Recoil velocity at 2PN order for spinning black hole binaries

We compute the flux of linear momentum carried by gravitational waves emitted from spinning binary black holes at 2PN order for generic orbits. In particular we provide explicit expressions of three new types of terms, namely next-to-leading order spin-orbit terms at 1.5 PN order, spin-orbit tail terms at 2PN order, and spin-spin terms at 2PN order. Restricting ourselves to quasi-circular orbits, we integrate the linear momentum flux over time to obtain the recoil velocity as function of orbital frequency. We find that in the so-called superkick configuration the higher-order spin corrections can increase the recoil velocity up to about a factor 3 with respect to the leading-order PN prediction. Furthermore, we provide expressions valid for generic orbits, and accurate at 2PN order, for the energy and angular momentum carried by gravitational waves emitted from spinning binary black holes. Specializing to quasi-circular orbits we compute the spin-spin terms at 2PN order in the expression for the evolution of the orbital frequency and found agreement with Mik\'oczi, Vas\'uth and Gergely. We also verified that in the limit of extreme mass ratio our expressions for the energy and angular momentum fluxes match the ones of Tagoshi, Shibata, Tanaka and Sasaki obtained in the context of black hole perturbation theory.Comment: 28 pages (PRD format), 1 figure, reference added, version published in PRD, except that the PRD version contains a sign error: the sign of the RHS of Eqs.(4.26) and (4.27) is wrong; it has been corrected in this replacemen

Effect of cell shape change on the function and differentiation of rabbit mammary cells in culture

We examined the role of cell shape, cytodifferentiation, and tissue topography on the induction and maintenance of functional differentiation in rabbit mammary cells grown as primary cultures on two-dimensional collagen surfaces or in three-dimensional collagen matrices. Mammary glands from mid-pregnant rabbits were dissociated into single cells, and epithelial cells were enriched by isopycnic centrifugation. Small spheroids of epithelial cells (approximately 50 cells) that formed on a rotary shaker were plated on or embedded in collagen gels. The cells were cultured for 1 d in serum-containing medium and then for up to 25 d in chemically defined medium. In some experiments, epithelial monolayers on gels were mechanically freed from the dishes on day 2 or 5. These gels retracted and formed floating collagen gels. On attached collagen gels, flat monolayers of a single cell type developed within a few days. The cells synthesized DNA until the achievement of confluence but did not accumulate milk proteins. No morphological changes were induced by prolactin (PRL). On floating gels, two cell types appeared in the absence of cell proliferation. The cells in direct contact with the medium became cuboidal and developed intracellular organelles typical of secretory cells. PRL-induced lipogenesis, resulting in large fat droplets filling the apical cytoplasm and accumulation of casein and α-lactalbumin in vesicles surrounding the fat droplets. We detected tranferrin in the presence or absence of PRL intracellularly in small vesicles but also in the collagen matrix in contact with the cell layer. The second cell type, rich in microfilaments and reminiscent of the myoepithelial cells, was situated between the secretory cell layer and the collagen matrix. In embedding gels, the cells formed hollow ductlike structures, which grew continuously in size. Secretory cells formed typical lumina distended by secretory products. We found few microfilament-rich cells in contact with the collagen gels. Storage and secretion of fat, caseins and alpha-lactalbumin required the presence of PRL, whereas the accumulation and vectorial discharge of transferrin was prolactin independent. There was no differentiation gradient between the tip and the cent of the outgrowth, since DNA synthesis and milk protein storage were random along the tubular structures. These results indicate that establishment of functional polarity and induction of cytodifferentiation are influenced by the nature of the interaction of the cells with the collagen structure. The morphological differentiation in turn plays an important role in the synthesis, storage, and secretion of fat and milk proteins

Physicians' attitudes toward medical and ethical challenges for patients in the vegetative state: comparing Canadian and German perspectives in a vignette survey

Background: Physicians treating patients in the vegetative state (VS) must deal with uncertainty in diagnosis and prognosis, as well as ethical issues. We examined whether physicians' attitudes toward medical and ethical challenges vary across two national medical practice settings. Methods: A comparative survey was conducted among German and Canadian specialty physicians, based on a case vignette about the VS. Similarities and differences of participants' attitudes toward medical and ethical challenges between the two samples were analyzed with non-parametric tests (Mann-Whitney-U-Test). Results: The overall response rate was 13.4%. Eighty percent of all participants correctly applied the diagnostic category of VS with no significant differences between countries. Many of the participants who chose the correct diagnosis of VS attributed capabilities to the patient, particularly the ability to feel pain (70%), touch (51%) and to experience hunger and thirst (35%). A large majority of participants (94%) considered the limitation of life-sustaining treatment (LST) under certain circumstances, but more Canadian participants were in favor of always limiting LST (32% vs. 12%; Chi-square: p < 0.001). Finding long-term care placement was considered more challenging by Canadian participants whereas discontinuing LST was much more challenging for German participants. Conclusions: Differences were found between two national medical practice settings with respect to physicians' experiences and attitudes about treatment limitation about VS in spite of comparable diagnostic knowledge

Hamiltonian of a spinning test-particle in curved spacetime

Using a Legendre transformation, we compute the unconstrained Hamiltonian of a spinning test-particle in a curved spacetime at linear order in the particle spin. The equations of motion of this unconstrained Hamiltonian coincide with the Mathisson-Papapetrou-Pirani equations. We then use the formalism of Dirac brackets to derive the constrained Hamiltonian and the corresponding phase-space algebra in the Newton-Wigner spin supplementary condition (SSC), suitably generalized to curved spacetime, and find that the phase-space algebra (q,p,S) is canonical at linear order in the particle spin. We provide explicit expressions for this Hamiltonian in a spherically symmetric spacetime, both in isotropic and spherical coordinates, and in the Kerr spacetime in Boyer-Lindquist coordinates. Furthermore, we find that our Hamiltonian, when expanded in Post-Newtonian (PN) orders, agrees with the Arnowitt-Deser-Misner (ADM) canonical Hamiltonian computed in PN theory in the test-particle limit. Notably, we recover the known spin-orbit couplings through 2.5PN order and the spin-spin couplings of type S_Kerr S (and S_Kerr^2) through 3PN order, S_Kerr being the spin of the Kerr spacetime. Our method allows one to compute the PN Hamiltonian at any order, in the test-particle limit and at linear order in the particle spin. As an application we compute it at 3.5PN order.Comment: Corrected typo in the ADM Hamiltonian at 3.5 PN order (eq. 6.20

On-sky observations with an achromatic hybrid phase knife coronagraph in the visible

CONTEXT: The four-quadrant phase mask stellar coronagraph, introduced by D. Rouan et al., is capable of achieving very high dynamical range imaging and was studied in the context of the direct detection of extra-solar planets. Achromatic four-quadrant phase mask is currently being developed for broadband IR applications. AIMS: We report on laboratory and on-sky tests of a prototype coronagraph in the visible. This prototype, the achromatic hybrid phase knife coronagraph, was derived from the four-quadrant phase mask principle. METHODS: The instrumental setup implementing the coronagraph itself was designed to record the pre- and post-coronagraphic images simultaneously so that an efficient real-time image selection procedure can be performed. We describe the coronagraph and the associated tools that enable robust and repeatable observations. We present an algorithm of image selection that has been tested against the real on-sky data of the binary star HD80081 (* 38 Lyn). RESULTS Although the observing conditions were poor, the efficiency of the proposed method is proven. From this experiment, we derive procedures that can apply to future focal instruments associating adaptive optics and coronagraphy, targeting high dynamic range imaging in astronomy, such as detecting extra-solar planets

Dietary Sodium Restriction Reverses Vascular Endothelial Dysfunction in Middle-Aged/Older Adults With Moderately Elevated Systolic Blood Pressure

ObjectivesThis study sought to determine the efficacy of dietary sodium restriction (DSR) for improving vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure (SBP) (130–159 mm Hg) and the associated physiological mechanisms.BackgroundVascular endothelial dysfunction develops with advancing age and elevated SBP, contributing to increased cardiovascular risk. DSR lowers BP, but its effect on vascular endothelial function and mechanisms involved are unknown.MethodsSeventeen subjects (11 men and 6 women; mean age, 62 ± 7 years) completed a, randomized crossover study of 4 weeks of both low (DSR) and normal sodium intake. Vascular endothelial function (endothelium-dependent dilation; EDD), nitric oxide (NO)/tetrahydrobiopterin (BH4) bioavailability, and oxidative stress-associated mechanisms were assessed following each condition.ResultsUrinary sodium excretion was reduced by ∼50% (to 70 ± 30 mmol/day), and conduit (brachial artery flow-mediated dilation [FMDBA]) and resistance (forearm blood flow responses to acetylcholine [FBFACh]) artery EDD were 68% and 42% (peak FBFACh) higher following DSR (p < 0.005). Low sodium markedly enhanced NO-mediated EDD (greater ΔFBFACh with endothelial NO synthase inhibition) without changing endothelial NO synthase expression/activation (Ser 1177 phosphorylation), restored BH4 bioactivity (less ΔFMDBA with acute BH4), abolished tonic superoxide suppression of EDD (less ΔFMDBA and ΔFBFACh with ascorbic acid infusion), and increased circulating superoxide dismutase activity (all p < 0.05). These effects were independent of ΔSBP. Other subject characteristics/dietary factors and endothelium-independent dilation were unchanged.ConclusionsDSR largely reversed both macro- and microvascular endothelial dysfunction by enhancing NO and BH4 bioavailability and reducing oxidative stress. Our findings support the emerging concept that DSR induces “vascular protection” beyond that attributable to its BP-lowering effects

UK science press officers, professional vision and the generation of expectations

Science press officers can play an integral role in helping promote expectations and hype about biomedical research. Using this as a starting point, this article draws on interviews with 10 UK-based science press officers, which explored how they view their role as science reporters and as generators of expectations. Using Goodwin’s notion of ‘professional vision’, we argue that science press officers have a specific professional vision that shapes how they produce biomedical press releases, engage in promotion of biomedical research and make sense of hype. We discuss how these insights can contribute to the sociology of expectations, as well as inform responsible science communication.This project was funded by the Wellcome Trust (Wellcome Trust Biomedical Strategic Award 086034)

On The Halo-Mass And Radial Scale Dependence Of The Lensing Is Low Effect

The canonical Lambda cold dark matter (ΛCDM) cosmological model makes precise predictions for the clustering and lensing properties of galaxies. It has been shown that the lensing amplitude of galaxies in the Baryon Oscillation Spectroscopic Survey (BOSS) is lower than expected given their clustering properties. We present new measurements and modelling of galaxies in the BOSS LOWZ sample. We focus on the radial and stellar mass dependence of the lensing amplitude mismatch. We find an amplitude mismatch of around 35 per cent when assuming ΛCDM with Planck Cosmological Microwave Background (CMB) constraints. This offset is independent of halo mass and radial scale in the range Mhalo ∼ 1013.3−1013.9h−1 M⊙ and r=0.1−60h−1Mpc (⁠k≈0.05−20hMpc−1⁠). The observation that the offset is both mass and scale independent places important constraints on the degree to which astrophysical processes (baryonic effects, assembly bias) can fully explain the effect. This scale independence also suggests that the ‘lensing is low’ effect on small and large radial scales probably have the same physical origin. Resolutions based on new physics require a nearly uniform suppression, relative to ΛCDM predictions, of the amplitude of matter fluctuations on these scales. The possible causes of this are tightly constrained by measurements of the CMB and of the low-redshift expansion history

A small source in Q2237+0305 ?

Microlensing in Q2237+0305 between 1985 and 1995 (eg. Irwin et al. 1989; Corrigan et al. 1991; Ostensen et al. 1996) has been interpreted in two different ways; as microlensing by stellar mass objects of a continuum source having dimensions significantly smaller than the microlens Einstein radius (ER) (eg. Wambsganss, Paczynski & Schneider 1990; Rauch & Blandford 1991), and as microlensing by very low mass objects of a source as large as 5 ER (Refsdal & Stabell 1993; Haugan 1996). In this paper we present evidence in favour of a small source. Limits on the source size (in units of ER) are obtained from the combination of limits on the number of microlens Einstein radii crossed by the source during the monitoring period with two separate light-curve features. Firstly, recently published monitoring data (Wozniak et al. 2000; OGLE web page) show large variations (~0.8-1.5 magnitudes) between image brightnesses over a period of 700 days or ~15% of the monitoring period. Secondly, the 1988 peak in the image A light-curve had a duration that is a small fraction (<0.02) of the monitoring period. Such rapid microlensing rises and short microlensing peaks only occur for small sources. We find that the observed large-rapid variation limits the source size to be <0.2 ER (95% confidence). The width of the light-curve peak provides a stronger constraint of <0.02 ER (99% confidence). The Einstein radius (projected into the source plane) of the average microlens mass (m) in Q2237+0305 is ER ~ 10^{17}\sqrt{m} cm. The interpretation that stars are responsible for microlensing in Q2237+0305 therefore results in limits on the continuum source size that are consistent with current accretion disc theory.Comment: 8 pages, 3 figures, accepted for publication in M.N.R.A.

Canonical formulation of self-gravitating spinning-object systems

Based on the Arnowitt-Deser-Misner (ADM) canonical formulation of general relativity, a canonical formulation of gravitationally interacting classical spinning-object systems is given to linear order in spin. The constructed position, linear momentum and spin variables fulfill standard Poisson bracket relations. A spatially symmetric time gauge for the tetrad field is introduced. The achieved formulation is of fully reduced form without unresolved constraints, supplementary, gauge, or coordinate conditions. The canonical field momentum is not related to the extrinsic curvature of spacelike hypersurfaces in standard ADM form. A new reduction of the tetrad degrees of freedom to the Einstein form of the metric field is suggested.Comment: 6 pages. v2: extended version; identical to the published one. v3: corrected misprints in (24) and (39); improved notation; added note regarding a further reference