Northern Shrimp (Pandalus borealis, Krøyer) from Spanish Bottom Trawl Survey 2009 in NAFO Div. 3LNO

The Spanish Institute of Oceanography carried out in 2009 two bottom trawl surveys in the NAFO Regulatory Area in Division 3NO and 3L during the months of June, July and August respectively. The results on Northern shrimp (Pandalus borealis) are presented and compared with those from previous surveys from the same series. In 2009 the catch (33 kg.) and estimated biomass (139 t.) confirm the decrease of shrimp importance from 2004 in 3NO. In 2009 the biomass estimated of northern shrimp in 3L Division was 74091 t. showing a drastic decline (50% with respect to 2008) after the upward trend a long the whole period studied. Catch results from the surveys and data analysis are discussed in this paper

Greenhouse effect gases emission implications on sustainability of the Campus of Vegazana, University of León

En este trabajo se presentan los resultados del estudio de emisiones de CO2, uno de los gases más importantes de efecto invernadero, debido a la actividad desarrollada en el Campus de Vegazana de la Universidad de León, para el año 2006. El estudio se enmarca en un proyecto más amplio de cálculo del indicador Huella Ecológica (HE), desarrollado para conocer en qué medida se alcanzan los objetivos de sostenibilidad establecidos para el Campus, así como para el desarrollo de propuestas encaminadas a la reducción de las emisiones de CO2. Los resultados obtenidos reflejan como el área de superficie biológicamente productiva necesaria para absorber las emisiones del Campus constituyen cerca del 99% del área total de HE. La mayor parte de estas emisiones proceden del gasto energético para electricidad (38%) y uso térmico (24%, seguido del transporte (19%) y la construcción del propio complejo universitario (16%, el cual hace referencia únicamente al año 2006, considerando una vida útil de 27 años para los edificios e instalaciones del Campus, inaugurado en 1979. Una vez analizadas cualitativa y cuantitativamente las emisiones producidas, se ha buscado conocer el total de superficie forestal necesaria para absorber dichas emisiones, considerando los datos del Tercer Inventario Forestal Nacional (2003) sobre cobertura de las masas forestales para el territorio nacional, y los aportados por Bravo (2007) en relación a las tasas de fijación del gas por parte de éstas. Como conclusión, puede estimarse que del total de la superficie forestal de la provincia de León, un 0.46% es necesaria como depósito y sumidero del CO2 emitido por el Campus de Vegazana (8.470.168 toneladas. Esta estimación se ha realizado considerando que las masas forestales son las únicas depositarias de CO2, tarea compartida en la naturaleza, no obstante, con el suelo, el agua y los cultivosIn this work, we present the results obtained about the CO2 emissions, one of the most important greenhouse gases, due to the normal activity developed in the Campus of Vegazana of the University of León for the year 2006. This study is all part of a wider project for evaluating the Fingerprint ecological indicator (HE, initially developed for assessing if the sustainability objectives established by the University policies for the Campus of Vegazana have been achieved, as well as the development of proposals and ideas directed towards the reduction of the emissions of CO2. Results obtained showed that the biologically productive area necessary for absorbing all emissions are close to the 99% of the total value of HE. The majority of these emissions come from the energy consumed for producing electricity (38%) and heating (24%), followed by the transport (19%) and the constructions of the buildings and infrastructures of the University (16%, which related just for the year 2006, considering a living period of 27 years as it was inaugurated in 1979. Once analyzed qualitatively and quantitatively the emissions produced, it was developed a method for estimating the total area covered necessary for absorbing them by considering data available from the Third National Forestry Inventory of Spain (2003), related with the forest cover of the territory, and data provided by Bravo(2007, about the absorption rate of the tree species. As a conclusion, we estimated that form the total area covered by forests of the Province of León, a 0.46% is necessary as sink of the CO2 produced in the Campus of Vegazana (8.470.168 ton. This assessment has been achieved considering that forests are the only warehouse of CO2, when actually soil, water and crops are in nature.Peer Reviewe

Efficacy and safety of switching to abacavir/lamivudine (ABC/3TC) plus rilpivirine (RPV) in virologically suppressed HIV-infected patients on HAART.

We analysed the efficacy and safety of switching from a regimen based on nonnucleoside reverse transcriptase inhibitors (NNRTI) or integrase inhibitors (INI) to ABC/3TC + RPV in virologically suppressed HIV-infected patients. This multicentre, retrospective study comprised asymptomatic HIV-infected patients who switched from 2 NRTI + NNRTI or 2 NRTI + INI to ABC/3TC + RPV between February 2013 and December 2013; all had undetectable HIV viral load prior to switching. Efficacy and safety, and changes in lipids and cardiovascular risk (CVR) were analysed at 48 weeks. Of 85 patients (74.1 % men, mean age 49.5 years), 83 (97.6 %) switched from a regimen based on NNRTI (EFV 74, RPV 5, ETV 2, NVP 2), and 45 (53 %) switched from TDF/FTC to ABC/3TC. The main reasons for switching were toxicity (58.8 %) and convenience (29.4 %). At 48 weeks, 78 (91.8 %) patients continued taking the same regimen; efficacy was 88 % by intention to treat, and 96 % by per protocol. Two patients were lost to follow-up and five ceased the new regimen (4 due to adverse effects and 1 virologic failure). Mean CD4 cell counts increased (744 vs. 885 cells/μL; p = 0.0001), and there were mean decreases in fasting total cholesterol (-15.9 mg/dL; p < 0.0001) and LDL-cholesterol (-11.0 mg/dL; p < 0.004), with no changes in HDL-cholesterol, triglycerides, total cholesterol:HDL-cholesterol ratio, and CVR. ABC/3TC + RPV is effective and safe in virologically-suppressed patients on antiretroviral therapy (ART). Forty-eight weeks after switching the lipid profile improved with decreases in total and LDL cholesterol.This study has been supported in part by the RD12/0017/0017 project (Plan Nacional R+D+ I) and cofinanced by Instituto de Salud Carlos III-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional and a grant from by Janssen Cilag

Recent Trends in SST, Chl-a, Productivity and Wind Stress in Upwelling and Open Ocean Areas in the Upper Eastern North Atlantic Subtropical Gyre

The global upper ocean has been warming during the last decades accompanied with a chlorophyll-a (Chl-a) and productivity decrease. Whereas subtropical gyres show similar trends, Eastern Boundary Upwelling Systems are thought to increase in productivity due to increased trade winds. This study analyzes recent trends in sea surface temperature (SST), Chl-a, net primary production (NPP) and meridional wind stress in the Eastern North Atlantic subtropical gyre (NASE) in order to examine if the global trends can be detected in open ocean and upwelling areas and how the ocean biota responds. Satellite data of such variables of the last 15–40 years were analyzed to calculate mean trends in upwelling areas in the Canary upwelling system and open ocean areas around the Azores, Madeira and the Canary Islands. Our results show significant warming in the area with a maximum of 2.7°C per century for the Azores. Moreover, a general decreasing trend for Chl-a and NPP seems to be more evident in the permanent upwelling areas, which will be responsible for a loss of 0.13% of the global NPP per century. Our results also highlight a significant expansion of the oceanic desert area of 10% with an increase in unproductive days of up to 84 days in the last 20 years. The competitive relationship of stratification and wind stress in the Canary upwelling system might be a more plausible explanation for the decrease in Chl-a and NPP in upwelling areas linked to the increase in upwelling favorable wind stress and the surface warming.En prens

Chronic lymphocytic leukemia patients with IGH translocations are characterized by a distinct genetic landscape with prognostic implications

Chromosome 14q32 rearrangements/translocations involving the immunoglobulin heavy chain (IGH) are rarely detected in chronic lymphocytic leukemia (CLL). The prognostic significance of the IGH translocation is controversial and its mutational profile remains unknown. Here, we present for the first time a comprehensive next-generation sequencing (NGS) analysis of 46 CLL patients with IGH rearrangement (IGHR-CLLs) and we demonstrate that IGHR-CLLs have a distinct mutational profile with recurrent mutations in NOTCH1, IGLL5, POT1, BCL2, FBXW7, ZMYM3, MGA, BRAF and HIST1H1E genes. Interestingly, BCL2 and FBXW7 mutations were significantly associated with this subgroup and almost half of BCL2, IGLL5 and HISTH1E mutations reported were previously identified in non-Hodgkin lymphomas. Notably, IGH/BCL2 rearrangements were associated with a lower mutation frequency and carried BCL2 and IGLL5 mutations, while the other IGHR-CLLs had mutations in genes related to poor prognosis (NOTCH1, SF3B1 and TP53) and shorter time to first treatment (TFT). Moreover, IGHR-CLLs patients showed a shorter TFT than CLL patients carrying 13q-, normal fluorescence in situ hybridization (FISH) and +12 CLL, being this prognosis particularly poor when NOTCH1, SF3B1, TP53, BIRC3 and BRAF were also mutated. The presence of these mutations not only was an independent risk factor within IGHR-CLLs, but also refined the prognosis of low-risk cytogenetic patients (13q-/normal FISH). Hence, our study demonstrates that IGHR-CLLs have a distinct mutational profile from the majority of CLLs and highlights the relevance of incorporating NGS and the status of IGH by FISH analysis to refine the risk-stratification CLL model

Role of surface states on the sensing properties of In0.5Ga0.5As surface quantum dots

Self-assembled uncapped III-V semiconductor quantum dots (QD) have recently emerged as good candidates to develop sensor devices due to their exceptional sensitivity to changes in the surrounding environment. Previous studies report that the external ambient conditions greatly influence the optical and electrical properties of In0.5Ga0.5As surface QD (SQD)2. Furthermore, it was found different electrical response depending on the two- or threedimensional nature of the surface. Surface quantum well (SQW) conductivity suffers a negligible variation when changing the external atmosphere, whereas SQDs conductivity shows a significant increment3 Surface states are generally proposed to be responsible for such effect, although this is still under discussion. In the case of the SQDs, this effect is enhanced by the high surface to volume ratio compared to SQWs

Implementation and analysis of list mode algorithm using tubes of response on a dedicated brain and breast PET

In this work we present an innovative algorithm for the reconstruction of PET images based on the List-Mode (LM) technique which improves their spatial resolution compared to results obtained with current MLEM algorithms. This study appears as a part of a large project with the aim of improving diagnosis in early Alzheimer disease stages by means of a newly developed hybrid PET-MR insert. At the present, Alzheimer is the most relevant neurodegenerative disease and the best way to apply an effective treatment is its early diagnosis. The PET device will consist of several monolithic LYSO crystals coupled to SiPM detectors. Monolithic crystals can reduce scanner costs with the advantage to enable implementation of very small virtual pixels in their geometry. This is especially useful for LM reconstruction algorithms, since they do not need a pre-calculated system matrix. We have developed an LM algorithm which has been initially tested with a large aperture (186 mm) breast PET system. Such an algorithm instead of using the common lines of response, incorporates a novel calculation of tubes of response. The new approach improves the volumetric spatial resolution about a factor 2 at the border of the field of view when compared with traditionally used MLEM algorithm. Moreover, it has also shown to decrease the image noise, thus increasing the image quality. © 2012 Elsevier B.V. All rights reserved.This work was supported by the Centre for Industrial Technological Development co-funded by FEDER through the Technology Fund (DREAM Project, IDI-20110718), by the Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I) under Grant. No. FIS2010-21216-CO2-01TEO 2008/114.Moliner Martínez, L.; Correcher, C.; González Martínez, AJ.; Conde Castellanos, PE.; Hernández Hernández, L.; Orero Palomares, A.; Rodríguez Álvarez, MJ.... (2013). Implementation and analysis of list mode algorithm using tubes of response on a dedicated brain and breast PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 702:129-132. https://doi.org/10.1016/j.nima.2012.08.029S12913270

Gourmetización y gentrificación: paisajes alimentarios desde la ciudad hasta el campo

El presente artículo busca contribuir al desarrollo y consolidación de los estudios sobre la gourmetización y la gentrificación alimentaria, enfatizando los efectos que estos procesos tienen en ámbitos que exceden a la vida urbana. En ese marco, se propone recuperar los engranajes de la cadena de valor y sus localizaciones –desde los barrios gentrificados hasta las comunidades rurales agrícolas–, indicando los procesos de valorización y desvalorización y cómo estos afectan de forma desigual a los actores involucrados. Se enfatiza sobre este punto, estableciendo un diálogo interdisciplinar. A partir de una revisión bibliográfica, el artículo se basa en cuatro casos que se recuperan de fuentes secundarias y que ilustran la forma en la que operan estos procesos en distintos niveles, territorios y escalas: el café de autor en cuanto símbolo de distinción en los barrios gentrificados; la palta o aguacate a partir de su manifestación gastronómica en el avocado toast; el vino, desde la turistificación de su producción hasta las estrategias de valorización en su consumo urbano; y la quinoa desde el patentamiento de nuevas variedades hasta el desarrollo de mercados expulsivos de amplios sectores de población. Se concluye que el auge de estos alimentos tiene efectos de acumulación del capital por desposesión en los ámbitos rural y urbano al igual que en los procesos de producción y de consumo. This article contributes to developing and consolidating research on the connections between food and gentrification while highlighting the effects of these processes in areas beyond urban life. To achieve this, we draw on the concept of value chains connecting gentrified neighborhoods to rural agricultural communities. In this chain, processes of valorization and devaluation are generated, which unevenly affect the actors involved in the production and consumption of food. The paper focuses on the conflicts and contestations along the value chain of gentrification, putting interdisciplinary contributions into dialogue while presenting four cases from secondary sources. These cases are illustrative of how these processes operate at different levels, territories, and scales: signature coffee, as a symbol of distinction in gentrified neighborhoods; the avocado from its gastronomic manifestation as avocado toast; wine, from the touristification of its production to valorization strategies in urban consumption; and quinoa, from the patenting of new varieties to the development of markets that exclude large sectors of the population. The boom in the circulation of these foods has the effect of capital accumulation by dispossession in both rural and urban areas and in both production and consumption processes

Muscle thickness and echogenicity measured by ultrasound could detect local sarcopenia and malnutrition in older patients hospitalized for hip fracture

Background: The aim of this work was to assess whether the muscle thickness and echogenicity were associated with dysphagia, malnutrition, sarcopenia, and functional capacity in acute hospital admission for a hip fracture. Methods: Observational study that assessed nutritional status by Global Leadership Initiative on Malnutrition, risk of dysphagia and sarcopenia by European Working Group on Sarcopenia in Older People and Barthel functional index. We measured muscle thickness and echogenicity of masseter, bicipital, and quadriceps rectus femoris (RF) and vastus intermedius (VI) by ultrasound. Results: One hundred and one patients were included in the study (29.7% sarcopenia and 43.8% malnutrition). Logistic regression models adjusted for age, sex, and body mass index showed an inverse association of the masseter thickness with both sarcopenia (OR: 0.56) and malnutrition (OR: 0.38) and quadriceps with sarcopenia (OR: 0.74). In addition, patients at high risk of dysphagia had lower masseter thickness (p: 0.0001) while patients able to self-feeding had thicker biceps (p: 0.002) and individuals with mobility on level surfaces higher thickness of biceps (p: 0.008) and quadriceps (p: 0.04). Conclusion: Thickness of the masseter was associated with risk of dysphagia, biceps with the ability to self-feed, and that of the quadriceps RF-VI with mobility

Potential Use of Near-Infrared Spectroscopy to Predict Fatty Acid Profile of Meat from Different European Autochthonous Pig Breeds

Autochthonous pig breeds provide products of differentiated quality, among which quality control is difficult to perform and insufficient for current market requirements. The present research evaluates the predictive ability of near‐infrared (NIR) spectroscopy, combined with chemometric methods as a rapid and affordable tool to assure traceability and quality control. Thus, NIR technology was assessed for intact and minced muscle Longissimus thoracis et lumborum samples collected from 12 European autochthonous pig breeds for the quantification of lipid content and fatty acid composition. Different tests were performed using different numbers of samples for calibration and validation. The best predictive ability was found using minced presentation and set with 80% of the samples for the calibration and the remaining 20% for the external validation test for the following traits: lipid content and saturated and polyunsaturated fatty acids, which attained both the highest determination coefficients (0.89, 0.61, and 0.65, respectively) and the lowest root mean square errors in external validation (0.62, 1.82, and 1.36, respectively). Lower predictive ability was observed for intact muscles. These results could contribute to improve the management of autochthonous breeds and to ensure quality of their products by traditional meat industry chains