Large Kinetic Power in FRII Radio Jets

We investigate the total kinetic powers (L_{j}) and ages (t_{age}) of powerful jets of four FR II radio sources (Cygnus A, 3C 223, 3C 284, and 3C 219) by the detail comparison of the dynamical model of expanding cocoons with observed ones. It is found that these sources have quite large kinetic powers with the ratio of L_{j} to the Eddington luminosity (L_{Edd}) resides in $0.02 <L_{j}/L_{Edd} <10$. Reflecting the large kinetic powers, we also find that the total energy stored in the cocoon (E_{c}) exceed the energy derived from the minimum energy condition (E_{min}): $2< E_{c}/E_{min} <160$. This implies that a large amount of kinetic power is carried by invisible components such as thermal leptons (electron and positron) and/or protons.Comment: 5 pages, accepted for publication in Astrophysics and Space Scienc

A Search for Rapid Photometric Variability in Symbiotic Binaries

We report on our survey for rapid (time scale of minutes) photometric variability in symbiotic binaries. These binaries are becoming an increasingly important place to study accretion onto white dwarfs since they are candidate Type Ia supernovae progenitors. Unlike in most cataclysmic variables, the white dwarfs in symbiotics typically accrete from a wind, at rates greater than or equal to 10^{-9} solar masses per year. In order to elucidate the differences between symbiotics and other white dwarf accretors, as well as search for magnetism in symbiotic white dwarfs, we have studied 35 primarily northern symbiotic binaries via differential optical photometry. Our study is the most comprehensive to date of rapid variability in symbiotic binaries. We have found one magnetic accretor, Z And, previously reported by Sokoloski & Bildsten (1999). In four systems (EG And, BX Mon, CM Aql, and BF Cyg), some evidence for flickering at a low level (roughly 10 mmag) is seen for the first time. These detections are, however, marginal. For 25 systems, we place tight upper limits (order of mmag) on both aperiodic and periodic variability, highlighting a major difference between symbiotics and cataclysmic variables. The remaining five of the objects included in our sample (the 2 recurrent novae RS Oph and T CrB, plus CH Cyg, o Ceti, and MWC 560) had previous detections of large-amplitude optical flickering, and we present our extensive observations of these systems in a separate paper. We discuss the impact of our results on the ``standard'' picture of wind-fed accretion, and speculate on the possibility that in most symbiotics, light from quasi-steady nuclear burning on the surface of the white dwarf hides the fluctuating emission from accretion.Comment: 24 pages, 17 figures. Submitted to MNRAS (12/21/00), and revised in response to referee comments (3/30/01

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In the last decades, much progress has been achieved in understanding the effects of the drugs of abuse in the brain. However, efficient treatments that prevent relapse have not been developed. Drug addiction is now considered a brain disease, because the abuse of drugs affects several brain functions. Neurological impairments observed in drug addicts may reflect drug-induced neuronal dysfunction and neurotoxicity. The drugs of abuse directly or indirectly affect neurotransmitter systems, particularly dopaminergic and glutamatergic neurons. This review explores the literature reporting cellular and molecular alterations reflecting the cytotoxicity induced by amphetamines, cocaine and opiates in neuronal systems. The neurotoxic effects of drugs of abuse are often associated with oxidative stress, mitochondrial dysfunction, apoptosis and inhibition of neurogenesis, among other mechanisms. Understanding the mechanisms that underlie brain dysfunction observed in drug-addicted individuals may contribute to improve the treatment of drug addiction, which may have social and economic consequences.http://www.sciencedirect.com/science/article/B6SYS-4S50K2J-1/1/7d11c902193bfa3f1f57030572f7034