510 research outputs found
Identifying Overlapping and Hierarchical Thematic Structures in Networks of Scholarly Papers: A Comparison of Three Approaches
We implemented three recently proposed approaches to the identification of
overlapping and hierarchical substructures in graphs and applied the
corresponding algorithms to a network of 492 information-science papers coupled
via their cited sources. The thematic substructures obtained and overlaps
produced by the three hierarchical cluster algorithms were compared to a
content-based categorisation, which we based on the interpretation of titles
and keywords. We defined sets of papers dealing with three topics located on
different levels of aggregation: h-index, webometrics, and bibliometrics. We
identified these topics with branches in the dendrograms produced by the three
cluster algorithms and compared the overlapping topics they detected with one
another and with the three pre-defined paper sets. We discuss the advantages
and drawbacks of applying the three approaches to paper networks in research
fields.Comment: 18 pages, 9 figure
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Light-triggered CO release from nanoporous non-wovens
The water insoluble and photoactive CO releasing molecule dimanganese decacarbonyl (CORM-1) has been non-covalently embedded into poly(l-lactide-co-d/ l-lactide) fibers via electrospinning to enable bioavailability and water accessibility of CORM-1. SEM images of the resulting hybrid non-wovens reveal a nanoporous fiber morphology. Slight CO release from the CORM-1 in the electrospinning process induces nanoporosity. IR spectra show the same set of carbonyl bands for the CORM-1 precursor and the non-woven. When the material was exposed to light (365-480 nm), CO release from the incorporated CORM-1 was measured via heterogeneous myoglobin assay, a portable CO electrode and an IR gas cuvette. The CO release rate was wavelength dependent. Irradiation at 365 nm resulted in four times faster release than at 480 nm. 3.4 μmol of CO per mg non-woven can be generated. Mouse fibroblast 3T3 cells were used to show that the hybrid material is non-toxic in the darkness and strongly photocytotoxic when light is applied
Применение тонкослойной хроматографии для индентификации дифенгидрамина гидрохлорида и прокаина гидрохлорида при их совместном присутствии
ТЕХНОЛОГИЯ ФАРМАЦЕВТИЧЕСКАЯДИМЕДРОЛНОВОКАИНХРОМАТОГРАФИЯ ТОНКОСЛОЙНАЯ /ИС
Measurement of the Transverse Beam Spin Asymmetry in Elastic Electron Proton Scattering and the Inelastic Contribution to the Imaginary Part of the Two-Photon Exchange Amplitude
We report on a measurement of the asymmetry in the scattering of transversely
polarized electrons off unpolarized protons, A, at two Q values of
\qsquaredaveragedlow (GeV/c) and \qsquaredaveragedhighII (GeV/c) and a
scattering angle of . The measured transverse
asymmetries are A(Q = \qsquaredaveragedlow (GeV/c)) =
(\experimentalasymmetry alulowcorr \statisticalerrorlow
\combinedsyspolerrorlowalucor) 10 and
A(Q = \qsquaredaveragedhighII (GeV/c)) = (\experimentalasymme
tryaluhighcorr \statisticalerrorhigh
\combinedsyspolerrorhighalucor) 10. The first
errors denotes the statistical error and the second the systematic
uncertainties. A arises from the imaginary part of the two-photon
exchange amplitude and is zero in the one-photon exchange approximation. From
comparison with theoretical estimates of A we conclude that
N-intermediate states give a substantial contribution to the imaginary
part of the two-photon amplitude. The contribution from the ground state proton
to the imaginary part of the two-photon exchange can be neglected. There is no
obvious reason why this should be different for the real part of the two-photon
amplitude, which enters into the radiative corrections for the Rosenbluth
separation measurements of the electric form factor of the proton.Comment: 4 figures, submitted to PRL on Oct.
Evidence for Strange Quark Contributions to the Nucleon's Form Factors at = 0.108 (GeV/c)
We report on a measurement of the parity violating asymmetry in the elastic
scattering of polarized electrons off unpolarized protons with the A4 apparatus
at MAMI in Mainz at a four momentum transfer value of = \Qsquare
(GeV/c) and at a forward electron scattering angle of 30. The measured asymmetry is = (\Aphys
\Deltastat \Deltasyst) 10. The
expectation from the Standard Model assuming no strangeness contribution to the
vector current is A = (\Azero \DeltaAzero) 10. We
have improved the statistical accuracy by a factor of 3 as compared to our
previous measurements at a higher . We have extracted the strangeness
contribution to the electromagnetic form factors from our data to be +
\FakGMs = \GEsGMs \DeltaGEsGMs at = \Qsquare (GeV/c).
As in our previous measurement at higher momentum transfer for + 0.230
, we again find the value for + \FakGMs to be positive,
this time at an improved significance level of 2 .Comment: 4 pages, 3 figure
Hard Two-Photon Contribution to Elastic Lepton-Proton Scattering: Determined by the OLYMPUS Experiment
The OLYMPUS collaboration reports on a precision measurement of the
positron-proton to electron-proton elastic cross section ratio, ,
a direct measure of the contribution of hard two-photon exchange to the elastic
cross section. In the OLYMPUS measurement, 2.01~GeV electron and positron beams
were directed through a hydrogen gas target internal to the DORIS storage ring
at DESY. A toroidal magnetic spectrometer instrumented with drift chambers and
time-of-flight scintillators detected elastically scattered leptons in
coincidence with recoiling protons over a scattering angle range of to . The relative luminosity between the two beam species
was monitored using tracking telescopes of interleaved GEM and MWPC detectors
at , as well as symmetric M{\o}ller/Bhabha calorimeters at
. A total integrated luminosity of 4.5~fb was collected. In
the extraction of , radiative effects were taken into account
using a Monte Carlo generator to simulate the convolutions of internal
bremsstrahlung with experiment-specific conditions such as detector acceptance
and reconstruction efficiency. The resulting values of , presented
here for a wide range of virtual photon polarization ,
are smaller than some hadronic two-photon exchange calculations predict, but
are in reasonable agreement with a subtracted dispersion model and a
phenomenological fit to the form factor data.Comment: 5 pages, 3 figures, 2 table
RNase 7 Contributes to the Cutaneous Defense against Enterococcus faecium
Background: Human skin is able to mount a fast response against invading microorganisms by the release of antimicrobial proteins such as the ribonuclease RNase 7. Because RNase 7 exhibits high activity against Enterococcus faecium the aim of this study was to further explore the role of RNase 7 in the cutaneous innate defense system against E. faecium. Methodology/Principal Findings: Absolute quantification using real-time PCR and ELISA revealed that primary keratinocytes expressed high levels of RNase 7. Immunohistochemistry showed RNase 7 expression in all epidermal layers of the skin with an intensification in the upper more differentiated layers. Furthermore, RNase 7 was secreted by keratinocytes in vitro and in vivo in a site-dependent way. RNase 7 was still active against E. faecium at low pH (5.5) or high NaCl (150 mM) concentration and the bactericidal activity of RNase 7 against E. faecium required no ribonuclease activity as shown by recombinant RNase 7 lacking enzymatic activity. To further explore the role of RNase 7 in cutaneous defense against E. faecium, we investigated whether RNase 7 contributes to the E. faecium killing activity of skin extracts derived from stratum corneum. Treatment of the skin extract with an RNase 7 specific antibody, which neutralizes the antimicrobial activity of RNase 7, diminished its E. faecium killing activity. Conclusions/Significance: Our data indicate that RNase 7 contributes to the E. faecium-killing activity of skin extracts an
Microscopic dynamics in liquid metals: the experimental point of view
The experimental results relevant for the understanding of the microscopic
dynamics in liquid metals are reviewed, with special regards to the ones
achieved in the last two decades. Inelastic Neutron Scattering played a major
role since the development of neutron facilities in the sixties. The last ten
years, however, saw the development of third generation radiation sources,
which opened the possibility of performing Inelastic Scattering with X rays,
thus disclosing previously unaccessible energy-momentum regions. The purely
coherent response of X rays, moreover, combined with the mixed
coherent/incoherent response typical of neutron scattering, provides enormous
potentialities to disentangle aspects related to the collectivity of motion
from the single particle dynamics.
If the last twenty years saw major experimental developments, on the
theoretical side fresh ideas came up to the side of the most traditional and
established theories. Beside the raw experimental results, therefore, we review
models and theoretical approaches for the description of microscopic dynamics
over different length-scales, from the hydrodynamic region down to the single
particle regime, walking the perilous and sometimes uncharted path of the
generalized hydrodynamics extension. Approaches peculiar of conductive systems,
based on the ionic plasma theory, are also considered, as well as kinetic and
mode coupling theory applied to hard sphere systems, which turn out to mimic
with remarkable detail the atomic dynamics of liquid metals. Finally, cutting
edges issues and open problems, such as the ultimate origin of the anomalous
acoustic dispersion or the relevance of transport properties of a conductive
systems in ruling the ionic dynamic structure factor are discussed.Comment: 53 pages, 41 figures, to appear in "The Review of Modern Physics".
Tentatively scheduled for July issu
Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine
Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important role as effector agents of the innate immune system. The AMP era was born more than 6 decades ago when the first cationic cyclic peptide antibiotics, namely polymyxins and tyrothricin, found their way into clinical use. Due to the good clinical experience in the treatment of, for example, infections of mucus membranes as well as the subsequent understanding of mode of action, AMPs are now considered for treatment of inflammatory skin diseases and for improving healing of infected wounds. Based on the preclinical findings, including pathobiochemistry and molecular medicine, targeted therapy strategies are developed and first results indicate that AMPs influence processes of diseased skin. Importantly, in contrast to other antibiotics, AMPs do not seem to propagate the development of antibiotic-resistant micro-organisms. Therefore, AMPs should be tested in clinical trials for their efficacy and tolerability in inflammatory skin diseases and chronic wounds. Apart from possible fields of application, these peptides appear suited as an example of the paradigm of translational medicine for skin diseases which is today seen as a `two-way road' - from bench to bedside and backwards from bedside to bench. Copyright (c) 2012 S. Karger AG, Base
Measurement of the parity violating asymmetry in the quasielastic electron-deuteron scattering and improved determination of the magnetic strange form factor and the isovector anapole radiative correction
A new measurement of the parity-violating asymmetry in the electron-deuteron quasielastic scattering for backward angles at ⟨Q[superscript 2]⟩=0.224 (GeV/c)[superscript 2], obtained in the A4 experiment at the Mainz Microtron accelerator (MAMI) facility, is presented. The measured asymmetry is A[subscript PV][superscript d]=(-20.11±0.87[subscript stat]±1.03[subscript sys])×10[superscript -6]. A combination of these data with the proton measurements of the parity-violating asymmetry in the A4 experiment yields a value for the effective isovector axial-vector form factor of G[subscript A][superscript e,(T=1)]=-0.19±0.43 and R[subscript A][superscript e(T=1),anap] =-0.41±0.35 for the anapole radiative correction. When combined with a reanalysis of measurements obtained in the G0 experiment at the Thomas Jefferson National Accelerator Facility, the uncertainties are further reduced to G[subscript M][superscript s]=0.17±0.11 for the magnetic strange form factors, and R[subscript A][superscript (T=1),anap]=-0.54±0.26.Deutsche Forschungsgemeinschaf
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