149 research outputs found
Test of hadronic interaction models with the KASCADE-Grande muon data
KASCADE-Grande is an air-shower observatory devoted for the detection of cosmic rays with energies in the interval of 1014 â 1018 eV, where the Grande array is responsible for the higher energy range. The experiment comprises different detection systems which allow precise measurements of the charged, electron and muon numbers of extensive air-showers (EAS). These data is employed not only to reconstruct the properties of the primary cosmic-ray particle but also to test hadronic interaction models at high energies. In this contribution, predictions of the muon content of EAS from QGSJET II-2, SIBYLL 2.1 and EPOS 1.99 are confronted with the experimental measurements performed with the KASCADE-Grande experiment in order to test the validity of these hadronic models commonly used in EAS simulations
Measuring Parton Densities in the Pomeron
We present a program to measure the parton densities in the pomeron using
diffractive deep inelastic scattering and diffractive photoproduction, and to
test the resulting parton densities by applying them to other processes such as
the diffractive production of jets in hadron-hadron collisions. Since QCD
factorization has been predicted NOT to apply to hard diffractive scattering,
this program of fitting and using parton densities might be expected to fail.
Its success or failure will provide useful information on the space-time
structure of the pomeron.Comment: Contains revisions based on Phys. Rev. D referee comments. RevTeX
version 3, epsf, 31 pages. Uuencoded compressed postscript figures appended.
Uncompressed postscript files available at
ftp://ftp.phys.psu.edu/pub/preprint/psuth136
2008-2009 President\u27s Report
The Linfield College President\u27s Annual Report is a collection of information about the year in review, including academics, student life and athletics, enrollment, finances, philanthropy, and leadership
On noise treatment in radio measurements of cosmic ray air showers
Precise measurements of the radio emission by cosmic ray air showers require
an adequate treatment of noise. Unlike to usual experiments in particle
physics, where noise always adds to the signal, radio noise can in principle
decrease or increase the signal if it interferes by chance destructively or
constructively. Consequently, noise cannot simply be subtracted from the
signal, and its influence on amplitude and time measurement of radio pulses
must be studied with care. First, noise has to be determined consistently with
the definition of the radio signal which typically is the maximum field
strength of the radio pulse. Second, the average impact of noise on radio pulse
measurements at individual antennas is studied for LOPES. It is shown that a
correct treatment of noise is especially important at low signal-to-noise
ratios: noise can be the dominant source of uncertainty for pulse height and
time measurements, and it can systematically flatten the slope of lateral
distributions. The presented method can also be transfered to other experiments
in radio and acoustic detection of cosmic rays and neutrinos.Comment: 4 pages, 6 figures, submitted to NIM A, Proceedings of ARENA 2010,
Nantes, Franc
The LOPES experiment - recent results, status and perspectives
The LOPES experiment at the Karlsruhe Institute of Technology has been taking
radio data in the frequency range from 40 to 80 MHz in coincidence with the
KASCADE-Grande air shower detector since 2003. Various experimental
configurations have been employed to study aspects such as the energy scaling,
geomagnetic dependence, lateral distribution, and polarization of the radio
emission from cosmic rays. The high quality per-event air shower information
provided by KASCADE-Grande has been the key to many of these studies and has
even allowed us to perform detailed per-event comparisons with simulations of
the radio emission. In this article, we give an overview of results obtained by
LOPES, and present the status and perspectives of the ever-evolving experiment.Comment: Proceedings of the ARENA2010 conference, Nantes, Franc
Investigation of the Properties of Galactic Cosmic Rays with the KASCADE-Grande Experiment
The properties of galactic cosmic rays are investigated with the
KASCADE-Grande experiment in the energy range between and
eV. Recent results are discussed. They concern mainly the all-particle energy
spectrum and the elemental composition of cosmic rays.Comment: Proc. RICAP 09, Nucl. Instr. and Meth. in pres
The spectrum of high-energy cosmic rays measured with KASCADE-Grande
The energy spectrum of cosmic rays between 10**16 eV and 10**18 eV, derived
from measurements of the shower size (total number of charged particles) and
the total muon number of extensive air showers by the KASCADE-Grande
experiment, is described. The resulting all-particle energy spectrum exhibits
strong hints for a hardening of the spectrum at approximately 2x10**16 eV and a
significant steepening at c. 8x10**16 eV. These observations challenge the view
that the spectrum is a single power law between knee and ankle. Possible
scenarios generating such features are discussed in terms of astrophysical
processes that may explain the transition region from galactic to extragalactic
origin of cosmic rays.Comment: accepted by Astroparticle Physics June 201
Air Shower Measurements with the LOPES Radio Antenna Array
LOPES is set up at the location of the KASCADE-Grande extensive air shower
experiment in Karlsruhe, Germany and aims to measure and investigate radio
pulses from Extensive Air Showers. Since radio waves suffer very little
attenuation, radio measurements allow the detection of very distant or highly
inclined showers. These waves can be recorded day and night, and provide a
bolometric measure of the leptonic shower component. LOPES is designed as a
digital radio interferometer using high bandwidths and fast data processing and
profits from the reconstructed air shower observables of KASCADE-Grande. The
LOPES antennas are absolutely amplitude calibrated allowing to reconstruct the
electric field strength which can be compared with predictions from detailed
Monte Carlo simulations. We report about the analysis of correlations present
in the radio signals measured by the LOPES 30 antenna array. Additionally,
LOPES operates antennas of a different type (LOPES-STAR) which are optimized
for an application at the Pierre Auger Observatory. Status, recent results of
the data analysis and further perspectives of LOPES and the possible large
scale application of this new detection technique are discussed.Comment: 8 pages, 10 figures, Contribution to the Arena 2008 conference, Rome,
June 200
Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence
<p>Abstract</p> <p>Background</p> <p>Chemotherapeutic drugs like Adriamycin (ADR) induces apoptosis or senescence in cancer cells but these cells often develop resistance and generate responses of short duration or complete failure. The methylxantine drug Pentoxifylline (PTX) used routinely in the clinics setting for circulatory diseases has been recently described to have antitumor properties. We evaluated whether pretreatment with PTX modifies apoptosis and senescence induced by ADR in cervix cancer cells.</p> <p>Methods</p> <p>HeLa (HPV 18+), SiHa (HPV 16+) cervix cancer cells and non-tumorigenic immortalized HaCaT cells (control) were treated with PTX, ADR or PTX + ADR. The cellular toxicity of PTX and survival fraction were determinated by WST-1 and clonogenic assay respectively. Apoptosis, caspase activation and ADR efflux rate were measured by flow cytometry, senescence by microscopy. IÎșBα and DNA fragmentation were determinated by ELISA. Proapoptotic, antiapoptotic and senescence genes, as well as HPV-E6/E7 mRNA expression, were detected by time real RT-PCR. p53 protein levels were assayed by Western blot.</p> <p>Results</p> <p>PTX is toxic (WST-1), affects survival (clonogenic assay) and induces apoptosis in cervix cancer cells. Additionally, the combination of this drug with ADR diminished the survival fraction and significantly increased apoptosis of HeLa and SiHa cervix cancer cells. Treatments were less effective in HaCaT cells. We found caspase participation in the induction of apoptosis by PTX, ADR or its combination. Surprisingly, in spite of the antitumor activity displayed by PTX, our results indicate that methylxantine, <it>per se </it>does not induce senescence; however it inhibits senescence induced by ADR and at the same time increases apoptosis. PTX elevates IÎșBα levels. Such sensitization is achieved through the up-regulation of proapoptotic factors such as <it>caspase </it>and <it>bcl </it>family gene expression. PTX and PTX + ADR also decrease E6 and E7 expression in SiHa cells, but not in HeLa cells. p53 was detected only in SiHa cells treated with ADR.</p> <p>Conclusion</p> <p>PTX is a good inducer of apoptosis but does not induce senescence. Furthermore, PTX reduced the ADR-induced senescence and increased apoptosis in cervix cancer cells.</p
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