Process planning and metallurgical issues for laser asisted spin froming of dual phase automotive steel

Postprint (published version

Tsunami hazard assessment in the southern Colombian Pacific basin and a proposal to regenerate a previous barrier island as protection

ABSTRACT: In this study, the tsunami hazard posed to 120 000 inhabitants of Tumaco (Colombia) is assessed, and an evaluation and analysis of regenerating the previous El Guano Island for tsunami protection is conducted. El Guano Island was a sandy barrier island in front of the city of Tumaco until its disappearance during the tsunami of 1979; the island is believed to have played a protective role, substantially reducing the scale of the disaster. The analysis is conducted by identifying seismotectonic parameters and focal mechanisms of tsunami generation in the area, determining seven potential generation sources, applying a numerical model for tsunami generation and propagation, and evaluating the effect of tsunamis on Tumaco. The results show that in the current situation, this area is vulnerable to impact and flooding by tsunamis originating nearby. El Guano Island was found to markedly reduce flood levels and the energy flux of tsunami waves in Tumaco during the 1979 tsunami. By reducing the risk of flooding due to tsunamis, the regeneration and morphological modification of El Guano Island would help to protect Tumaco

Buenas prácticas de innovación docente en la Universidad de Córdoba

El proyecto, que no ha necesitado una inversión económica externa para su puesta en marcha, oferta al alumnado de una formación de carácter transversal dirigida a su futuro profesional como docente, investigador de la Historia o gestor del patrimonio histórico documental. Se trata de una iniciativa que fomenta el conocimiento práctico de los archivos históricos y de los recursos digitales disponibles que aporta las competencias necesarias para un posterior proceso de autoaprendizaje y mejora de aptitudes

P29 274. Indicaciones de la válvula aórtica ats 3f enable® sin sutura

La válvula ATS 3f Enable® (Medtronic) es una prótesis biológica de pericardio, diseñada como una válvula tubular para optimizar sus características hemodinámicas y disminuir el estrés.ObjetivosDescripción de las posibles indicaciones de la válvula aórtica 3f Enable® sin sutura seg?estra experiencia.Material y métodosDesde mayo de 2010 se han implantado 10 válvulas 3f Enable®, eligiendo pacientes con anillo aórtico pequeño (< 21mm) e índice de masa corporal (IMC) igual o superior a 30 o con estenosis protésica de 19mm. El tamaño de los implantes fue: 19mm: 5, 21mm: 4, y 23mm: 1. Perfil clínico de los pacientes: edad media: 72 años. Estenosis aórtica protésica: 2 pacientes. EuroSCORE medio: 6,3. El IMC medio de los pacientes con estenosis nativa: 32. En tres pacientes se realizaron injertos concomitantes.ResultadosTodos los implantes se realizaron con éxito. En dos pacientes fue necesaria la recolocación de la prótesis por insuficiencia antes de descontinuar la circulación extracorpórea. El tiempo medio de isquemia fue de 61 min, con un rango de 22–81 min. Los gradientes pico obtenidos fueron 21±6mmHg y los gradientes medios de 11±3mmHg. Un paciente requirió reintervención por insuficiencia grave debido a inframedición de la prótesis.ConclusionesLa prótesis 3f Enable® presenta un excelente comportamiento hemodinámico en pacientes con anillo aórtico pequeño y con un IMC igual o superior a 30 y consiguiente riesgo de mismatch. La estenosis protésica de 19mm también se podría considerar como indicación de implante de esta válvula

Resource use efficiency is affected by phytoplankton community changes and geochemical shifts over time in a coastal upwelling area (NE Atlantic).

abstractTime series records are crucial to understand the dynamical processes that occur within phytoplankton communities. This is even more important in the context of the current global change that is already forcing alterations of unprecedented nature and might have unknown consequences for multiple ecosystem processes. Here we present time series analyses of the biogeochemical trends that occurred in the shelf of the Galician coast (station 2 off A Coruña, NE Atlantic) since late 1980s. Upwelling strength and sea temperature in the area have not changed substantially during the last decades. However, while nitrate fertilization from upwelled waters has remained relatively stable, phosphate concentration has increased leading to a negative trend in the N:P ratio. Those trends have impacted the phytoplankton resource use efficiency jointly with the evenness of the community. Phytoplankton used resources more efficiently at higher values of upwelling strength and at lower values of nutrient concentration and evenness. Phytoplankton communities that were more even had higher dinoflagellate diversity contrasting to dominance of diatoms that used resources more efficiently. Moreover, variability in resource use efficiency increased with evenness.IEO (RADIALES-11

Polynic analysis of a periglaciar deposit in Moucide (Lugo)

[Resumen] Se realizó el análisis polínico de un depósito orgánico de características periglaciares en Moucide (Lugo) y de un nivel de turba cercano al anterior. Se efectuó la interpretación paleoecológica del mismo y su comparación con otros análisis realizados en la zona.[Abstract] It was made a polynic analysis of an organic deposit with periglaciar characteristics from Moucide (Lugo) and with a level of turf (sod-peat) near to the mentioned before. It was worked ont its paleoecologie interpretation and its comparison to the other analysis made in the place

Nanostructured multilayer compartments : towards multifunctionality and ‘‘cell-like’’ hierarchical complexity

In living organisms, there are phenomena that require the presence of specific biomolecules with distinct function and in variable concentrations at a given time, such as the healing and regeneration of tissue and organ lesions. In this work, we propose the use of a compartmented drug delivery device for the multiple release of bioactive agents. It consists of nanostructured microcapsules confined within a millimetric container that can be easily handled, mimicking the concept of cells which possess organelles with specialized functions. Each hierarchical structure was conceived using the layer-by-layer (LbL) method to form micro and macrocapsules that could individually carry either molecules and release them with distinct kinetics or magnetic nanoparticles (MNPs) to be used in targeted therapies. Furthermore, the internal microcontainers were constructed with a temperature-responsive elastin-like recombinamer (ELR) to further add smart properties to the proposed system. Sacrificial CaCO3 microparticles empty or entrapping either rhodamine or Fe3O4 MNPs were incubated in chitosan and ELR solutions using LbL for the conception of the microcapsules. Then, the microcapsules were suspended in alginate which was ionically crosslinked in CaCl2 drop-wise. Rhodamine could be encapsulated at this point in the alginate. The bead was coated with chitosan and alginate to build the external macrocapsule compartment. All structures were coated with 3 bilayers. The CaCO3 cores were chelated and the alginate beads liquefied using EDTA. Fluorescence microscopy using FITC and rhodamine markers showed a uniform distribution of the microcapsules within the macroreservoir. The release of rhodamine from either in the micro or macrocapsule was assessed at 25 and 37 °C in PBS. While the release from the macrocapsule follows a profile similar to that of traditional drug delivery systems, it is more sustained and delayed when released from the internal compartments. Such retention is more pronounced at 37 ºC (65% of release in comparison to 90%). This is due to the temperature responsive behavior of ELRs, which undergo a phase transition and make the LbL shell less permeable. For the magnetic response, the incorporation of the MNPs was observed by transmitted light microscopy. The attraction of the devices was observed by applying an external magnetic field along a defined trajectory. The results let foresee the use of such multilayer devices as compartmented structures to encapsulate growth factors, MNPs and stem cells for their controlled differentiation and maintenance or for guided regeneration of tissues and organs.Fundo Social Europeu (FSE)Fundação para a Ciência e a Tecnologia (FCT)Programa Diferencial de Potencial Humano (POPH

Expansion of CD8+CD57+ T Cells in an Immunocompetent Patient with Acute Toxoplasmosis

CD57+ T cells increase in several viral infections like cytomegalovirus, herpesvirus, parvovirus, HIV and hepatitis C virus and are associated with several clinical conditions related to immune dysfunction and ageing. We report for the first time an expansion of CD8+ CD57+ T cells in a young patient with an acute infection with Toxoplasma gondii. Our report supports the concept that CD8+ CD57+ T cells could be important in the control of chronic phase of intracellular microorganisms and that the high numbers of these cells may reflect the continuing survey of the immune system, searching for parasite proliferation in the tissues