Quiste óseo esencial: Resultados del tratamiento mediante punción intracavitaria con corticoides

Se presenta n los resultado s de l tratamient o de treint a quiste s óseo s esenciales mediante punción intracavitaria con acetato de metil-prednisolona. Se ha obtenido una respuesta favorable en el 93% de los casos con curación completa en el 77% de los casos. Estos resultados apoyan que debe ser el tratamiento inicial de elección en este tipo de lesiones.The results of 30 unicameral bone cyst treated by intracavitary injection of methylprednisolone acetate wer e reviewed. Satisfactory respons e was found in 93% of the cases. Complete restoration of bone architecture was observed in 77% of the cases. These results strongly support the local injection of steroids as the primary elective treatment for unicameral bone cyst

First data of Neandertal bird and carnivore exploitation in the Cantabrian Region (Axlor; Barandiaran excavations; Dima, Biscay, Northern Iberian Peninsula)

Neandertals were top predators who basically relied on middle-to large-sized ungulates for dietary purposes, but there is growing evidence that supports their consumption of plants, leporids, tortoises, marine resources, carnivores and birds. The Iberian Peninsula has provided the most abundant record of bird exploitation for meat in Europe, starting in the Middle Pleistocene. However, the bird and carnivore exploitation record was hitherto limited to the Mediterranean area of the Iberian Peninsula. Here we present the first evidence of bird and carnivore exploitation by Neandertals in the Cantabrian region. We have found cut-marks in two golden eagles, one raven, one Wolf and one lynx remain from the Mousterian levels of Axlor. The obtaining of meat was likely the primary purpose of the cut-marks on the golden eagle and lynx remains. Corvids, raptors, felids and canids in Axlor could have likely acted as commensals of the Neandertals, scavenging upon the carcasses left behind by these hunter-gatherers. This could have brought them closer to Neandertal groups who could have preyed upon them. These new results provide additional information on their dietary scope and indicate a more complex interaction between Neandertals and their environment

Zero Ripple Current with Coupled Inductors in Continuous Conduction Mode under PWM Signals

This article presents a generalized analysis to explain current ripple of an m windings coupled inductor with a given coupling factor k ij for each pair of windings and then studies more in detail its use in the continuous conduction mode and with pulsewidth modulated signals. To determine the current ripple, a generalized expression of the equivalent inductance of each winding is calculated, including the influence of voltage unbalance. In the ideal case, the equivalent inductance shows that the current ripple can only become m times smaller than that with uncoupled inductors. But in the unbalanced case, some divergences of the equivalent inductance appear that are responsible for zero ripple current. The proposed generalized expressions of the equivalent inductance also describe the current ripple of the new appearing intervals due to out-of-phase signals. An easy to design condition is proposed that achieves zero current ripple in all windings but one. Experimental results are provided that validate the presented theoretical expressions under the given conditions

Hemangioma intramuscular: (aportación de 6 casos y revisión de la literatura)

Se presentan seis casos de hemangioma intramuscular. Se discute la etiología, histopatología, métodos diagnósticos y el tratamiento óptimo. El tratamiento de elección debe ser la escisión ampliada siempre que ésta sea posible, siendo los resultados satisfactorios.Six cases of haemangioma arising in skeletal muscle are described. The aetiology, pathology, diagnosis and treatment of thes e tumours are discussed. Wide excision remains the treatment of choice whereve r possible with satisfactory results

Design of Zero-Ripple-Current Coupled Inductors with PWM signals in Continuous Conduction Mode

Coupled inductors are widely used in multiple outputs and interleaved dc-dc converters. Also filters often use coupled inductors as their inductive part. A generalized design procedure is proposed in this article focused on current ripple minimization and applicable to coupled inductors exposed to pulsewidth modulation signals and in continuous conduction mode. The design provides a very large inductance for all windings but one. Compared to other designs, it adapts to the existing magnetic properties of the magnetic device changing only the inductance ratio, simplifying the design and manufacturing process. It is based on the equivalent inductance value and its divergences. The only assumption applied is that the coupling coefficient among all windings is the same, which is an acceptable approximation in many magnetic core architectures. The theoretical results are experimentally verified. Not only almost zero ripple current is achieved, but also mass and volume is reduced compared to noncoupled inductors. This is an additional advantage of coupled inductors in mass and volume critical applications such as aerospace

Do Gender-Related Stereotypes Affect Spatial Performance? Exploring When, How and to Whom Using a Chronometric Two-Choice Mental Rotation Task

It is a common belief that males have superior visuospatial abilities and that differences in this and other cognitive domains (e.g., math) contribute to the reduced interest and low representation of girls and women in STEM education and professions. However, previous studies show that gender-related implicit associations and explicit beliefs, as well as situational variables, might affect cognitive performance in those gender-stereotyped domains and produce between-gender spurious differences. Therefore, the present study aimed to provide information on when, how and who might be affected by the situational reactivation of stereotypic gender-science beliefs/associations while performing a 3D mental rotation chronometric task (3DMRT). More specifically, we assessed the explicit beliefs and implicit associations (by the Implicit Association Test) held by female and male students of humanities and STEM majors and compared their performance in a 3DMRT after receiving stereotype- congruent, incongruent and nullifying experimental instructions. Our results show that implicit stereotypic gender-science associations correlate with 3DMRT performance in both females and males, but that inter-gender differences emerge only under stereotype-reactivating conditions. We also found that changes in self-confidence mediate these instructions’ effects and that academic specialization moderates them, hence promoting 3DMRT performance differences between male and female humanities, but not STEM, students. Taken together, these observations suggest that the common statement “males have superior mental rotation abilities” simplifies a much more complex reality and might promote stereotypes which, in turn, might induce artefactual performance differences between females and males in such tasks

Living Lab on improving groundwater governance in the Requena-Utiel aquifer

Resumen del trabajo presentado en el 7th IAHR Europe Congress, celebrado en Atenas (Grecia) del 07 al 09 de septiembre de 2022.The European research projects InTheMED and eGROUNDWATER share the aim of promoting innovative and sustainable management of the Mediterranean aquifers. One of the ways to achieve this objective is the creation of dynamic spaces in which all interested actors can cooperate, experiment and evaluate innovative ideas, different scenarios and new technologies on real cases of interest. In this regard, a living lab on improving groundwater governance, coordinated by the eGROUNDWATER team with the participation of the InTheMED team, was organized including all stakeholders who play a significant role in the management of the Requena-Utiel aquifer, which is a shared pilot site of the two projects. The aim of the living lab was to identify, together with stakeholders, problems and mitigation measures, and to evaluate possible strategies to satisfy the individual needs according to a sustainable use of the groundwater resources.Research financed by the InTheMED project, which is part of the PRIMA Programme supported by the European Union’s Horizon 2020 Research and Innovation Programme (GA n. 1923). It has also received funding from the eGROUNDWATER project (GA n. 1921), part of the PRIMA programme supported by the European Union’s Horizon 2020 research and innovation programme

The Koskobilo (Olazti, Navarre, Northern Iberian Peninsula) paleontological collection: New insights for the Middle and Late Pleistocene in Western Pyrenees

The destroyed site(s) of Koskobilo (Olazti, Navarre, Northern Iberian Peninsula) have yielded unique archaeo-paleontological evidence in the Western Pyrenees region. The quarry uncovered a karstic site with faunal remains in 1940, and fossils were recovered both in situ and from the quarry dump. Ten years later, while the quarry was still working, a new visit to the dump yielded a large lithic assemblage and additional fossil remains with a different taphonomic pattern, which has been interpreted as the remains coming from a different site or zone within the same karst system. Here we re-study the paleontological evidence and provide new dating on a speleothem covering a Stephanorhinus hemitoechus tooth, which has yielded a minimum date of c. 220 ka for part of the assemblage. In total, the fossil assemblage comprises 38 mammal and six avian taxa and three fish remains. The faunal evidence indicates that in 1940 a mix of taxa from both the Middle and Upper Pleistocene were recovered, and it is difficult to assign most of them to a concrete period. However, based on biochronological criteria some of the identified taxa (e.g., Ursus thibetanus, Ursus cf. deningeri, Cuon cf. priscus, Macaca sylvanus, cf. Megaceroides) could be roughly contemporaneous with the dated rhino tooth, which would provide a new window to the Middle Pleistocene of the region, with deposits from MIS 7d and/or older. Despite the difficulties in studying this collection, recovered without stratigraphic context and in a salvage operation, Koskobilo has yielded an important paleontological assemblage which helps to understand the paleoecology of the Middle Pleistocene human occupations in the Western Pyrenees

Artificial Intelligence on FDG PET Images Identifies Mild Cognitive Impairment Patients with Neurodegenerative Disease

[EN] The purpose of this project is to develop and validate a Deep Learning (DL) FDG PET imaging algorithm able to identify patients with any neurodegenerative diseases (Alzheimer's Disease (AD), Frontotemporal Degeneration (FTD) or Dementia with Lewy Bodies (DLB)) among patients with Mild Cognitive Impairment (MCI). A 3D Convolutional neural network was trained using images from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. The ADNI dataset used for the model training and testing consisted of 822 subjects (472 AD and 350 MCI). The validation was performed on an independent dataset from La Fe University and Polytechnic Hospital. This dataset contained 90 subjects with MCI, 71 of them developed a neurodegenerative disease (64 AD, 4 FTD and 3 DLB) while 19 did not associate any neurodegenerative disease. The model had 79% accuracy, 88% sensitivity and 71% specificity in the identification of patients with neurodegenerative diseases tested on the 10% ADNI dataset, achieving an area under the receiver operating characteristic curve (AUC) of 0.90. On the external validation, the model preserved 80% balanced accuracy, 75% sensitivity, 84% specificity and 0.86 AUC. This binary classifier model based on FDG PET images allows the early prediction of neurodegenerative diseases in MCI patients in standard clinical settings with an overall 80% classification balanced accuracy.This work was financially supported by INBIO 2019 (DEEPBRAIN), INNVA1/2020/83(DEEPPET) funded by Generalitat Valenciana, and PID2019-107790RB-C22 funded by MCIN/AEI/10.13039/501100011033/. Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: AbbVie, Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org).The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Therapeutic Research Institute at the University of Southern California. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of Southern California.Prats-Climent, J.; Gandia-Ferrero, MT.; Torres-Espallardo, I.; Álvarez-Sanchez, L.; Martinez-Sanchis, B.; Cháfer-Pericás, C.; Gómez-Rico, I.... (2022). Artificial Intelligence on FDG PET Images Identifies Mild Cognitive Impairment Patients with Neurodegenerative Disease. Journal of Medical Systems. 46(8):1-13. https://doi.org/10.1007/s10916-022-01836-w11346