377 research outputs found
Experimental Biological Protocols with Formal Semantics
Both experimental and computational biology is becoming increasingly
automated. Laboratory experiments are now performed automatically on
high-throughput machinery, while computational models are synthesized or
inferred automatically from data. However, integration between automated tasks
in the process of biological discovery is still lacking, largely due to
incompatible or missing formal representations. While theories are expressed
formally as computational models, existing languages for encoding and
automating experimental protocols often lack formal semantics. This makes it
challenging to extract novel understanding by identifying when theory and
experimental evidence disagree due to errors in the models or the protocols
used to validate them. To address this, we formalize the syntax of a core
protocol language, which provides a unified description for the models of
biochemical systems being experimented on, together with the discrete events
representing the liquid-handling steps of biological protocols. We present both
a deterministic and a stochastic semantics to this language, both defined in
terms of hybrid processes. In particular, the stochastic semantics captures
uncertainties in equipment tolerances, making it a suitable tool for both
experimental and computational biologists. We illustrate how the proposed
protocol language can be used for automated verification and synthesis of
laboratory experiments on case studies from the fields of chemistry and
molecular programming
Angka Kematian Dan Faktor Risiko Stroke Sebagai Penyebab Dasar Kematian Di Kabupaten Padang Pariaman Provinsi Sumatera Barat
Mortality data are one of important indicators for the publich health The aim of this study is to know about the death rate, characteristics and risk factors of stroke as underlying cause of death in Padang Pariaman district. The mortality data in 2010 was analyzed using SPSS 16. The results showed that the entire death data was amount of 2642 and crude death rate was 6.71. Proportion of stroke in the district was 19.3% and stroke mortality rate was 1.29 per 1000 population in the year 2010, The risk factors of stroke as underlying cause of death after adjusted with education, employment and place of death were age and gender. The age of 40 â 64 years had the risk with OR of 6.45 (95% CI 2.77 â 14.28, p < 0.0001) and age of > 65 years had the risk of 10.29 (95% CI 4.47 â 23.69, p < 0.0001) compared to 20 â 39 year old. Women had greater risk than that of men with OR of 1.43 (95% CI 1.16 â 1.76, p < 0.001). The mortality rate of stroke as an underlying cause of death is high, so it is necessary to prevent the disease by appropriate intervention program
The ALHAMBRA survey: Accurate merger fractions by PDF analysis of photometric close pairs
Our goal is to develop and test a novel methodology to compute accurate close
pair fractions with photometric redshifts. We improve the current methodologies
to estimate the merger fraction f_m from photometric redshifts by (i) using the
full probability distribution functions (PDFs) of the sources in redshift
space, (ii) including the variation in the luminosity of the sources with z in
both the selection of the samples and in the luminosity ratio constrain, and
(iii) splitting individual PDFs into red and blue spectral templates to deal
robustly with colour selections. We test the performance of our new methodology
with the PDFs provided by the ALHAMBRA photometric survey. The merger fractions
and rates from the ALHAMBRA survey are in excellent agreement with those from
spectroscopic work, both for the general population and for red and blue
galaxies. With the merger rate of bright (M_B <= -20 - 1.1z) galaxies evolving
as (1+z)^n, the power-law index n is larger for blue galaxies (n = 2.7 +- 0.5)
than for red galaxies (n = 1.3 +- 0.4), confirming previous results.
Integrating the merger rate over cosmic time, we find that the average number
of mergers per galaxy since z = 1 is N_m = 0.57 +- 0.05 for red galaxies and
N_m = 0.26 +- 0.02 for blue galaxies. Our new methodology exploits
statistically all the available information provided by photometric redshift
codes and provides accurate measurements of the merger fraction by close pairs
only using photometric redshifts. Current and future photometric surveys will
benefit of this new methodology.Comment: Submitted to A&A, 15 pages, 15 figures, 6 tables. Comments are
welcome. Close pair systems available at
https://cloud.iaa.csic.es/alhambra/catalogues/ClosePairs
The ALHAMBRA Survey: Bayesian Photometric Redshifts with 23 bands for 3 squared degrees
The ALHAMBRA (Advance Large Homogeneous Area Medium Band Redshift
Astronomical) survey has observed 8 different regions of the sky, including
sections of the COSMOS, DEEP2, ELAIS, GOODS-N, SDSS and Groth fields using a
new photometric system with 20 contiguous ~ filters covering the
optical range, combining them with deep imaging. The observations,
carried out with the Calar Alto 3.5m telescope using the wide field (0.25 sq.
deg FOV) optical camera LAICA and the NIR instrument Omega-2000, correspond to
~700hrs on-target science images. The photometric system was designed to
maximize the effective depth of the survey in terms of accurate spectral-type
and photo-zs estimation along with the capability of identification of
relatively faint emission lines. Here we present multicolor photometry and
photo-zs for ~438k galaxies, detected in synthetic F814W images, complete down
to I~24.5 AB, taking into account realistic noise estimates, and correcting by
PSF and aperture effects with the ColorPro software. The photometric ZP have
been calibrated using stellar transformation equations and refined internally,
using a new technique based on the highly robust photometric redshifts measured
for emission line galaxies. We calculate photometric redshifts with the BPZ2
code, which includes new empirically calibrated templates and priors. Our
photo-zs have a precision of for I<22.5 and 1.4% for
22.5<I<24.5. Precisions of less than 0.5% are reached for the brighter
spectroscopic sample, showing the potential of medium-band photometric surveys.
The global shows a mean redshift =0.56 for I=0.86 for
I<24.5 AB. The data presented here covers an effective area of 2.79 sq. deg,
split into 14 strips of 58.5'x15.5' and represents ~32 hrs of on-target.Comment: The catalog data and a full resolution version of this paper is
available at https://cloud.iaa.csic.es/alhambra
J-PLUS: analysis of the intracluster light in the Coma cluster
The intracluster light (ICL) is a luminous component of galaxy clusters
composed of stars that are gravitationally bound to the cluster potential but
do not belong to the individual galaxies. Previous studies of the ICL have
shown that its formation and evolution are intimately linked to the
evolutionary stage of the cluster. Thus, the analysis of the ICL in the Coma
cluster will give insights into the main processes driving the dynamics in this
highly complex system. Using a recently developed technique, we measure the ICL
fraction in Coma at several wavelengths, using the J-PLUS unique filter system.
The combination of narrow- and broadband filters provides valuable information
on the dynamical state of the cluster, the ICL stellar types, and the
morphology of the diffuse light. We use the Chebyshev-Fourier Intracluster
Light Estimator (CICLE) to disentangle the ICL from the light of the galaxies,
and to robustly measure the ICL fraction in seven J-PLUS filters. We obtain the
ICL fraction distribution of the Coma cluster at different optical wavelengths,
which varies from , showing the highest values in the narrowband
filters J0395, J0410, and J0430. This ICL fraction excess is distinctive
pattern recently observed in dynamically active clusters (mergers), indicating
a higher amount of bluer stars in the ICL compared to the cluster galaxies.
Both the high ICL fractions and the excess in the bluer filters are indicative
of a merging state. The presence of younger/lower-metallicity stars the ICL
suggests that the main mechanism of ICL formation for the Coma cluster is the
stripping of the stars in the outskirts of infalling galaxies and, possibly,
the disruption of dwarf galaxies during past/ongoing mergers.Comment: 10 pages, 3 figures, 1 table. Accepted for publication in A&
Evidence for Ubiquitous, High-EW Nebular Emission in z~7 Galaxies: Towards a Clean Measurement of the Specific Star Formation Rate using a Sample of Bright, Magnified Galaxies
Growing observational evidence now indicates that nebular line emission has a
significant impact on the rest-frame optical fluxes of z~5-7 galaxies observed
with Spitzer. This line emission makes z~5-7 galaxies appear more massive, with
lower specific star formation rates. However, corrections for this line
emission have been very difficult to perform reliably due to huge uncertainties
on the overall strength of such emission at z>~5.5. Here, we present the most
direct observational evidence yet for ubiquitous high-EW [OIII]+Hbeta line
emission in Lyman-break galaxies at z~7, while also presenting a strategy for
an improved measurement of the sSFR at z~7. We accomplish this through the
selection of bright galaxies in the narrow redshift window z~6.6-7.0 where the
IRAC 4.5 micron flux provides a clean measurement of the stellar continuum
light. Observed 4.5 micron fluxes in this window contrast with the 3.6 micron
fluxes which are contaminated by the prominent [OIII]+Hbeta lines. To ensure a
high S/N for our IRAC flux measurements, we consider only the brightest
(H_{160}<26 mag) magnified galaxies we have identified in CLASH and other
programs targeting galaxy clusters. Remarkably, the mean rest-frame optical
color for our bright seven-source sample is very blue, [3.6]-[4.5]=-0.9+/-0.3.
Such blue colors cannot be explained by the stellar continuum light and require
that the rest-frame EW of [OIII]+Hbeta be greater than 637 Angstroms for the
average source. The bluest four sources from our seven-source sample require an
even more extreme EW of 1582 Angstroms. Our derived lower limit for the mean
[OIII]+Hbeta EW could underestimate the true EW by ~2x based on a simple
modeling of the redshift distribution of our sources. We can also set a robust
lower limit of >~4 Gyr^-1 on the specific star formation rates based on the
mean SED for our seven-source sample. (abridged)Comment: 9 pages, 6 figures, 1 table, submitted to the Astrophysical Journa
Stable nondegenerate optical parametric oscillation at degenerate frequencies in Na:KTP
We report the realization of a light source specifically designed for the
generation of bright continuous-variable entangled beams and for
Heisenberg-limited inteferometry. The source is a nondegenerate, single-mode,
continuous-wave optical parametric oscillator in Na:KTP, operated at frequency
degeneracy and just above threshold, which is also of interest for the study of
critical fluctuations at the transition point. The residual
frequency-difference jitter is 150 kHz for a 3 MHz cold cavity half-width
at half maximum. We observe 4 dB of photon-number-difference squeezing at 200
kHz. The Na:KTP crystal is noncritically phase-matched for a 532 nm pump and
polarization crosstalk is therefore practically nonexistent
CLASH: z ~ 6 young galaxy candidate quintuply lensed by the frontier field cluster RXC J2248.7-4431
We present a quintuply lensed z ~ 6 candidate discovered in the field of the
galaxy cluster RXC J2248.7-4431 (z ~ 0.348) targeted within the Cluster Lensing
and Supernova survey with Hubble (CLASH) and selected in the deep HST Frontier
Fields survey. Thanks to the CLASH 16-band HST imaging, we identify the
quintuply lensed z ~ 6 candidate as an optical dropout in the inner region of
the cluster, the brightest image having magAB=24.81+-0.02 in the f105w filter.
We perform a detailed photometric analysis to verify its high-z and lensed
nature. We get as photometric redshift z_phot ~ 5.9, and given the extended
nature and NIR colours of the lensed images, we rule out low-z early type and
galactic star contaminants. We perform a strong lensing analysis of the
cluster, using 13 families of multiple lensed images identified in the HST
images. Our final best model predicts the high-z quintuply lensed system with a
position accuracy of 0.8''. The magnifications of the five images are between
2.2 and 8.3, which leads to a delensed UV luminosity of L_1600 ~ 0.5L*_1600 at
z=6. We also estimate the UV slope from the observed NIR colours, finding a
steep beta=-2.89+-0.38. We use singular and composite stellar population SEDs
to fit the photometry of the hiz candidate, and we conclude that it is a young
(age <300 Myr) galaxy with mass of M ~ 10^8Msol, subsolar metallicity
(Z<0.2Zsol) and low dust content (AV ~ 0.2-0.4).Comment: 21 pages, 13 figures, 6 tables, submitted to MNRAS on 11 Aug 2013,
accepted on 23 Nov 201
A Census of Star-Forming Galaxies in the z~9-10 Universe based on HST+Spitzer Observations Over 19 CLASH clusters: Three Candidate z~9-10 Galaxies and Improved Constraints on the Star Formation Rate Density at z~9
We utilise a two-color Lyman-Break selection criterion to search for z~9-10
galaxies over the first 19 clusters in the CLASH program. A systematic search
yields three z~9-10 candidates. While we have already reported the most robust
of these candidates, MACS1149-JD, two additional z~9 candidates are also found
and have H_{160}-band magnitudes of ~26.2-26.9. A careful assessment of various
sources of contamination suggests <~1 contaminants for our z~9-10 selection. To
determine the implications of these search results for the LF and SFR density
at z~9, we introduce a new differential approach to deriving these quantities
in lensing fields. Our procedure is to derive the evolution by comparing the
number of z~9-10 galaxy candidates found in CLASH with the number of galaxies
in a slightly lower redshift sample (after correcting for the differences in
selection volumes), here taken to be z~8. This procedure takes advantage of the
fact that the relative volumes available for the z~8 and z~9-10 selections
behind lensing clusters are not greatly dependent on the details of the lensing
models. We find that the normalization of the UV LF at z~9 is just
0.28_{-0.20}^{+0.39}\times that at z~8, ~1.4_{-0.8}^{+3.0}x lower than
extrapolating z~4-8 LF results. While consistent with the evolution in the UV
LF seen at z~4-8, these results marginally favor a more rapid evolution at z>8.
Compared to similar evolutionary findings from the HUDF, our result is less
insensitive to large-scale structure uncertainties, given our many independent
sightlines on the high-redshift universe.Comment: 22 pages, 11 figures, 5 tables, accepted for publication in the
Astrophysical Journal, updated to include the much deeper Spitzer/IRAC
observations over our three z~9-10 candidate
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