Production of scalar KKˉK\bar K molecules in ϕ\phi radiative decays

The potentialities of the production of the scalar $K\bar K$ molecules in the $\phi$ radiative decays are considered beyond the narrow resonance width approximation. It is shown that $BR(\phi\rightarrow\gamma f_0(a_0)\rightarrow\gamma\pi\pi(\pi\eta))\approx (1\div 2)\times 10^{-5}\ ,\BR(\phi\rightarrow\gamma (f_0+a_0)\rightarrow\gamma K^+K^-)\alt 10^{-6}$and$BR(\phi\rightarrow\gamma (f_0+a_0) \to \gamma K^0\bar K^0)\alt 10^{-8}$. The mass spectra in the$\pi\pi\ ,\ \pi\eta\ ,\ K^+K^-\ ,\ K^0\bar K^0$channels are calculated. The imaginary part of the amplitude$\phi\rightarrow\gamma f_0(a_0)$is calculated analytically. It is obtained the phase of the scalar resonance production amplitude that causes the interference patterns in the reaction$e^+e^-\rightarrow\gamma \pi^+\pi^-$in the$\phi$ meson mass region.Comment: 19 pages, revtex, 4 eps files of figure

Effective chiral restoration in the rho'-meson in lattice QCD

In simulations with dynamical quarks it has been established that the ground state rho in the infrared is a strong mixture of the two chiral representations (0,1)+(1,0) and (1/2,1/2)_b. Its angular momentum content is approximately the 3S1 partial wave which is consistent with the quark model. Effective chiral restoration in an excited rho-meson would require that in the infrared this meson couples predominantly to one of the two representations. The variational method allows one to study the mixing of interpolators with different chiral transformation properties in the non-perturbatively determined excited state at different resolution scales. We present results for the first excited state of the rho-meson using simulations with n_f=2 dynamical quarks. We point out, that in the infrared a leading contribution to rho'= rho(1450) comes from (1/2,1/2)_b, in contrast to the rho. Its approximate chiral partner would be a h_1(1380) state. The rho' wave function contains a significant contribution of the 3D1 wave which is not consistent with the quark model prediction.Comment: 4 pp, a few short remarks have been added, a reference updated. To appear in PR

Epsilon Indi Ba/Bb: the nearest binary brown dwarf

We have carried out high angular resolution near-infrared imaging and low-resolution (R~1000) spectroscopy of the nearest known brown dwarf, Eps Indi B, using the ESO VLT NAOS/CONICA adaptive optics system. We find it to be a close binary (as also noted by Volk et al. 2003) with an angular separation of 0.732 arcsec, corresponding to 2.65AU at the 3.626pc distance of the Eps Indi system. In our discovery paper (Scholz et al. 2003), we concluded that Eps Indi B was a ~50Mjup T2.5 dwarf: our revised finding is that the two system components (Eps Indi Ba and Eps Indi Bb) have spectral types of T1 and T6, respectively, and estimated masses of 47 and 28Mjup, respectively, assuming an age of 1.3Gyr. Errors in the masses are +/-10 and +/-7Mjup, respectively, dominated by the uncertainty in the age determination (0.8-2Gyr range). This uniquely well-characterised T dwarf binary system should prove important in the study of low-mass, cool brown dwarfs. The two components are bright and relatively well-resolved: Eps Indi B is the only T dwarf binary in which spectra have been obtained for both components. They have a well-established distance and age. Finally, their orbital motion can be measured on a fairly short timescale (nominal orbital period 15 yrs), permitting an accurate determination of the true total system mass, helping to calibrate brown dwarf evolutionary models.Comment: Accepted for publication by Astronomy & Astrophysics main journal. This replacement version includes minor changes made following comments by the referee, along with a reworking of the photometric data and derived quantities using 2MASS catalogue photometry as the basis, with only a minor impact on the final result

A detector for continuous measurement of ultra-cold atoms in real time

We present the first detector capable of recording high-bandwidth real time atom number density measurements of a Bose Einstein condensate. Based on a two-color Mach-Zehnder interferometer, our detector has a response time that is six orders of magnitude faster than current detectors based on CCD cameras while still operating at the shot-noise limit. With this minimally destructive system it may be possible to implement feedback to stabilize a Bose-Einstein condensate or an atom laser.Comment: 3 pages, 3 figures, submitted to optics letter

Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.

BACKGROUND: An open-label study indicated that selective depletion of B cells with the use of rituximab led to sustained clinical improvements for patients with rheumatoid arthritis. To confirm these observations, we conducted a randomized, double-blind, controlled study. METHODS: We randomly assigned 161 patients who had active rheumatoid arthritis despite treatment with methotrexate to receive one of four treatments: oral methotrexate (> or =10 mg per week) (control); rituximab (1000 mg on days 1 and 15); rituximab plus cyclophosphamide (750 mg on days 3 and 17); or rituximab plus methotrexate. Responses defined according to the criteria of the American College of Rheumatology (ACR) and the European League against Rheumatism (EULAR) were assessed at week 24 (primary analyses) and week 48 (exploratory analyses). RESULTS: At week 24, the proportion of patients with 50 percent improvement in disease symptoms according to the ACR criteria, the primary end point, was significantly greater with the rituximab-methotrexate combination (43 percent, P=0.005) and the rituximab-cyclophosphamide combination (41 percent, P=0.005) than with methotrexate alone (13 percent). In all groups treated with rituximab, a significantly higher proportion of patients had a 20 percent improvement in disease symptoms according to the ACR criteria (65 to 76 percent vs. 38 percent, P< or =0.025) or had EULAR responses (83 to 85 percent vs. 50 percent, P< or =0.004). All ACR responses were maintained at week 48 in the rituximab-methotrexate group. The majority of adverse events occurred with the first rituximab infusion: at 24 weeks, serious infections occurred in one patient (2.5 percent) in the control group and in four patients (3.3 percent) in the rituximab groups. Peripheral-blood immunoglobulin concentrations remained within normal ranges. CONCLUSIONS: In patients with active rheumatoid arthritis despite methotrexate treatment, a single course of two infusions of rituximab, alone or in combination with either cyclophosphamide or continued methotrexate, provided significant improvement in disease symptoms at both weeks 24 and 48

Nuclear Shadowing in a Parton Recombination Model

Deep inelastic structure functions $F_2^A(x)$ are investigated in a $Q^2$ rescaling model with parton recombination effects. We find that the model can explain experimentally measured $F_2^A(x)$ structure functions reasonably well in the wide Bjorken$-x$ range ($0.005<x<0.8$). In the very small $x$ region ($x<0.02$), recombination results are very sensitive to input sea-quark and gluon distributions.Comment: preprint MKPH-T-93-04, IU/NTC 92-20, 25 pages, TEX file (without Figs. 1-14)., (address after April 1: Saga U., Japan

Local gauge invariance implies Siegert's hypothesis

The nonrelativistic Ward-Takahashi identity, a consequence of local gauge invariance in quantum mechanics, shows the necessity of exchange current contributions in case of nonlocal and/or isospin-dependent potentials. It also implies Siegert's hypothesis: in the nonrelativistic limit, two-body charge densities identically vanish. Neither current conservation, which follows from global gauge invariance, nor the constraints of (lowest order) relativity are sufficient to arrive at this result. Furthermore, a low-energy theorem for exchange contributions is established.Comment: 5 pages, REVTE

Age- and activity-related differences in the abundance of Myosin essential and regulatory light chains in human muscle

Traditional methods for phenotyping skeletal muscle (e.g., immunohistochemistry) are labor-intensive and ill-suited to multixplex analysis, i.e., assays must be performed in a series. Addressing these concerns represents a largely unmet research need but more comprehensive parallel analysis of myofibrillar proteins could advance knowledge regarding age- and activity-dependent changes in human muscle. We report a label-free, semi-automated and time efficient LC-MS proteomic workflow for phenotyping the myofibrillar proteome. Application of this workflow in old and young as well as trained and untrained human skeletal muscle yielded several novel observations that were subsequently verified by multiple reaction monitoring (MRM).We report novel data demonstrating that human ageing is associated with lesser myosin light chain 1 content and greater myosin light chain 3 content, consistent with an age-related reduction in type II muscle fibers. We also disambiguate conflicting data regarding myosin regulatory light chain, revealing that age-related changes in this protein more closely reflect physical activity status than ageing per se. This finding reinforces the need to control for physical activity levels when investigating the natural process of ageing. Taken together, our data confirm and extend knowledge regarding age- and activity-related phenotypes. In addition, the MRM transitions described here provide a methodological platform that can be fine-tuned to suite multiple research needs and thus advance myofibrillar phenotyping

A multibeam atom laser: coherent atom beam splitting from a single far detuned laser

We report the experimental realisation of a multibeam atom laser. A single continuous atom laser is outcoupled from a Bose-Einstein condensate (BEC) via an optical Raman transition. The atom laser is subsequently split into up to five atomic beams with slightly different momenta, resulting in multiple, nearly co-propagating, coherent beams which could be of use in interferometric experiments. The splitting process itself is a novel realization of Bragg diffraction, driven by each of the optical Raman laser beams independently. This presents a significantly simpler implementation of an atomic beam splitter, one of the main elements of coherent atom optics

Discovery of a 66 mas Ultracool Binary with Laser Guide Star Adaptive Optics

We present the discovery of 2MASS J21321145+1341584AB as a closely separated (0.066") very low-mass field dwarf binary resolved in the near-infrared by the Keck II Telescope using laser guide star adaptive optics. Physical association is deduced from the angular proximity of the components and constraints on their common proper motion. We have obtained a near-infrared spectrum of the binary and find that it is best described by an L5+/-0.5 primary and an L7.5+/-0.5 secondary. Model-dependent masses predict that the two components straddle the hydrogen burning limit threshold with the primary likely stellar and the secondary likely substellar. The properties of this sytem - close projected separation (1.8+/-0.3 AU) and near unity mass ratio - are consistent with previous results for very low-mass field binaries. The relatively short estimated orbital period of this system (~7-12 yr) makes it a good target for dynamical mass measurements. Interestingly, the system's angular separation is the tightest yet for any very low-mass binary published from a ground-based telescope and is the tightest binary discovered with laser guide star adaptive optics to date.Comment: 10 pages, 3 figures; accepted for publication to A