, dan memicu rasa bermain. Pembaca akan menemukan banyak inspirasi kreatif sendiri, bersama dengan langkah-demi-langkah instruksi untuk menjahit pakaian sepuluh unik untuk anak laki-laki dan perempuan. Pakaian disajikan dalam berbagai gaya kain, dengan pilihan rincian konstruksi dan dekoratif embelishments-termasuk embrodery, patcwork, dan trim-sehingga setiap pakaian dapat dirancang khusus untuk anak tertentu yang ada dalam pikiran

    Bizarre organism from the skin of mahi mahi, Coryphaena hippurus L. (Teleostei: Coryphaenidae)

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    Superficial stellate cells of an unknown origin were detected on the epidermis of juvenile mahi mahi, Coryphaena hippurus L., up to 60 days of age. The cells occurred in large numbers, and were detected in both wild and cultured fish. International authorities were unable to identify the organism and there was no pathology associated with the presence of the cells on the skin. Because of the fine cytoplasmic interdigitations between the organism and the host cell, and the close ecological association with both wild and cultured juveniles examined, it was thought that the cells could possibly be highly modified skin cells. We report here that the spinous cells possess DNA sequences encoding 16S subunit ribosomal RNA genes distinct from those of mahi mahi, and also that restriction enzyme digests of genomic DNA from the spinous cells and from mahi mahi produced distinct patterns after electrophoretic separation. This suggests that the spinous cells are a bizarre commensal organism displaying a close physical and ecological association with the fish host
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