Artefactos inéditos del paleolítico antiguo hallados en el territorio de Álava

En el presente trabajo se estudia un conjunto de cantos tallados, artefactos sobre lasca, núcleos y productos brutos de talla, en lutita, procedentes de los embalses de Urrúnaga y Ullibarri-Gamboa (Álava). Las características morfotécnicas de los instrumentos los sitúa en una etapa tardía dentro del Achelense Superior

La actividad pecuaria en la Rioja alavesa durante la prehistoria reciente

Se documenta la actividad pastoril en La Rioja Alavesa, desde el Neolítico, por el análisis de cuevas redil.-----------------The activity pastoril is documented in La Rioja from Álava, from the Neolithic one, for the analysis of sheepfold caves

El abrigo de Peña Parda (Laguardia - Álava) y su relleno arqueológico

Se presentan los resultados de las campañas de sondeo desarrolladas en el abrigo de Peña Parda (Laguardia, Álava) durante los años 1997-1998, así como el estudio pormenorizado del ajuar recuperado, que sitúa el yacimiento en una cronología del Calcolítico-Bronce Medio

Characterization of two second-site mutations preventing wild type protein aggregation caused by a dominant negative PMA1 mutant

The correct biogenesis and localization of Pma1 at the plasma membrane is essential for yeast growth. A subset of PMA1 mutations behave as dominant negative because they produce aberrantly folded proteins that form protein aggregates, which in turn provoke the aggregation of the wild type protein. One approach to understand this dominant negative effect is to identify second-site mutations able to suppress the dominant lethal phenotype caused by those mutant alleles. We isolated and characterized two intragenic second-site suppressors of the PMA1-D378T dominant negative mutation. We present here the analysis of these new mutations that are located along the amino-terminal half of the protein and include a missense mutation, L151F, and an in-frame 12bp deletion that eliminates four residues from Cys409 to Ala412. The results show that the suppressor mutations disrupt the interaction between the mutant and wild type enzymes, and this enables the wild type Pma1 to reach the plasma membraneThis work was supported by the Spanish Ministerio de Ciencia e Innovación Grant BFU2008-0428

Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP

STUDY OBJECTIVES: This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy. DESIGN: Observational study, before and after CPAP therapy. SETTING AND PATIENTS: We studied 30 patients with apnoea/hypopnoea index (AHI) >15/h that were compared with themselves after three months of CPAP therapy. FMD was assessed non-invasively in vivo using the Laser-Doppler flowmetry. Circulating cell-free DNA (cf-DNA) and microparticles (MPs) were measured as markers of endothelial damage and the vascular endothelial growth factor (VEGF) was determined as a marker of endothelial restoration process. MEASUREMENTS AND RESULTS: After three month with CPAP, FMD significantly increased (1072.26 ± 483.21 vs. 1604.38 ± 915.69 PU, p< 0.005) cf-DNA and MPs significantly decreased (187.93 ± 115.81 vs. 121.28 ± 78.98 pg/ml, p<0.01, and 69.60 ± 62.60 vs. 39.82 ± 22.14 U/μL, p<0.05, respectively) and VEGF levels increased (585.02 ± 246.06 vs. 641.11 ± 212.69 pg/ml, p<0.05). These changes were higher in patients with more severe disease. There was a relationship between markers of damage (r = -0.53, p<0.005) but not between markers of damage and restoration, thus suggesting that both types of markers should be measured together. CONCLUSIONS: CPAP therapy improves FMD. This improvement may be related to an increase of endothelial restoration process and a decrease of endothelial damage

Evolution of transport under cumulative damage in metro systems

One dominant aspect of cities is transport and massive passenger mobilization which remains a challenge with the increasing demand on the public as cities grow. In addition, public transport infrastructure suffers from traffic congestion and deterioration, reducing its efficiency. In this paper, we study the capacity of transport in 33 worldwide metro systems under the accumulation of damage. We explore the gradual reduction of functionality in these systems associated with damage that occurs stochastically. The global transport of each network is modeled as the diffusive movement of Markovian random walkers on networks considering the capacity of transport of each link, where these links are susceptible to damage. Monte Carlo simulations of this process in metro networks show the evolution of the functionality of the system under damage considering all the complexity in the transportation structure. This information allows us to compare and classify the effect of damage in metro systems. Our findings provide a general framework for the characterization of the capacity to maintain the transport under failure in different systems described by networks.Comment: 9 pages; 4 figure

Evaluation of the agronomic performance of 'Syrah' and 'Tempranillo' when grafted on 12 rootstocks

Beyond pest resistance, rootstocks significantly influence the performance of grapevine varieties. However, the effect of the rootstock is strongly affected by its interaction with the environment, and it is therefore necessary to evaluate their influence in a particular terroir. With the aim of evaluating the influence of 12 rootstocks on the agronomic performance of 'Syrah' and 'Tempranillo', a trial was established in 2011 and 2012 in Miranda de Arga (Navarra, Spain), under the typical environmental conditions of the Ebro Valley. Growth and yield, as well as industrial and phenolic maturity parameters were analysed during four consecutive seasons (2015-2018). Most rootstocks showed a similar performance with both varieties, not always following the trends reported in bibliography, which highlights the relevance of studying rootstocks in different conditions. 3309 C was the rootstock conferring the highest vigour, whereas the lowest were provided by 420 A MGt and 'Fercal'. The implications on grape composition were much more diverse, and were partially conditioned by yield. Results were obtained during the four first harvests of the vineyard, and could therefore change to some extent as the vineyard reaches stability

Identification of gastric cancer from speckle patterns

Speckle technique is based on the light intensity distribution randomly formed when a laser light is reflected on a rough surface, creating a pattern of illuminated grains (constructively) and dark (destructive) on scales of 1 μm. When the samples are displaced or deformed, the speckle pattern is altered. In this paper we present speckle patterns obtained from samples of gastric mucosa that is physically altered for the carcinogenesis process. Biopsies were studied with different diagnoses and were grouped according to the characteristics of speckle patterns. Speckle patterns were obtained by illuminating the samples with green laser. Morphological parameters of the speckle patterns reveal existence of 3 descriptors: the average grain size, hydraulic radius and the radio of the Weddel disc, which showed a high, intermediate and low value. The comparison shows agreement between the histopathological diagnosis and the values obtained by the speckle technique, making this technique emerge as a new classification system for quantitative diagnosis of precancerous lesions.Facultad de Ingenierí

Identification of gastric cancer from speckle patterns

Speckle technique is based on the light intensity distribution randomly formed when a laser light is reflected on a rough surface, creating a pattern of illuminated grains (constructively) and dark (destructive) on scales of 1 μm. When the samples are displaced or deformed, the speckle pattern is altered. In this paper we present speckle patterns obtained from samples of gastric mucosa that is physically altered for the carcinogenesis process. Biopsies were studied with different diagnoses and were grouped according to the characteristics of speckle patterns. Speckle patterns were obtained by illuminating the samples with green laser. Morphological parameters of the speckle patterns reveal existence of 3 descriptors: the average grain size, hydraulic radius and the radio of the Weddel disc, which showed a high, intermediate and low value. The comparison shows agreement between the histopathological diagnosis and the values obtained by the speckle technique, making this technique emerge as a new classification system for quantitative diagnosis of precancerous lesions.Facultad de Ingenierí

Three-dimensional airway volumes and most constricted areas in children

poster abstractObjective: The objectives of this retrospective study using cone beam computed tomography (CBCT) were to determine if there are differences in the volume of various airway segments and the most constricted area (MCA) of children with different dentoskeletal patterns. Methods: The initial CBCTs of 83 orthodontic patients (30 Angle’s Class I; 26 Class II; and 27 Class III) were collected from a private orthodontic office. Following reliability studies, various parameters of the craniofacial complex, airway volume, and MCA were measured utilizing Dolphin 3D software. Comparisons among the three dental and the skeletal malocclusion classes were performed using one-way ANOVA and Fishers Protected Least Significant. Associations of the airway volumes and the MCA with other parameters were determined using correlation coefficients, accepting p < 0.05 as significant for all tests. Results: Maxillary right sinus volume was the only airway segment showing significant difference among different dental classes. Maxillary sinus volume also correlated moderately with anterior facial height and mandibular length. No significant differences were found between the MCA and different dentoskeletal classifications. Conclusions: The only significant difference in airway parameters among the dentoskeletal classes was that the dental Class II subjects had greater right sinus volume than the other classes. Shorter anterior facial height or mandibular length could be indicators for decreased airway volume in children. Funding: IUSD Graduate Research Committee, IUPUI Three-Dimensional Imaging of the Craniofacial Complex Center, Jarabak Endowed Professorshi