MicroTCA implementation of synchronous Ethernet-Based DAQ systems for large scale experiments

Large LAr TPCs are among the most powerful detectors to address open problems in particle and astro-particle physics, such as CP violation in leptonic sector, neutrino properties and their astrophysical implications, proton decay search etc. The scale of such detector implies severe constraints on their readout and DAQ system. In this article we describe a data acquisition scheme for this new generation of large detectors. The main challenge is to propose a scalable and easy to use solution able to manage a large number of channels at the lowest cost. It is interesting to note that these constraints are very similar to those existing in Network Telecommunication Industry. We propose to study how emerging technologies like ATCA and $\mu$TCA could be used in neutrino experiments. We describe the design of an Advanced Mezzanine Board (AMC) including 32 ADC channels. This board receives 32 analogical channels at the front panel and sends the formatted data through the $\mu$TCA backplane using a Gigabit Ethernet link. The gigabit switch of the MCH is used to centralize and to send the data to the event building computer. The core of this card is a FPGA (ARIA-GX from ALTERA) including the whole system except the memories. A hardware accelerator has been implemented using a NIOS II $\mu$P and a Gigabit MAC IP. Obviously, in order to be able to reconstruct the tracks from the events a time synchronisation system is mandatory. We decided to implement the IEEE1588 standard also called Precision Timing Protocol, another emerging and promising technology in Telecommunication Industry. In this article we describe a Gigabit PTP implementation using the recovered clock of the gigabit link. By doing so the drift is directly cancelled and the PTP will be used only to evaluate and to correct the offset.Comment: Talk presented at the 2009 Real Time Conference, Beijing, May '09, submitted to the proceeding

Design and operation of a field telescope for cosmic ray geophysical tomography

International audienceThe cosmic ray muon tomography gives an access to the density structure of geological targets. In the present article we describe a muon telescope adapted to harsh environmental conditions. In particular the design optimizes the total weight and power consumption to ease the deployment and increase the autonomy of the detector. The muon telescopes consist of at least two scintillator detection matrices readout by photosensors via optical fibres. Two photosensor options have been studied. The baseline option foresees one multianode photomultiplier (MAPM) per matrix. A second option using one multipixel photon counter (MPPC) per bar is under development. The readout electronics and data acquisition system developed for both options are detailed. We present a first data set acquired in open-sky conditions compared with the muon flux detected across geological objects

Introducing genetic testing for cardiovascular disease in primary care: a qualitative study

Background: While primary care systematically offers conventional cardiovascular risk assessment, genetic tests for coronary heart disease (CHD) are increasingly commercially available to patients. It is unclear how individuals may respond to these new sources of risk information. Aim: To explore how patients who have had a recent conventional cardiovascular risk assessment, perceive additional information from genetic testing for CHD. Design and setting: Qualitative interview study in 12 practices in Nottinghamshire from both urban and rural settings. Method: Interviews were conducted with 29 adults, who consented to genetic testing after having had a conventional cardiovascular risk assessment. Results: Individuals’ principal motivation for genetic testing was their family history of CHD and a desire to convey the results to their children. After testing, however, there was limited recall of genetic test results and scepticism about the value of informing their children. Participants dealt with conflicting findings from the genetic test, family history, and conventional assessment by either focusing on genetic risk or environmental lifestyle factors. In some participants, genetic test results appeared to reinforce healthy behaviour but others were falsely reassured, despite having an ‘above-average’ conventional cardiovascular risk score. Conclusion: Although genetic testing was acceptable, participants were unclear how to interpret genetic risk results. To facilitate healthy behaviour, health professionals should explore patients’ understanding of genetic test results in light of their family history and conventional risk assessment

Toxic factors of Vibrio strains pathogenic to shrimp

Vibriosis is a major disease problem in shrimp aquaculture. 'Syndrome 93' is a seasonal juvenile vibriosis caused by Vibrio penaeicida which affects Litopenaeus stylirostris in grow-out ponds in New Caledonia. This study assessed the toxic activities of extracellular products (ECPs) from V: penaeicida, V. alginolyticus and V, nigripulchritudo using in vivo injections in healthy juvenile L. stylirostris (= Penaeus stylirostris) and in vitro assays on shrimp primary cell cultures and the fish cell line epithelioma papulosum cyprini (EPC). Toxic effects of ECPs were demonstrated for all pathogenic Vibrio strains tested both in vivo and in vitro, but for shrimp only; no effect was observed on the fish cell line. ECP toxicity for New Caledonian V. penaeicida was found only after cultivation at low temperature (20 degrees C) and not at higher temperature (30 degrees C). This points to the fact that 'Syndrome 93' episodes are triggered by temperature drops. The assays used here demonstrate the usefulness of primary shrimp cell cultures to study virulence mechanisms of shrimp pathogenic bacteria

A Compact Ring for Thom X-Ray Source

International audienceThe goal of X-ray sources based on Compton back scattering processes is to develop a compact device, which could produce an intense flux of monochromatic X-rays. Compton back-scattering resuls from collisions between laser pulses and relativistic electron bunches. Due to the relative low value of the Compton cross section, a high charge electron beam, a low emittance and a high focusing at the interaction point are required for the electron beam. In addition, the X-ray flux is related to the characteristics of the electron beam, which are themselves dynamically affected by the Compton interaction. One possible configuration is to inject frequently into a storage ring with a low emittance linear accelerator without waiting for the synchrotron equilibrium. As a consequence, the optics should be designed taking into account the characteristics of the electron beam from the linear accelerator. The accelerator ring design for a 50 MeV electron beam, aiming at producing a flux higher than 1013 ph/s, will be presented

Altering micro-environments to change population health behaviour: towards an evidence base for choice architecture interventions.

BACKGROUND: The idea that behaviour can be influenced at population level by altering the environments within which people make choices (choice architecture) has gained traction in policy circles. However, empirical evidence to support this idea is limited, especially its application to changing health behaviour. We propose an evidence-based definition and typology of choice architecture interventions that have been implemented within small-scale micro-environments and evaluated for their effects on four key sets of health behaviours: diet, physical activity, alcohol and tobacco use. DISCUSSION: We argue that the limitations of the evidence base are due not simply to an absence of evidence, but also to a prior lack of definitional and conceptual clarity concerning applications of choice architecture to public health intervention. This has hampered the potential for systematic assessment of existing evidence. By seeking to address this issue, we demonstrate how our definition and typology have enabled systematic identification and preliminary mapping of a large body of available evidence for the effects of choice architecture interventions. We discuss key implications for further primary research, evidence synthesis and conceptual development to support the design and evaluation of such interventions. SUMMARY: This conceptual groundwork provides a foundation for future research to investigate the effectiveness of choice architecture interventions within micro-environments for changing health behaviour. The approach we used may also serve as a template for mapping other under-explored fields of enquiry

Antenatal screening and its possible meaning from unborn baby's perspective

In recent decades antenatal screening has become one of the most routine procedure of pregnancy-follow up and the subject of hot debate in bioethics circles. In this paper the rationale behind doing antenatal screening and the actual and potential problems that it may cause will be discussed. The paper will examine the issue from the point of wiew of parents, health care professionals and, most importantly, the child-to-be. It will show how unthoughtfully antenatal screening is performed and how pregnancy is treated almost as a disease just since the emergence of antenatal screening. Genetic screening and ethical problems caused by the procedure will also be addressed and I will suggest that screening is more to do with the interests of others rather than those of the child-to be

A comprehensive evaluation of colonic mucosal isolates of Sutterella wadsworthensis from inflammatory bowel disease

Peer reviewedPublisher PD

The LAGUNA design study- towards giant liquid based underground detectors for neutrino physics and astrophysics and proton decay searches

The feasibility of a next generation neutrino observatory in Europe is being considered within the LAGUNA design study. To accommodate giant neutrino detectors and shield them from cosmic rays, a new very large underground infrastructure is required. Seven potential candidate sites in different parts of Europe and at several distances from CERN are being studied: Boulby (UK), Canfranc (Spain), Fr\'ejus (France/Italy), Pyh\"asalmi (Finland), Polkowice-Sieroszowice (Poland), Slanic (Romania) and Umbria (Italy). The design study aims at the comprehensive and coordinated technical assessment of each site, at a coherent cost estimation, and at a prioritization of the sites within the summer 2010.Comment: 5 pages, contribution to the Workshop "European Strategy for Future Neutrino Physics", CERN, Oct. 200