Synchronous communication in PLM environments using annotated CAD models

The connection of resources, data, and knowledge through communication technology plays a vital role in current collaborative design methodologies and Product Lifecycle Management (PLM) systems, as these elements act as channels for information and meaning. Despite significant advances in the area of PLM, most communication tools are used as separate services that are disconnected from existing development environments. Consequently, during a communication session, the specific elements being discussed are usually not linked to the context of the discussion, which may result in important information getting lost or becoming difficult to access. In this paper, we present a method to add synchronous communication functionality to a PLM system based on annotated information embedded in the CAD model. This approach provides users a communication channel that is built directly into the CAD interface and is valuable when individuals need to be contacted regarding the annotated aspects of a CAD model. We present the architecture of a new system and its integration with existing PLM systems, and describe the implementation details of an annotation-based video conferencing module for a commercial CAD application.This work was supported by the Spanish Ministry of Economy and Competitiveness and the FEDER Funds, through the ANNOTA project (Ref. TIN2013-46036-C3-1-R).Camba, JD.; Contero, M.; Salvador Herranz, GM.; Plumed, R. (2016). Synchronous communication in PLM environments using annotated CAD models. Journal of Systems Science and Systems Engineering. 25(2):142-158. https://doi.org/10.1007/s11518-016-5305-5S142158252Abrahamson, S., Wallace, D., Senin, N. & Sferro, P. (2000). Integrated design in a service marketplace. Computer-Aided Design, 32(2):97–107.Ahmed, S. (2005). 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Induction of Amyloid-beta(42) Production by Fipronil and Other Pyrazole Insecticides

Generation of amyloid-β peptides (Aβs) by proteolytic cleavage of the amyloid-β protein precursor (AβPP), especially increased production of Aβ42/Aβ43 over Aβ40, and their aggregation as oligomers and plaques, represent a characteristic feature of Alzheimer’s disease (AD). In familial AD (FAD), altered Aβ production originates from specific mutations of AβPP or presenilins 1/2 (PS1/PS2), the catalytic subunits of γ-secretase. In sporadic AD, the origin of altered production of Aβs remains unknown. We hypothesize that the ‘human chemical exposome’ contains products able to favor the production of Aβ42/Aβ43 over Aβ40 and shorter Aβs. To detect such products, we screened a library of 3500 + compounds in a cell-based assay for enhanced Aβ42/Aβ43 production. Nine pyrazole insecticides were found to induce a β- and γ-secretase-dependent, 3-10-fold increase in the production of extracellular Aβ42 in various cell lines and neurons differentiated from induced pluripotent stem cells derived from healthy and FAD patients. Immunoprecipitation/mass spectrometry analyses showed increased production of Aβs cleaved at positions 42/43, and reduced production of peptides cleaved at positions 38 and shorter. Strongly supporting a direct effect on γ-secretase activity, pyrazoles shifted the cleavage pattern of another γ-secretase substrate, alcadeinα, and shifted the cleavage of AβPP by highly purified γ-secretase toward Aβ42/Aβ43. Focusing on fipronil, we showed that some of its metabolites, in particular the persistent fipronil sulfone, also favor the production of Aβ42/Aβ43 in both cell-based and cell-free systems. Fipronil administered orally to mice and rats is known to be metabolized rapidly, mostly to fipronil sulfone, which stably accumulates in adipose tissue and brain. In conclusion, several widely used pyrazole insecticides enhance the production of toxic, aggregation prone Aβ42/Aβ43 peptides, suggesting the possible existence of environmental “Alzheimerogens” which may contribute to the initiation and propagation of the amyloidogenic process in sporadic AD

Next generation emergency services based on the Pan-European Mobile Emergency Application (PEMEA) protocol: Leveraging mobile positioning and context information

In this paper, we analyze requirements of next generation 112 emergency services in the era of ubiquitous mobile devices and sensors and present the design, implementation, and piloting results of our testbed, which was developed within the H2020 project NEXES. The system leverages a multihop location-aware PEMEA routing network that finds the geographically closest responsible public service answering point (PSAP) and supports cross-border application roaming. Our reference mobile implementation utilizes multiple device and network-based positioning technologies, which, combined, both outperform traditional cell-tower based positioning and provide a means for detecting fraudulent calls. The system is extensible and can establish a variety of communication channels after the initial emergency session is set up; we demonstrate this with an interoperable WebRTC-based video call. The obtained results demonstrate the viability and flexibility of PEMEA-based over-the-top emergency services, show high user acceptance when comparing them with existing solutions, and thus pave the road for further rollout of such systems

FPGA Development Approach for Accelerator Systems with High Integration Complexity”. In: IPAC2013

Abstract This paper presents a Field Programmable Gate Array (FPGA) development workflow for custom hardware as part of an accelerator control systems. The workflow is narrowed down to three equally important parts: requirements analysis, implementation and testing. Each part is presented with milestones and guidelines, which addresses subjects such as knowledge alignment and development standards. These are presented and have been proven to increase efficiency and quality of control systems

Slovenia and the European Union: Macroeconomic Development Scenarios.

Consistent projections are presented for Slovenia's economic development in the form of two scenarios: one assuming accession to the European Union in 2005, and another assuming that no accession takes place before 2010. If accession does not take place, the growth of GDP will fluctuate between 3 and 4 percent, while in the accession scenario it achieves 5-6% in the years before and after accession. In both scenarios some reorientation of trade to former Yugoslav regions is expected, but in case of accession the high share of trade with the EU is maintained. Budgetary policy and agreement with social parters are expected to take care of moderate wage developments, which are even more crucial in case of accession due to the increased competitive pressures. The forecasts assume not only that external conditions will be favorable, or at least not adverse, but that internal structural reforms and economic policy making will fulfill all the ambitious targets that the official national and international documents prescribe.

Using the physical properties of artefacts to manage through‐life knowledge flows in the built environment: an initial exploration

Effective through‐life management of built facilities requires effective through‐life knowledge management to support it. The KIM (Immortal Information and Through‐Life Knowledge Management) project attempted to develop such an approach, based on a dichotomy of knowledge and information. Knowledge is conceived in terms of communities of practice. An initial philosophical analysis demonstrates deficiencies in this conception. Drawing inspiration from production theory, a tripartite analysis is offered, suggesting that knowledge flows consist of: social practices, information and physical properties. Literature on physical properties from design studies, production management and ethnomethodology is briefly reviewed to demonstrate the information bearing functions of physical properties. Fieldwork conforming to the unique adequacy requirement of methods was carried out on construction sites, in hotel and hospital facilities during the use stage of their life cycles. Safety barriers on construction sites were found to have informational properties beyond their function as a physical barrier. The quality of information delivered by wayfinding signs was found to depend upon both the physical placement of the signs in relation to the surrounding environment and the physical layout of the sign itself. It was found that social practices are institutionalized to repair the knowledge flow when the physically instantiated wayfinding system breaks down. Finally, through the investigation of practices surrounding emergency resuscitation equipment, it was found that if the physical properties of information are not designed to mesh with the work practices of the setting, this will lead to a breakdown in the knowledge flow. It is suggested that elements of knowledge management, ethnomethodology, production management and design studies might be integrated to form the basis of a hybrid discipline