Broadening Girls' Horizons: Effects of Life Skills Education Programme in Rural Uttar Pradesh

This report is the result of a collaborative project undertaken by Prerana and the Population Council to implement a life skills education programme for unmarried adolescent girls in rural Uttar Pradesh and to evaluate its effectiveness. The intervention programme aimed to empower unmarried adolescent girls aged 13-17 years and address their vulnerabilities by building their agency; fostering egalitarian gender role attitudes; building awareness about sexual and reproductive health matters; developing vocational skills and future work aspirations; and influencing perceptions about marriage and their ability to negotiate marriage-related decisions, delaying marriage and first pregnancy

Articulation Testing in Hindi Speech

The profession or speech-language pathology deals with one of the most basic functions or humanity--communication. Speech-language pathologists are trained to provide remedial services to children and adults with communication disorders in a wide variety of work settings. Communication disorders can be broadly divided into five categories: voice disorders, fluency disorders, dysphagia, language disorders, and articulation disorders. Before a speech-language pathologist begins speech therapy. it is necessary to perform an evaluation. Evaluation refers to the processes used to determine a diagnosis. There arc two main reasons [or performing evaluation tasks. First. we need to evaluate to arrive at a good understanding of a client\u27s problem. The other reason to perform evaluation tests is to be able to monitor the client\u27s progress in treatment and describe changes in the communication disturbances. Speech-language pathologists use standardized tests to determine the presence or absence of communication disorders. Most test currently used in speech-language pathology arc based on Standard English. The area that I have addressed is Articulation. Articulation disorders occur when a person produces sounds, syllables, or words in a way that listeners do not always understand what is being said or may be distracted by the manner in which it is said. Such disorders arc most often seen in pre-school or school-age children who do not develop certain sounds at the usual age. Speech-language pathologists work with clients having articulation disorders and help them to learn proper production of speech sounds. Indian schools teach 58 different languages. Hindi is the official language spoken by the majority of the people in India and only about 5 to 10% of the lndian population speaks English. When I return home. I will be working with predominantly Hindi speaking clients. The field of speech pathology in India is very new. I will have to use the knowledge I have received in English, and adapt it to the Hindi language. There are no tests that I can use while performing an evaluation in Hindi. Translating tests that are used to evaluate language, voice or fluency disorders, does not pose too much of a problem apart from adapting them to the cultural situation, since the basic concepts are the same. But, it is impossible to take an English articulation test and translate it into Hindi, expecting it to function in the same way, which is to detect articulation errors

Broadening girls\u27 horizons: Effects of life skills education programme in rural Uttar Pradesh

This report is the result of a collaborative project undertaken by Prerana, a Delhi-based NGO, and the Population Council to implement a life-skills education program for unmarried adolescent girls in rural Uttar Pradesh and to evaluate its effectiveness. The intervention program aimed to empower unmarried adolescent girls aged 13–17 years and address their vulnerabilities by: building their agency, fostering egalitarian gender role attitudes, building awareness about sexual and reproductive health matters, developing vocational skills and future work aspirations, and influencing perceptions about marriage and the ability to negotiate marriage-related decisions (delaying marriage and first pregnancy)

Algunas cuestiones pendientes : evaluación de la investigación cualitativa en convocatorias competitivas. "No midas mi peso con una jarra"

La investigación cualitativa es un paradigma de la investigación científica en ciencias sociales de amplia aplicación en las ciencias de la salud. Ofrece herramientas rigurosas que permiten explicar los problemas de salud desde la perspectiva de los actores involucrados (pacientes, cuidadores y profesionales). Está ampliamente aceptada en el mundo científico sanitario internacional como válida y necesaria. Sin embargo, es necesario que los proyectos de índole cualitativa se realicen de forma creíble para lo cual se requiere de diseños rigurosos. Muchos investigadores han trabajado sobre los criterios de rigor y algunos de ellos ofrecen estrategias que potencian la realización de estudios de mejor calidad. Es necesario conocer dichos criterios para su aplicación en la evaluación de proyectos presentados en las convocatorias competitivas tanto nacionales como regionales. En este articulo se presentan las consideraciones metodológicas y conceptuales del paradigma cualitativo y las necesidades especiales que presentan los diseños cualitativos para que no se cometa la equivocación de terminar midiendo "el peso en litros y con una jarra"

A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells

<p>Abstract</p> <p>Background</p> <p>The rapid onset of potentially lethal neuroinflammation is a defining feature of viral encephalitis. Microglia and astrocytes are likely to play a significant role in viral encephalitis pathophysiology as they are ideally positioned to respond to invading central nervous system (CNS) pathogens by producing key inflammatory mediators. Recently, DNA-dependent activator of IFN regulatory factor (DAI) has been reported to function as an intracellular sensor for DNA viruses. To date, the expression and functional role of DAI in the inflammatory responses of resident CNS cells to neurotropic DNA viruses has not been reported.</p> <p>Methods</p> <p>Expression of DAI and its downstream effector molecules was determined in C57BL/6-derived microglia and astrocytes, either at rest or following exposure to herpes simplex virus type 1 (HSV-1) and/or murine gammaherpesvirus-68 (MHV-68), by immunoblot analysis. In addition, such expression was studied in ex vivo microglia/macrophages and astrocytes from uninfected animals or mice infected with HSV-1. Inflammatory cytokine production by glial cultures following transfection with a DAI specific ligand (B-DNA), or following HSV-1 challenge in the absence or presence of siRNA directed against DAI, was assessed by specific capture ELISA. The production of soluble neurotoxic mediators by HSV-1 infected glia following DAI knockdown was assessed by analysis of the susceptibility of neuron-like cells to conditioned glial media.</p> <p>Results</p> <p>We show that isolated microglia and astrocytes constitutively express DAI and its effector molecules, and show that such expression is upregulated following DNA virus challenge. We demonstrate that these resident CNS cells express DAI <it>in situ</it>, and show that its expression is similarly elevated in a murine model of HSV-1 encephalitis. Importantly, we show B-DNA transfection can elicit inflammatory cytokine production by isolated glial cells and DAI knockdown can significantly reduce microglial and astrocyte responses to HSV-1. Finally, we demonstrate that HSV-1 challenged microglia and astrocytes release neurotoxic mediators and show that such production is significantly attenuated following DAI knockdown.</p> <p>Conclusions</p> <p>The functional expression of DAI by microglia and astrocytes may represent an important innate immune mechanism underlying the rapid and potentially lethal inflammation associated with neurotropic DNA virus infection.</p

Interventions for treating cholestasis in pregnancy (Review)

BACKGROUND: Obstetric cholestasis has been linked to adverse maternal and fetal/neonatal outcomes. As the pathophysiology is poorly understood, therapies have been empiric. The first version of this review, published in 2001, and including nine randomised controlled trials involving 227 women, concluded that there was insufficient evidence to recommend any of the interventions alone or in combination. This is the first update. OBJECTIVES: To evaluate the effectiveness and safety of therapeutic and delivery interventions in women with cholestasis of pregnancy. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (20 February 2013) and reference lists of identified studies. SELECTION CRITERIA: Randomised controlled trials that compared two intervention strategies for women with a clinical diagnosis of obstetric cholestasis. DATA COLLECTION AND ANALYSIS: The review authors independently assessed trials for eligibility and risk of bias. We independently extracted data and checked these for accuracy. MAIN RESULTS: We included 21 trials with a total of 1197 women. They were mostly at moderate to high risk of bias. They assessed 11 different interventions resulting in 15 different comparisons.Compared with placebo, ursodeoxycholic acid (UDCA) showed improvement in pruritus in five (228 women) out of seven trials. There were no significant differences in instances of fetal distress in the UDCA groups compared with placebo (average risk ratio (RR) 0.67; 95% confidence interval (CI) 0.22 to 2.02; five trials, 304 women; random-effects analysis: T² = 0.74; I² = 48%). There were significantly fewer total preterm births with UDCA (RR 0.46; 95% CI 0.28 to 0.73; two trials, 179 women). The difference for spontaneous preterm births was not significant (RR 0.99; 95% CI 0.41 to 2.36, two trials, 109 women).Two trials (48 women) reported lower (better) pruritus scores for S-adenosylmethionine (SAMe) compared with placebo, while two other trials of 34 women reported no significant differences between groups.UDCA was more effective in improving pruritus than either SAMe (four trials; 133 women) or cholestyramine (one trial; 84 women), as was combined UDCA+SAMe when compared with placebo (one trial; 16 women) and SAMe alone (two trials; 68 women). However, combined UDCA+SAMe was no more effective than UDCA alone in regard to pruritus improvement (one trial; 53 women) and two trials (80 women) reported data were insufficient to draw any conclusions from. In one trial comparing UDCA and dexamethasone (83 women), a significant improvement with UDCA was seen only in a subgroup of women with severe obstetric cholestasis (23 women).Danxiaoling significantly improved pruritus in comparison to Yiganling. No significant differences were seen in pruritus improvement with other interventions.Eight trials reported fetal or neonatal deaths, with two deaths reported overall (both in the placebo groups).Women receiving UDCA and cholestyramine experienced nausea, vomiting and diarrhoea. Guar gum caused mild abdominal distress, diarrhoea and flatulence during the first days of treatment. Women found charcoal suspension unpleasant to swallow. Dexamethasone caused nausea, dizziness and stomach pain in one woman.One trial (62 women) looked at the timing of delivery intervention. There were no stillbirths or neonatal deaths in 'early delivery' or the 'await spontaneous labour' group. There were no significant differences in the rates of caesarean section, meconium passage or admission to neonatal intensive care unit between the two groups. AUTHORS' CONCLUSIONS: Different approaches to assessing and reporting pruritus precluded pooling of trials comparing the effects of UDCA versus placebo on pruritus, but examination of individual trials suggests that UDCA significantly improves pruritus, albeit by a small amount. Fewer instances of fetal distress/asphyxial events were seen in the UDCA groups when compared with placebo but the difference was not statistically significant. Large trials of UDCA to determine fetal benefits or risks are needed.A single trial was too small to rule in or out a clinically important effect of early term delivery on caesarean section.There is insufficient evidence to indicate that SAMe, guar gum, activated charcoal, dexamethasone, cholestyramine, Salvia, Yinchenghao decoction (YCHD), Danxioling and Yiganling, or Yiganling alone or in combination are effective in treating women with cholestasis of pregnancy

Hedonic shopping motivations in collectivistic and individualistic consumer cultures

We reinvestigate what constitutes hedonic customer experiences in collectivistic versus individualistic cultures using four country samples (N=2,336) in Germany and the U.S. as well as Oman and India. Across country samples, intrinsically enjoyable customer experiences are associated with the same underlying hedonic shopping motivations as shown in the original U.S. context. In comparison with individualistic cultures, we find that a hedonic shopping experience in collectivistic cultures is less strongly associated with selforiented gratification shopping, yet more strongly associated with others-oriented role shopping

Brain temperature monitoring in newborn infants:Current methodologies and prospects

Brain tissue temperature is a dynamic balance between heat generation from metabolism, passive loss of energy to the environment, and thermoregulatory processes such as perfusion. Perinatal brain injuries, particularly neonatal encephalopathy, and seizures, have a significant impact on the metabolic and haemodynamic state of the developing brain, and thereby likely induce changes in brain temperature. In healthy newborn brains, brain temperature is higher than the core temperature. Magnetic resonance spectroscopy (MRS) has been used as a viable, non-invasive tool to measure temperature in the newborn brain with a reported accuracy of up to 0.2 degrees Celcius and a precision of 0.3 degrees Celcius. This measurement is based on the separation of chemical shifts between the temperature-sensitive water peaks and temperature-insensitive singlet metabolite peaks. MRS thermometry requires transport to an MRI scanner and a lengthy single-point measurement. Optical monitoring, using near infrared spectroscopy (NIRS), offers an alternative which overcomes this limitation in its ability to monitor newborn brain tissue temperature continuously at the cot side in real-time. Near infrared spectroscopy uses linear temperature-dependent changes in water absorption spectra in the near infrared range to estimate the tissue temperature. This review focuses on the currently available methodologies and their viability for accurate measurement, the potential benefits of monitoring newborn brain temperature in the neonatal intensive care unit, and the important challenges that still need to be addressed

Promoting parent-child interaction and communication for healthy development of adolescents: Lessons from a pilot project in rural Bihar

There is a recognition in India’s policies and programs of the need to actively engage parents in enabling their adolescent children to make safe and healthy transitions to adulthood. The Population Council, in partnership with CEDPA India, initiated an intervention project for parents of adolescents aimed at developing and testing a program to foster closer relationships between parents and their adolescent children. The project was formulated on the hypothesis that a program intended to build parenting skills would enable parents to develop closer relationships with their adolescent children and communicate more effectively with them on various concerns, particularly those related to growing up and sexual and reproductive health matters, and thereby enable healthier development of adolescents in the long run. The intervention was implemented by CEDPA India in a rural setting in the state of Bihar. The Population Council evaluated the feasibility, acceptability, and effectiveness of the intervention on parent-child relations and communication. This report documents the intervention, examines the feasibility of implementing the model, and evaluates its effectiveness and acceptability