580 research outputs found
Projections of climate change on the behaviour of clays in the UK
The impact of expected climate change on clay cuttings and embankments used for roads and railways is not well understood. Volume sensitive clays respond to seasonal variations in climate through vertical and horizontal displacements. These cause a variety of impacts at differing temporal and spatial scales, for example short term changes such as seasonal displacement of railway tracks or long term progressive failure of the slope. Daily changes in soil moisture content in the surface layers of a clay slope are simulated using a water balance model and expressed as soil moisture deficit and potential for surface runoff. Model results are validated against a 10 year run of field data in the UK. The impacts of anticipated climate change on soil water contents and equivalent pore water pressures are evaluated using stochastic climatic data over the 21st century based on the UK Climate Impacts Programme. Results indicate that recent summers considered to be exceptionally dry are likely to become the average condition later in the 21st century. Although winter rainfall is predicted to increase, average winter runoff will remain the same, although extreme wet events are still likely to occur. The implications for the design and maintenance of clay slopes and embankments are dis-cussed
Online Human Activity Recognition using Low-Power Wearable Devices
Human activity recognition~(HAR) has attracted significant research interest
due to its applications in health monitoring and patient rehabilitation. Recent
research on HAR focuses on using smartphones due to their widespread use.
However, this leads to inconvenient use, limited choice of sensors and
inefficient use of resources, since smartphones are not designed for HAR. This
paper presents the first HAR framework that can perform both online training
and inference. The proposed framework starts with a novel technique that
generates features using the fast Fourier and discrete wavelet transforms of a
textile-based stretch sensor and accelerometer. Using these features, we design
an artificial neural network classifier which is trained online using the
policy gradient algorithm. Experiments on a low power IoT device (TI-CC2650
MCU) with nine users show 97.7% accuracy in identifying six activities and
their transitions with less than 12.5 mW power consumption.Comment: This is in proceedings of ICCAD 2018. The datasets are available at
https://github.com/gmbhat/human-activity-recognitio
Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain
Cerebral white matters lesions (WML) are seen in 94% of the population aged 64 and over and are associated
with cognitive decline and depression. We used immunohistochemistry and stereological methods on post mortem
brain samples derived from the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort
to investigate the axonal density within deep subcortical lesions. There was no significant difference between the
lesional and control white matter, therefore, we conclude that there is axonal preservation within these lesions that
are characterized by demyelination
Functional and genetic analysis of regulatory regions of coliphage H-19B: location of shiga-like toxin and lysis genes suggest a role for phage functions in toxin release
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74784/1/j.1365-2958.1998.00890.x.pd
Actors and networks or agents and structures: towards a realist view of information systems
Actor-network theory (ANT) has achieved a measure of popularity in the analysis of information systems. This paper looks at ANT from the perspective of the social realism of Margaret Archer. It argues that the main issue with ANT from a realist perspective is its adoption of a `flat' ontology, particularly with regard to human beings. It explores the value of incorporating concepts from ANT into a social realist approach, but argues that the latter offers a more productive way of approaching information systems
Measurement of Pion Enhancement at Low Transverse Momentum and of the Delta-Resonance Abundance in Si-Nucleus Collisions at AGS Energy
We present measurements of the pion transverse momentum (p_t) spectra in
central Si-nucleus collisions in the rapidity range 2.0<y<5.0 for p_t down to
and including p_t=0. The data exhibit an enhanced pion yield at low p_t
compared to what is expected for a purely thermal spectral shape. This
enhancement is used to determine the Delta-resonance abundance at freeze-out.
The results are consistent with a direct measurement of the Delta-resonance
yield by reconstruction of proton-pion pairs and imply a temperature of the
system at freeze-out close to 140 MeV.Comment: 12 pages + 4 figures (uuencoded at end-of-file
Virtual distillation for quantum error mitigation
Theoretical Physic
Renewable Energy
This chapter presents an in-depth examination of major renewable energy technologies, including their installed capacity and energy supply in 2009 , the current state of market and technology development, their economic and financial feasibility in 2009 and in the near future,
as well as major issues they may face relative to their sustainability
or implementation. Renewable energy sources have been important for humankind since the beginning of civilization. For centuries, biomass has been used for heating, cooking, steam generation, and power production;
solar energy has been used for heating and drying; geothermal energy has been used for hot water supplies; hydropower, for movement;
and wind energy, for pumping and irrigation. For many decades renewable energy sources have also been used to produce electricity or
other modern energy carriers
Hadron yields and spectra in Au+Au collisions at the AGS
Inclusive double differential multiplicities and rapidity density
distributions of hadrons are presented for 10.8 A GeV/c Au+Au collisions as
measured at the AGS by the E877 collaboration. The results indicate that large
amounts of stopping and collective transverse flow effects are present. The
data are also compared to the results from the lighter Si+Al system.Comment: 12 pages, latex, 10 figures, submitted to Nuclear Physics A (Quark
Matter 1996 Proceedings
Final analysis from RESONATE: Up to six years of followâup on ibrutinib in patients with previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma
Ibrutinib, a onceâdaily oral inhibitor of Bruton's tyrosine kinase, is approved in the United States and Europe for treatment of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The phase 3 RESONATE study showed improved efficacy of singleâagent ibrutinib over ofatumumab in patients with relapsed/refractory CLL/SLL, including those with highârisk features. Here we report the final analysis from RESONATE with median followâup on study of 65.3âmonths (range, 0.3â71.6) in the ibrutinib arm. Median progressionâfree survival (PFS) remained significantly longer for patients randomized to ibrutinib vs ofatumumab (44.1 vs 8.1âmonths; hazard ratio [HR]: 0.148; 95% confidence interval [CI]: 0.113â0.196; PË.001). The PFS benefit with ibrutinib vs ofatumumab was preserved in the genomic highârisk population with del(17p), TP53 mutation, del(11q), and/or unmutated IGHV status (median PFS 44.1 vs 8.0âmonths; HR: 0.110; 95% CI: 0.080â0.152), which represented 82% of patients. Overall response rate with ibrutinib was 91% (complete response/complete response with incomplete bone marrow recovery, 11%). Overall survival, censored for crossover, was better with ibrutinib than ofatumumab (HR: 0.639; 95% CI: 0.418â0.975). With up to 71âmonths (median 41âmonths) of ibrutinib therapy, the safety profile remained consistent with prior reports; cumulatively, allâgrade (gradeââ„3) hypertension and atrial fibrillation occurred in 21% (9%) and 12% (6%) of patients, respectively. Only 16% discontinued ibrutinib because of adverse events (AEs). These longâterm results confirm the robust efficacy of ibrutinib in relapsed/refractory CLL/SLL irrespective of highârisk clinical or genomic features, with no unexpected AEs. This trial is registered at www.clinicaltrials.gov (NCT01578707)
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