Evaluation of the potential of retrofitting a coal power plant to oxy-firing using CFD and process co-simulation

A new approach has been developed in order to estimate the potential of retrofitting an existing power plant to oxy-firing and the safe operation regime of the retrofitted boiler under oxy-combustion condition has been determined. Computational Fluid Dynamics (CFD) techniques have been employed to simulate the coal combustion and heat transfer to the furnace water walls and heat exchangers under air-firing and oxy-firing conditions. A set of reduced order models (ROM) has been developed to link the CFD predictions to the whole plant process model in order to simulate the performance of the power plant under different load and oxygen enrichment conditions in an efficient manner. Simulation results of a 500° MWe power plant unit indicate that it is possible to retrofit it to oxy-firing without affecting its overall performance. Further, the feasible range of oxygen enrichment for different power loads is identified to be between 25% and 27%. However, the peak temperature on the superheater platen 2 may increase in the oxy-coal mode at a high power load beyond 450° MWe

Weighing the Quiescent Central Black Hole in an Elliptical Galaxy with X-ray Emitting Gas

We present a Chandra study of the hot ISM in the giant elliptical galaxy NGC4649. In common with other group-centred ellipticals, its temperature profile rises with radius in the outer parts of the galaxy, from ~0.7keV at 2kpc to ~0.9keV by 20kpc. However, within the central ~2kpc the trend reverses and the temperature peaks at ~1.1keV within the innermost 200pc. Under the assumption of hydrostatic equilibrium, we demonstrate that the central temperature spike arises due to the gravitational influence of a quiescent central super-massive black hole. We constrain the black hole mass (MBH) to $(3.35^{+0.67}_{-0.95})\times 10^9$Msun (90% confidence), in good agreement with stellar kinematics measurements. This is the first direct measurement of MBH based on studies of hydrostatic X-ray emitting gas, which are sensitive to the most massive black holes, and is a crucial validation of both mass-determination techniques. This agreement clearly demonstrates the gas must be close to hydrostatic, even in the very centre of the galaxy, which is consistent with the lack of morphological disturbances in the X-ray image. NGC4649 is now one of only a handful of galaxies for which MBH has been measured by more than one method. At larger radii, we were able to decompose the gravitating mass profile into stellar and dark matter (DM) components. Unless one accounts for the DM, a standard Virial analysis of the stars dramatically over-estimates the stellar mass of the galaxy. We find the measured J-band stellar mass-to-light ratio, 1.37+/-0.10 Msun/Lsun, is in good agreement with simple stellar population model calculations for this object.Comment: 13 pages, 6 figures, accepted for publication in ApJ. Minor revisions to match published versio

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

SummaryCancer-associated inflammation is thought to be a barrier to immune surveillance, particularly in pancreatic ductal adenocarcinoma (PDA). Gr-1+ CD11b+ cells are a key feature of cancer inflammation in PDA, but remain poorly understood. Using a genetically engineered mouse model of PDA, we show that tumor-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) is necessary and sufficient to drive the development of Gr-1+ CD11b+ cells that suppressed antigen-specific T cells. In vivo, abrogation of tumor-derived GM-CSF inhibited the recruitment of Gr-1+ CD11b+ cells to the tumor microenvironment and blocked tumor development—a finding that was dependent on CD8+ T cells. In humans, PDA tumor cells prominently expressed GM-CSF in vivo. Thus, tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment

Mechanisms of tethering and cargo transfer during epididymosome-sperm interactions

Abstract Background The mammalian epididymis is responsible for the provision of a highly specialized environment in which spermatozoa acquire functional maturity and are subsequently stored in preparation for ejaculation. Making important contributions to both processes are epididymosomes, small extracellular vesicles released from the epididymal soma via an apocrine secretory pathway. While considerable effort has been focused on defining the cargo transferred between epididymosomes and spermatozoa, comparatively less is known about the mechanistic basis of these interactions. To investigate this phenomenon, we have utilized an in vitro co-culture system to track the transfer of biotinylated protein cargo between mouse epididymosomes and recipient spermatozoa isolated from the caput epididymis; an epididymal segment that is of critical importance for promoting sperm maturation. Results Our data indicate that epididymosome-sperm interactions are initiated via tethering of the epididymosome to receptors restricted to the post-acrosomal domain of the sperm head. Thereafter, epididymosomes mediate the transfer of protein cargo to spermatozoa via a process that is dependent on dynamin, a family of mechanoenzymes that direct intercellular vesicle trafficking. Notably, upon co-culture of sperm with epididymosomes, dynamin 1 undergoes a pronounced relocation between the peri- and post-acrosomal domains of the sperm head. This repositioning of dynamin 1 is potentially mediated via its association with membrane rafts and ideally locates the enzyme to facilitate the uptake of epididymosome-borne proteins. Accordingly, disruption of membrane raft integrity or pharmacological inhibition of dynamin both potently suppress the transfer of biotinylated epididymosome proteins to spermatozoa. Conclusion Together, these data provide new mechanistic insight into epididymosome-sperm interactions with potential implications extending to the manipulation of sperm maturation for the purpose of fertility regulation

The Two-dimensional XMM-Newton Group Survey: z<0.012 groups

We present the results of the 2-dimensional XMM-Newton Group Survey (2dXGS), an archival study of nearby galaxy groups. In this paper we consider eleven nearby systems (z<0.012) in Mulchaey et al. (2003), which span a broad range in X-ray luminosity from 10^40 to 10^43 ergs/s. We measure the iron abundance and temperature distribution in these systems and derive pressure and entropy maps. We find statistically significant evidence for structure in the entropy and pressure of the gas component of seven groups on the 10-20% level. The XMM-Newton data for the three groups with best statistics also suggest patchy metalicity distributions within the central 20--50 kpc of the brightest group galaxy, probed with 2-10 kpc resolution. This provides insights into the processes associated with thermalization of the stellar mass loss. Analysis of the global properties of the groups reveals a subclass of X-ray faint groups, which are characterized by both higher entropy and lower pressure. We suggest that the merger history of the central elliptical is responsible for both the source and the observed thermodynamical properties of the hot gas of the X-ray faint groups.Comment: 18 pages, ApJ, 646, 143, 200

A detector module with highly efficient surface-alpha event rejection operated in CRESST-II Phase 2

The cryogenic dark matter experiment CRESST-II aims at the direct detection of WIMPs via elastic scattering off nuclei in scintillating CaWO$_4$ crystals. We present a new, highly improved, detector design installed in the current run of CRESST-II Phase 2 with an efficient active rejection of surface-alpha backgrounds. Using CaWO$_4$ sticks instead of metal clamps to hold the target crystal, a detector housing with fully-scintillating inner surface could be realized. The presented detector (TUM40) provides an excellent threshold of ${\sim}\,0.60\,$keV and a resolution of $\sigma\,{\approx}\,0.090$ keV (at 2.60$\,$keV). With significantly reduced background levels, TUM40 sets stringent limits on the spin-independent WIMP-nucleon scattering cross section and probes a new region of parameter space for WIMP masses below 3$\,$GeV/c$^2$. In this paper, we discuss the novel detector design and the surface-alpha event rejection in detail.Comment: 9 pages, 6 figure

The polymer phase of the TDAE-C60_{60} organic ferromagnet

The high-pressure Electron Spin Resonance (ESR) measurements were preformed on TDAE-C$_{60}$ single crystals and stability of the polymeric phase was established in the $P - T$ parameter space. At 7 kbar the system undergoes a ferromagnetic to paramagnetic phase transition due to the pressure-induced polymerization. The polymeric phase remains stable after the pressure release. The depolymerization of the pressure-induced phase was observed at the temperature of 520 K. Below room temperature, the polymeric phase behaves as a simple Curie-type insulator with one unpaired electron spin per chemical formula. The TDAE$^+$ donor-related unpaired electron spins, formerly ESR-silent, become active above the temperature of 320 K and the Curie-Weiss behavior is re-established.Comment: Submitted to Phys. Rev.

An increase in fat-free mass is associated with higher appetite and energy intake in older adults: a randomised control trial

Cross-sectional studies in younger adults have demonstrated a positive association between energy intake (EI) and fat-free mass (FFM), with this relationship seemingly mediated by resting metabolic rate (RMR). Establishing a causal effect longitudinally would be prudent in older adults suffering from loss of appetite. We investigated the effects of FFM on RMR, appetite and EI in 39 healthy older adults (age: 66 ± 4 years, BMI: 25.1 ± 3.5 kg·m2) assigned to either 12-week resistance training + protein supplementation group (RT + PRO) or control group (CON). Body composition, subjective appetite, leptin, insulin, RMR and laboratory-measured ad libitum EI were measured at baseline, weeks 6 and 12 of the intervention, while daily EI at baseline and week 12. FFM (+1.2 kg; p = 0.002), postprandial subjective appetite (+8 mm; p = 0.027), ad libitum EI (+119 kcal; p = 0.012) and daily EI (+133 kcal; p = 0.010) increased from baseline to week 12 in the RT + PRO. RMR, fasted subjective appetite, leptin and insulin concentrations remained unchanged (all p > 0.05). The increases ad libitum EI correlated with increases in FFM (r = 0.527, p = 0.001), with 54% of the change in EI attributed to FFM changes. In conclusion, FFM increases were associated with an increased ad libitum EI and postprandial appetite in older adults

A Non-Invasive method of quantifying pancreatic volume in mice using micro-MRI

In experimental models of pancreatic growth and recovery, changes in pancreatic size are assessed by euthanizing a large cohort of animals at varying time points and measuring organ mass. However, to ascertain this information in clinical practice, patients with pancreatic disorders routinely undergo non-invasive cross-sectional imaging of the pancreas using magnetic resonance imaging (MRI) or computed tomography (CT). The aim of the current study was to develop a thinsliced, optimized sequence protocol using a high field MRI to accurately calculate pancreatic volumes in the most common experimental animal, the mouse. Using a 7 Telsa Bruker micro-MRI system, we performed abdominal imaging in whole-fixed mice in three standard planes: axial, sagittal, and coronal. The contour of the pancreas was traced using Vitrea software and then transformed into a 3-dimensional (3D) reconstruction, from which volumetric measurements were calculated. Images were optimized using heart perfusion-fixation, T1 sequence analysis, and 0.2 to 0.4 mm thick slices. As proof of principle, increases in pancreatic volume among mice of different ages correlated tightly with increasing body weight. In summary, this is the first study to measure pancreatic volumes in mice, using a high field 7 Tesla micro-MRI and a thin-sliced, optimized sequence protocol. We anticipate that micro-MRI will improve the ability to non-invasively quantify changes in pancreatic size and will dramatically reduce the number of animals required to serially assess pancreatic growth and recovery.© 2014 Paredes et al

Achieving homogeneity in a high-Fe β-Ti alloy laser-printed from blended elemental powders

Blended Elemental powders are an emerging alternative to pre-alloyed powders in metal additive manufacturing due to the wider range of alloys producible with them and the cost savings from not developing novel feedstock. In this study, in situ alloying and concurrent microstructure evolution during SLM are investigated by performing SLM on a BE Ti-185 powder while tracking the surface temperatures via Infra-red imaging and phase transformation via synchrotron X-ray Diffraction. We then performed post-mortem electron microscopy (Backscatter Electron imaging, Energy Dispersive X-ray Spectroscopy and Electron Backscatter Diffraction) to further gain insight into microstructure development. We show that although exothermic mixing aids the melting process, laser melting results only in a mixture of alloyed and unmixed regions. Full alloying and thus a consistent microstructure is only achieved through further thermal cycling in the heat-affected zone