Un San José atribuido a La Roldana en el Convento de Santa María la Real de Bormujos, Sevilla.

Atrio: Revista de historia del arte nº 17 (2011), p. 59-68La artista Luisa Roldán, escultora de Cámara de Carlos II y Felipe V, hija del gran maestro escultórico Pedro Roldán, es una de las artistas de finales del barroco sevillano que despiertan más interés por la proliferación de sus obras en un periodo relativamente corto y fecundo a caballo entre su etapa andaluza de Sevilla (1671-1683), Cádiz (1687-1689) y la etapa cortesana de Madrid (1692-1706). La obra que presentamos es una aportación basada principalmente en un estudio com­parativo con otras obras de la autora. Por sus similitudes nos han llevado a pensar en la atribución a su mano.The artist Luisa Roldán, sculptor of House of Carlos II and Felipe V, daughter of the great sculptural master Pedro Roldán, is one of the last of the Sevil­lian baroque artists that arouse more interest in the proliferation of their works in a relatively short and fruitful period between his Andalusian stage of Seville (1671- 1683), Cádiz (1684-1687) and the courtly stage of Madrid (1692-1706). The study of the work we present, is a contribution based primarily on a comparative study with other works of the author that, by their similarities, have led us to think about possible attribution to her hand.Versión del edito

Morphological variation and different branch modularity across contrasting flow conditions in dominant Pocillopora reef-building corals

© 2015, Springer-Verlag Berlin Heidelberg. Pocillopora corals, the dominant reef-builders in the Eastern Tropical Pacific, exhibit a high level of phenotypic plasticity, making the interpretation of morphological variation and the identification of species challenging. To test the hypothesis that different coral morphospecies represent phenotypes that develop in different flow conditions, we compared branch characters in three Pocillopora morphospecies (P.damicornis, P. verrucosa, and P. meandrina) from two communities in the Gulf of California exposed to contrasting flow conditions. Morphological variation and branch modularity (i.e., the tendency of different sets of branch traits to vary in a coordinated way) were assessed in colonies classified as Pocillopora type 1 according to two mitochondrial regions. Our results can be summarized as follows. (1) Pocillopora type 1 morphospecies corresponded to a pattern of morphological variation in the Gulf of California. Overall, P.damicornis had the thinnest branches and its colonies the highest branch density, followed by P.verrucosa, and then by P.meandrina, which had the thickest branches and its colonies the lowest branch density. (2) The differentiation among morphospecies was promoted by different levels of modularity of traits. P.verrucosa had the highest coordination of traits, followed by P.damicornis, and P.meandrina. (3) The variation and modularity of branch traits were related to water flow condition. Morphology under the high-flow condition was more similar among morphospecies than under the low-flow condition and seemed to be related to mechanisms for coping with these conditions. Our results provide the first evidence that in scleractinian corals different levels of modularity can be promoted by different environmental conditions

Habitat selection and diet of Western Capercaillie

P. 260-272Ecological features and conservation requirements of populations at the latitudinal limits of a species’ geographical range frequently differ from those in other parts of the range. Identifying such differences is key to implementing effective conservation strategies for threatened range-edge populations especially, in the context of rapid global warming, at the lower-latitude range edge. We studied habitat selection and diet of the endangered Cantabrian Capercaillie Tetrao urogallus cantabricus in a recently discovered population at the southernmost edge of the sub-species’ range. This is the only Western Capercaillie population in the Mediterranean biogeographical region. We combined non-systematic surveys based on questionnaires, reports and field sampling with data from radiotracking to assess habitat selection. Diet was surveyed by micro-histological methods from droppings collected in the new population, which inhabits Pyrenean Oak Quercus pyrenaica forests and Scots Pine Pinus sylvestris plantations, and in two Cantabrian populations inhabiting Eurosiberian forests. Capercaillie preferred large (> 500 ha) and medium-sized (100–500 ha) Pyrenean Oak forest fragments and large Scots Pine plantations. Forest fragments smaller than 100 ha and non-forested habitats were always avoided. Diet differed markedly between Mediterranean and Eurosiberian populations. Bilberry Vaccinium myrtillus is common in the diet of most Capercaillie populations but was scarce in the study area and so was rare in the diet of the new population. Instead, Rockrose Halimium lasianthum was described for the first time as a major food resource for the Capercaillie and was consumed in autumn and winter. Pine needles were also heavily consumed in winter. We document for the first time the strong preference of Capercaillie for Pyrenean Oak forests and a moderately high consumption of the leaves, buds and acorns of this tree species throughout the year. Habitat selection and diet of this Mediterranean population differ from those of the core Cantabrian and other populations. Our results suggest a wider environmental tolerance (phenotypic plasticity) in the species than previously recognized. We advocate specific protection for this unique range-edge Capercaillie population and its Pyrenean Oak forest habitatS

Association between Use of Enhanced Recovery after Surgery Protocol and Postoperative Complications in Total Hip and Knee Arthroplasty in the Postoperative Outcomes Within Enhanced Recovery after Surgery Protocol in Elective Total Hip and Knee Arthroplasty Study (POWER2)

Importance: The Enhanced Recovery After Surgery (ERAS) care protocol has been shown to improve outcomes compared with traditional care in certain types of surgery. Objective: To assess the association of use of the ERAS protocols with complications in patients undergoing elective total hip arthroplasty (THA) and total knee arthroplasty (TKA). Design, Setting, and Participants: This multicenter, prospective cohort study included patients recruited from 131 centers in Spain from October 22 through December 22, 2018. All consecutive adults scheduled for elective THA or TKA were eligible for inclusion. Patients were stratified between those treated in a self-designated ERAS center (ERAS group) and those treated in a non-ERAS center (non-ERAS group). Data were analyzed from June 15 through September 15, 2019. Exposures: Total hip or knee arthroplasty and perioperative management. Sixteen individual ERAS items were assessed in all included patients, whether they were treated at a center that was part of an established ERAS protocol or not. Main Outcomes and Measures: The primary outcome was postoperative complications within 30 days after surgery. Secondary outcomes included length of stay and mortality. Results: During the 2-month recruitment period, 6146 patients were included (3580 women [58.2%]; median age, 71 [interquartile range (IQR), 63-76] years). Of these, 680 patients (11.1%) presented with postoperative complications. No differences were found in the number of patients with overall postoperative complications between ERAS and non-ERAS groups (163 [10.2%] vs 517 [11.4%]; odds ratio [OR], 0.89; 95% CI, 0.74-1.07; P =.22). Fewer patients in the ERAS group had moderate to severe complications (73 [4.6%] vs 279 [6.1%]; OR, 0.74; 95% CI, 0.56-0.96; P =.02). The median overall adherence rate with the ERAS protocol was 50.0% (IQR, 43.8%-62.5%), with the rate for ERAS facilities being 68.8% (IQR, 56.2%-81.2%) vs 50.0% (IQR, 37.5%-56.2%) at non-ERAS centers (P <.001). Among the patients with the highest and lowest quartiles of adherence to ERAS components, the patients with the highest adherence had fewer overall postoperative complications (144 [10.6%] vs 270 [13.0%]; OR, 0.80; 95% CI, 0.64-0.99; P <.001) and moderate to severe postoperative complications (59 [4.4%] vs 143 [6.9%]; OR, 0.62; 95% CI, 0.45-0.84; P <.001) and shorter median length of hospital stay (4 [IQR, 3-5] vs 5 [IQR, 4-6] days; OR, 0.97; 95% CI, 0.96-0.99; P <.001). Conclusions and Relevance: An increase in adherence to the ERAS program was associated with a decrease in postoperative complications, although only a few ERAS items were individually associated with improved outcomes

The little skate genome and the evolutionary emergence of wing-like fins

Skates are cartilaginous fish whose body plan features enlarged wing-like pectoral fins, enabling them to thrive in benthic environments1,2. However, the molecular underpinnings of this unique trait remain unclear. Here we investigate the origin of this phenotypic innovation by developing the little skate Leucoraja erinacea as a genomically enabled model. Analysis of a high-quality chromosome-scale genome sequence for the little skate shows that it preserves many ancestral jawed vertebrate features compared with other sequenced genomes, including numerous ancient microchromosomes. Combining genome comparisons with extensive regulatory datasets in developing fins—including gene expression, chromatin occupancy and three-dimensional conformation—we find skate-specific genomic rearrangements that alter the three-dimensional regulatory landscape of genes that are involved in the planar cell polarity pathway. Functional inhibition of planar cell polarity signalling resulted in a reduction in anterior fin size, confirming that this pathway is a major contributor to batoid fin morphology. We also identified a fin-specific enhancer that interacts with several hoxa genes, consistent with the redeployment of hox gene expression in anterior pectoral fins, and confirmed its potential to activate transcription in the anterior fin using zebrafish reporter assays. Our findings underscore the central role of genome reorganization and regulatory variation in the evolution of phenotypes, shedding light on the molecular origin of an enigmatic trait

River Restoration in Spain: Theoretical and Practical Approach in the Context of the European Water Framework Directive.

River restoration is becoming a priority in many countries because of increasing the awareness of environmental degradation. In Europe, the EU Water Framework Directive (WFD) has significantly reinforced river restoration, encouraging the improvement of ecological status for water bodies. To fulfill the WFD requirements, the Spanish Ministry of the Environment developed in 2006 a National Strategy for River Restoration whose design and implementation are described in this paper. At the same time many restoration projects have been conducted, and sixty of them have been evaluated in terms of stated objectives and pressures and implemented restoration measures. Riparian vegetation enhancement, weir removal and fish passes were the most frequently implemented restoration measures, although the greatest pressures came from hydrologic alteration caused by flow regulation for irrigation purposes. Water deficits in quantity and quality associated with uncontrolled water demands seriously affect Mediterranean rivers and represent the main constraint to achieving good ecological status of Spanish rivers, most of them intensively regulated. Proper environmental allocation of in-stream flows would need deep restrictions in agricultural water use which seem to be of very difficult social acceptance. This situation highlights the need to integrate land-use and rural development policies with water resources and river management, and identifies additional difficulties in achieving the WFD objectives and good ecological status of rivers in Mediterranean countries

Estrategias de estudio y trabajo en estudiantes universitarios de la UIB

El estudio se centra en el conocimiento de los procesos de aprendizaje que se desarrollan en la enseñanza superior, siendo su objetivo principal la evaluación de las estrategias de aprendizaje utilizadas por estudiantes universitarios a lo largo de su formación inicial. Responde a un diseño descriptivo-exploratorio, dirigido a las estrategias de estudio y trabajo de la población universitaria de la Universidad de las Islas Baleares (UIB). Para ello, se procedió a la elaboración de un cuestionario como instrumento de recogida de datos1 sobre estrategias de estudio y trabajo, categorizado en cuatro grupos de estrategias (disposicionales y de apoyo; de búsqueda, recogida y selección de información; de procesamiento y uso de información; metacognitivas, de regulación y control) y sus correspondientes subcategorías. Se trabajó con una muestra de 949 estudiantes de la UIB, clasificados por ámbitos disciplinares y estudios, agrupados en grandes dimensiones (sexo; estudios de ciclo corto y de ciclo largo; rama de estudios; dedicación al estudio y actividad laboral), aportando, para cada una de ellas los datos estadísticos en los que se constata una diferencia significativa.L’estudi està centrat en el coneixement dels processos d’aprenentatge que es desenvolupen a l’ensenyament superior, i el l’objectiu principal és l’avaluació de les estratègies d’aprenentatge utilitzades per estudiants universitaris al llarg de la seva formació inicial. Respon a un disseny descriptiu-exploratori, dirigit a les estratègies d’estudi i treball de la població universitària de la Universitat de les Illes Balears (UIB). En aquest sentit, es va confeccionar un qüestionari com a instrument de recollida de dades sobre estratègies d’estudi i treball, categoritzat en quatre grups d’estratègies (disposicionals i de suport; de cerca, recollida i selecció d’informació; de processament i ús d’informació; metacognitives, de regulació i control) i les subcategories corresponents. Es va treballar amb una mostra de 949 estudiants de la UIB, classificats per àmbits disciplinaris i estudis, agrupats en grans dimensions (sexe; estudis de cicle curt i de cicle llarg; branca d’estudis; dedicació a l’estudi i activitat laboral), que varen aportar, per a cadascuna, dades estadístiques en els quals es constata una diferència significativa.The study is focused on the knowledge of learning processes developed in Higher Education and the main objective is to assess the learning strategies of university students along their initial training. This is a response to a descriptive-exploratory design addressed to the learning and working strategies among the students of the University of the Balearic Islands (UIB). Regarding to this, a question paper was designed as a tool for the collection of data on the studying and working strategies sorted by four strategy groups (dispositional and backup groups; research, collection and selection of information; processing and use of information; metacognitive, regulation and control groups) with their respective subcategories. We took a sample of 949 students from the UIB, sorted by study and disciplinary areas, and we gathered them in larger-dimension groups (gender, shorter and longer degrees, field of study and commitment to studies and work). These groups provided, for each of the samples, statistical information in which an important difference is stated

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

Compelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food intake and energy expenditure. The anorectic effect of E2 is mainly mediated by its action on the arcuate nucleus (ARC), whereas its effects on brown adipose tissue (BAT) thermogenesis occur in the ventromedial nucleus (VMH). Here, we demonstrate that central E2 decreases hypothalamic ceramide levels and endoplasmic reticulum (ER) stress. Pharmacological or genetic blockade of ceramide synthesis and amelioration of ER stress selectively occurring in the VMH recapitulate the effect of E2, leading to increased BAT thermogenesis, weight loss, and metabolic improvement. These findings demonstrate that E2 regulation of ceramide-induced hypothalamic lipotoxicity and ER stress is an important determinant of energy balance, suggesting that dysregulation of this mechanism may underlie some changes in energy homeostasis seen in females.</p

Additional file 11 of Comparative 3D genome analysis between neural retina and retinal pigment epithelium reveals differential cis-regulatory interactions at retinal disease loci [Dataset]

Additional file 11. Peer review history.Ghent University European Commission Research Foundation - Flanders Junta de AndalucíaPeer reviewe