Vacuum Boundary Effects

The effect of boundary conditions on the vacuum structure of quantum field theories is analysed from a quantum information viewpoint. In particular, we analyse the role of boundary conditions on boundary entropy and entanglement entropy. The analysis of boundary effects on massless free field theories points out the relevance of boundary conditions as a new rich source of information about the vacuum structure. In all cases the entropy does not increase along the flow from the ultraviolet to the infrared.Comment: 10 page

Double-delta potentials: one dimensional scattering. The Casimir effect and kink fluctuations

The path is explored between one-dimensional scattering through Dirac-$\delta$ walls and one-dimensional quantum field theories defined on a finite length interval with Dirichlet boundary conditions. It is found that two $\delta$'s are related to the Casimir effect whereas two $\delta$'s plus the first transparent P$\ddot{\rm o}$sch-Teller well arise in the context of the sine-Gordon kink fluctuations, both phenomena subjected to Dirichlet boundary conditions. One or two delta wells will be also explored in order to describe absorbent plates, even though the wells lead to non unitary Quantum Field Theories.Comment: 15 pages. To be published in the International Journal of Theoretical Physic

Boundary conditions: The path integral approach

The path integral approach to quantum mechanics requires a substantial generalisation to describe the dynamics of systems confined to bounded domains. Non-local boundary conditions can be introduced in Feynman's approach by means of boundary amplitude distributions and complex phases to describe the quantum dynamics in terms of the classical trajectories. The different prescriptions involve only trajectories reaching the boundary and correspond to different choices of boundary conditions of selfadjoint extensions of the Hamiltonian. One dimensional particle dynamics is analysed in detail.Comment: 8 page

La inhibición de la síntesis de óxido nítrico durante la colestasis inducida experimentalmente reduce la lesión hepatocelular al facilitar la homeostasis de nitrosotioles

Comunicaciones a congreso

Vacuum Energy and Renormalization on the Edge

The vacuum dependence on boundary conditions in quantum field theories is analysed from a very general viewpoint. From this perspective the renormalization prescriptions not only imply the renormalization of the couplings of the theory in the bulk but also the appearance of a flow in the space of boundary conditions. For regular boundaries this flow has a large variety of fixed points and no cyclic orbit. The family of fixed points includes Neumann and Dirichlet boundary conditions. In one-dimensional field theories pseudoperiodic and quasiperiodic boundary conditions are also RG fixed points. Under these conditions massless bosonic free field theories are conformally invariant. Among all fixed points only Neumann boundary conditions are infrared stable fixed points. All other conformal invariant boundary conditions become unstable under some relevant perturbations. In finite volumes we analyse the dependence of the vacuum energy along the trajectories of the renormalization group flow providing an interesting framework for dark energy evolution. On the contrary, the renormalization group flow on the boundary does not affect the leading behaviour of the entanglement entropy of the vacuum in one-dimensional conformally invariant bosonic theories.Comment: 10 pages, 1 eps figur

On the semiclassical mass of S2{\mathbb S}^2-kinks

One-loop mass shifts to the classical masses of stable kinks arising in a massive non-linear ${\mathbb S}^2$-sigma model are computed. Ultraviolet divergences are controlled using the heat kernel/zeta function regularization method. A comparison between the results achieved from exact and high-temperature asymptotic heat traces is analyzed in depth.Comment: RevTex file, 15 pages, 2 figures. Version to appear in Journal of Physics

Nuclear Translocation of b-Catenin during Mesenchymal Stem Cells Differentiation into Hepatocytes Is Associated with a Tumoral Phenotype

Wnt/b-catenin pathway controls biochemical processes related to cell differentiation. In committed cells the alteration of this pathway has been associated with tumors as hepatocellular carcinoma or hepatoblastoma. The present study evaluated the role of Wnt/b-catenin activation during human mesenchymal stem cells differentiation into hepatocytes. The differentiation to hepatocytes was achieved by the addition of two different conditioned media. In one of them, b-catenin nuclear translocation, up-regulation of genes related to the Wnt/b-catenin pathway, such as Lrp5 and Fzd3, as well as the oncogenes c-myc and p53 were observed. While in the other protocol there was a Wnt/b-catenin inactivation. Hepatocytes with nuclear translocation of b-catenin also had abnormal cellular proliferation, and expressed membrane proteins involved in hepatocellular carcinoma, metastatic behavior and cancer stem cells. Further, these cells had also increased auto-renewal capability as shown in spheroids formation assay. Comparison of both differentiation protocols by 2D-DIGE proteomic analysis revealed differential expression of 11 proteins with altered expression in hepatocellular carcinoma. Cathepsin B and D, adenine phosphoribosyltransferase, triosephosphate isomerase, inorganic pyrophosphatase, peptidyl-prolyl cis-trans isomerase A or lactate dehydrogenase b-chain were up-regulated only with the protocol associated with Wnt signaling activation while other proteins involved in tumor suppression, such as transgelin or tropomyosin b-chain were downregulated in this protocol. In conclusion, our results suggest that activation of the Wnt/b-catenin pathway during human mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotyp

A study of the interplay between ionized gas and star clusters in the central region of NGC 5253 with 2D spectroscopy

ABRIDGED: A detailed 2D study of the central region of NGC5253 has been performed to characterize the stellar and ionized gas structure as well as the extinction distribution, physical properties and kinematics of the ionized gas in the central ~210pc x 130pc. We utilized optical integral field spectroscopy (IFS) data obtained with FLAMES. A detailed extinction map for the ionized gas in NGC5253 shows that the largest extinction is associated with the prominent Giant HII region. There is an offset of ~0.5" between the peak of the optical continuum and the extinction peak in agreement with findings in the infrared. We found that stars suffer less extinction than gas by a factor of 0.33. The [SII]l6717/[SII]l6731 map shows an electron density (N_e) gradient declining from the peak of emission in Ha (790cm^-3) outwards, while the argon line ratio traces areas with $N_e~4200 - 6200cm^(-3). The area polluted with extra nitrogen, as deduced from the excess [NII]/Ha, extends up to distances of 3.3" (~60pc) from the maximum pollution, which is offset by ~1.5" from the peak of continuum emission. Wolf-Rayet features are distributed in an irregular pattern over a larger area (~100pc x 100pc) and associated with young stellar clusters. We measured He^+ abundances over most of the field of view and values of He^++/H^+<~0.0005 in localized areas which do not coincide, in general, with the areas presenting W-R emission or extra nitrogen. The line profiles are complex. Up to three emission components were needed to reproduce them. One of them, associated with the giant HII region, presents supersonic widths and [NII] and [SII] emission lines shifted up to 40km/s with respect to Ha. Similarly, one of the narrow components presents offsets in the [NII] line of <~20km/s. This is the first time that maps with such velocity offsets for a starburst galaxy have been presented.Comment: accepted in Astronomy & Astrophysics. 21 pages, 22 figure

Buenas prácticas de transferencia del conocimiento en la Universidad de Córdoba

La iniciativa consiste en proporcionar la materia prima. El proyecto, que se ha realizado con cerdos y ha tenido una duración de tres años, demuestra que la administración de Cardiotrofina-1 en el transplante hepático incrementa la supervivencia del animal, mejora su función cardiaca, respiratoria y renal, y también consigue reducir el daño hepatocelecuar y el estrés oxidativo y nitrosativo en el injerto