Real-Time and Low-Cost Sensing Technique Based on Photonic Bandgap Structures

This paper was published in OPTICS LETTERS and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OL.36.002707. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law[EN] A technique for the development of low-cost and high-sensitivity photonic biosensing devices is proposed and experimentally demonstrated. In this technique, a photonic bandgap structure is used as transducer, but its readout is performed by simply using a broadband source, an optical filter, and a power meter, without the need of obtaining the transmission spectrum of the structure; thus, a really low-cost system and real-time results are achieved. Experimental results show that it is possible to detect very low refractive index variations, achieving a detection limit below 2 x 10(-6) refractive index units using this low-cost measuring technique. (C) 2011 Optical Society of America[This work was funded by the Spanish Ministerio de Ciencia e Innovacion (MICINN) under contracts TEC2008-06333, JCI-009-5805, and TEC2008-05490. Support by the Universidad Politecnica de Valencia through program PAID-06-09 and the Conselleria d'Educacio through program GV-2010-031 is acknowledged.García Castelló, J.; Toccafondo, V.; Pérez Millán, P.; Sánchez Losilla, N.; Cruz, JL.; Andres, MV.; García-Rupérez, J. (2011). Real-Time and Low-Cost Sensing Technique Based on Photonic Bandgap Structures. Optics Letters. 36(14):2707-2709. https://doi.org/10.1364/OL.36.002707S270727093614Fan, X., White, I. M., Shopova, S. I., Zhu, H., Suter, J. D., & Sun, Y. (2008). Sensitive optical biosensors for unlabeled targets: A review. Analytica Chimica Acta, 620(1-2), 8-26. doi:10.1016/j.aca.2008.05.022Homola, J., Yee, S. S., & Gauglitz, G. (1999). Surface plasmon resonance sensors: review. Sensors and Actuators B: Chemical, 54(1-2), 3-15. doi:10.1016/s0925-4005(98)00321-9Kersey, A. D., Davis, M. A., Patrick, H. J., LeBlanc, M., Koo, K. P., Askins, C. G., … Friebele, E. J. (1997). Fiber grating sensors. Journal of Lightwave Technology, 15(8), 1442-1463. doi:10.1109/50.618377De Vos, K., Bartolozzi, I., Schacht, E., Bienstman, P., & Baets, R. (2007). Silicon-on-Insulator microring resonator for sensitive and label-free biosensing. Optics Express, 15(12), 7610. doi:10.1364/oe.15.007610Iqbal, M., Gleeson, M. A., Spaugh, B., Tybor, F., Gunn, W. G., Hochberg, M., … Gunn, L. C. (2010). Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation. IEEE Journal of Selected Topics in Quantum Electronics, 16(3), 654-661. doi:10.1109/jstqe.2009.2032510Xu, D.-X., Vachon, M., Densmore, A., Ma, R., Delâge, A., Janz, S., … Schmid, J. H. (2010). Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach. Optics Letters, 35(16), 2771. doi:10.1364/ol.35.002771Skivesen, N., Têtu, A., Kristensen, M., Kjems, J., Frandsen, L. H., & Borel, P. I. (2007). Photonic-crystal waveguide biosensor. Optics Express, 15(6), 3169. doi:10.1364/oe.15.003169Lee, M. R., & Fauchet, P. M. (2007). Nanoscale microcavity sensor for single particle detection. Optics Letters, 32(22), 3284. doi:10.1364/ol.32.003284García-Rupérez, J., Toccafondo, V., Bañuls, M. J., Castelló, J. G., Griol, A., Peransi-Llopis, S., & Maquieira, Á. (2010). Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime. Optics Express, 18(23), 24276. doi:10.1364/oe.18.024276Toccafondo, V., García-Rupérez, J., Bañuls, M. J., Griol, A., Castelló, J. G., Peransi-Llopis, S., & Maquieira, A. (2010). Single-strand DNA detection using a planar photonic-crystal-waveguide-based sensor. Optics Letters, 35(21), 3673. doi:10.1364/ol.35.003673Luff, B. J., Wilson, R., Schiffrin, D. J., Harris, R. D., & Wilkinson, J. S. (1996). Integrated-optical directional coupler biosensor. Optics Letters, 21(8), 618. doi:10.1364/ol.21.000618Sepúlveda, B., Río, J. S. del, Moreno, M., Blanco, F. J., Mayora, K., Domínguez, C., & Lechuga, L. M. (2006). Optical biosensor microsystems based on the integration of highly sensitive Mach–Zehnder interferometer devices. Journal of Optics A: Pure and Applied Optics, 8(7), S561-S566. doi:10.1088/1464-4258/8/7/s41Densmore, A., Vachon, M., Xu, D.-X., Janz, S., Ma, R., Li, Y.-H., … Schmid, J. H. (2009). Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection. Optics Letters, 34(23), 3598. doi:10.1364/ol.34.003598Povinelli, M. L., Johnson, S. G., & Joannopoulos, J. D. (2005). Slow-light, band-edge waveguides for tunable time delays. Optics Express, 13(18), 7145. doi:10.1364/opex.13.007145Garcia, J., Sanchis, P., Martinez, A., & Marti, J. (2008). 1D periodic structures for slow-wave induced non-linearity enhancement. Optics Express, 16(5), 3146. doi:10.1364/oe.16.003146Pérez-Millán, P., Torres-Peiró, S., Cruz, J. L., & Andrés, M. V. (2008). Fabrication of chirped fiber Bragg gratings by simple combination of stretching movements. Optical Fiber Technology, 14(1), 49-53. doi:10.1016/j.yofte.2007.07.00

Algebraic coarsening in voter models with intermediate states

The introduction of intermediate states in the dynamics of the voter model modifies the ordering process and restores an effective surface tension. The logarithmic coarsening of the conventional voter model in two dimensions is eliminated in favour of an algebraic decay of the density of interfaces with time, compatible with Model A dynamics at low temperatures. This phenomenon is addressed by deriving Langevin equations for the dynamics of appropriately defined continuous fields. These equations are analyzed using field theoretical arguments and by means of a recently proposed numerical technique for the integration of stochastic equations with multiplicative noise. We find good agreement with lattice simulations of the microscopic model.Comment: 11 pages, 5 figures; minor typos correcte

Real-time observation of antigen¿antibody association using a low-cost biosensing system based on photonic bandgap structures

This paper was published in OPTICS LETTERS and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OL.37.003684. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law[EN] In this letter, we present experimental results of antibody detection using a biosensor based on photonic bandgap structures, which are interrogated using a power-based readout technique. This interrogation method allows a realtime monitoring of the association process between the antigen probes and the target antibodies, allowing the instantaneous observation of any interaction event between molecules. because etunable lasers and optical spectrum analyzers are avoided for the readout, a drastic reduction of the final cost of the platform is obtained. Furthermore, the performance of the biosensing system is significantly enhanced due to the large number of data values obtained per second.This work was partially funded by the European Commission under contract FP7-295043-BELERA, from the Spanish Ministerio de Ciencia e Innovacion (MICINN) under contracts TEC2008-06333 and CTQ2010-15943 (subprogram BQU), and from Generalitat Valenciana through the PROMETEO grants 2010-008 and 2012-087.García Castelló, J.; Toccafondo, V.; Escorihuela Fuentes, J.; Bañuls Polo, MJ.; Maquieira Catala, Á.; García-Rupérez, J. (2012). Real-time observation of antigen¿antibody association using a low-cost biosensing system based on photonic bandgap structures. Optics Letters. 37(17):3684-3686. https://doi.org/10.1364/OL.37.003684S368436863717Luchansky, M. S., & Bailey, R. C. (2011). High-Q Optical Sensors for Chemical and Biological Analysis. Analytical Chemistry, 84(2), 793-821. doi:10.1021/ac2029024Qavi, A. J., & Bailey, R. C. (2010). Multiplexed Detection and Label-Free Quantitation of MicroRNAs Using Arrays of Silicon Photonic Microring Resonators. Angewandte Chemie International Edition, 49(27), 4608-4611. doi:10.1002/anie.201001712García-Rupérez, J., Toccafondo, V., Bañuls, M. J., Castelló, J. G., Griol, A., Peransi-Llopis, S., & Maquieira, Á. (2010). Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime. Optics Express, 18(23), 24276. doi:10.1364/oe.18.024276Toccafondo, V., García-Rupérez, J., Bañuls, M. J., Griol, A., Castelló, J. G., Peransi-Llopis, S., & Maquieira, A. (2010). Single-strand DNA detection using a planar photonic-crystal-waveguide-based sensor. Optics Letters, 35(21), 3673. doi:10.1364/ol.35.003673Claes, T., Molera, J. G., De Vos, K., Schacht, E., Baets, R., & Bienstman, P. (2009). Label-Free Biosensing With a Slot-Waveguide-Based Ring Resonator in Silicon on Insulator. IEEE Photonics Journal, 1(3), 197-204. doi:10.1109/jphot.2009.2031596Scullion, M. G., Di Falco, A., & Krauss, T. F. (2011). Slotted photonic crystal cavities with integrated microfluidics for biosensing applications. Biosensors and Bioelectronics, 27(1), 101-105. doi:10.1016/j.bios.2011.06.023Zlatanovic, S., Mirkarimi, L. W., Sigalas, M. M., Bynum, M. A., Chow, E., Robotti, K. M., … Grot, A. (2009). Photonic crystal microcavity sensor for ultracompact monitoring of reaction kinetics and protein concentration. Sensors and Actuators B: Chemical, 141(1), 13-19. doi:10.1016/j.snb.2009.06.007Sepúlveda, B., Río, J. S. del, Moreno, M., Blanco, F. J., Mayora, K., Domínguez, C., & Lechuga, L. M. (2006). Optical biosensor microsystems based on the integration of highly sensitive Mach–Zehnder interferometer devices. Journal of Optics A: Pure and Applied Optics, 8(7), S561-S566. doi:10.1088/1464-4258/8/7/s41Claes, T., Bogaerts, W., & Bienstman, P. (2011). Vernier-cascade label-free biosensor with integrated arrayed waveguide grating for wavelength interrogation with low-cost broadband source. Optics Letters, 36(17), 3320. doi:10.1364/ol.36.003320Zinoviev, K. E., Gonzalez-Guerrero, A. B., Dominguez, C., & Lechuga, L. M. (2011). Integrated Bimodal Waveguide Interferometric Biosensor for Label-Free Analysis. Journal of Lightwave Technology, 29(13), 1926-1930. doi:10.1109/jlt.2011.2150734Densmore, A., Vachon, M., Xu, D.-X., Janz, S., Ma, R., Li, Y.-H., … Schmid, J. H. (2009). Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection. Optics Letters, 34(23), 3598. doi:10.1364/ol.34.003598Castelló, J. G., Toccafondo, V., Pérez-Millán, P., Losilla, N. S., Cruz, J. L., Andrés, M. V., & García-Rupérez, J. (2011). Real-time and low-cost sensing technique based on photonic bandgap structures. Optics Letters, 36(14), 2707. doi:10.1364/ol.36.002707Krishnamoorthy, G., Bianca Beusink, J., & Schasfoort, R. B. M. (2010). High-throughput surface plasmon resonance imaging-based biomolecular kinetic screening analysis. Analytical Methods, 2(8), 1020. doi:10.1039/c0ay00112

Laboratorio de prácticas para la enseñanza de sistemas de control de tiempo real

El presente trabajo describe el diseño y desarrollo de un laboratorio de prácticas especialmente concebido para apoyar el aprendizaje en sistemas de control de tiempo real. La herramienta desarrollada permite realizar experiencias de control de tiempo real sobre un motor de corriente continua tanto en modo simulación (basado en el modelo del proceso) o bien realizando pruebas prácticas usando el motor físico. Así, mediante la asignación de periodos de muestreo, tiempos de cómputo de tareas y prioridades de ejecución, el usuario final de la aplicación (profesores y estudiantes) puede observar el comportamiento correcto o incorrecto del sistema de control permitiendo, por contraste, reafirmar los aspectos teóricos de la metodología de implementación de sistemas de tiempo real.Postprint (published version

Understanding the build-up of SMBH and Galaxies

Trabajo presentado a la Conferencia: Exploring the Hot and Energetic Universe: The first scientific conference dedicated to the Athena X-ray observatory; celebrada en Madrid (España) del 8 a 10 de septiembre de 2015.One of the main open questions in modern Astrophysics is understanding the coupled growth of supermassive black holes by accretion and their host galaxies via star formation, from their peak at redshifts z~ 1-4 to the present time. The generic scenario proposed involves an early phase of intense black hole growth that takes place behind large obscuring columns of inflowing dust and gas clouds. It is postulated that this is followed by a blow-out stage during which some form of AGN feedback controls the fate of the interstellar medium and hence, the evolution of the galaxy. X-rays are essential for testing this scenario as they uniquely probe AGN at both the early heavily obscured stage and the later blow-out phase. X-ray spectral analysis can identify the smoking gun evidence of heavily obscured black hole growth (e.g. intense iron Kalpha line). It therefore provides the most robust method for compiling clean samples of deeply shrouded AGN with well-defined selection functions and unbiased determinations of their intrinsic properties (accretion luminosity, obscuring column). X-rays are also the best window for studying in detail AGN feedback. This process ultimately originates in the innermost regions close to the supermassive black hole and is dominated, in terms of energy and mass flux, by highly ionised material that remains invisible at other wavelengths. The most important epoch for investigating the relation between AGN and galaxies is the redshift range z~1-4, when most black holes and stars we see in the present-day Universe were put in place. Unfortunately, exhaustive efforts with current high-energy telescopes only scrape the tip of the iceberg of the most obscured AGN population. Moreover, Xray studies of the incidence, nature and energetics of AGN feedback are limited to the local Universe. The Athena observatory will provide the technological leap required for a breakthrough in our understanding of AGN and galaxy evolution at the heyday of the Universe. The excellent survey capabilities of Athena/WFI (effective area, angular resolution, field of view) will allow to measure the incidence of feedback in the shape of warm absorbers and Ultra Fast Outflows among the general population of AGN, as well as to complete the census of black hole growth by detecting and characterising significant samples of the most heavily obscured (including Compton thick) AGN, to redshifts z~3-4. The outstanding spectral throughput and resolution of Athena/X-IFU will permit measuring the energetics of those outflows to assess their influence on their host galaxies. The demographics of the heavily obscured and outflowing populations relative to their hosts are fundamental for understanding how major black hole growth events relate to the build-up of galaxies.Peer Reviewe

Evolution of opinions on social networks in the presence of competing committed groups

Public opinion is often affected by the presence of committed groups of individuals dedicated to competing points of view. Using a model of pairwise social influence, we study how the presence of such groups within social networks affects the outcome and the speed of evolution of the overall opinion on the network. Earlier work indicated that a single committed group within a dense social network can cause the entire network to quickly adopt the group's opinion (in times scaling logarithmically with the network size), so long as the committed group constitutes more than about 10% of the population (with the findings being qualitatively similar for sparse networks as well). Here we study the more general case of opinion evolution when two groups committed to distinct, competing opinions $A$ and $B$, and constituting fractions $p_A$ and $p_B$ of the total population respectively, are present in the network. We show for stylized social networks (including Erd\H{o}s-R\'enyi random graphs and Barab\'asi-Albert scale-free networks) that the phase diagram of this system in parameter space $(p_A,p_B)$ consists of two regions, one where two stable steady-states coexist, and the remaining where only a single stable steady-state exists. These two regions are separated by two fold-bifurcation (spinodal) lines which meet tangentially and terminate at a cusp (critical point). We provide further insights to the phase diagram and to the nature of the underlying phase transitions by investigating the model on infinite (mean-field limit), finite complete graphs and finite sparse networks. For the latter case, we also derive the scaling exponent associated with the exponential growth of switching times as a function of the distance from the critical point.Comment: 23 pages: 15 pages + 7 figures (main text), 8 pages + 1 figure + 1 table (supplementary info

Statistical physics of language dynamics

Language dynamics is a rapidly growing field that focuses on all processes related to the emergence, evolution, change and extinction of languages. Recently, the study of self-organization and evolution of language and meaning has led to the idea that a community of language users can be seen as a complex dynamical system, which collectively solves the problem of developing a shared communication framework through the back-and-forth signaling between individuals. We shall review some of the progress made in the past few years and highlight potential future directions of research in this area. In particular, the emergence of a common lexicon and of a shared set of linguistic categories will be discussed, as examples corresponding to the early stages of a language. The extent to which synthetic modeling is nowadays contributing to the ongoing debate in cognitive science will be pointed out. In addition, the burst of growth of the web is providing new experimental frameworks. It makes available a huge amount of resources, both as novel tools and data to be analyzed, allowing quantitative and large-scale analysis of the processes underlying the emergence of a collective information and language dynamics

Corpora as open educational resources for language teaching

Corpora, large electronic collections of texts, have been used in language teaching for several decades. Also known as Data‐Driven Learning (DDL), this method has been gaining popularity because empirical research has consistently shown its effectiveness for learning. However, corpora are still underutilized, especially with learners of languages other than English, at lower proficiency levels, and in non‐university contexts. This is regrettable because DDL has a great potential for developing modular flipped content, especially for hybrid, remote, and online courses. This article first provides an overview of DDL applications and findings of empirical research. Next, it outlines obstacles to wider DDL implementation as well as available and possible solutions. Corpus user guides and exercise collections tied to specific corpora are discussed as one promising direction, and an example of such new open educational resources for teaching German is presented. The article concludes with a discussion of implications and future directions