588 research outputs found
The dS/CFT Correspondence and the Big Smash
Recent observations suggest that the cosmological equation-of-state parameter
w is close to -1. To say this is to imply that w could be slightly less than
-1, which leads to R.Caldwell's "Phantom cosmologies". These often have the
property that they end in a "Big Smash", a final singularity in which the
Universe is destroyed in a finite proper time by excessive *expansion*. We show
that, classically, this fate is not inevitable: there exist Smash-free Phantom
cosmologies, obtained by a suitable perturbation of the deSitter equation of
state, in which the spacetime is in fact asymptotically deSitter. [Contrary to
popular belief, such cosmologies, which violate the Dominant Energy Condition,
do not necessarily violate causality.] We also argue, however, that the
physical interpretation of these classically acceptable spacetimes is radically
altered by ``holography'', as manifested in the dS/CFT correspondence. It is
shown that, if the boundary CFTs have conventional properties, then recent
ideas on "time as an inverse renormalization group flow" can be used to rule
out these cosmologies. Very recently, however, it has been argued that the CFTs
in dS/CFT are of a radically unconventional form, and this opens up the
possibility that Smash-free Phantom spacetimes offer a simple model of a
"bouncing" cosmology in which the quantum-mechanical entanglement of the field
theories in the infinite past and future plays an essential role.Comment: 22 pages, clarification of triple analytic continuation, additional
Comments added in the light of hep-th/020724
Exploratory fMRI analysis without spatial normalization
Author Manuscript received 2010 March 11. 21st International Conference, IPMI 2009, Williamsburg, VA, USA, July 5-10, 2009. ProceedingsWe present an exploratory method for simultaneous parcellation of multisubject fMRI data into functionally coherent areas. The method is based on a solely functional representation of the fMRI data and a hierarchical probabilistic model that accounts for both inter-subject and intra-subject forms of variability in fMRI response. We employ a Variational Bayes approximation to fit the model to the data. The resulting algorithm finds a functional parcellation of the individual brains along with a set of population-level clusters, establishing correspondence between these two levels. The model eliminates the need for spatial normalization while still enabling us to fuse data from several subjects. We demonstrate the application of our method on a visual fMRI study.McGovern Institute for Brain Research at MIT. Neurotechnology ProgramNational Science Foundation (U.S.) (CAREER Grant 0642971)National Institutes of Health (U.S.) (NIBIB NAMIC U54-EB005149)National Institutes of Health (U.S.) (NCRR NAC P41-RR13218
The Covariant Entropy Bound, Brane Cosmology, and the Null Energy Condition
In discussions of Bousso's Covariant Entropy Bound, the Null Energy Condition
is always assumed, as a sufficient {\em but not necessary} condition which
helps to ensure that the entropy on any lightsheet shall necessarily be finite.
The spectacular failure of the Strong Energy Condition in cosmology has,
however, led many astrophysicists and cosmologists to consider models of dark
energy which violate {\em all} of the energy conditions, and indeed the current
data do not completely rule out such models. The NEC also has a questionable
status in brane cosmology: it is probably necessary to violate the NEC in the
bulk in order to obtain a "self-tuning" theory of the cosmological constant. In
order to investigate these proposals, we modify the Karch-Randall model by
introducing NEC-violating matter into in such a way that the brane
cosmological constant relaxes to zero. The entropy on lightsheets remains
finite. However, we still find that the spacetime is fundamentally incompatible
with the Covariant Entropy Bound machinery, in the sense that it fails the
Bousso-Randall consistency condition. We argue that holography probably forbids
all {\em cosmological} violations of the NEC, and that holography is in fact
the fundamental physical principle underlying the cosmological version of the
NEC.Comment: 21 pages, 3 figures, version 2:corrected and greatly improved
discussion of the Bousso-Randall consistency check, references added;
version3: more references added, JHEP versio
De Sitter and Schwarzschild-De Sitter According to Schwarzschild and De Sitter
When de Sitter first introduced his celebrated spacetime, he claimed,
following Schwarzschild, that its spatial sections have the topology of the
real projective space RP^3 (that is, the topology of the group manifold SO(3))
rather than, as is almost universally assumed today, that of the sphere S^3.
(In modern language, Schwarzschild was disturbed by the non-local correlations
enforced by S^3 geometry.) Thus, what we today call "de Sitter space" would not
have been accepted as such by de Sitter. There is no real basis within
classical cosmology for preferring S^3 to RP^3, but the general feeling appears
to be that the distinction is in any case of little importance. We wish to
argue that, in the light of current concerns about the nature of de Sitter
space, this is a mistake. In particular, we argue that the difference between
"dS(S^3)" and "dS(RP^3)" may be very important in attacking the problem of
understanding horizon entropies. In the approach to de Sitter entropy via
Schwarzschild-de Sitter spacetime, we find that the apparently trivial
difference between RP^3 and S^3 actually leads to very different perspectives
on this major question of quantum cosmology.Comment: 26 pages, 8 figures, typos fixed, references added, equation numbers
finally fixed, JHEP versio
Answering a Basic Objection to Bang/Crunch Holography
The current cosmic acceleration does not imply that our Universe is basically
de Sitter-like: in the first part of this work we argue that, by introducing
matter into *anti-de Sitter* spacetime in a natural way, one may be able to
account for the acceleration just as well. However, this leads to a Big Crunch,
and the Euclidean versions of Bang/Crunch cosmologies have [apparently]
disconnected conformal boundaries. As Maldacena and Maoz have recently
stressed, this seems to contradict the holographic principle. In the second
part we argue that this "double boundary problem" is a matter not of geometry
but rather of how one chooses a conformal compactification: if one chooses to
compactify in an unorthodox way, then the appearance of disconnectedness can be
regarded as a *coordinate effect*. With the kind of matter we have introduced
here, namely a Euclidean axion, the underlying compact Euclidean manifold has
an unexpectedly non-trivial topology: it is in fact one of the 75 possible
underlying manifolds of flat compact four-dimensional Euclidean spaces.Comment: 29 pages, 3 figures, added references and comparison with "cyclic"
cosmology, JHEP versio
The interrelation between temperature regimes and fish size in juvenile Atlantic cod (Gadus morhua): effects on growth and feed conversion efficiency
The present paper describes the growth properties of juvenile Atlantic cod (Gadus morhua) reared at 7, 10, 13 and 16 °C, and a group reared under âtemperature stepsâ i.e. with temperature reduced successively from 16 to 13 and 10 °C. Growth rate and feed conversion efficiency of juvenile Atlantic cod were significantly influenced by the interaction of temperature and fish size. Overall growth was highest in the 13 °C and the T-step groups but for different reasons, as the fish at 13 °C had 10% higher overall feeding intake compared to the T-step group, whereas the T-step had 8% higher feeding efficiency. After termination of the laboratory study the fish were reared in sea pens at ambient conditions for 17 months. The groups performed differently when reared at ambient conditions in the sea as the T-step group was 11.6, 11.5, 5.3 and 7.5% larger than 7, 10, 13 and 16 °C, respectively in June 2005. Optimal temperature for growth and feed conversion efficiency decreased with size, indicating an ontogenetic reduction in optimum temperature for growth with increasing size. The results suggest an optimum temperature for growth of juvenile Atlantic cod in the size range 5â50 g dropping from 14.7 °C for 5â10 g juvenile to 12.4 °C for 40â50 g juvenile. Moreover, a broader parabolic regression curve between growth, feed conversion efficiency and temperature as size increases, indicate increased temperature tolerance with size. The study confirms that juvenile cod exhibits ontogenetic variation in temperature optimum, which might partly explain different spatial distribution of juvenile and adult cod in ocean waters. Our study also indicates a physiological mechanism that might be linked to cod migrations as cod may maximize their feeding efficiency by active thermoregulation
A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules
Plants are an excellent source of drug leads. However availability is limited by access to source species, low abundance and recalcitrance to chemical synthesis. Although plant genomics is yielding a wealth of genes for natural product biosynthesis, the translation of this genetic information into small molecules for evaluation as drug leads represents a major bottleneck. For example, the yeast platform for artemisinic acid production is estimated to have taken >150 person years to develop. Here we demonstrate the power of plant transient transfection technology for rapid, scalable biosynthesis and isolation of triterpenes, one of the largest and most structurally diverse families of plant natural products. Using pathway engineering and improved agro-infiltration methodology we are able to generate gram-scale quantities of purified triterpene in just a few weeks. In contrast to heterologous expression in microbes, this system does not depend on re-engineering of the host. We next exploit agro-infection for quick and easy combinatorial biosynthesis without the need for generation of multi-gene constructs, so affording an easy entrée to suites of molecules, some new-to-nature, that are recalcitrant to chemical synthesis. We use this platform to purify a suite of bespoke triterpene analogs and demonstrate differences in anti-proliferative and anti-inflammatory activity in bioassays, providing proof of concept of this system for accessing and evaluating medicinally important bioactives. Together with new genome mining algorithms for plant pathway discovery and advances in plant synthetic biology, this advance provides new routes to synthesize and access previously inaccessible natural products and analogs and has the potential to reinvigorate drug discovery pipelines
Intercalibration of the barrel electromagnetic calorimeter of the CMS experiment at start-up
Calibration of the relative response of the individual channels of the barrel electromagnetic calorimeter of the CMS detector was accomplished, before installation, with cosmic ray muons and test beams. One fourth of the calorimeter was exposed to a beam of high energy electrons and the relative calibration of the channels, the intercalibration, was found to be reproducible to a precision of about 0.3%. Additionally, data were collected with cosmic rays for the entire ECAL barrel during the commissioning phase. By comparing the intercalibration constants obtained with the electron beam data with those from the cosmic ray data, it is demonstrated that the latter provide an intercalibration precision of 1.5% over most of the barrel ECAL. The best intercalibration precision is expected to come from the analysis of events collected in situ during the LHC operation. Using data collected with both electrons and pion beams, several aspects of the intercalibration procedures based on electrons or neutral pions were investigated
Measurement of the branching fraction
The branching fraction is measured in a data sample
corresponding to 0.41 of integrated luminosity collected with the LHCb
detector at the LHC. This channel is sensitive to the penguin contributions
affecting the sin2 measurement from The
time-integrated branching fraction is measured to be . This is the most precise measurement to
date
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