4,588 research outputs found
Cyclotron waves in a collisionless plasma
Plasma waves with resonances near electron cyclotron frequency investigated in long collisionless plasma column - wavelength dispersion curves and relation
Experimental investigation of the fundamental modes of a collisionless plasma quarterly report no. 3, sep. 11 - dec. 10, 1964
Plasma waves between electron cyclotron frequency and upper hybrid frequency in collisionless hydrogen plasm
Phenomenological model for predicting the energy resolution of neutron-damaged coaxial HPGe detectors
The peak energy resolution of germanium detectors deteriorates with
increasing neutron fluence. This is due to hole capture at neutron-created
defects in the crystal which prevents the full energy of the gamma-ray from
being recorded by the detector. A phenomenological model of coaxial HPGe
detectors is developed that relies on a single, dimensionless parameter that is
related to the probability for immediate trapping of a mobile hole in the
damaged crystal. As this trap parameter is independent of detector dimensions
and type, the model is useful for predicting energy resolution as a function of
neutron fluence.Comment: 7 pages, 7 figure
Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis.
11 p.-4 fig.-1 tab.Background: Increased circulating levels of endoglin+ endothelial microparticles (EMPs) have been identified in several cardiovascular disorders, related to severity. Endoglin is an auxilary receptor for transforming growth factor β (TGF-β) important in the regulation of vascular structure.Results: We quantified the number of microparticles in plasma of six patients with chronic thromboembolic pulmonary hypertension (CTEPH) and age- and sex-matched pulmonary embolic (PE) and healthy controls and investigated the role of microparticle endoglin in the regulation of pulmonary endothelial function in vitro. Results show significantly increased levels of endoglin+ EMPs in CTEPH plasma, compared to healthy and disease controls. Co-culture of human pulmonary endothelial cells with CTEPH microparticles increased intracellular levels of endoglin and enhanced
TGF-β-induced angiogenesis and Smad1,5,8 phosphorylation in cells, without affecting BMPRII expression. In an in vitro model, we generated endothelium-derived MPs with enforced membrane localization of endoglin. Co-culture of these MPs with endothelial cells increased cellular endoglin content, improved cell survival and stimulated
angiogenesis in a manner similar to the effects induced by overexpressed protein.Conclusions: Increased generation of endoglin+ EMPs in CTEPH is likely to represent a protective mechanism supporting endothelial cell survival and angiogenesis, set to counteract the effects of vascular occlusion and endothelial damage.This research was supported by a project grant (PG 11/13/28765) from the British Heart Foundation and by grants from Ministerio de Economia y Competitividad of Spain (SAF2013-43421-R to CB)Peer reviewe
Experimental investigation of the fundamental modes of a collisionless plasma Final report, 10 Mar. 1964 - 31 Oct. 1967
Propagation of electron cyclotron waves and effects of low frequency noise in collisionless plasm
Low grade glioma: An Update for Radiologists
With the recent publication of a new World Health Organization (WHO) brain tumour classification that reflects increased understanding of glioma tumour genetics there is a need for radiologists to understand the changes and their implications for patient management. There has also been an increasing trend for adopting earlier, more aggressive surgical approaches to low grade glioma treatment. We will summarise these changes, give some context to the increased role of tumour genetics and discuss the associated implications for radiologists of their adoption. We will discuss the earlier and more radical surgical resection of low grade gliomas and what it means for imaging patients
Native valve endocarditis due to Micrococcus luteus: a case report and review of the literature
<p>Abstract</p> <p>Introduction</p> <p><it>Micrococcus luteus </it>endocarditis is a rare case of infective endocarditis. A total of 17 cases of infective endocarditis due to <it>M luteus </it>have been reported in the literature to date, all involving prosthetic valves. To the best of our knowledge, we describe the first case of native aortic valve <it>M luteus </it>endocarditis in an immunosuppressed patient in this report.</p> <p>Case report</p> <p>A 74-year-old Greek-Cypriot woman was admitted to our Internal Medicine Clinic due to fever and malaise and the diagnosis of aortic valve <it>M luteus </it>endocarditis was made. She was immunosuppressed due to methotrexate and steroid treatment. Our patient was unsuccessfully treated with vancomycin, gentamicin and rifampicin for four weeks. The aortic valve was replaced and she was discharged in good condition.</p> <p>Conclusions</p> <p>Prosthetic infective endocarditis due to <it>M luteus </it>is rare. To the best of our knowledge, we report the first case in the literature involving a native valve.</p
Improving the economic value of photographic screening for optical coherence tomography-detectable macular oedema : a prospective, multicentre, UK study
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Impact of WRF Physics and Grid Resolution on Low-level Wind Prediction: Towards the Assessment of Climate Change Impact on Future Wind Power
The Weather Research and Forecast (WRF) model is used in short-range simulations to explore the sensitivity of model physics and horizontal grid resolution. We choose five events with the clear-sky conditions to study the impact of different planetary boundary layer (PBL), surface and soil-layer physics on low-level wind forecast for two wind farms; one in California (CA) and the other in Texas (TX). Short-range simulations are validated with field measurements. Results indicate that the forecast error of the CA case decreases with increasing grid resolution due to the improved representation of valley winds. Besides, the model physics configuration has a significant impact on the forecast error at this location. In contrast, the forecast error of the TX case exhibits little dependence on grid resolution and is relatively independent of physics configuration. Therefore, the occurrence frequency of lowest root mean square errors (RMSEs) at this location is used to determine an optimal model configuration for subsequent decade-scale regional climate model (RCM) simulations. In this study, we perform two sets of 20-year RCM simulations using the data from the NCAR Global Climate Model (GCM) simulations; one set models the present climate and the other simulates the future climate. These RCM simulations will be used to assess the impact of climate change on future wind energy
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