Assessing the Retrofit Potential of Building Control Systems

It is well known that building control systems frequently under-perform, leading to wasted energy and poor space conditions for occupants. There are many reasons for this, including insufficient design or commissioning, deterioration of equipment over time, changes in building usage and poor maintenance. Therefore, building control systems are prime candidates for retrofits and upgrades. Such activities, though, can be very challenging in their own right. For example, information regarding the design intent and current control logic may be difficult or impossible to obtain due to lack of documentation, proprietary data and communication formats or unrecorded modifications. In addition, there is a great deal of variability in control system configuration and components, so each potential retrofit activity can become a time-consuming and expensive operation requiring a high level of expertise. To reduce these barriers to implementing building control system retrofits, a method has been developed to assist in the identification and assessment of building control system operation and retrofit potential. The components of the method include a system identification process that categorizes the building by type and usage, then it produces an information model of the control system, which can be compared to other similar buildings by category. Control system requirements to meet two performance levels are provided, namely current best practice and high performance, along with suggested control technology packages to achieve the desired level of performance. This paper describes the method and demonstrates it via a case study

SNPs Meet CNVs in Genome-Wide Association Studies: HGV2007 Meeting Report

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Long-term effects of allergen sensitization and exposure in adult asthma: a prospective study.

BACKGROUND: : We investigated the effects of sensitization and exposure to common domestic allergens on longitudinal changes in lung function and bronchial hyperresponsiveness. METHODS: : Subjects attended 2 visits that were 4 years apart. Skin prick testing was performed and household dust samples were collected for quantification of mite, dog, and cat allergens at baseline. Measurements of lung function, exhaled nitric oxide, and bronchial hyperresponsiveness were completed at both visits. RESULTS: : Dust samples were collected in 165 of the 200 subjects completing both visits. Mean length of follow-up was 47 months. Bronchial hyperresponsiveness, measured at both visits in 86 subjects, deteriorated in those exposed to high mite allergen levels compared with those not exposed [mean (95% CI) doubling dose change PD20 = -0.44 (-1.07 to 0.19) vs 0.82 (0.27 to 1.36)], but improved in those exposed to high dog allergen levels compared with those not exposed [1.10 (0.33 to 1.86) vs 0.10 (-0.39 to 0.58)]. The associations were significant in the multivariate models. Cat allergen exposure was not associated with any changes in lung function, exhaled nitric oxide, or bronchial hyperresponsiveness. CONCLUSIONS: : In a 4-year prospective cohort of persons with asthma, exposure to high levels of dust mite allergens at baseline was associated with a subsequent increase in bronchial hyperresponsiveness

SNPs Meet CNVs in Genome-Wide Association Studies: HGV2007 Meeting Report

SNPs meet CNVs in genome-wide association studies: HGV2007 meeting repor

Activity Assay of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer Cells Using Peptide-Conjugated Magnetic Beads

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with limited treatment options. Epidermal growth factor receptor I (EGFR) has emerged as a promising target in TNBC. Limited success of the EGFR kinase inhibiting small molecules in clinical trials may be attributed in part to inaccuracy in identifying EGFR signatures in patient tumors. In light of the absence of a simple correlation between EGFR expression and its degree of activation, a simple and reliable tool that can quantify EGFR kinase activity in tumor samples may be of therapeutic value in predicting patient-specific EGFR targeted therapies. This study reports the development of an assay that can quantitatively profile EGFR kinase activities and inhibitor sensitivities in TNBC cell lysates by using peptide reporters covalently tethered to magnetic beads in a controlled orientation. The use of magnetic beads provides rapid sample handling and easy product isolation. The potential of this approach was demonstrated by screening a set of five clinically relevant EGFR tyrosine kinase inhibitors. Formatted for microwell plates, this magnetic bead-based kinase assay may be used as a complementary approach for direct high-throughput screening of small molecule inhibitors.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140099/1/adt.2012.454.pd

Genomic variation in a global village: Report of the 10th annual Human Genome Variation Meeting 2008

The Centre for Applied Genomics of the Hospital for Sick Children and the University of Toronto hosted the 10th Human Genome Variation (HGV) Meeting in Toronto, Canada, in October 2008, welcoming about 240 registrants from 34 countries. During the 3 days of plenary workshops, keynote address, and poster sessions, a strong cross-disciplinary trend was evident, integrating expertise from technology and computation, through biology and medicine, to ethics and law. Single nucleotide polymorphisms (SNPs) as well as the larger copy number variants (CNVs) are recognized by ever-improving array and next-generation sequencing technologies, and the data are being incorporated into studies that are increasingly genome-wide as well as global in scope. A greater challenge is to convert data to information, through databases, and to use the information for greater understanding of human variation. In the wake of publications of the first individual genome sequences, an inaugural public forum provided the opportunity to debate whether we are ready for personalized medicine through direct-to-consumer testing. The HGV meetings foster collaboration, and fruits of the interactions from 2008 are anticipated for the 11th annual meeting in September 2009. Hum Mutat 30:1–5, 2009. © 2009 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63049/1/21008_ftp.pd

Constraining the bright-end of the UV luminosity function for z 7-9 galaxies: results from CANDELS/GOODS-South

The recent Hubble Space Telescope near-infrared imaging with the Wide-Field Camera #3 (WFC 3) of the Great Observatories Origins Deep Survey South (GOODS-S) field in the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS) programme covering nearly 100 arcmin2, along with already existing Advanced Camera for Surveys optical data, makes possible the search for bright galaxy candidates at redshift z ≈ 7–9 using the Lyman break technique. We present the first analysis of z′-drop z ≈ 7 candidate galaxies in this area, finding 19 objects. We also analyse Y-drops at z ≈ 8, trebling the number of bright (HAB < 27 mag) Y-drops from our previous work, and compare our results with those of other groups based on the same data. The bright high-redshift galaxy candidates we find serve to better constrain the bright end of the luminosity function at those redshift, and may also be more amenable to spectroscopic confirmation than the fainter ones presented in various previous work on the smaller fields (the Hubble Ultra Deep Field and the WFC 3 Early Release Science observations). We also look at the agreement with previous luminosity functions derived from WFC 3 drop-out counts, finding a generally good agreement, except for the luminosity function of Yan et al. at z ≈ 8, which is strongly ruled out